ENSG00000072501

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000322213 ENSG00000072501 HEK293_OSMI2_2hA HEK293_TMG_2hB SMC1A protein_coding protein_coding 113.1318 72.52362 156.5285 6.240629 0.9225413 1.109796 17.595632 17.131339 22.464288 2.640841 1.3375278 0.3907956 0.16876667 0.2340000 0.14356667 -0.09043333 4.247470e-03 8.530921e-47 FALSE TRUE
ENST00000470241 ENSG00000072501 HEK293_OSMI2_2hA HEK293_TMG_2hB SMC1A protein_coding protein_coding 113.1318 72.52362 156.5285 6.240629 0.9225413 1.109796 3.008697 5.328382 1.794663 1.462204 1.1552421 -1.5646733 0.03210417 0.0719000 0.01146667 -0.06043333 2.631939e-01 8.530921e-47 FALSE TRUE
ENST00000675504 ENSG00000072501 HEK293_OSMI2_2hA HEK293_TMG_2hB SMC1A protein_coding protein_coding 113.1318 72.52362 156.5285 6.240629 0.9225413 1.109796 9.095770 13.079684 5.314389 2.339415 1.1157637 -1.2977424 0.10310000 0.1854333 0.03386667 -0.15156667 1.089428e-04 8.530921e-47 FALSE TRUE
MSTRG.34295.10 ENSG00000072501 HEK293_OSMI2_2hA HEK293_TMG_2hB SMC1A protein_coding   113.1318 72.52362 156.5285 6.240629 0.9225413 1.109796 4.009398 0.000000 11.937094 0.000000 1.4033390 10.2224441 0.02630417 0.0000000 0.07626667 0.07626667 2.168914e-34 8.530921e-47 FALSE TRUE
MSTRG.34295.11 ENSG00000072501 HEK293_OSMI2_2hA HEK293_TMG_2hB SMC1A protein_coding   113.1318 72.52362 156.5285 6.240629 0.9225413 1.109796 5.627271 0.000000 9.924055 0.000000 1.5921600 9.9562389 0.03920833 0.0000000 0.06336667 0.06336667 2.949948e-26 8.530921e-47 FALSE TRUE
MSTRG.34295.4 ENSG00000072501 HEK293_OSMI2_2hA HEK293_TMG_2hB SMC1A protein_coding   113.1318 72.52362 156.5285 6.240629 0.9225413 1.109796 54.662546 34.429796 71.760032 4.667210 0.9634097 1.0593049 0.48592917 0.4718000 0.45840000 -0.01340000 9.180418e-01 8.530921e-47 FALSE TRUE
MSTRG.34295.9 ENSG00000072501 HEK293_OSMI2_2hA HEK293_TMG_2hB SMC1A protein_coding   113.1318 72.52362 156.5285 6.240629 0.9225413 1.109796 12.021427 0.000000 21.535849 0.000000 2.0005427 11.0731942 0.08208333 0.0000000 0.13766667 0.13766667 8.530921e-47 8.530921e-47 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000072501 E001 2847.821136 5.161936e-03 9.448274e-27 1.191709e-24 X 53374149 53378563 4415 - 3.231 3.649 1.389
ENSG00000072501 E002 5656.100010 2.425393e-03 2.064093e-17 9.674325e-16 X 53378564 53380053 1490 - 3.635 3.869 0.777
ENSG00000072501 E003 1103.546535 6.578724e-04 1.303476e-03 4.988577e-03 X 53380054 53380182 129 - 2.986 3.098 0.371
ENSG00000072501 E004 453.945181 2.071235e-04 7.876192e-02 1.575285e-01 X 53380183 53380186 4 - 2.611 2.702 0.302
ENSG00000072501 E005 939.240227 2.680604e-04 6.885167e-02 1.414692e-01 X 53380620 53380730 111 - 2.928 3.013 0.282
ENSG00000072501 E006 748.471924 6.303323e-04 7.245761e-01 8.180596e-01 X 53381018 53381087 70 - 2.837 2.903 0.219
ENSG00000072501 E007 26.381155 1.495185e-03 1.920606e-01 3.163306e-01 X 53381678 53382231 554 - 1.437 1.400 -0.125
ENSG00000072501 E008 1063.750287 9.113255e-04 3.897599e-01 5.338185e-01 X 53382232 53382383 152 - 2.999 3.044 0.148
