ENSG00000072135

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000175756 ENSG00000072135 HEK293_OSMI2_2hA HEK293_TMG_2hB PTPN18 protein_coding protein_coding 26.51979 39.90685 16.09724 1.753299 0.3011784 -1.309288 7.792218 12.436745 5.759932 0.1878030 0.4588336 -1.109142 0.2938292 0.3125667 0.3573667 0.04480000 0.51533575 0.01779236 FALSE  
ENST00000462321 ENSG00000072135 HEK293_OSMI2_2hA HEK293_TMG_2hB PTPN18 protein_coding retained_intron 26.51979 39.90685 16.09724 1.753299 0.3011784 -1.309288 3.142449 4.518673 1.457522 0.4513390 0.2788235 -1.625706 0.1207458 0.1132333 0.0909000 -0.02233333 0.65037235 0.01779236    
ENST00000483617 ENSG00000072135 HEK293_OSMI2_2hA HEK293_TMG_2hB PTPN18 protein_coding retained_intron 26.51979 39.90685 16.09724 1.753299 0.3011784 -1.309288 4.052400 7.156014 1.751678 0.4844736 0.2441198 -2.024220 0.1463125 0.1800667 0.1091000 -0.07096667 0.07436705 0.01779236    
ENST00000489215 ENSG00000072135 HEK293_OSMI2_2hA HEK293_TMG_2hB PTPN18 protein_coding retained_intron 26.51979 39.90685 16.09724 1.753299 0.3011784 -1.309288 3.709519 7.818663 1.653830 1.2757055 0.1218937 -2.234258 0.1227042 0.1938667 0.1025667 -0.09130000 0.03062968 0.01779236 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000072135 E001 0.3729606 0.0288720463 5.211996e-01 6.550831e-01 2 130356036 130356044 9 + 0.174 0.085 -1.185
ENSG00000072135 E002 0.5181333 0.0203638807 1.861137e-01 3.088721e-01 2 130356045 130356045 1 + 0.297 0.085 -2.186
ENSG00000072135 E003 0.8105550 0.0148889833 2.046495e-02 5.247020e-02 2 130356046 130356046 1 + 0.472 0.085 -3.186
ENSG00000072135 E004 1.0320003 0.0137521432 6.252736e-02 1.308976e-01 2 130356047 130356050 4 + 0.472 0.156 -2.185
ENSG00000072135 E005 2.0285261 0.0565400671 1.628926e-02 4.336455e-02 2 130356051 130356052 2 + 0.693 0.273 -2.170
ENSG00000072135 E006 2.4714165 0.2278266109 1.162692e-01 2.146385e-01 2 130356053 130356054 2 + 0.693 0.376 -1.515
ENSG00000072135 E007 2.9863407 0.1506959036 1.324179e-01 2.374421e-01 2 130356055 130356055 1 + 0.734 0.448 -1.295
ENSG00000072135 E008 3.8313511 0.2317582686 1.360989e-01 2.426159e-01 2 130356056 130356065 10 + 0.839 0.519 -1.358
ENSG00000072135 E009 67.0796500 0.0083147869 2.190454e-01 3.492438e-01 2 130356066 130356200 135 + 1.691 1.801 0.372
ENSG00000072135 E010 1.3275530 0.0115914380 3.548876e-01 4.992269e-01 2 130356600 130356655 56 + 0.174 0.361 1.400
ENSG00000072135 E011 0.2966881 0.0290785164 5.198104e-02   2 130358864 130358866 3 + 0.297 0.000 -10.971
ENSG00000072135 E012 34.2145897 0.0037585564 5.082755e-01 6.437271e-01 2 130358867 130358892 26 + 1.432 1.505 0.251
ENSG00000072135 E013 49.2325930 0.0071748750 8.006811e-01 8.729678e-01 2 130358893 130358949 57 + 1.636 1.646 0.035
ENSG00000072135 E014 42.4084793 0.0008066014 3.207545e-01 4.639225e-01 2 130358950 130358975 26 + 1.605 1.571 -0.116
ENSG00000072135 E015 1.7079031 0.1084520809 2.561204e-01 3.930781e-01 2 130359177 130359232 56 + 0.539 0.320 -1.177
ENSG00000072135 E016 17.9483793 0.0012756810 4.173586e-09 5.512224e-08 2 130359233 130359309 77 + 1.498 1.047 -1.586
ENSG00000072135 E017 22.6552998 0.0105885856 2.161847e-09 3.010406e-08 2 130359397 130359492 96 + 1.616 1.126 -1.705
ENSG00000072135 E018 0.4407149 0.0228731433 1.858579e-01 3.085828e-01 2 130359493 130359607 115 + 0.297 0.085 -2.189
ENSG00000072135 E019 15.8262586 0.0011462458 3.774501e-14 1.139551e-12 2 130359608 130359646 39 + 1.524 0.909 -2.187
