ENSG00000072786

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000176763 ENSG00000072786 HEK293_OSMI2_2hA HEK293_TMG_2hB STK10 protein_coding protein_coding 15.77487 22.90203 11.20202 1.041207 0.4528055 -1.031059 2.4333687 3.792564 2.0206299 0.4235900 0.01462392 -0.9050450 0.15728750 0.1678333 0.18100000 0.01316667 0.873621452 0.005978621 FALSE TRUE
ENST00000517360 ENSG00000072786 HEK293_OSMI2_2hA HEK293_TMG_2hB STK10 protein_coding retained_intron 15.77487 22.90203 11.20202 1.041207 0.4528055 -1.031059 4.3617874 8.134085 1.9361920 0.8034724 0.30313097 -2.0650985 0.23786667 0.3560000 0.17276667 -0.18323333 0.005978621 0.005978621 FALSE FALSE
MSTRG.27299.2 ENSG00000072786 HEK293_OSMI2_2hA HEK293_TMG_2hB STK10 protein_coding   15.77487 22.90203 11.20202 1.041207 0.4528055 -1.031059 1.8692645 2.384364 1.0087894 0.1244493 0.50440002 -1.2327869 0.13738333 0.1044000 0.09256667 -0.01183333 0.845076338 0.005978621 FALSE TRUE
MSTRG.27299.4 ENSG00000072786 HEK293_OSMI2_2hA HEK293_TMG_2hB STK10 protein_coding   15.77487 22.90203 11.20202 1.041207 0.4528055 -1.031059 5.5058986 7.288522 4.5385974 1.2408218 0.83946304 -0.6821826 0.35043333 0.3145667 0.40023333 0.08566667 0.629495069 0.005978621 TRUE TRUE
MSTRG.27299.8 ENSG00000072786 HEK293_OSMI2_2hA HEK293_TMG_2hB STK10 protein_coding   15.77487 22.90203 11.20202 1.041207 0.4528055 -1.031059 0.5277933 0.120199 0.6950524 0.1201990 0.34779525 2.4370116 0.04022083 0.0051000 0.06343333 0.05833333 0.399161578 0.005978621 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000072786 E001 61.4589050 0.0169968946 9.601108e-01 9.789089e-01 5 172042079 172043110 1032 - 1.736 1.761 0.082
ENSG00000072786 E002 86.6810276 0.0110788523 5.208090e-02 1.128610e-01 5 172043111 172043737 627 - 1.783 1.936 0.515
ENSG00000072786 E003 108.4209041 0.0095128381 7.058162e-04 2.919728e-03 5 172043738 172043831 94 - 1.816 2.048 0.779
ENSG00000072786 E004 422.6021164 0.0090757662 1.909890e-05 1.190285e-04 5 172043832 172044580 749 - 2.408 2.633 0.750
ENSG00000072786 E005 118.0096776 0.0003852118 9.949951e-05 5.195239e-04 5 172044581 172044667 87 - 1.901 2.069 0.563
ENSG00000072786 E006 65.6674941 0.0003859312 3.613095e-03 1.204685e-02 5 172044668 172044685 18 - 1.654 1.819 0.559
ENSG00000072786 E007 210.1432803 0.0005732522 9.173125e-03 2.671639e-02 5 172044686 172045022 337 - 2.204 2.300 0.319
ENSG00000072786 E008 0.1817044 0.0401045861 1.000000e+00   5 172045426 172045480 55 - 0.000 0.088 9.785
ENSG00000072786 E009 103.1868671 0.0020880457 4.752009e-01 6.139336e-01 5 172052929 172053042 114 - 1.928 1.981 0.175
ENSG00000072786 E010 0.0000000       5 172053043 172053200 158 -      
ENSG00000072786 E011 108.3608983 0.0032875815 2.786254e-02 6.774484e-02 5 172054569 172054694 126 - 1.898 2.022 0.416
ENSG00000072786 E012 120.9630104 0.0011135675 9.612676e-03 2.781058e-02 5 172055588 172055721 134 - 1.947 2.068 0.406
ENSG00000072786 E013 76.5888507 0.0007994360 7.960599e-01 8.698001e-01 5 172055722 172055776 55 - 1.819 1.850 0.106
ENSG00000072786 E014 0.7404218 0.5376412028 9.046528e-01 9.432964e-01 5 172057012 172057348 337 - 0.168 0.263 0.813
ENSG00000072786 E015 109.8016579 0.0003587738 4.673088e-01 6.068121e-01 5 172057349 172057463 115 - 1.961 2.008 0.158
ENSG00000072786 E016 65.7108882 0.0003894853 5.609091e-01 6.888178e-01 5 172057464 172057473 10 - 1.783 1.775 -0.026
ENSG00000072786 E017 128.9918334 0.0002355929 8.378699e-01 8.986336e-01 5 172061139 172061268 130 - 2.047 2.074 0.090
ENSG00000072786 E018 2.6246064 0.1419894873 1.580445e-01 2.725259e-01 5 172061269 172061533 265 - 0.721 0.438 -1.292
