ENSG00000072041

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000266682 ENSG00000072041 HEK293_OSMI2_2hA HEK293_TMG_2hB SLC6A15 protein_coding protein_coding 35.5754 11.03019 53.19801 1.803599 2.077903 2.268878 3.522406 1.002203 6.572629 0.005122495 0.3582353 2.7011657 0.08896667 0.0953000 0.12443333 0.02913333 4.637182e-01 4.178284e-11 FALSE TRUE
ENST00000309283 ENSG00000072041 HEK293_OSMI2_2hA HEK293_TMG_2hB SLC6A15 protein_coding protein_coding 35.5754 11.03019 53.19801 1.803599 2.077903 2.268878 2.109307 2.267130 2.003824 0.594935840 0.2787783 -0.1772789 0.09075000 0.1995000 0.03753333 -0.16196667 4.178284e-11 4.178284e-11 FALSE TRUE
ENST00000450363 ENSG00000072041 HEK293_OSMI2_2hA HEK293_TMG_2hB SLC6A15 protein_coding protein_coding 35.5754 11.03019 53.19801 1.803599 2.077903 2.268878 4.217337 1.957196 5.855261 0.238439329 0.2025650 1.5760550 0.13137083 0.1806333 0.11010000 -0.07053333 5.763070e-03 4.178284e-11 FALSE TRUE
ENST00000680379 ENSG00000072041 HEK293_OSMI2_2hA HEK293_TMG_2hB SLC6A15 protein_coding protein_coding 35.5754 11.03019 53.19801 1.803599 2.077903 2.268878 10.099638 3.076303 13.595104 0.672700141 1.4253610 2.1401963 0.28746250 0.2744333 0.25420000 -0.02023333 7.793974e-01 4.178284e-11 FALSE TRUE
MSTRG.7728.20 ENSG00000072041 HEK293_OSMI2_2hA HEK293_TMG_2hB SLC6A15 protein_coding   35.5754 11.03019 53.19801 1.803599 2.077903 2.268878 11.239071 1.039541 18.617433 0.549961099 0.7268062 4.1495987 0.25675417 0.0998000 0.35130000 0.25150000 2.644122e-01 4.178284e-11 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000072041 E001 0.1515154 0.0438790116 1.000000e+00   12 84859491 84859504 14 - 0.062 0.000 -7.927
ENSG00000072041 E002 6.4943805 0.0025755970 4.853837e-04 2.104270e-03 12 84859505 84859712 208 - 0.672 1.126 1.743
ENSG00000072041 E003 171.2373113 0.0020079685 1.227720e-12 2.971229e-11 12 84859713 84860834 1122 - 2.079 2.358 0.933
ENSG00000072041 E004 325.4370928 0.0052024878 1.664318e-09 2.367025e-08 12 84860835 84861415 581 - 2.359 2.622 0.875
ENSG00000072041 E005 216.4155886 0.0003209608 2.200470e-04 1.049723e-03 12 84861416 84861593 178 - 2.225 2.351 0.419
ENSG00000072041 E006 333.4149928 0.0012043995 1.594384e-02 4.260544e-02 12 84861594 84861867 274 - 2.422 2.508 0.287
ENSG00000072041 E007 208.8525242 0.0001974940 6.750123e-01 7.804118e-01 12 84861868 84862006 139 - 2.232 2.263 0.105
ENSG00000072041 E008 221.9571816 0.0002155501 6.704197e-01 7.768674e-01 12 84863439 84863601 163 - 2.258 2.290 0.105
ENSG00000072041 E009 1.8938633 0.0084744617 6.075106e-01 7.274805e-01 12 84863602 84863851 250 - 0.378 0.486 0.575
ENSG00000072041 E010 1.0309706 0.0145807601 1.903450e-01 3.141988e-01 12 84864350 84864353 4 - 0.317 0.000 -12.934
ENSG00000072041 E011 5.2248457 0.0032721489 8.834014e-02 1.725871e-01 12 84864354 84864716 363 - 0.773 0.486 -1.255
ENSG00000072041 E012 3.2922711 0.0273782201 2.232639e-01 3.542881e-01 12 84864717 84864849 133 - 0.611 0.376 -1.164
