ENSG00000072274

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000360110 ENSG00000072274 HEK293_OSMI2_2hA HEK293_TMG_2hB TFRC protein_coding protein_coding 57.6344 15.01656 100.0523 2.094461 2.800848 2.735312 49.178749 10.571975 86.951171 0.8688618 0.9359055 3.038762 0.8035833 0.7215667 0.86996667 0.1484 0.2281268320 0.0002248572 FALSE TRUE
ENST00000420415 ENSG00000072274 HEK293_OSMI2_2hA HEK293_TMG_2hB TFRC protein_coding protein_coding 57.6344 15.01656 100.0523 2.094461 2.800848 2.735312 2.250527 3.641962 1.793611 1.9908072 0.2624678 -1.017784 0.0917375 0.2194667 0.01806667 -0.2014 0.0002248572 0.0002248572 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000072274 E001 1.4048617 0.0096136395 4.816432e-01 6.198347e-01 3 196027183 196027260 78 - 0.251 0.461 1.269
ENSG00000072274 E002 238.5100257 0.0117647065 2.696084e-37 7.821824e-35 3 196049284 196049475 192 - 1.950 2.817 2.895
ENSG00000072274 E003 1569.8837551 0.0189911329 5.869553e-11 1.076030e-09 3 196049476 196050366 891 - 2.912 3.418 1.682
ENSG00000072274 E004 2350.1302602 0.0003934872 1.542714e-05 9.818343e-05 3 196050367 196052184 1818 - 3.169 3.337 0.558
ENSG00000072274 E005 349.9765386 0.0002139375 1.405462e-08 1.686153e-07 3 196053418 196053491 74 - 2.374 2.326 -0.160
ENSG00000072274 E006 270.5727091 0.0064469437 1.069784e-03 4.200447e-03 3 196053492 196053508 17 - 2.263 2.199 -0.214
ENSG00000072274 E007 326.7843455 0.0215078501 7.045005e-02 1.440869e-01 3 196053509 196053558 50 - 2.342 2.300 -0.139
ENSG00000072274 E008 258.9904380 0.0207960949 2.544522e-02 6.279662e-02 3 196055080 196055110 31 - 2.245 2.169 -0.256
ENSG00000072274 E009 488.4717092 0.0005084081 3.050674e-12 6.918136e-11 3 196055111 196055301 191 - 2.520 2.450 -0.234
ENSG00000072274 E010 2.2089973 0.0067274303 1.281150e-03 4.914054e-03 3 196055302 196055561 260 - 0.251 0.881 3.075
ENSG00000072274 E011 1.6888749 0.0115485179 6.364282e-03 1.956819e-02 3 196057962 196058210 249 - 0.193 0.758 3.079
ENSG00000072274 E012 0.9890372 0.0124949828 3.388303e-02 7.952228e-02 3 196058211 196058282 72 - 0.126 0.584 3.077
ENSG00000072274 E013 2.3092073 0.0533136770 2.028707e-01 3.298142e-01 3 196058283 196058283 1 - 0.348 0.679 1.617
ENSG00000072274 E014 215.5675471 0.0005755825 2.290926e-04 1.088151e-03 3 196058284 196058325 42 - 2.161 2.140 -0.071
ENSG00000072274 E015 202.0909930 0.0002003752 3.934975e-02 8.981990e-02 3 196058326 196058365 40 - 2.125 2.169 0.148
ENSG00000072274 E016 268.4169599 0.0001669112 1.458527e-04 7.293099e-04 3 196058574 196058632 59 - 2.253 2.250 -0.012
ENSG00000072274 E017 0.3289534 0.0305743009 1.762165e-01   3 196058633 196058958 326 - 0.046 0.289 3.077
ENSG00000072274 E018 268.0025192 0.0001714154 1.286192e-04 6.529077e-04 3 196060180 196060247 68 - 2.253 2.247 -0.017
