ENSG00000072518

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000350490 ENSG00000072518 HEK293_OSMI2_2hA HEK293_TMG_2hB MARK2 protein_coding protein_coding 31.06732 44.49397 24.14687 2.341161 1.294226 -0.8815008 2.2312450 3.5542643 2.2579340 0.9374484 1.1584747 -0.6522257 0.06927083 0.07826667 0.08890000 0.01063333 9.309929e-01 2.797731e-14 FALSE TRUE
ENST00000408948 ENSG00000072518 HEK293_OSMI2_2hA HEK293_TMG_2hB MARK2 protein_coding protein_coding 31.06732 44.49397 24.14687 2.341161 1.294226 -0.8815008 11.5665868 21.5936604 5.6847224 1.3181657 0.3124103 -1.9235784 0.34653333 0.48880000 0.23600000 -0.25280000 3.067831e-05 2.797731e-14 FALSE TRUE
ENST00000502399 ENSG00000072518 HEK293_OSMI2_2hA HEK293_TMG_2hB MARK2 protein_coding protein_coding 31.06732 44.49397 24.14687 2.341161 1.294226 -0.8815008 6.8764690 7.0435078 6.0534862 1.1955806 0.5831610 -0.2181934 0.22936667 0.15630000 0.24953333 0.09323333 7.779229e-02 2.797731e-14 FALSE TRUE
ENST00000508192 ENSG00000072518 HEK293_OSMI2_2hA HEK293_TMG_2hB MARK2 protein_coding protein_coding 31.06732 44.49397 24.14687 2.341161 1.294226 -0.8815008 1.5216124 0.5045292 2.0911210 0.5045292 1.3034240 2.0298344 0.05310833 0.01076667 0.09253333 0.08176667 4.515211e-01 2.797731e-14 FALSE TRUE
ENST00000513765 ENSG00000072518 HEK293_OSMI2_2hA HEK293_TMG_2hB MARK2 protein_coding protein_coding 31.06732 44.49397 24.14687 2.341161 1.294226 -0.8815008 2.9609278 6.7496399 0.3342101 0.8251269 0.3342101 -4.2955852 0.08392917 0.15206667 0.01326667 -0.13880000 3.394392e-02 2.797731e-14 FALSE TRUE
ENST00000543220 ENSG00000072518 HEK293_OSMI2_2hA HEK293_TMG_2hB MARK2 protein_coding protein_coding 31.06732 44.49397 24.14687 2.341161 1.294226 -0.8815008 1.6136449 0.0000000 3.2667378 0.0000000 1.0217238 8.3561164 0.06823750 0.00000000 0.13163333 0.13163333 2.797731e-14 2.797731e-14 FALSE FALSE
MSTRG.5647.6 ENSG00000072518 HEK293_OSMI2_2hA HEK293_TMG_2hB MARK2 protein_coding   31.06732 44.49397 24.14687 2.341161 1.294226 -0.8815008 0.8422413 0.0000000 2.0525124 0.0000000 0.5238461 7.6882590 0.03516667 0.00000000 0.08660000 0.08660000 2.954809e-12 2.797731e-14 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000072518 E001 2.2175156 0.0079531717 6.930578e-01 7.941362e-01 11 63838928 63839004 77 + 0.505 0.467 -0.186
ENSG00000072518 E002 4.2072563 0.0493487146 5.551546e-01 6.840346e-01 11 63839005 63839092 88 + 0.732 0.665 -0.277
ENSG00000072518 E003 4.7575557 0.0036205023 1.986623e-01 3.245151e-01 11 63839093 63839109 17 + 0.827 0.686 -0.565
ENSG00000072518 E004 11.9906581 0.0014488833 1.908935e-04 9.249865e-04 11 63839110 63839137 28 + 1.269 0.952 -1.141
ENSG00000072518 E005 31.9736904 0.0221488441 2.633905e-05 1.588103e-04 11 63839138 63839294 157 + 1.685 1.341 -1.183
ENSG00000072518 E006 47.3255230 0.0223514343 6.619940e-04 2.759661e-03 11 63839295 63839429 135 + 1.798 1.554 -0.830
ENSG00000072518 E007 48.4636729 0.0192576607 1.413210e-02 3.852428e-02 11 63839430 63839463 34 + 1.754 1.602 -0.516
ENSG00000072518 E008 116.8308568 0.0035008921 4.123848e-07 3.709466e-06 11 63839464 63839560 97 + 2.147 1.973 -0.581
ENSG00000072518 E009 0.6558305 0.0509827592 4.998204e-01 6.360847e-01 11 63849963 63850029 67 + 0.274 0.171 -0.862
ENSG00000072518 E010 0.0000000       11 63868470 63868909 440 +      
ENSG00000072518 E011 0.0000000       11 63869276 63869372 97 +      
ENSG00000072518 E012 1.0673860 0.0186475044 9.960464e-01 1.000000e+00 11 63880148 63880228 81 + 0.274 0.294 0.138
ENSG00000072518 E013 0.0000000       11 63888547 63888695 149 +      
ENSG00000072518 E014 0.0000000       11 63888696 63888964 269 +      
ENSG00000072518 E015 0.0000000       11 63890222 63890295 74 +      
ENSG00000072518 E016 104.8354604 0.0064911983 2.376258e-04 1.123471e-03 11 63895159 63895185 27 + 2.084 1.941 -0.480
ENSG00000072518 E017 190.8948659 0.0067584709 1.995434e-05 1.238140e-04 11 63895186 63895281 96 + 2.347 2.197 -0.501