ENSG00000072041 E013 4.1541091 0.0773502147 3.375562e-02 7.926352e-02 12 84864850 84864985 136 - 0.713 0.227 -2.603
ENSG00000072041 E014 6.9703035 0.0040455976 4.728598e-02 1.043457e-01 12 84864986 84865523 538 - 0.882 0.574 -1.268
ENSG00000072041 E015 15.1664300 0.0016291595 6.578803e-04 2.744203e-03 12 84865524 84867033 1510 - 1.189 0.765 -1.587
ENSG00000072041 E016 128.8123294 0.0005355456 9.366618e-01 9.641699e-01 12 84867034 84867079 46 - 2.024 2.045 0.072
ENSG00000072041 E017 193.5000217 0.0002486766 4.290371e-01 5.717768e-01 12 84867080 84867193 114 - 2.206 2.200 -0.021
ENSG00000072041 E018 5.9861148 0.0028249124 2.822695e-02 6.846305e-02 12 84867194 84867892 699 - 0.686 0.997 1.216
ENSG00000072041 E019 6.1817498 0.0721010175 3.038645e-02 7.272134e-02 12 84867893 84868072 180 - 0.672 1.031 1.394
ENSG00000072041 E020 0.5891098 0.0183541203 4.766520e-01 6.152545e-01 12 84868073 84869275 1203 - 0.208 0.000 -12.132
ENSG00000072041 E021 0.2966881 0.0270545938 1.000000e+00   12 84870285 84870477 193 - 0.117 0.000 -11.093
ENSG00000072041 E022 190.3255450 0.0001904122 1.878605e-03 6.848500e-03 12 84870478 84870561 84 - 2.214 2.131 -0.279
ENSG00000072041 E023 207.6937458 0.0002385068 1.196455e-01 2.194620e-01 12 84870562 84870670 109 - 2.241 2.211 -0.100
ENSG00000072041 E024 228.0269681 0.0002225512 8.549116e-04 3.455082e-03 12 84872602 84872794 193 - 2.292 2.209 -0.275
ENSG00000072041 E025 4.1595334 0.0047004304 7.736289e-02 1.552478e-01 12 84872795 84873086 292 - 0.699 0.376 -1.541
ENSG00000072041 E026 216.8511094 0.0001954927 1.937770e-06 1.511901e-05 12 84873087 84873264 178 - 2.279 2.148 -0.438
ENSG00000072041 E027 128.4079056 0.0002614127 5.187903e-05 2.910976e-04 12 84873265 84873328 64 - 2.056 1.907 -0.498
ENSG00000072041 E028 0.7331366 0.0191830661 1.000000e+00 1.000000e+00 12 84874317 84874485 169 - 0.208 0.227 0.159
ENSG00000072041 E029 0.4396707 0.0347938077 7.076720e-01 8.055165e-01 12 84874486 84874528 43 - 0.165 0.000 -11.616
ENSG00000072041 E030 0.1515154 0.0438790116 1.000000e+00   12 84876281 84876496 216 - 0.062 0.000 -9.988
ENSG00000072041 E031 125.5264585 0.0002459922 1.580160e-03 5.894353e-03 12 84876497 84876607 111 - 2.039 1.929 -0.371
ENSG00000072041 E032 0.8167960 0.0142578865 4.553795e-02 1.011849e-01 12 84880179 84880263 85 - 0.117 0.486 2.744
ENSG00000072041 E033 5.2270332 0.0030686838 8.464299e-01 9.045676e-01 12 84880264 84880844 581 - 0.725 0.710 -0.062
ENSG00000072041 E034 3.2213040 0.0047179955 3.157266e-02 7.501731e-02 12 84880845 84880890 46 - 0.454 0.813 1.575
ENSG00000072041 E035 190.2531684 0.0019742295 1.248960e-23 1.188407e-21 12 84880891 84882346 1456 - 2.092 2.450 1.195
ENSG00000072041 E036 113.6713386 0.0003331641 8.880862e-05 4.694605e-04 12 84882347 84883413 1067 - 1.932 2.101 0.567
ENSG00000072041 E037 11.5224684 0.0115807049 2.126700e-01 3.416987e-01 12 84883414 84883443 30 - 0.983 1.147 0.598
