ENSG00000072682

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000166534 ENSG00000072682 HEK293_OSMI2_2hA HEK293_TMG_2hB P4HA2 protein_coding protein_coding 13.78995 16.48308 11.51462 0.6429624 0.03420206 -0.5171411 3.481816 4.810501 3.047978 0.1827508 0.31075674 -0.6566049 0.2540833 0.2936333 0.2645333 -0.0291000 0.78910220 0.02119659 FALSE  
ENST00000360568 ENSG00000072682 HEK293_OSMI2_2hA HEK293_TMG_2hB P4HA2 protein_coding protein_coding 13.78995 16.48308 11.51462 0.6429624 0.03420206 -0.5171411 1.730610 1.875055 2.050018 0.1265877 0.06828576 0.1280505 0.1278583 0.1139000 0.1780000 0.0641000 0.02119659 0.02119659 FALSE  
ENST00000379086 ENSG00000072682 HEK293_OSMI2_2hA HEK293_TMG_2hB P4HA2 protein_coding protein_coding 13.78995 16.48308 11.51462 0.6429624 0.03420206 -0.5171411 4.384449 6.837955 1.593936 1.0574271 1.59393552 -2.0940571 0.3007792 0.4194333 0.1376333 -0.2818000 0.12231833 0.02119659 FALSE  
MSTRG.26890.8 ENSG00000072682 HEK293_OSMI2_2hA HEK293_TMG_2hB P4HA2 protein_coding   13.78995 16.48308 11.51462 0.6429624 0.03420206 -0.5171411 2.886550 1.615735 3.639434 1.6157351 1.85872213 1.1665804 0.2248958 0.0924000 0.3170333 0.2246333 0.43569483 0.02119659 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000072682 E001 36.8315838 0.0105890183 1.680542e-01 0.2856701062 5 132190147 132191837 1691 - 1.619 1.527 -0.313
ENSG00000072682 E002 41.1125788 0.0016270938 2.910599e-03 0.0100017109 5 132191838 132192609 772 - 1.708 1.547 -0.550
ENSG00000072682 E003 8.8065044 0.0275890160 4.790523e-02 0.1054567504 5 132192610 132192612 3 - 1.128 0.880 -0.916
ENSG00000072682 E004 32.6582091 0.0238825726 8.220143e-01 0.8877779959 5 132192613 132192670 58 - 1.483 1.524 0.142
ENSG00000072682 E005 48.6086778 0.0135910859 1.332583e-02 0.0366789553 5 132192671 132192708 38 - 1.528 1.736 0.710
ENSG00000072682 E006 203.8088343 0.0030931653 3.268132e-05 0.0001926857 5 132192709 132192985 277 - 2.178 2.338 0.534
ENSG00000072682 E007 122.8515526 0.0041332490 2.310714e-04 0.0010961210 5 132192986 132193040 55 - 1.948 2.125 0.591
ENSG00000072682 E008 107.6109219 0.0010460139 7.211368e-06 0.0000494990 5 132193041 132193080 40 - 1.885 2.067 0.612
ENSG00000072682 E009 0.8072441 0.0160562257 3.962812e-01 0.5400716940 5 132193081 132193271 191 - 0.150 0.306 1.304
ENSG00000072682 E010 0.2934659 0.0293403048 7.172067e-01   5 132193392 132193568 177 - 0.150 0.099 -0.696
ENSG00000072682 E011 127.2289476 0.0043763869 3.374834e-02 0.0792507744 5 132194926 132195022 97 - 2.016 2.118 0.341
ENSG00000072682 E012 0.4815130 0.0205782127 8.844203e-01 0.9301296627 5 132195023 132195258 236 - 0.150 0.179 0.305
ENSG00000072682 E013 97.3195187 0.0008147073 3.058884e-01 0.4480273352 5 132195412 132195480 69 - 1.942 1.988 0.155
ENSG00000072682 E014 4.7240417 0.0695060437 5.843502e-01 0.7083159062 5 132195481 132195730 250 - 0.674 0.780 0.433
ENSG00000072682 E015 27.8822914 0.0007402180 6.076766e-01 0.7275965674 5 132198206 132198271 66 - 1.412 1.453 0.141
ENSG00000072682 E016 68.7281144 0.0003900237 8.369037e-01 0.8979998927 5 132198321 132198380 60 - 1.811 1.826 0.050
ENSG00000072682 E017 92.8765141 0.0003598694 3.759723e-01 0.5203481544 5 132198879 132198932 54 - 1.921 1.961 0.133
ENSG00000072682 E018 111.1407773 0.0002979305 5.630830e-01 0.6905921469 5 132203748 132203847 100 - 2.010 2.036 0.087
ENSG00000072682 E019 102.4796927 0.0003139480 8.873487e-01 0.9320091284 5 132204082 132204152 71 - 1.991 1.991 0.002
