ENSG00000071889

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000359889 ENSG00000071889 HEK293_OSMI2_2hA HEK293_TMG_2hB FAM3A protein_coding protein_coding 94.7677 166.9369 44.169 9.127853 1.241079 -1.917957 13.361015 29.549615 2.9233588 2.2200685 1.4791844 -3.333002 0.12949167 0.17950000 0.068133333 -0.1113666667 0.58687099 1.024079e-06 FALSE  
ENST00000369641 ENSG00000071889 HEK293_OSMI2_2hA HEK293_TMG_2hB FAM3A protein_coding protein_coding 94.7677 166.9369 44.169 9.127853 1.241079 -1.917957 7.711643 13.238528 3.5336678 1.5425506 0.2052086 -1.902517 0.08195417 0.07890000 0.079866667 0.0009666667 0.98123793 1.024079e-06 FALSE  
ENST00000369643 ENSG00000071889 HEK293_OSMI2_2hA HEK293_TMG_2hB FAM3A protein_coding protein_coding 94.7677 166.9369 44.169 9.127853 1.241079 -1.917957 4.779613 10.954945 4.5526768 1.2962312 1.0256667 -1.264946 0.05066667 0.06650000 0.102700000 0.0362000000 0.51214691 1.024079e-06 FALSE  
ENST00000419205 ENSG00000071889 HEK293_OSMI2_2hA HEK293_TMG_2hB FAM3A protein_coding protein_coding 94.7677 166.9369 44.169 9.127853 1.241079 -1.917957 15.229872 30.401816 7.8583286 3.2211357 0.8098467 -1.950503 0.15340417 0.18353333 0.178433333 -0.0051000000 0.98725181 1.024079e-06 FALSE  
ENST00000447601 ENSG00000071889 HEK293_OSMI2_2hA HEK293_TMG_2hB FAM3A protein_coding protein_coding 94.7677 166.9369 44.169 9.127853 1.241079 -1.917957 23.463182 36.344589 10.0864902 7.7665423 1.3826578 -1.848284 0.24943333 0.21390000 0.227000000 0.0131000000 0.91892980 1.024079e-06 FALSE  
ENST00000475657 ENSG00000071889 HEK293_OSMI2_2hA HEK293_TMG_2hB FAM3A protein_coding retained_intron 94.7677 166.9369 44.169 9.127853 1.241079 -1.917957 7.098347 8.016197 2.9551915 0.8647118 0.2747005 -1.436591 0.08545417 0.04783333 0.066666667 0.0188333333 0.08822744 1.024079e-06    
ENST00000621967 ENSG00000071889 HEK293_OSMI2_2hA HEK293_TMG_2hB FAM3A protein_coding nonsense_mediated_decay 94.7677 166.9369 44.169 9.127853 1.241079 -1.917957 6.531686 12.784923 0.3188796 0.5825266 0.3188796 -5.281868 0.06541667 0.07730000 0.007466667 -0.0698333333 0.04210972 1.024079e-06 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000071889 E001 9.456295 1.773947e-03 1.977466e-01 3.234126e-01 X 154506159 154506159 1 - 1.019 0.862 -0.590
ENSG00000071889 E002 17.108469 1.106367e-03 9.020690e-01 9.416025e-01 X 154506160 154506170 11 - 1.141 1.132 -0.032
ENSG00000071889 E003 16.889199 1.102417e-03 7.661617e-01 8.487337e-01 X 154506171 154506172 2 - 1.096 1.132 0.129
ENSG00000071889 E004 110.284650 1.574108e-03 5.329503e-03 1.682820e-02 X 154506173 154506203 31 - 1.786 1.934 0.499
ENSG00000071889 E005 1249.400558 1.384718e-03 6.378773e-04 2.672770e-03 X 154506204 154506534 331 - 2.894 2.975 0.271
ENSG00000071889 E006 772.799019 3.605158e-04 2.369679e-02 5.918792e-02 X 154506535 154506639 105 - 2.712 2.760 0.161
ENSG00000071889 E007 523.559532 1.228217e-03 1.741028e-01 2.934958e-01 X 154506640 154506710 71 - 2.548 2.590 0.142
ENSG00000071889 E008 1150.517733 1.073580e-04 4.283081e-02 9.623293e-02 X 154506711 154506906 196 - 2.896 2.929 0.112
