ENSG00000071794

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000310053 ENSG00000071794 HEK293_OSMI2_2hA HEK293_TMG_2hB HLTF protein_coding protein_coding 22.21276 3.759284 39.04697 0.1695694 0.9201158 3.373218 8.4376541 2.2799763 14.127661 0.31956350 0.0697337 2.6261388 0.45657500 0.6033000 0.36220000 -0.24110000 1.432740e-02 3.875044e-20 FALSE TRUE
ENST00000465259 ENSG00000071794 HEK293_OSMI2_2hA HEK293_TMG_2hB HLTF protein_coding protein_coding 22.21276 3.759284 39.04697 0.1695694 0.9201158 3.373218 4.2434792 0.0000000 8.041908 0.00000000 0.4206449 9.6531869 0.15032917 0.0000000 0.20630000 0.20630000 4.613583e-18 3.875044e-20 FALSE TRUE
ENST00000481663 ENSG00000071794 HEK293_OSMI2_2hA HEK293_TMG_2hB HLTF protein_coding processed_transcript 22.21276 3.759284 39.04697 0.1695694 0.9201158 3.373218 0.6325892 0.2445649 0.421306 0.12498736 0.2176877 0.7606785 0.04113333 0.0682000 0.01076667 -0.05743333 5.725617e-01 3.875044e-20 TRUE FALSE
MSTRG.23881.1 ENSG00000071794 HEK293_OSMI2_2hA HEK293_TMG_2hB HLTF protein_coding   22.21276 3.759284 39.04697 0.1695694 0.9201158 3.373218 0.1699618 0.9623834 0.000000 0.21404425 0.0000000 -6.6034534 0.04585000 0.2561667 0.00000000 -0.25616667 3.875044e-20 3.875044e-20 FALSE TRUE
MSTRG.23881.4 ENSG00000071794 HEK293_OSMI2_2hA HEK293_TMG_2hB HLTF protein_coding   22.21276 3.759284 39.04697 0.1695694 0.9201158 3.373218 6.0661132 0.1468004 12.707949 0.07483291 0.9946562 6.3417930 0.19664583 0.0389000 0.32470000 0.28580000 1.014895e-03 3.875044e-20 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000071794 E001 0.8814403 0.0142414479 2.449237e-06 1.869011e-05 3 149030001 149030126 126 - 0.000 0.821 14.526
ENSG00000071794 E002 49.3841495 0.0227433345 1.008617e-25 1.180232e-23 3 149030127 149030396 270 - 1.195 2.225 3.506
ENSG00000071794 E003 27.6345759 0.0192184632 8.529920e-20 5.287853e-18 3 149030397 149030397 1 - 0.993 1.945 3.299
ENSG00000071794 E004 242.6842063 0.0280772309 3.642238e-08 4.033265e-07 3 149030398 149030684 287 - 2.056 2.618 1.876
ENSG00000071794 E005 357.1658292 0.0163609496 6.234615e-06 4.342865e-05 3 149030685 149030994 310 - 2.264 2.648 1.283
ENSG00000071794 E006 237.3819016 0.0002523680 3.763212e-28 5.392808e-26 3 149030995 149031360 366 - 2.077 2.507 1.437
ENSG00000071794 E007 40.6488132 0.0017489542 2.495384e-03 8.750350e-03 3 149031361 149031363 3 - 1.346 1.673 1.121
ENSG00000071794 E008 291.7576700 0.0002193569 3.087731e-01 4.510528e-01 3 149031364 149032200 837 - 2.215 2.341 0.422
ENSG00000071794 E009 189.7395964 0.0018442434 3.271650e-01 4.706132e-01 3 149032201 149032372 172 - 2.039 2.085 0.154
ENSG00000071794 E010 76.3378669 0.0033614221 9.786479e-01 9.907651e-01 3 149034918 149034922 5 - 1.643 1.733 0.304
ENSG00000071794 E011 116.7966253 0.0351601176 6.344463e-01 7.489000e-01 3 149034923 149034988 66 - 1.829 1.888 0.200
ENSG00000071794 E012 72.0883242 0.0822030918 7.272307e-01 8.200451e-01 3 149034989 149034998 10 - 1.621 1.704 0.280
ENSG00000071794 E013 160.4129055 0.0553311995 6.590578e-01 7.679792e-01 3 149039049 149039229 181 - 1.964 2.037 0.245
ENSG00000071794 E014 113.4024446 0.0006897852 2.804124e-01 4.202697e-01 3 149039581 149039693 113 - 1.805 1.954 0.502
ENSG00000071794 E015 123.9436858 0.0002382329 7.846571e-02 1.570201e-01 3 149040031 149040141 111 - 1.860 1.856 -0.012