ENSG00000072135 E020 1.2963344 0.0134567848 5.611400e-02 1.199006e-01 2 130359647 130359921 275 + 0.539 0.217 -1.924
ENSG00000072135 E021 1.8270540 0.1173805868 7.688877e-03 2.299671e-02 2 130362156 130362430 275 + 0.735 0.215 -2.794
ENSG00000072135 E022 4.5424020 0.0082841334 9.533949e-03 2.762120e-02 2 130368897 130369132 236 + 0.923 0.580 -1.394
ENSG00000072135 E023 97.1220988 0.0031246815 8.475778e-01 9.053449e-01 2 130369133 130369201 69 + 1.922 1.938 0.056
ENSG00000072135 E024 103.9527089 0.0005669644 4.624498e-01 6.023016e-01 2 130369765 130369827 63 + 1.927 1.981 0.182
ENSG00000072135 E025 91.5494805 0.0003232991 1.758177e-01 2.957438e-01 2 130370048 130370088 41 + 1.850 1.931 0.274
ENSG00000072135 E026 86.9076409 0.0003717861 1.476791e-01 2.585373e-01 2 130370089 130370127 39 + 1.825 1.912 0.293
ENSG00000072135 E027 104.9696377 0.0003081815 1.128186e-04 5.808394e-04 2 130370128 130370190 63 + 1.831 2.013 0.611
ENSG00000072135 E028 63.3729859 0.0050819432 2.182613e-08 2.526825e-07 2 130370191 130370309 119 + 1.432 1.834 1.371
ENSG00000072135 E029 25.9187999 0.0015922020 5.687795e-03 1.778522e-02 2 130370310 130370390 81 + 1.183 1.436 0.885
ENSG00000072135 E030 5.6909298 0.0030662028 2.712915e-01 4.100279e-01 2 130370391 130370432 42 + 0.868 0.743 -0.495
ENSG00000072135 E031 4.1822286 0.0044044139 8.162997e-04 3.317791e-03 2 130370433 130370556 124 + 0.947 0.499 -1.866
ENSG00000072135 E032 51.0221363 0.0004554250 3.453181e-02 8.077377e-02 2 130370557 130370623 67 + 1.721 1.634 -0.294
ENSG00000072135 E033 5.4100397 0.0099482073 6.021027e-03 1.866791e-02 2 130370624 130370668 45 + 0.993 0.648 -1.360
ENSG00000072135 E034 4.6801122 0.0034151115 1.275837e-02 3.534401e-02 2 130370669 130370704 36 + 0.923 0.604 -1.287
ENSG00000072135 E035 46.2298988 0.0010426309 5.508767e-05 3.071185e-04 2 130370705 130370746 42 + 1.752 1.556 -0.666
ENSG00000072135 E036 46.7810996 0.0011129486 7.158341e-03 2.163433e-02 2 130370747 130370782 36 + 1.713 1.588 -0.422
ENSG00000072135 E037 2.9872736 0.0092846686 1.434355e-03 5.420916e-03 2 130370783 130370874 92 + 0.838 0.361 -2.184
ENSG00000072135 E038 80.4664729 0.0034641331 2.179767e-04 1.040832e-03 2 130370875 130370964 90 + 1.961 1.806 -0.522
ENSG00000072135 E039 77.4852936 0.0121675114 2.827039e-03 9.755055e-03 2 130371199 130371287 89 + 1.954 1.786 -0.566
ENSG00000072135 E040 1.6628637 0.0204960804 4.818789e-01 6.200865e-01 2 130371288 130371313 26 + 0.472 0.361 -0.603
ENSG00000072135 E041 1.7391257 0.0080686212 2.013073e-02 5.175758e-02 2 130371998 130372088 91 + 0.647 0.270 -1.995
ENSG00000072135 E042 5.7290367 0.0266285128 2.574104e-02 6.340693e-02 2 130372089 130372256 168 + 0.971 0.671 -1.179
ENSG00000072135 E043 89.6656452 0.0047553940 4.919616e-06 3.506420e-05 2 130372257 130372483 227 + 2.038 1.837 -0.675
ENSG00000072135 E044 11.8010065 0.0130330934 3.515609e-01 4.958062e-01 2 130372608 130372872 265 + 1.123 1.044 -0.286
ENSG00000072135 E045 72.5429825 0.0003963153 1.818076e-01 3.035018e-01 2 130372873 130372947 75 + 1.834 1.799 -0.120
ENSG00000072135 E046 82.8961234 0.0003990265 1.871394e-01 3.101532e-01 2 130373157 130373220 64 + 1.887 1.856 -0.105
ENSG00000072135 E047 690.0740579 0.0014588472 1.815114e-02 4.745690e-02 2 130373221 130374665 1445 + 2.731 2.804 0.243
ENSG00000072135 E048 450.7043069 0.0080098969 1.791955e-05 1.123638e-04 2 130374666 130375405 740 + 2.438 2.648 0.700