ENSG00000072133

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000262752 ENSG00000072133 HEK293_OSMI2_2hA HEK293_TMG_2hB RPS6KA6 protein_coding protein_coding 2.693968 0.4535782 4.581583 0.01715301 0.2482237 3.308107 0.89976083 0.34831998 1.6647219 0.09021888 0.3588640 2.224601 0.36083750 0.75470000 0.37110000 -0.38360000 2.144718e-01 3.868885e-05 FALSE TRUE
ENST00000620340 ENSG00000072133 HEK293_OSMI2_2hA HEK293_TMG_2hB RPS6KA6 protein_coding protein_coding 2.693968 0.4535782 4.581583 0.01715301 0.2482237 3.308107 0.29239953 0.08189217 0.3824738 0.08189217 0.3824738 2.094582 0.22780833 0.19476667 0.07646667 -0.11830000 7.772392e-01 3.868885e-05 FALSE TRUE
MSTRG.34531.1 ENSG00000072133 HEK293_OSMI2_2hA HEK293_TMG_2hB RPS6KA6 protein_coding   2.693968 0.4535782 4.581583 0.01715301 0.2482237 3.308107 0.07308822 0.02336603 0.0000000 0.02336603 0.0000000 -1.738380 0.02761667 0.05053333 0.00000000 -0.05053333 1.983567e-01 3.868885e-05 FALSE TRUE
MSTRG.34531.4 ENSG00000072133 HEK293_OSMI2_2hA HEK293_TMG_2hB RPS6KA6 protein_coding   2.693968 0.4535782 4.581583 0.01715301 0.2482237 3.308107 1.12907603 0.00000000 1.4791082 0.00000000 0.2156109 7.218305 0.30308750 0.00000000 0.31963333 0.31963333 3.868885e-05 3.868885e-05 FALSE TRUE
MSTRG.34531.5 ENSG00000072133 HEK293_OSMI2_2hA HEK293_TMG_2hB RPS6KA6 protein_coding   2.693968 0.4535782 4.581583 0.01715301 0.2482237 3.308107 0.18435986 0.00000000 0.3014271 0.00000000 0.1157414 4.960823 0.05390417 0.00000000 0.06456667 0.06456667 2.923528e-01 3.868885e-05 FALSE TRUE
MSTRG.34531.6 ENSG00000072133 HEK293_OSMI2_2hA HEK293_TMG_2hB RPS6KA6 protein_coding   2.693968 0.4535782 4.581583 0.01715301 0.2482237 3.308107 0.11528400 0.00000000 0.7538520 0.00000000 0.2143798 6.255221 0.02676667 0.00000000 0.16830000 0.16830000 4.269305e-02 3.868885e-05 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000072133 E001 0.0000000       X 84058346 84058349 4 -      
ENSG00000072133 E002 161.3164040 0.0019888939 4.051680e-09 5.366932e-08 X 84058350 84063790 5441 - 2.036 2.240 0.684
ENSG00000072133 E003 24.6606475 0.0008528860 2.455256e-01 3.806671e-01 X 84063791 84064201 411 - 1.255 1.369 0.398
ENSG00000072133 E004 6.5156931 0.0148001904 1.876879e-01 3.108257e-01 X 84064202 84064225 24 - 0.786 0.543 -1.035
ENSG00000072133 E005 23.7005907 0.0044846117 9.449088e-01 9.694355e-01 X 84064226 84064402 177 - 1.261 1.265 0.014
ENSG00000072133 E006 26.9283487 0.0008066829 8.355489e-02 1.651098e-01 X 84064971 84065111 141 - 1.285 1.440 0.538
ENSG00000072133 E007 25.3727682 0.0007909953 4.357824e-01 5.779572e-01 X 84096194 84096311 118 - 1.273 1.353 0.280
ENSG00000072133 E008 16.4067771 0.0011418533 2.723995e-01 4.112781e-01 X 84097772 84097848 77 - 1.127 1.005 -0.442
