ENSG00000072364

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000265343 ENSG00000072364 HEK293_OSMI2_2hA HEK293_TMG_2hB AFF4 protein_coding protein_coding 8.842726 3.024805 15.43824 0.1453239 0.3698983 2.347766 8.0051830 3.016144442 13.4939908 0.144611860 0.3749508 2.157833 0.93040833 0.9971666667 0.87390000 -0.12326667 7.634310e-10 7.63431e-10 FALSE TRUE
MSTRG.26915.2 ENSG00000072364 HEK293_OSMI2_2hA HEK293_TMG_2hB AFF4 protein_coding   8.842726 3.024805 15.43824 0.1453239 0.3698983 2.347766 0.4172574 0.002820248 0.9142697 0.002820248 0.2432285 6.171818 0.02949167 0.0009333333 0.05956667 0.05863333 2.029851e-03 7.63431e-10 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000072364 E001 1303.9633141 0.0231186349 4.034723e-14 1.213472e-12 5 132875395 132881186 5792 - 2.791 3.365 1.906
ENSG00000072364 E002 79.1563953 0.0015464541 9.550023e-04 3.805046e-03 5 132883340 132883560 221 - 1.675 1.802 0.432
ENSG00000072364 E003 36.0006552 0.0005840341 2.122383e-02 5.406179e-02 5 132885076 132885119 44 - 1.343 1.471 0.442
ENSG00000072364 E004 53.6429046 0.0013029332 9.136616e-05 4.813684e-04 5 132886310 132886403 94 - 1.520 1.555 0.119
ENSG00000072364 E005 43.8328404 0.0018556552 1.022376e-04 5.323534e-04 5 132887521 132887592 72 - 1.440 1.439 -0.005
ENSG00000072364 E006 54.6825807 0.0004645781 3.007487e-05 1.789164e-04 5 132887846 132887982 137 - 1.531 1.555 0.084
ENSG00000072364 E007 51.5503313 0.0004838436 2.542679e-05 1.539085e-04 5 132888097 132888160 64 - 1.506 1.515 0.032
ENSG00000072364 E008 58.7055068 0.0020148668 2.888198e-05 1.725187e-04 5 132889079 132889173 95 - 1.560 1.580 0.068
ENSG00000072364 E009 1.4811368 0.0104922247 1.132569e-01 2.102771e-01 5 132891817 132892163 347 - 0.301 0.000 -19.270
ENSG00000072364 E010 94.7699617 0.0011508557 2.105723e-10 3.514119e-09 5 132892164 132892404 241 - 1.771 1.723 -0.163
ENSG00000072364 E011 59.7261205 0.0016869491 2.954818e-05 1.761260e-04 5 132893030 132893118 89 - 1.566 1.592 0.089
ENSG00000072364 E012 137.6807105 0.0002665318 1.041143e-13 2.952274e-12 5 132896323 132896810 488 - 1.928 1.911 -0.058
ENSG00000072364 E013 118.3856079 0.0003234412 4.799585e-11 8.940678e-10 5 132896811 132897203 393 - 1.862 1.863 0.003
ENSG00000072364 E014 35.2377361 0.0005780246 5.325924e-03 1.681945e-02 5 132897204 132897240 37 - 1.341 1.421 0.279
ENSG00000072364 E015 34.0324700 0.0009083007 1.546423e-03 5.785938e-03 5 132898230 132898282 53 - 1.331 1.366 0.121
ENSG00000072364 E016 39.5215000 0.0013053489 4.724514e-04 2.054741e-03 5 132898283 132898392 110 - 1.397 1.421 0.085
ENSG00000072364 E017 31.0216012 0.0006301913 4.009267e-04 1.778065e-03 5 132899104 132899141 38 - 1.299 1.278 -0.074
ENSG00000072364 E018 39.2672280 0.0768092225 9.763196e-03 2.818064e-02 5 132899587 132899641 55 - 1.402 1.312 -0.315
ENSG00000072364 E019 0.2966881 0.0270137278 1.000000e+00   5 132900872 132901082 211 - 0.079 0.000 -16.950
ENSG00000072364 E020 37.9574279 0.0008189559 9.512108e-07 7.926282e-06 5 132902442 132902487 46 - 1.391 1.254 -0.481
ENSG00000072364 E021 0.2966881 0.0270137278 1.000000e+00   5 132903861 132904180 320 - 0.079 0.000 -16.950
ENSG00000072364 E022 33.0260606 0.0009430087 5.148635e-07 4.543053e-06 5 132904368 132904404 37 - 1.337 1.137 -0.707
ENSG00000072364 E023 0.2965864 0.1909396861 2.169033e-02   5 132926701 132927120 420 - 0.000 0.488 23.406
ENSG00000072364 E024 45.0489531 0.0004908972 1.913309e-09 2.689351e-08 5 132927121 132927207 87 - 1.469 1.253 -0.749
ENSG00000072364 E025 0.0000000       5 132927208 132927562 355 -      
ENSG00000072364 E026 32.2627851 0.0006328036 3.329402e-10 5.376738e-09 5 132932178 132932222 45 - 1.341 0.925 -1.499
ENSG00000072364 E027 116.0448293 0.0002461061 1.342956e-14 4.341622e-13 5 132934147 132934619 473 - 1.860 1.787 -0.246
ENSG00000072364 E028 79.5129275 0.0024085444 8.908552e-11 1.584991e-09 5 132934620 132934941 322 - 1.704 1.580 -0.421
ENSG00000072364 E029 46.0970195 0.0004578304 1.572081e-12 3.727951e-11 5 132937067 132937193 127 - 1.488 1.136 -1.228
ENSG00000072364 E030 4.7359578 0.0033267722 7.625754e-02 1.535183e-01 5 132937649 132937740 92 - 0.602 0.493 -0.506
ENSG00000072364 E031 49.9159076 0.0006133196 1.015097e-06 8.408339e-06 5 132963259 132963634 376 - 1.500 1.439 -0.212