ENSG00000072310

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000261646 ENSG00000072310 HEK293_OSMI2_2hA HEK293_TMG_2hB SREBF1 protein_coding protein_coding 23.11685 24.68268 19.92421 2.678907 1.480998 -0.3088372 2.7875612 4.5141461 1.601209 0.3533467 0.2050988 -1.4895022 0.12061250 0.1842000 0.07993333 -0.10426667 9.851602e-08 9.851602e-08 FALSE TRUE
ENST00000478616 ENSG00000072310 HEK293_OSMI2_2hA HEK293_TMG_2hB SREBF1 protein_coding protein_coding 23.11685 24.68268 19.92421 2.678907 1.480998 -0.3088372 1.3567742 0.9066949 1.205492 0.2480835 0.1105764 0.4070274 0.05887917 0.0355000 0.06086667 0.02536667 1.319515e-01 9.851602e-08 FALSE FALSE
ENST00000487401 ENSG00000072310 HEK293_OSMI2_2hA HEK293_TMG_2hB SREBF1 protein_coding retained_intron 23.11685 24.68268 19.92421 2.678907 1.480998 -0.3088372 0.7703021 0.0000000 1.296968 0.0000000 0.7837042 7.0300805 0.03608750 0.0000000 0.06440000 0.06440000 1.671574e-01 9.851602e-08 FALSE FALSE
ENST00000490796 ENSG00000072310 HEK293_OSMI2_2hA HEK293_TMG_2hB SREBF1 protein_coding retained_intron 23.11685 24.68268 19.92421 2.678907 1.480998 -0.3088372 3.2962149 3.8594916 2.464668 0.3538879 1.2649080 -0.6449091 0.13737083 0.1601667 0.12120000 -0.03896667 8.192315e-01 9.851602e-08 FALSE FALSE
ENST00000580540 ENSG00000072310 HEK293_OSMI2_2hA HEK293_TMG_2hB SREBF1 protein_coding retained_intron 23.11685 24.68268 19.92421 2.678907 1.480998 -0.3088372 1.5051482 0.6429403 1.790777 0.3781138 0.5285786 1.4635965 0.06718333 0.0237000 0.08753333 0.06383333 5.383052e-02 9.851602e-08 FALSE TRUE
ENST00000584760 ENSG00000072310 HEK293_OSMI2_2hA HEK293_TMG_2hB SREBF1 protein_coding retained_intron 23.11685 24.68268 19.92421 2.678907 1.480998 -0.3088372 1.2984312 0.7091842 1.216062 0.3993091 0.2244090 0.7695987 0.05651250 0.0263000 0.06280000 0.03650000 2.420564e-01 9.851602e-08 FALSE TRUE
ENST00000662439 ENSG00000072310 HEK293_OSMI2_2hA HEK293_TMG_2hB SREBF1 protein_coding retained_intron 23.11685 24.68268 19.92421 2.678907 1.480998 -0.3088372 4.1214098 6.7692166 1.966762 0.3654934 0.4041862 -1.7779797 0.17617917 0.2780000 0.10163333 -0.17636667 1.794059e-03 9.851602e-08 FALSE TRUE
MSTRG.13775.8 ENSG00000072310 HEK293_OSMI2_2hA HEK293_TMG_2hB SREBF1 protein_coding   23.11685 24.68268 19.92421 2.678907 1.480998 -0.3088372 2.4032429 2.5301231 3.806451 0.6630133 0.6108902 0.5873334 0.10340000 0.1027667 0.19126667 0.08850000 1.973152e-01 9.851602e-08 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000072310 E001 0.0000000       17 17810399 17810512 114 -      
ENSG00000072310 E002 0.0000000       17 17811012 17811333 322 -      
ENSG00000072310 E003 0.3299976 0.0274424043 4.588178e-01   17 17811334 17811355 22 - 0.000 0.164 9.529
ENSG00000072310 E004 11.5751261 0.0068782624 3.557046e-01 5.000532e-01 17 17811356 17811564 209 - 0.988 1.090 0.372
ENSG00000072310 E005 15.4470452 0.0020349617 3.983521e-01 5.420829e-01 17 17811565 17811616 52 - 1.112 1.191 0.283
ENSG00000072310 E006 20.0582285 0.0009401525 4.518543e-01 5.927654e-01 17 17811617 17811690 74 - 1.233 1.294 0.216
ENSG00000072310 E007 17.7291236 0.0022241506 7.271539e-02 1.478668e-01 17 17811691 17811730 40 - 1.096 1.263 0.593
ENSG00000072310 E008 21.3023853 0.0075404336 2.032216e-01 3.302571e-01 17 17811731 17811784 54 - 1.221 1.338 0.411