ENSG00000072274 E019 3.0584671 0.0778868843 7.302593e-01 8.222758e-01 3 196060248 196060604 357 - 0.479 0.463 -0.083
ENSG00000072274 E020 1.2524159 0.0145723127 1.000000e+00 1.000000e+00 3 196062391 196062581 191 - 0.251 0.289 0.271
ENSG00000072274 E021 232.9454042 0.0001739336 1.204198e-03 4.654703e-03 3 196062582 196062645 64 - 2.191 2.198 0.025
ENSG00000072274 E022 8.3617899 0.0078696393 3.007315e-01 4.424718e-01 3 196062646 196062853 208 - 0.827 0.757 -0.276
ENSG00000072274 E023 244.0166197 0.0001616337 4.341605e-05 2.482207e-04 3 196062854 196062939 86 - 2.216 2.196 -0.067
ENSG00000072274 E024 5.4262279 0.0028869670 1.392325e-01 2.470074e-01 3 196062940 196063192 253 - 0.605 0.933 1.322
ENSG00000072274 E025 2.2937801 0.0063671353 4.942245e-01 6.311893e-01 3 196063225 196063424 200 - 0.370 0.584 1.076
ENSG00000072274 E026 265.1009722 0.0001700685 1.173136e-04 6.015458e-04 3 196064309 196064428 120 - 2.249 2.243 -0.021
ENSG00000072274 E027 356.6096553 0.0002808534 6.755280e-06 4.670173e-05 3 196065443 196065600 158 - 2.378 2.366 -0.037
ENSG00000072274 E028 340.0665217 0.0001514506 1.445300e-13 4.014777e-12 3 196067518 196067606 89 - 2.368 2.261 -0.356
ENSG00000072274 E029 284.5898840 0.0001534827 1.380102e-09 1.993718e-08 3 196067607 196067657 51 - 2.288 2.209 -0.265
ENSG00000072274 E030 316.1908955 0.0001431733 7.256045e-09 9.173082e-08 3 196068032 196068130 99 - 2.331 2.272 -0.196
ENSG00000072274 E031 312.4209343 0.0071045663 2.964591e-04 1.365606e-03 3 196069455 196069568 114 - 2.328 2.247 -0.270
ENSG00000072274 E032 2.7398954 0.0055157285 2.769713e-01 4.164693e-01 3 196069569 196069700 132 - 0.463 0.289 -1.010
ENSG00000072274 E033 2.2853491 0.0066013314 4.056434e-01 5.493101e-01 3 196071119 196071187 69 - 0.410 0.289 -0.730
ENSG00000072274 E034 245.4336712 0.0079767326 7.381746e-05 3.984414e-04 3 196071396 196071439 44 - 2.227 2.115 -0.375
ENSG00000072274 E035 290.7097009 0.0028882136 4.200376e-12 9.300474e-11 3 196071440 196071498 59 - 2.308 2.120 -0.628
ENSG00000072274 E036 371.2589553 0.0001575310 9.242467e-21 6.485029e-19 3 196072003 196072152 150 - 2.411 2.247 -0.546
ENSG00000072274 E037 478.7844917 0.0001623234 2.178845e-27 2.923341e-25 3 196073930 196074125 196 - 2.522 2.348 -0.577
ENSG00000072274 E038 0.8189741 0.0353215814 6.742670e-01 7.797719e-01 3 196074197 196074433 237 - 0.161 0.290 1.080
ENSG00000072274 E039 511.9899973 0.0043968193 2.648831e-16 1.083362e-14 3 196075159 196075360 202 - 2.556 2.317 -0.798
ENSG00000072274 E040 268.5116650 0.0088636239 6.295547e-09 8.064592e-08 3 196077064 196077122 59 - 2.277 2.037 -0.802
ENSG00000072274 E041 6.1284763 0.0406958639 1.044474e-01 1.972629e-01 3 196081831 196082042 212 - 0.730 0.461 -1.207
ENSG00000072274 E042 188.9519471 0.0046786262 7.807459e-10 1.181578e-08 3 196082043 196082129 87 - 2.125 1.893 -0.778