ENSG00000071626

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000233078 ENSG00000071626 HEK293_OSMI2_2hA HEK293_TMG_2hB DAZAP1 protein_coding protein_coding 152.6134 231.6896 114.0341 5.366164 0.8420044 -1.022664 63.43804 108.852847 49.580031 3.9057392 2.8634624 -1.1343896 0.40155417 0.46966667 0.43446667 -0.03520000 6.018625e-01 1.030531e-07 FALSE TRUE
ENST00000585485 ENSG00000071626 HEK293_OSMI2_2hA HEK293_TMG_2hB DAZAP1 protein_coding retained_intron 152.6134 231.6896 114.0341 5.366164 0.8420044 -1.022664 7.79955 7.462783 4.899728 0.5665090 0.1002732 -0.6060026 0.05332083 0.03213333 0.04296667 0.01083333 7.649053e-02 1.030531e-07 FALSE FALSE
ENST00000586579 ENSG00000071626 HEK293_OSMI2_2hA HEK293_TMG_2hB DAZAP1 protein_coding processed_transcript 152.6134 231.6896 114.0341 5.366164 0.8420044 -1.022664 10.81502 5.660587 14.983611 1.6498158 0.8272591 1.4027780 0.08490833 0.02416667 0.13130000 0.10713333 1.030531e-07 1.030531e-07 FALSE TRUE
ENST00000587079 ENSG00000071626 HEK293_OSMI2_2hA HEK293_TMG_2hB DAZAP1 protein_coding protein_coding 152.6134 231.6896 114.0341 5.366164 0.8420044 -1.022664 20.34883 47.243048 4.163659 1.1257083 1.3332415 -3.5010228 0.11402083 0.20393333 0.03663333 -0.16730000 3.738788e-06 1.030531e-07 FALSE TRUE
ENST00000592453 ENSG00000071626 HEK293_OSMI2_2hA HEK293_TMG_2hB DAZAP1 protein_coding protein_coding 152.6134 231.6896 114.0341 5.366164 0.8420044 -1.022664 14.95543 12.015711 16.841183 2.7515362 0.8939293 0.4867277 0.11550000 0.05230000 0.14776667 0.09546667 8.509751e-04 1.030531e-07 FALSE TRUE
ENST00000592522 ENSG00000071626 HEK293_OSMI2_2hA HEK293_TMG_2hB DAZAP1 protein_coding protein_coding 152.6134 231.6896 114.0341 5.366164 0.8420044 -1.022664 16.60566 30.892323 9.512914 0.3127146 0.6503325 -1.6982402 0.10310833 0.13343333 0.08350000 -0.04993333 2.731172e-04 1.030531e-07 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000071626 E001 0.8909948 1.369686e-02 6.054913e-03 1.875425e-02 19 1407419 1407542 124 + 0.558 0.080 -3.688
ENSG00000071626 E002 2.3593323 1.349405e-01 3.300058e-05 1.943080e-04 19 1407543 1407554 12 + 0.946 0.080 -5.281
ENSG00000071626 E003 5.1574050 9.744142e-02 1.089568e-09 1.604472e-08 19 1407555 1407568 14 + 1.272 0.080 -6.457
ENSG00000071626 E004 10.1721566 2.556409e-02 7.911560e-27 1.004572e-24 19 1407569 1407585 17 + 1.568 0.000 -15.750
ENSG00000071626 E005 26.9428597 1.282600e-01 3.126287e-16 1.264714e-14 19 1407586 1407612 27 + 1.971 0.259 -6.827
ENSG00000071626 E006 26.3453308 1.402295e-01 3.917024e-15 1.369383e-13 19 1407613 1407616 4 + 1.961 0.259 -6.793
ENSG00000071626 E007 34.7344777 7.671122e-02 2.723764e-24 2.781719e-22 19 1407617 1407624 8 + 2.081 0.304 -6.883
ENSG00000071626 E008 34.3743268 1.255230e-01 1.578372e-16 6.637468e-15 19 1407625 1407626 2 + 2.072 0.384 -6.364