ENSG00000072041 E038 42.2367507 0.0006299379 8.484069e-01 9.058679e-01 12 84883444 84883858 415 - 1.552 1.557 0.019
ENSG00000072041 E039 190.8587260 0.0002241931 2.203173e-04 1.050790e-03 12 84883859 84883997 139 - 2.219 2.115 -0.348
ENSG00000072041 E040 150.4318998 0.0002215353 5.420691e-04 2.317350e-03 12 84883998 84884040 43 - 2.117 2.006 -0.371
ENSG00000072041 E041 7.2513986 0.0022864925 4.088565e-02 9.267857e-02 12 84884041 84885379 1339 - 0.891 0.574 -1.299
ENSG00000072041 E042 0.8921407 0.0130183017 2.520990e-01 3.884235e-01 12 84885380 84885434 55 - 0.284 0.000 -12.729
ENSG00000072041 E043 177.5402554 0.0002057083 1.102073e-05 7.250720e-05 12 84885435 84885561 127 - 2.193 2.059 -0.450
ENSG00000072041 E044 134.7909733 0.0009021772 1.928018e-03 7.002095e-03 12 84885911 84885986 76 - 2.071 1.959 -0.374
ENSG00000072041 E045 98.5010802 0.0029276685 1.067477e-02 3.039392e-02 12 84885987 84886026 40 - 1.937 1.816 -0.408
ENSG00000072041 E046 84.9104874 0.0005669724 8.636816e-03 2.537796e-02 12 84886027 84886068 42 - 1.873 1.759 -0.384
ENSG00000072041 E047 7.7844594 0.0021217209 4.941650e-04 2.137692e-03 12 84890795 84891831 1037 - 0.737 1.169 1.624
ENSG00000072041 E048 51.4219273 0.0004856576 8.433399e-02 1.663559e-01 12 84891832 84891832 1 - 1.655 1.565 -0.305
ENSG00000072041 E049 374.4126225 0.0005996316 5.049618e-06 3.590298e-05 12 84891833 84892298 466 - 2.510 2.410 -0.333
ENSG00000072041 E050 84.5098228 0.0004733254 1.121861e-06 9.217733e-06 12 84892299 84892308 10 - 1.889 1.647 -0.820
ENSG00000072041 E051 1.2125613 0.0272775755 6.512111e-01 7.621312e-01 12 84908938 84910500 1563 - 0.317 0.227 -0.646
ENSG00000072041 E052 1.2104850 0.0114816992 6.444530e-01 7.567492e-01 12 84910501 84910810 310 - 0.317 0.227 -0.647
ENSG00000072041 E053 11.1179283 0.0080706832 3.404568e-16 1.368814e-14 12 84910811 84911712 902 - 0.627 1.504 3.259
ENSG00000072041 E054 5.1702718 0.0122684065 1.634910e-04 8.070268e-04 12 84911713 84911743 31 - 0.540 1.079 2.158
ENSG00000072041 E055 5.2829622 0.0193476430 1.337808e-05 8.629635e-05 12 84911744 84911889 146 - 0.499 1.126 2.521
ENSG00000072041 E056 1.9874264 0.2339438782 3.726673e-01 5.170925e-01 12 84911890 84911937 48 - 0.377 0.569 0.968
ENSG00000072041 E057 4.4432424 0.1309113781 2.719814e-01 4.107987e-01 12 84911938 84912003 66 - 0.611 0.848 0.971
ENSG00000072041 E058 0.0000000       12 84912004 84912024 21 -      
ENSG00000072041 E059 186.9579037 0.0060116336 1.656120e-04 8.162842e-04 12 84912523 84912705 183 - 2.222 2.038 -0.617
ENSG00000072041 E060 94.4697065 0.0042588619 1.156584e-01 2.137714e-01 12 84912706 84912876 171 - 1.910 1.834 -0.255
ENSG00000072041 E061 0.3030308 0.3849382907 1.000000e+00   12 84912887 84913016 130 - 0.117 0.000 -10.098
ENSG00000072041 E062 0.1472490 0.0451749686 1.000000e+00   12 84913287 84913499 213 - 0.062 0.000 -9.979
ENSG00000072041 E063 0.0000000       12 84913500 84913629 130 -