ENSG00000071994

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000167218 ENSG00000071994 HEK293_OSMI2_2hA HEK293_TMG_2hB PDCD2 protein_coding nonsense_mediated_decay 121.7042 139.924 119.2511 15.42624 1.428129 -0.2306228 8.856291 10.894364 8.921276 1.4039864 1.0678725 -0.28796743 0.07307917 0.07753333 0.07503333 -0.00250000 9.335184e-01 6.985381e-33 TRUE TRUE
ENST00000392090 ENSG00000071994 HEK293_OSMI2_2hA HEK293_TMG_2hB PDCD2 protein_coding protein_coding 121.7042 139.924 119.2511 15.42624 1.428129 -0.2306228 38.355708 43.447331 42.210141 5.7593900 0.9825545 -0.04166817 0.31547083 0.30910000 0.35386667 0.04476667 4.473467e-02 6.985381e-33 FALSE TRUE
ENST00000453163 ENSG00000071994 HEK293_OSMI2_2hA HEK293_TMG_2hB PDCD2 protein_coding protein_coding 121.7042 139.924 119.2511 15.42624 1.428129 -0.2306228 7.400461 5.664981 9.524359 0.3931448 0.4784877 0.74852043 0.06179167 0.04100000 0.07996667 0.03896667 6.593354e-06 6.985381e-33 FALSE TRUE
ENST00000544866 ENSG00000071994 HEK293_OSMI2_2hA HEK293_TMG_2hB PDCD2 protein_coding nonsense_mediated_decay 121.7042 139.924 119.2511 15.42624 1.428129 -0.2306228 29.082080 44.250163 21.187573 4.9403432 0.4674087 -1.06210964 0.23871250 0.31610000 0.17763333 -0.13846667 6.985381e-33 6.985381e-33 FALSE TRUE
ENST00000614056 ENSG00000071994 HEK293_OSMI2_2hA HEK293_TMG_2hB PDCD2 protein_coding protein_coding 121.7042 139.924 119.2511 15.42624 1.428129 -0.2306228 20.566014 20.461102 25.631693 1.4044627 0.6171300 0.32490273 0.17019583 0.14976667 0.21490000 0.06513333 9.138748e-02 6.985381e-33 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000071994 E001 2.415018 0.0107528910 1.453461e-02 3.944332e-02 6 170575295 170575327 33 - 0.738 0.330 -1.973
ENSG00000071994 E002 421.234749 0.0040665984 1.170999e-10 2.043687e-09 6 170575328 170577435 2108 - 2.749 2.508 -0.801
ENSG00000071994 E003 357.576815 0.0021581647 2.449684e-01 3.799929e-01 6 170577436 170577558 123 - 2.578 2.529 -0.163
ENSG00000071994 E004 335.145283 0.0031020791 9.060629e-01 9.442678e-01 6 170577559 170577593 35 - 2.527 2.516 -0.037
ENSG00000071994 E005 555.179133 0.0025543234 9.626808e-01 9.804161e-01 6 170577594 170577717 124 - 2.747 2.732 -0.048
ENSG00000071994 E006 2.581757 0.0164941363 7.891116e-01 8.650035e-01 6 170578482 170578488 7 - 0.599 0.550 -0.224
ENSG00000071994 E007 4.792739 0.0039044203 1.207571e-01 2.210405e-01 6 170578489 170578506 18 - 0.638 0.843 0.834
ENSG00000071994 E008 211.244505 0.0010917966 1.770385e-29 2.832721e-27 6 170578507 170578656 150 - 2.091 2.421 1.101
ENSG00000071994 E009 537.329623 0.0001739177 1.692410e-14 5.395859e-13 6 170578857 170578882 26 - 2.657 2.767 0.366
ENSG00000071994 E010 722.674615 0.0031149098 3.738896e-07 3.391050e-06 6 170578883 170578970 88 - 2.768 2.897 0.431
ENSG00000071994 E011 35.085557 0.0007183367 3.592713e-11 6.826042e-10 6 170578971 170579721 751 - 1.751 1.344 -1.395
ENSG00000071994 E012 756.298886 0.0010629598 3.677793e-13 9.651570e-12 6 170580002 170580092 91 - 2.793 2.917 0.413
ENSG00000071994 E013 477.796303 0.0005426058 5.650770e-08 6.018561e-07 6 170580093 170580105 13 - 2.619 2.707 0.293
ENSG00000071994 E014 126.443522 0.0057692734 7.237067e-06 4.965200e-05 6 170581089 170581744 656 - 2.226 1.987 -0.802
ENSG00000071994 E015 27.745666 0.0123944090 4.383538e-04 1.922067e-03 6 170581745 170581746 2 - 1.615 1.296 -1.099
ENSG00000071994 E016 28.887059 0.0102832179 1.896502e-03 6.903458e-03 6 170581747 170581747 1 - 1.611 1.342 -0.923
ENSG00000071994 E017 64.783534 0.0028991274 7.565624e-03 2.268430e-02 6 170581748 170581791 44 - 1.898 1.750 -0.501
ENSG00000071994 E018 588.878604 0.0068359422 1.274968e-01 2.306631e-01 6 170581792 170582265 474 - 2.809 2.727 -0.275
ENSG00000071994 E019 198.388604 0.0020302809 4.450304e-05 2.538454e-04 6 170582266 170582848 583 - 2.379 2.223 -0.520
ENSG00000071994 E020 106.787640 0.0019286335 2.124035e-07 2.025837e-06 6 170582849 170583056 208 - 2.146 1.920 -0.759
ENSG00000071994 E021 1239.689145 0.0001104975 1.374916e-04 6.925465e-04 6 170583057 170583188 132 - 3.074 3.097 0.077
ENSG00000071994 E022 1017.396477 0.0008294765 8.214199e-01 8.874102e-01 6 170583505 170583623 119 - 3.011 2.992 -0.065
ENSG00000071994 E023 751.284914 0.0017315423 3.925586e-02 8.963798e-02 6 170583624 170583747 124 - 2.910 2.837 -0.242
ENSG00000071994 E024 7.430807 0.0023179605 9.183040e-06 6.156702e-05 6 170584055 170584298 244 - 1.158 0.616 -2.095
ENSG00000071994 E025 400.513886 0.0040455761 3.862980e-03 1.275721e-02 6 170584299 170584392 94 - 2.668 2.540 -0.427
ENSG00000071994 E026 208.754225 0.0141172715 3.620519e-04 1.626889e-03 6 170584393 170584491 99 - 2.448 2.195 -0.843
ENSG00000071994 E027 153.203411 0.0384528947 5.726050e-04 2.431224e-03 6 170584492 170584692 201 - 2.366 1.993 -1.247