ENSG00000072310 E009 34.2479731 0.0079966565 1.242473e-02 3.455668e-02 17 17811785 17811972 188 - 1.354 1.557 0.698
ENSG00000072310 E010 21.9831178 0.0008800040 4.556510e-02 1.012310e-01 17 17811973 17812056 84 - 1.196 1.360 0.575
ENSG00000072310 E011 11.8104492 0.0014707155 2.479770e-01 3.835386e-01 17 17812057 17812072 16 - 0.967 1.090 0.450
ENSG00000072310 E012 304.8139378 0.0024402660 3.546291e-05 2.070367e-04 17 17812073 17812711 639 - 2.345 2.478 0.443
ENSG00000072310 E013 60.3543994 0.0004404802 9.557742e-01 9.762527e-01 17 17812712 17812824 113 - 1.742 1.738 -0.013
ENSG00000072310 E014 30.6585140 0.0006591513 6.065091e-01 7.266442e-01 17 17812825 17812851 27 - 1.427 1.461 0.117
ENSG00000072310 E015 15.7174841 0.0011156743 4.385628e-06 3.161748e-05 17 17812910 17813367 458 - 1.412 1.019 -1.392
ENSG00000072310 E016 70.1519988 0.0007440387 9.387835e-02 1.811946e-01 17 17813368 17813479 112 - 1.749 1.828 0.264
ENSG00000072310 E017 117.9026122 0.0002567991 1.266565e-04 6.441185e-04 17 17813569 17813769 201 - 1.925 2.065 0.468
ENSG00000072310 E018 93.8876903 0.0003362952 4.468077e-02 9.961678e-02 17 17814245 17814343 99 - 1.872 1.952 0.269
ENSG00000072310 E019 60.1455440 0.0007029258 2.721672e-01 4.110216e-01 17 17814344 17814402 59 - 1.700 1.755 0.184
ENSG00000072310 E020 40.9984065 0.0005676280 9.661352e-01 9.827401e-01 17 17814403 17814410 8 - 1.577 1.573 -0.013
ENSG00000072310 E021 6.5184117 0.0025638517 5.331168e-02 1.150464e-01 17 17814411 17814614 204 - 0.988 0.749 -0.921
ENSG00000072310 E022 34.7828404 0.0005990274 8.875013e-01 9.320763e-01 17 17814615 17814615 1 - 1.502 1.510 0.026
ENSG00000072310 E023 102.2451063 0.0002831351 4.063215e-02 9.218949e-02 17 17814616 17814747 132 - 1.911 1.989 0.261
ENSG00000072310 E024 3.3944756 0.0045752320 2.887310e-02 6.974629e-02 17 17814748 17814834 87 - 0.814 0.488 -1.411
ENSG00000072310 E025 90.3778460 0.0003479125 2.841483e-03 9.798863e-03 17 17814835 17814944 110 - 1.824 1.948 0.415
ENSG00000072310 E026 145.9397011 0.0002740774 6.580108e-01 7.672436e-01 17 17815221 17815329 109 - 2.113 2.126 0.043
ENSG00000072310 E027 3.2398622 0.0049388181 8.624345e-01 9.152949e-01 17 17815330 17815373 44 - 0.575 0.602 0.120
ENSG00000072310 E028 7.9969935 0.0472022932 6.550414e-03 2.005521e-02 17 17815597 17815859 263 - 1.143 0.754 -1.461
ENSG00000072310 E029 182.3566361 0.0018599237 3.791290e-01 5.234094e-01 17 17815860 17816028 169 - 2.237 2.209 -0.092
ENSG00000072310 E030 175.3047590 0.0019573466 8.314300e-01 8.943392e-01 17 17816207 17816373 167 - 2.191 2.202 0.035
ENSG00000072310 E031 1.2878016 0.0100671686 9.836083e-02 1.880245e-01 17 17816374 17816395 22 - 0.518 0.228 -1.732
ENSG00000072310 E032 93.9368511 0.0010044940 1.647917e-01 2.814133e-01 17 17816457 17816524 68 - 1.886 1.944 0.198
ENSG00000072310 E033 147.2209542 0.0028808567 3.967195e-01 5.404941e-01 17 17816525 17816718 194 - 2.096 2.134 0.129
ENSG00000072310 E034 133.9736398 0.0030335989 3.659148e-01 5.102336e-01 17 17816958 17817122 165 - 2.054 2.095 0.140
ENSG00000072310 E035 48.3317320 0.0004885165 2.716805e-01 4.104488e-01 17 17817123 17817136 14 - 1.603 1.662 0.203
ENSG00000072310 E036 9.0443359 0.0024099151 7.745981e-06 5.278038e-05 17 17817137 17817255 119 - 1.233 0.749 -1.801
ENSG00000072310 E037 123.4170232 0.0002799346 8.367061e-01 8.978682e-01 17 17817256 17817423 168 - 2.052 2.044 -0.027