ENSG00000072501 E009 1099.562088 7.571352e-05 6.693317e-01 7.761604e-01 X 53382506 53382660 155 - 3.010 3.064 0.180
ENSG00000072501 E010 1100.979541 7.147201e-05 6.351335e-01 7.494852e-01 X 53383097 53383253 157 - 3.006 3.070 0.214
ENSG00000072501 E011 851.808104 8.242660e-05 2.234135e-01 3.544690e-01 X 53394778 53394888 111 - 2.903 2.946 0.144
ENSG00000072501 E012 1163.001101 2.962576e-04 3.105724e-02 7.402557e-02 X 53396227 53396380 154 - 3.043 3.073 0.100
ENSG00000072501 E013 1161.830069 2.288763e-04 4.424807e-07 3.955766e-06 X 53396472 53396614 143 - 3.057 3.051 -0.019
ENSG00000072501 E014 518.010353 6.661157e-04 9.160471e-06 6.142658e-05 X 53396615 53396617 3 - 2.717 2.685 -0.106
ENSG00000072501 E015 1042.751008 1.207767e-03 7.619696e-04 3.121818e-03 X 53399589 53399730 142 - 3.011 3.002 -0.031
ENSG00000072501 E016 7.191870 9.152048e-03 5.858495e-02 1.242026e-01 X 53402287 53402379 93 - 0.969 0.772 -0.757
ENSG00000072501 E017 938.408783 3.575163e-04 3.619647e-10 5.812267e-09 X 53403566 53403672 107 - 2.975 2.940 -0.116
ENSG00000072501 E018 888.905844 1.193739e-04 4.391138e-19 2.525464e-17 X 53403777 53403893 117 - 2.960 2.901 -0.198
ENSG00000072501 E019 5.401274 3.540665e-03 2.569009e-01 3.939192e-01 X 53404799 53405011 213 - 0.841 0.737 -0.409
ENSG00000072501 E020 929.043238 1.783421e-03 8.650627e-07 7.284027e-06 X 53405012 53405149 138 - 2.979 2.921 -0.194
ENSG00000072501 E021 778.332730 1.674185e-03 1.119098e-06 9.196627e-06 X 53405245 53405391 147 - 2.902 2.844 -0.192
ENSG00000072501 E022 824.300944 1.472339e-03 3.575519e-08 3.964481e-07 X 53405493 53405672 180 - 2.930 2.864 -0.221
ENSG00000072501 E023 776.423997 1.123398e-04 2.999764e-19 1.757799e-17 X 53405771 53405956 186 - 2.905 2.838 -0.221
ENSG00000072501 E024 805.531653 2.758606e-03 2.137681e-05 1.316340e-04 X 53409062 53409269 208 - 2.919 2.857 -0.207
ENSG00000072501 E025 649.342708 4.890392e-03 1.460498e-04 7.301409e-04 X 53409421 53409503 83 - 2.832 2.752 -0.268
ENSG00000072501 E026 849.545736 2.140993e-03 7.677572e-07 6.538222e-06 X 53411761 53411901 141 - 2.945 2.875 -0.231
ENSG00000072501 E027 1318.506807 1.263257e-03 6.086652e-13 1.547159e-11 X 53411995 53412253 259 - 3.141 3.057 -0.278
ENSG00000072501 E028 1078.151548 1.096410e-03 1.448472e-18 7.822369e-17 X 53412900 53413138 239 - 3.063 2.950 -0.378
ENSG00000072501 E029 838.536685 1.791236e-03 5.717833e-24 5.662448e-22 X 53413232 53413435 204 - 2.978 2.789 -0.626
ENSG00000072501 E030 569.418723 8.640748e-04 2.131705e-47 1.134396e-44 X 53414758 53414870 113 - 2.829 2.573 -0.853
ENSG00000072501 E031 694.360824 3.014321e-03 5.165462e-20 3.284932e-18 X 53414981 53415169 189 - 2.905 2.683 -0.740
ENSG00000072501 E032 17.309845 4.169653e-03 7.909811e-06 5.378450e-05 X 53421895 53422013 119 - 1.358 0.978 -1.359
ENSG00000072501 E033 14.921342 1.200219e-01 2.002230e-02 5.153686e-02 X 53422014 53422040 27 - 1.295 0.930 -1.318
ENSG00000072501 E034 12.585515 1.172045e-01 6.108561e-02 1.284618e-01 X 53422041 53422194 154 - 1.202 0.931 -0.985
ENSG00000072501 E035 473.495969 8.608232e-03 8.440614e-09 1.054573e-07 X 53422492 53423150 659 - 2.739 2.517 -0.740