ENSG00000071889 E009 693.991885 1.118307e-04 1.043347e-01 1.970912e-01 X 154507203 154507246 44 - 2.676 2.710 0.114
ENSG00000071889 E010 787.249192 9.707551e-05 6.395894e-01 7.529488e-01 X 154507247 154507329 83 - 2.763 2.759 -0.011
ENSG00000071889 E011 41.332568 6.016482e-03 5.123202e-02 1.113454e-01 X 154507330 154507405 76 - 1.604 1.464 -0.478
ENSG00000071889 E012 734.478079 1.087679e-04 6.007514e-02 1.267279e-01 X 154507406 154507490 85 - 2.753 2.726 -0.091
ENSG00000071889 E013 41.679089 5.239915e-04 4.273208e-06 3.087142e-05 X 154507491 154507591 101 - 1.719 1.437 -0.961
ENSG00000071889 E014 32.179588 1.586461e-02 4.099187e-03 1.342261e-02 X 154507680 154507810 131 - 1.589 1.338 -0.865
ENSG00000071889 E015 483.566312 1.891143e-04 3.726415e-01 5.170898e-01 X 154507811 154507861 51 - 2.528 2.552 0.081
ENSG00000071889 E016 100.442152 3.852972e-04 8.806506e-01 9.274480e-01 X 154507862 154507882 21 - 1.865 1.876 0.039
ENSG00000071889 E017 29.117642 8.040070e-04 4.001274e-02 9.106334e-02 X 154507883 154507885 3 - 1.478 1.324 -0.532
ENSG00000071889 E018 496.974220 2.036104e-04 3.796922e-01 5.239426e-01 X 154508289 154508315 27 - 2.574 2.560 -0.047
ENSG00000071889 E019 503.951776 1.196054e-04 5.031471e-01 6.391205e-01 X 154508316 154508347 32 - 2.575 2.565 -0.031
ENSG00000071889 E020 6.352523 2.705015e-03 4.904803e-02 1.074642e-01 X 154508453 154508473 21 - 0.959 0.692 -1.046
ENSG00000071889 E021 830.489706 1.996502e-04 6.338863e-02 1.323384e-01 X 154508474 154508571 98 - 2.806 2.780 -0.086
ENSG00000071889 E022 545.941986 1.485605e-04 5.881450e-02 1.246015e-01 X 154508572 154508597 26 - 2.630 2.597 -0.110
ENSG00000071889 E023 38.102297 6.107337e-04 2.394769e-01 3.735083e-01 X 154508598 154508652 55 - 1.524 1.445 -0.272
ENSG00000071889 E024 22.491339 4.692903e-03 5.603054e-01 6.883085e-01 X 154508653 154508768 116 - 1.181 1.244 0.223
ENSG00000071889 E025 12.409494 6.082095e-02 7.751460e-01 8.551203e-01 X 154508769 154508811 43 - 0.959 1.007 0.178
ENSG00000071889 E026 41.653124 4.750432e-03 4.178213e-09 5.517565e-08 X 154508812 154511412 2601 - 1.791 1.401 -1.331
ENSG00000071889 E027 474.519486 1.595158e-04 1.241646e-03 4.782146e-03 X 154511848 154511867 20 - 2.593 2.530 -0.211
ENSG00000071889 E028 416.248703 2.126157e-04 3.296475e-04 1.499417e-03 X 154511868 154511871 4 - 2.548 2.472 -0.254
ENSG00000071889 E029 109.360331 1.077611e-03 1.807395e-01 3.021208e-01 X 154512314 154512411 98 - 1.952 1.895 -0.189
ENSG00000071889 E030 3.252548 5.064117e-03 1.841542e-01 3.064417e-01 X 154512412 154512431 20 - 0.703 0.483 -0.990
ENSG00000071889 E031 669.752877 1.010893e-04 6.597622e-03 2.018018e-02 X 154512823 154512936 114 - 2.726 2.683 -0.145
ENSG00000071889 E032 457.992208 1.075347e-03 7.803004e-01 8.588014e-01 X 154515760 154515812 53 - 2.528 2.526 -0.006
ENSG00000071889 E033 340.239040 2.642773e-04 9.290891e-03 2.701204e-02 X 154515813 154515909 97 - 2.331 2.406 0.250
ENSG00000071889 E034 339.816701 4.910862e-04 7.277925e-02 1.479775e-01 X 154515910 154515968 59 - 2.349 2.403 0.183
ENSG00000071889 E035 649.288121 2.125619e-03 2.057385e-01 3.333436e-01 X 154515969 154516242 274 - 2.641 2.684 0.146