ENSG00000072310 E038 67.2919465 0.0004120694 1.932943e-01 3.179121e-01 17 17817424 17817451 28 - 1.827 1.767 -0.204
ENSG00000072310 E039 53.6513206 0.0042731493 3.712214e-01 5.156490e-01 17 17817452 17817457 6 - 1.727 1.675 -0.176
ENSG00000072310 E040 3.7257223 0.0052022875 2.479418e-04 1.166596e-03 17 17817458 17817525 68 - 0.945 0.417 -2.276
ENSG00000072310 E041 3.0540103 0.0161531072 1.513139e-03 5.678790e-03 17 17817526 17817547 22 - 0.871 0.377 -2.221
ENSG00000072310 E042 6.6971133 0.0060079032 2.980990e-04 1.371793e-03 17 17817548 17817591 44 - 1.112 0.671 -1.696
ENSG00000072310 E043 8.2901068 0.0021680195 4.864165e-04 2.108217e-03 17 17817592 17817695 104 - 1.156 0.767 -1.460
ENSG00000072310 E044 182.7975976 0.0011308786 1.523797e-01 2.649183e-01 17 17817696 17817916 221 - 2.250 2.206 -0.148
ENSG00000072310 E045 3.3497258 0.0647692435 1.614347e-02 4.304792e-02 17 17817917 17818149 233 - 0.843 0.422 -1.861
ENSG00000072310 E046 1.0276452 0.0155109825 9.923172e-01 9.992798e-01 17 17818223 17818259 37 - 0.283 0.284 0.005
ENSG00000072310 E047 134.5354080 0.0004894961 2.502204e-01 3.861981e-01 17 17818260 17818374 115 - 2.114 2.075 -0.131
ENSG00000072310 E048 9.0594843 0.0020248837 1.225728e-02 3.415161e-02 17 17818375 17818742 368 - 1.142 0.872 -0.996
ENSG00000072310 E049 71.5012895 0.0003611806 4.125742e-01 5.561276e-01 17 17819013 17819026 14 - 1.842 1.804 -0.127
ENSG00000072310 E050 76.9255634 0.0003542476 9.737214e-01 9.876197e-01 17 17819027 17819071 45 - 1.848 1.845 -0.009
ENSG00000072310 E051 84.3425381 0.0004330712 6.787909e-01 7.831793e-01 17 17819072 17819120 49 - 1.875 1.891 0.054
ENSG00000072310 E052 107.6719126 0.0003233015 3.457764e-01 4.899095e-01 17 17819121 17819234 114 - 2.015 1.979 -0.119
ENSG00000072310 E053 112.0955926 0.0012780206 4.071279e-01 5.507376e-01 17 17819320 17819454 135 - 2.032 1.999 -0.109
ENSG00000072310 E054 49.4685595 0.0005059438 2.468042e-01 3.821896e-01 17 17819538 17819543 6 - 1.704 1.642 -0.211
ENSG00000072310 E055 75.4434768 0.0026661353 2.745828e-02 6.692426e-02 17 17819544 17819615 72 - 1.913 1.805 -0.363
ENSG00000072310 E056 50.8199875 0.0097265754 1.057251e-01 1.991955e-01 17 17819616 17819636 21 - 1.749 1.634 -0.391
ENSG00000072310 E057 72.5360562 0.0116857292 3.062140e-01 4.483759e-01 17 17819637 17819725 89 - 1.872 1.801 -0.240
ENSG00000072310 E058 2.1046994 0.0068734328 9.522769e-03 2.759430e-02 17 17819726 17820007 282 - 0.711 0.284 -2.165
ENSG00000072310 E059 0.8115992 0.0154786085 2.312951e-01 3.640259e-01 17 17820008 17820089 82 - 0.376 0.165 -1.580
ENSG00000072310 E060 96.9074807 0.0019572181 7.825530e-01 8.603919e-01 17 17820090 17820322 233 - 1.953 1.940 -0.041
ENSG00000072310 E061 53.7922539 0.0010010762 3.718809e-01 5.163640e-01 17 17820323 17820404 82 - 1.727 1.680 -0.162
ENSG00000072310 E062 60.8492250 0.0083317487 9.481010e-03 2.749053e-02 17 17820405 17820521 117 - 1.856 1.695 -0.545
ENSG00000072310 E063 1.1028855 0.0117833610 5.357826e-02 1.155117e-01 17 17820522 17820864 343 - 0.000 0.377 13.700
ENSG00000072310 E064 2.5765693 0.0156041610 2.628446e-01 4.006624e-01 17 17823518 17823607 90 - 0.376 0.576 1.004
ENSG00000072310 E065 1.1362967 0.0120988339 5.354555e-02 1.154569e-01 17 17823608 17823618 11 - 0.000 0.377 13.699
ENSG00000072310 E066 51.4222349 0.0077020673 2.667850e-06 2.019887e-05 17 17836727 17837187 461 - 1.867 1.567 -1.017