ENSG00000072422

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000337910 ENSG00000072422 HEK293_OSMI2_2hA HEK293_TMG_2hB RHOBTB1 protein_coding protein_coding 2.257205 1.379309 3.095433 0.1249577 0.1588728 1.160427 1.1716802 0.63678203 2.38181479 0.42610014 0.13939342 1.886754 0.50236667 0.4276667 0.77523333 0.3475667 0.64442150 0.00133674 FALSE TRUE
ENST00000357917 ENSG00000072422 HEK293_OSMI2_2hA HEK293_TMG_2hB RHOBTB1 protein_coding protein_coding 2.257205 1.379309 3.095433 0.1249577 0.1588728 1.160427 0.7768850 0.71488914 0.06637659 0.35906640 0.06637659 -3.246558 0.38484167 0.5540333 0.01993333 -0.5341000 0.39605069 0.00133674 FALSE TRUE
MSTRG.4023.3 ENSG00000072422 HEK293_OSMI2_2hA HEK293_TMG_2hB RHOBTB1 protein_coding   2.257205 1.379309 3.095433 0.1249577 0.1588728 1.160427 0.1597712 0.02763765 0.59995551 0.01522024 0.13656644 4.018456 0.05471667 0.0183000 0.19063333 0.1723333 0.00133674 0.00133674 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000072422 E001 15.8420423 0.0012011001 5.423621e-04 2.318498e-03 10 60869438 60869673 236 - 1.087 1.373 1.010
ENSG00000072422 E002 26.6044510 0.0007649445 6.629022e-04 2.762839e-03 10 60869674 60869794 121 - 1.334 1.554 0.759
ENSG00000072422 E003 33.9677676 0.0007076118 2.933882e-07 2.720983e-06 10 60869795 60869998 204 - 1.396 1.690 1.007
ENSG00000072422 E004 37.4602030 0.0005921724 4.268334e-08 4.669533e-07 10 60869999 60870461 463 - 1.442 1.739 1.013
ENSG00000072422 E005 50.8684781 0.0005350833 1.077590e-01 2.022251e-01 10 60870462 60871069 608 - 1.675 1.750 0.253
ENSG00000072422 E006 15.9982206 0.0012204699 2.930605e-01 4.340949e-01 10 60871070 60871173 104 - 1.184 1.271 0.307
ENSG00000072422 E007 4.5886255 0.0049212814 1.797201e-01 3.008095e-01 10 60871174 60871177 4 - 0.654 0.838 0.746
ENSG00000072422 E008 15.1130053 0.0012591234 4.247585e-01 5.677001e-01 10 60871178 60871325 148 - 1.170 1.238 0.239
ENSG00000072422 E009 14.3157692 0.0012285803 2.387008e-01 3.726445e-01 10 60871326 60871443 118 - 1.216 1.106 -0.392
ENSG00000072422 E010 8.0007155 0.0021164255 3.471542e-02 8.110311e-02 10 60871444 60871471 28 - 1.034 0.776 -0.982
ENSG00000072422 E011 21.6335080 0.0009839650 2.060713e-01 3.337716e-01 10 60871472 60871651 180 - 1.387 1.291 -0.336
ENSG00000072422 E012 0.4396707 0.0337799054 2.531109e-01 3.895802e-01 10 60871652 60871667 16 - 0.231 0.000 -9.534
ENSG00000072422 E013 0.5964967 0.0207607160 7.118330e-01 8.087088e-01 10 60872043 60872184 142 - 0.231 0.162 -0.635
ENSG00000072422 E014 12.3796987 0.0016428632 1.594068e-01 2.743231e-01 10 60872185 60872290 106 - 1.163 1.021 -0.514
ENSG00000072422 E015 14.0726260 0.0083196340 4.582606e-01 5.985996e-01 10 60874954 60875042 89 - 1.197 1.121 -0.272
ENSG00000072422 E016 0.0000000       10 60875043 60875043 1 -      
ENSG00000072422 E017 0.0000000       10 60877118 60877183 66 -      
ENSG00000072422 E018 16.8851293 0.0025181838 5.905101e-01 7.133589e-01 10 60877908 60878058 151 - 1.263 1.214 -0.171
ENSG00000072422 E019 16.8367812 0.0011770591 5.784776e-01 7.035653e-01 10 60886112 60886230 119 - 1.263 1.214 -0.170
ENSG00000072422 E020 43.6332332 0.0005864882 4.728431e-01 6.118848e-01 10 60888212 60888848 637 - 1.655 1.616 -0.135
ENSG00000072422 E021 25.6431194 0.0019031063 7.628651e-03 2.284507e-02 10 60888849 60889185 337 - 1.481 1.281 -0.691
ENSG00000072422 E022 16.8692453 0.0011636747 1.176434e-03 4.561719e-03 10 60892810 60892995 186 - 1.334 1.040 -1.048
ENSG00000072422 E023 9.1678616 0.0019043365 9.418180e-04 3.760428e-03 10 60910887 60910957 71 - 1.112 0.705 -1.550
ENSG00000072422 E024 8.7282054 0.0019148856 4.905713e-04 2.124474e-03 10 60910958 60910990 33 - 1.104 0.665 -1.692
ENSG00000072422 E025 19.4984525 0.0011528102 1.576066e-05 1.000741e-04 10 60911351 60911552 202 - 1.416 1.039 -1.331
ENSG00000072422 E026 7.4715101 0.0022992352 1.386825e-03 5.263966e-03 10 60941804 60941854 51 - 1.044 0.620 -1.668
ENSG00000072422 E027 5.3938646 0.0031505989 1.616256e-03 6.012661e-03 10 60943971 60944185 215 - 0.929 0.449 -2.048
ENSG00000072422 E028 2.7128520 0.0157097677 1.101016e-01 2.056821e-01 10 60944650 60944869 220 - 0.654 0.372 -1.373
ENSG00000072422 E029 0.8200183 0.0171039921 7.811971e-01 8.594344e-01 10 60985845 60985945 101 - 0.231 0.280 0.367
ENSG00000072422 E030 0.8200183 0.0171039921 7.811971e-01 8.594344e-01 10 61001399 61001440 42 - 0.231 0.280 0.367