ENSG00000072133 E009 14.4062605 0.0011884805 5.437522e-01 6.743138e-01 X 84102037 84102092 56 - 1.069 1.005 -0.235
ENSG00000072133 E010 13.7591852 0.0014636977 8.922756e-01 9.351783e-01 X 84102093 84102198 106 - 1.045 1.039 -0.021
ENSG00000072133 E011 0.0000000       X 84104492 84104498 7 -      
ENSG00000072133 E012 19.0993544 0.0009240165 5.549384e-01 6.838483e-01 X 84104499 84104657 159 - 1.181 1.128 -0.190
ENSG00000072133 E013 18.4158848 0.0009751159 6.994702e-01 7.991954e-01 X 84105787 84105876 90 - 1.151 1.202 0.181
ENSG00000072133 E014 16.1294784 0.0011058508 6.708893e-01 7.772435e-01 X 84106365 84106487 123 - 1.097 1.154 0.206
ENSG00000072133 E015 17.7730299 0.0040392735 6.105261e-01 7.298459e-01 X 84106910 84107040 131 - 1.135 1.202 0.237
ENSG00000072133 E016 15.4412700 0.0011432498 3.792733e-01 5.235323e-01 X 84107623 84107725 103 - 1.101 1.005 -0.350
ENSG00000072133 E017 14.0898799 0.0017743143 1.306909e-01 2.351125e-01 X 84116229 84116287 59 - 1.074 0.883 -0.711
ENSG00000072133 E018 14.7113557 0.0012206196 1.839677e-01 3.061931e-01 X 84117060 84117148 89 - 1.088 0.927 -0.591
ENSG00000072133 E019 10.0140960 0.0016938519 1.204920e-01 2.206644e-01 X 84117384 84117454 71 - 0.944 0.711 -0.910
ENSG00000072133 E020 18.4161810 0.0010358320 1.073968e-02 3.054405e-02 X 84119885 84120027 143 - 1.196 0.883 -1.147
ENSG00000072133 E021 13.8744001 0.0013185365 2.564803e-02 6.321475e-02 X 84134782 84134819 38 - 1.083 0.776 -1.160
ENSG00000072133 E022 18.8266288 0.0010200114 2.675060e-01 4.058347e-01 X 84135104 84135210 107 - 1.185 1.071 -0.409
ENSG00000072133 E023 0.7363589 0.0156506788 5.448467e-01 6.752600e-01 X 84139177 84139232 56 - 0.214 0.000 -9.715
ENSG00000072133 E024 14.2268625 0.0014613737 5.290458e-02 1.143129e-01 X 84145478 84145557 80 - 1.088 0.833 -0.954
ENSG00000072133 E025 12.8950260 0.0014341186 1.836381e-02 4.792958e-02 X 84146978 84147058 81 - 1.055 0.711 -1.320
ENSG00000072133 E026 13.8633505 0.0013066978 1.400219e-01 2.480525e-01 X 84148042 84148123 82 - 1.069 0.883 -0.694
ENSG00000072133 E027 15.9289389 0.0021024479 4.886612e-02 1.071400e-01 X 84156075 84156191 117 - 1.131 0.883 -0.916
ENSG00000072133 E028 11.5853512 0.0015375023 1.485639e-02 4.016695e-02 X 84164328 84164387 60 - 1.014 0.635 -1.492
ENSG00000072133 E029 6.1293817 0.0026572336 1.212708e-02 3.383961e-02 X 84186061 84186170 110 - 0.786 0.262 -2.624
ENSG00000072133 E030 4.5998575 0.0099428580 5.007670e-02 1.092984e-01 X 84186763 84186874 112 - 0.684 0.262 -2.208
ENSG00000072133 E031 0.4439371 0.0216420774 1.000000e+00 1.000000e+00 X 84187065 84187157 93 - 0.141 0.000 -9.006
ENSG00000072133 E032 1.3726095 0.0104050771 8.323373e-01 8.949493e-01 X 84187364 84187459 96 - 0.306 0.262 -0.302
ENSG00000072133 E033 13.8893081 0.0202437112 9.030912e-01 9.423580e-01 X 84187819 84188199 381 - 1.045 1.040 -0.021