ENSG00000071794 E016 74.6602381 0.0003312215 5.433080e-05 3.033810e-04 3 149040142 149040156 15 - 1.661 1.429 -0.795
ENSG00000071794 E017 3.2695828 0.0072046543 9.579118e-01 9.776140e-01 3 149040157 149040259 103 - 0.460 0.511 0.253
ENSG00000071794 E018 159.0118916 0.0002250288 6.364858e-07 5.514764e-06 3 149041490 149041668 179 - 1.980 1.806 -0.584
ENSG00000071794 E019 14.8652661 0.0012532640 4.195703e-02 9.464686e-02 3 149041669 149041680 12 - 0.998 0.740 -0.993
ENSG00000071794 E020 8.0439602 0.0020431737 2.264415e-02 5.701124e-02 3 149041681 149042044 364 - 0.778 0.327 -2.151
ENSG00000071794 E021 141.2710326 0.0004789086 6.819200e-06 4.708865e-05 3 149042166 149042290 125 - 1.929 1.766 -0.550
ENSG00000071794 E022 174.1315005 0.0002258349 6.495666e-04 2.714425e-03 3 149046080 149046259 180 - 2.013 1.942 -0.237
ENSG00000071794 E023 133.6678196 0.0002407679 5.009981e-05 2.823351e-04 3 149048028 149048163 136 - 1.904 1.766 -0.467
ENSG00000071794 E024 126.6148202 0.0022153338 2.271956e-05 1.390320e-04 3 149048863 149049001 139 - 1.884 1.703 -0.610
ENSG00000071794 E025 68.2699386 0.0095140535 5.945293e-03 1.846453e-02 3 149050232 149050269 38 - 1.619 1.448 -0.585
ENSG00000071794 E026 95.9432513 0.0032771953 1.278850e-02 3.541607e-02 3 149050270 149050375 106 - 1.757 1.674 -0.283
ENSG00000071794 E027 1.9916928 0.1258216829 5.639787e-02 1.204189e-01 3 149052045 149052144 100 - 0.267 0.736 2.392
ENSG00000071794 E028 102.0106642 0.0048448536 4.649275e-04 2.025832e-03 3 149055303 149055400 98 - 1.789 1.620 -0.574
ENSG00000071794 E029 89.1536539 0.0003228574 1.594304e-04 7.892861e-04 3 149059718 149059804 87 - 1.732 1.555 -0.603
ENSG00000071794 E030 36.9103430 0.0007054898 1.060048e-01 1.996171e-01 3 149059805 149059807 3 - 1.354 1.279 -0.262
ENSG00000071794 E031 91.0407983 0.0003754079 8.749427e-05 4.632808e-04 3 149060643 149060687 45 - 1.742 1.555 -0.636
ENSG00000071794 E032 121.8183636 0.0015419343 3.616001e-09 4.831374e-08 3 149060779 149060858 80 - 1.874 1.555 -1.082
ENSG00000071794 E033 134.1824190 0.0003777904 2.458172e-08 2.815558e-07 3 149063431 149063524 94 - 1.912 1.663 -0.842
ENSG00000071794 E034 118.8373591 0.0003448362 7.125036e-09 9.025253e-08 3 149064791 149064866 76 - 1.862 1.568 -0.997
ENSG00000071794 E035 107.7066552 0.0002696519 2.094573e-05 1.293216e-04 3 149068240 149068335 96 - 1.815 1.629 -0.627
ENSG00000071794 E036 145.7876991 0.0002122882 8.905245e-06 5.991236e-05 3 149071252 149071443 192 - 1.942 1.790 -0.511
ENSG00000071794 E037 79.8681333 0.0003600622 2.988959e-02 7.174888e-02 3 149071583 149071657 75 - 1.678 1.618 -0.205
ENSG00000071794 E038 70.5391166 0.0038516936 6.363767e-03 1.956693e-02 3 149073225 149073322 98 - 1.632 1.496 -0.462
ENSG00000071794 E039 115.6171360 0.0002443502 6.461079e-06 4.484455e-05 3 149074215 149074348 134 - 1.845 1.652 -0.654
ENSG00000071794 E040 163.1370471 0.0023429409 8.755074e-08 8.987389e-07 3 149075881 149076047 167 - 1.994 1.767 -0.767
ENSG00000071794 E041 2.7248625 0.0150248840 3.199355e-11 6.132217e-10 3 149083632 149083735 104 - 0.108 1.193 5.690
ENSG00000071794 E042 164.4111912 0.0003801918 2.431450e-07 2.292608e-06 3 149084682 149084889 208 - 1.996 1.813 -0.613
ENSG00000071794 E043 118.4756360 0.0009219322 4.158653e-07 3.737934e-06 3 149086317 149086554 238 - 1.859 1.618 -0.815