ENSG00000072786 E019 0.5944058 0.3518128117 9.071832e-01 9.450558e-01 5 172061534 172061630 97 - 0.169 0.166 -0.024
ENSG00000072786 E020 0.8157519 0.0160270793 1.891324e-01 3.126450e-01 5 172063463 172063600 138 - 0.384 0.161 -1.667
ENSG00000072786 E021 1.5425694 0.0508507114 8.897497e-01 9.335321e-01 5 172064365 172064719 355 - 0.384 0.370 -0.078
ENSG00000072786 E022 88.3173755 0.0003113493 2.122143e-01 3.411368e-01 5 172064720 172064812 93 - 1.849 1.921 0.242
ENSG00000072786 E023 109.5714407 0.0003248281 6.260196e-01 7.420276e-01 5 172082326 172082505 180 - 1.994 1.996 0.007
ENSG00000072786 E024 97.8997297 0.0002836996 4.850915e-02 1.065239e-01 5 172082961 172083084 124 - 1.987 1.932 -0.185
ENSG00000072786 E025 104.7680505 0.0003026443 3.344244e-01 4.781743e-01 5 172090232 172090362 131 - 1.989 1.973 -0.054
ENSG00000072786 E026 5.4339957 0.0036665355 6.965475e-01 7.968624e-01 5 172092428 172092912 485 - 0.793 0.756 -0.148
ENSG00000072786 E027 150.7743634 0.0002787006 2.955546e-01 4.366796e-01 5 172093412 172093696 285 - 2.142 2.130 -0.042
ENSG00000072786 E028 142.9381811 0.0002443118 1.944558e-01 3.193428e-01 5 172093697 172093960 264 - 2.126 2.104 -0.071
ENSG00000072786 E029 39.6156514 0.0006067626 3.540566e-01 4.983318e-01 5 172096426 172096437 12 - 1.502 1.579 0.263
ENSG00000072786 E030 78.8800020 0.0003676711 6.188819e-01 7.364245e-01 5 172096438 172096560 123 - 1.855 1.853 -0.006
ENSG00000072786 E031 0.0000000       5 172105571 172105655 85 -      
ENSG00000072786 E032 33.4822618 0.0006410975 3.605965e-02 8.369958e-02 5 172105656 172105657 2 - 1.568 1.455 -0.387
ENSG00000072786 E033 59.7760644 0.0034216982 1.612361e-03 6.000056e-03 5 172105658 172105737 80 - 1.837 1.685 -0.513
ENSG00000072786 E034 54.8600049 0.0009749926 1.867901e-05 1.166727e-04 5 172106620 172106661 42 - 1.828 1.632 -0.662
ENSG00000072786 E035 57.4117608 0.0004988898 2.359180e-06 1.806254e-05 5 172106662 172106709 48 - 1.855 1.648 -0.700
ENSG00000072786 E036 74.4927204 0.0015809433 1.329066e-06 1.075005e-05 5 172106710 172106802 93 - 1.961 1.761 -0.672
ENSG00000072786 E037 45.1376965 0.0008278363 2.044035e-04 9.828831e-04 5 172106803 172106814 12 - 1.736 1.553 -0.625
ENSG00000072786 E038 0.2966881 0.0276863928 5.985561e-02   5 172106815 172106815 1 - 0.289 0.000 -13.223
ENSG00000072786 E039 0.3729606 0.0349448135 5.626207e-01 6.901860e-01 5 172106816 172107034 219 - 0.168 0.088 -1.079
ENSG00000072786 E040 0.2214452 0.0402270686 1.000000e+00   5 172107035 172107073 39 - 0.000 0.088 9.788
ENSG00000072786 E041 59.3816902 0.0005475237 1.653148e-05 1.044887e-04 5 172107780 172107852 73 - 1.855 1.669 -0.628
ENSG00000072786 E042 0.1817044 0.0401045861 1.000000e+00   5 172107853 172108288 436 - 0.000 0.088 9.785
ENSG00000072786 E043 0.0000000       5 172114597 172114800 204 -      
ENSG00000072786 E044 0.1472490 0.0426767662 2.208424e-01   5 172114996 172115144 149 - 0.168 0.000 -12.223
ENSG00000072786 E045 107.6728402 0.0004332106 6.593460e-05 3.604938e-04 5 172117481 172117630 150 - 2.073 1.949 -0.417
ENSG00000072786 E046 65.4811178 0.0004445499 7.918139e-04 3.230050e-03 5 172127373 172127421 49 - 1.866 1.733 -0.450
ENSG00000072786 E047 102.5140701 0.0093983414 1.835092e-03 6.711571e-03 5 172156624 172156788 165 - 2.075 1.918 -0.527
ENSG00000072786 E048 73.5903658 0.0084947435 1.194316e-03 4.621505e-03 5 172187887 172188077 191 - 1.945 1.770 -0.588
ENSG00000072786 E049 31.2547049 0.0012630844 1.956335e-02 5.054784e-02 5 172188078 172188185 108 - 1.551 1.416 -0.463
ENSG00000072786 E050 10.3106471 0.0017316459 1.791224e-01 3.000451e-01 5 172188186 172188255 70 - 1.092 0.967 -0.457