ENSG00000072682 E020 125.6144889 0.0002874699 8.058863e-01 0.8766033064 5 132207708 132207884 177 - 2.072 2.086 0.047
ENSG00000072682 E021 147.8174863 0.0002447193 7.680804e-01 0.8501432695 5 132209138 132209331 194 - 2.140 2.155 0.049
ENSG00000072682 E022 108.3384912 0.0002781959 5.494821e-01 0.6792053727 5 132210284 132210379 96 - 1.996 2.023 0.090
ENSG00000072682 E023 54.4216004 0.0005197220 9.283665e-01 0.9589291818 5 132210380 132210380 1 - 1.712 1.722 0.034
ENSG00000072682 E024 91.6446760 0.0004955579 2.434714e-01 0.3782560630 5 132210381 132210440 60 - 1.966 1.927 -0.132
ENSG00000072682 E025 82.5045216 0.0018547957 1.821200e-01 0.3038682007 5 132210441 132210489 49 - 1.930 1.876 -0.181
ENSG00000072682 E026 76.0133703 0.0018348650 1.270523e-01 0.2300352642 5 132210490 132210523 34 - 1.901 1.837 -0.217
ENSG00000072682 E027 62.6840315 0.0004309310 9.128634e-03 0.0266043996 5 132213916 132213923 8 - 1.848 1.736 -0.378
ENSG00000072682 E028 106.2969722 0.0003343230 7.141005e-04 0.0029492316 5 132213924 132214040 117 - 2.075 1.963 -0.376
ENSG00000072682 E029 49.6896006 0.0005043163 1.578477e-01 0.2722583757 5 132214041 132214053 13 - 1.722 1.656 -0.225
ENSG00000072682 E030 52.4700850 0.0004772118 2.357637e-01 0.3692830981 5 132217197 132217222 26 - 1.736 1.682 -0.181
ENSG00000072682 E031 113.1940097 0.0008184530 1.869649e-02 0.0486677929 5 132217223 132217348 126 - 2.081 2.003 -0.263
ENSG00000072682 E032 0.5106578 0.2767501317 9.240680e-01 0.9561678752 5 132217349 132217751 403 - 0.150 0.180 0.315
ENSG00000072682 E033 63.6957686 0.0005573238 1.337634e-02 0.0367939306 5 132217752 132217778 27 - 1.851 1.745 -0.359
ENSG00000072682 E034 87.5318255 0.0039458327 1.025289e-02 0.0293881268 5 132217779 132217848 70 - 1.996 1.877 -0.401
ENSG00000072682 E035 85.8846430 0.0087864175 4.720538e-02 0.1042006677 5 132218545 132218644 100 - 1.986 1.871 -0.387
ENSG00000072682 E036 0.9931898 0.1263418269 6.312730e-01 0.7463027135 5 132218645 132218668 24 - 0.350 0.248 -0.689
ENSG00000072682 E037 0.1515154 0.0436592068 3.054917e-01   5 132222045 132222091 47 - 0.150 0.000 -9.236
ENSG00000072682 E038 2.2079517 0.0150372645 5.608274e-01 0.6887398020 5 132226697 132226931 235 - 0.542 0.446 -0.469
ENSG00000072682 E039 3.3654562 0.0692219271 3.847736e-01 0.5289202046 5 132226932 132227085 154 - 0.712 0.554 -0.684
ENSG00000072682 E040 16.4283401 0.0220954432 4.216953e-01 0.5648310747 5 132227086 132227221 136 - 1.274 1.186 -0.310
ENSG00000072682 E041 3.4142960 0.0585886735 2.773587e-01 0.4169194405 5 132227222 132227258 37 - 0.744 0.552 -0.828
ENSG00000072682 E042 1.2940426 0.0105576690 9.851600e-01 0.9947329438 5 132227259 132227538 280 - 0.351 0.358 0.042
ENSG00000072682 E043 2.9119555 0.0053490252 5.736236e-01 0.6995533521 5 132227539 132227789 251 - 0.635 0.551 -0.373
ENSG00000072682 E044 47.1770519 0.0075988577 5.307436e-02 0.1146157093 5 132227790 132227857 68 - 1.735 1.611 -0.423
ENSG00000072682 E045 0.0000000       5 132228138 132228258 121 -      
ENSG00000072682 E046 0.5890081 0.0271973389 6.235759e-01 0.7401333644 5 132248907 132250956 2050 - 0.262 0.179 -0.698
ENSG00000072682 E047 0.0000000       5 132277209 132277341 133 -      
ENSG00000072682 E048 0.0000000       5 132277342 132277488 147 -      
ENSG00000072682 E049 0.0000000       5 132277489 132277600 112 -      
ENSG00000072682 E050 0.0000000       5 132277707 132277922 216 -      
ENSG00000072682 E051 0.0000000       5 132280782 132280954 173 -      
ENSG00000072682 E052 0.0000000       5 132295178 132295315 138 -