ENSG00000072518 E018 182.9813358 0.0082763824 5.926541e-04 2.506732e-03 11 63895282 63895338 57 + 2.313 2.188 -0.415
ENSG00000072518 E019 197.4208375 0.0087041666 3.490298e-04 1.576338e-03 11 63895580 63895633 54 + 2.349 2.218 -0.438
ENSG00000072518 E020 0.4741261 0.0209391884 2.419826e-01 3.765298e-01 11 63895880 63895949 70 + 0.274 0.094 -1.864
ENSG00000072518 E021 2.2809915 0.0081111489 7.165232e-02 1.460955e-01 11 63895950 63898086 2137 + 0.654 0.389 -1.279
ENSG00000072518 E022 0.3289534 0.0294647788 6.093101e-01   11 63898087 63898231 145 + 0.158 0.094 -0.864
ENSG00000072518 E023 200.9866832 0.0059307927 1.973629e-04 9.525581e-04 11 63898232 63898280 49 + 2.347 2.230 -0.392
ENSG00000072518 E024 3.2149875 0.0343418406 2.556448e-02 6.304825e-02 11 63898281 63898607 327 + 0.798 0.467 -1.450
ENSG00000072518 E025 183.1045794 0.0040250465 2.771049e-03 9.586512e-03 11 63898608 63898659 52 + 2.277 2.205 -0.242
ENSG00000072518 E026 148.6052191 0.0065889496 3.742511e-02 8.626760e-02 11 63898660 63898673 14 + 2.174 2.121 -0.177
ENSG00000072518 E027 1.9059796 0.0308041498 5.537160e-01 6.828123e-01 11 63898674 63898762 89 + 0.504 0.428 -0.384
ENSG00000072518 E028 213.0449214 0.0054631522 1.205285e-01 2.207163e-01 11 63898763 63898833 71 + 2.307 2.290 -0.057
ENSG00000072518 E029 1.1361975 0.1216658359 8.224666e-01 8.880709e-01 11 63898834 63899051 218 + 0.274 0.342 0.446
ENSG00000072518 E030 177.6926280 0.0018431858 1.320547e-01 2.369720e-01 11 63899052 63899108 57 + 2.220 2.214 -0.022
ENSG00000072518 E031 1.6627514 0.0212995229 1.576953e-01 2.720575e-01 11 63899109 63899873 765 + 0.560 0.342 -1.134
ENSG00000072518 E032 385.2704623 0.0007440790 7.709783e-04 3.153680e-03 11 63899874 63900110 237 + 2.570 2.540 -0.099
ENSG00000072518 E033 3.1174956 0.0652339387 9.972139e-02 1.900512e-01 11 63900111 63900558 448 + 0.765 0.498 -1.166
ENSG00000072518 E034 334.1143848 0.0001411354 1.036195e-04 5.387048e-04 11 63900559 63900678 120 + 2.514 2.478 -0.118
ENSG00000072518 E035 285.2389040 0.0009789534 2.721284e-01 4.109814e-01 11 63900780 63900879 100 + 2.411 2.427 0.055
ENSG00000072518 E036 264.1826789 0.0007215727 6.061120e-01 7.263475e-01 11 63900957 63901069 113 + 2.366 2.398 0.106
ENSG00000072518 E037 245.5196272 0.0002234773 7.071405e-01 8.051352e-01 11 63902198 63902330 133 + 2.329 2.364 0.116
ENSG00000072518 E038 13.1054222 0.0020866271 2.312835e-01 3.640118e-01 11 63902601 63902603 3 + 0.990 1.155 0.597
ENSG00000072518 E039 182.6377600 0.0011549003 7.369307e-01 8.272409e-01 11 63902604 63902686 83 + 2.187 2.242 0.186
ENSG00000072518 E040 176.3038993 0.0008587985 3.802113e-01 5.245060e-01 11 63902687 63902782 96 + 2.160 2.233 0.242
ENSG00000072518 E041 183.1703997 0.0002344043 3.458880e-01 4.900293e-01 11 63903061 63903132 72 + 2.181 2.252 0.238
ENSG00000072518 E042 125.1933713 0.0002470376 3.491058e-01 4.933318e-01 11 63903133 63903158 26 + 2.012 2.088 0.255
ENSG00000072518 E043 1.5457785 0.0091830686 4.887867e-01 6.263049e-01 11 63903159 63903403 245 + 0.440 0.344 -0.541
ENSG00000072518 E044 79.4586232 0.0021628688 2.327188e-01 3.656743e-01 11 63903986 63904097 112 + 1.799 1.900 0.342
ENSG00000072518 E045 53.8566374 0.0014399132 3.334913e-01 4.772183e-01 11 63904098 63904147 50 + 1.635 1.731 0.327
ENSG00000072518 E046 1.0382558 0.2827476652 2.717798e-01 4.105662e-01 11 63904148 63904354 207 + 0.441 0.229 -1.337
ENSG00000072518 E047 419.5536051 0.0004098236 3.861884e-01 5.303768e-01 11 63904786 63905043 258 + 2.543 2.605 0.209
ENSG00000072518 E048 18.1898408 0.0010386871 5.164601e-01 6.510332e-01 11 63906088 63906114 27 + 1.178 1.275 0.346
ENSG00000072518 E049 29.5817148 0.0040356356 1.923895e-05 1.198028e-04 11 63906115 63907567 1453 + 1.608 1.352 -0.878
ENSG00000072518 E050 222.7358681 0.0002281437 4.787643e-01 6.171905e-01 11 63908260 63908304 45 + 2.267 2.330 0.210
ENSG00000072518 E051 2119.7700123 0.0074473056 7.312502e-09 9.237391e-08 11 63908877 63911020 2144 + 3.119 3.354 0.783