ENSG00000071626 E009 38.3977825 7.558637e-02 4.621222e-21 3.353032e-19 19 1407627 1407632 6 + 2.109 0.561 -5.596
ENSG00000071626 E010 53.3408932 4.976597e-02 9.969807e-19 5.512989e-17 19 1407633 1407647 15 + 2.194 1.061 -3.884
ENSG00000071626 E011 54.7898733 3.140309e-02 6.379586e-25 6.945939e-23 19 1407648 1407649 2 + 2.198 1.098 -3.765
ENSG00000071626 E012 134.6334089 2.766401e-02 1.501648e-11 3.038046e-10 19 1407650 1407676 27 + 2.431 1.823 -2.038
ENSG00000071626 E013 130.7311211 2.350203e-02 1.103896e-08 1.350276e-07 19 1407677 1407679 3 + 2.357 1.879 -1.601
ENSG00000071626 E014 333.6969019 1.667531e-02 6.581310e-05 3.599335e-04 19 1407680 1407734 55 + 2.648 2.372 -0.920
ENSG00000071626 E015 633.4044672 8.436887e-03 1.378239e-04 6.940546e-04 19 1407735 1407802 68 + 2.873 2.679 -0.645
ENSG00000071626 E016 3.5980858 1.991733e-01 8.846495e-01 9.302602e-01 19 1407803 1407971 169 + 0.558 0.618 0.265
ENSG00000071626 E017 7.0300238 2.344809e-03 3.391248e-01 4.830503e-01 19 1409824 1409882 59 + 0.946 0.811 -0.517
ENSG00000071626 E018 13.2652749 1.304525e-03 1.551923e-01 2.686444e-01 19 1409883 1410079 197 + 1.208 1.055 -0.551
ENSG00000071626 E019 15.0013094 3.377709e-02 6.723879e-01 7.783627e-01 19 1415740 1415940 201 + 1.179 1.116 -0.226
ENSG00000071626 E020 23.3814489 8.216628e-04 9.322175e-01 9.613084e-01 19 1415970 1416235 266 + 1.330 1.320 -0.035
ENSG00000071626 E021 23.1306539 8.680273e-04 2.637393e-01 4.016487e-01 19 1416236 1416456 221 + 1.261 1.336 0.263
ENSG00000071626 E022 23.8399683 8.416800e-04 2.390584e-01 3.730061e-01 19 1416457 1416555 99 + 1.273 1.352 0.275
ENSG00000071626 E023 17.7054792 7.327017e-03 1.414133e-01 2.499724e-01 19 1416556 1416703 148 + 1.097 1.232 0.483
ENSG00000071626 E024 45.6152791 1.566583e-02 4.987112e-01 6.351377e-01 19 1416704 1417499 796 + 1.563 1.607 0.152
ENSG00000071626 E025 713.6920638 3.737713e-03 1.540099e-04 7.649495e-04 19 1417500 1417540 41 + 2.889 2.748 -0.468
ENSG00000071626 E026 1743.9207148 6.082569e-04 6.745695e-12 1.444830e-10 19 1418204 1418370 167 + 3.259 3.143 -0.385
ENSG00000071626 E027 1470.9855405 1.087584e-04 5.704891e-07 4.992722e-06 19 1418666 1418731 66 + 3.153 3.081 -0.240
ENSG00000071626 E028 755.5744271 1.175161e-04 1.469782e-03 5.539005e-03 19 1421148 1421150 3 + 2.859 2.794 -0.216
ENSG00000071626 E029 2074.8250261 4.806090e-04 1.002605e-01 1.908796e-01 19 1421151 1421258 108 + 3.279 3.241 -0.126
ENSG00000071626 E030 1611.8693637 1.540145e-03 7.619423e-01 8.456716e-01 19 1422348 1422396 49 + 3.158 3.135 -0.076
ENSG00000071626 E031 78.2385953 1.034247e-02 5.845261e-13 1.488997e-11 19 1422397 1422585 189 + 2.138 1.662 -1.602
ENSG00000071626 E032 1888.5502866 5.444611e-04 7.275991e-01 8.202652e-01 19 1425878 1425960 83 + 3.218 3.206 -0.039
ENSG00000071626 E033 30.7075681 7.423120e-04 1.724121e-10 2.921813e-09 19 1425961 1425962 2 + 1.709 1.285 -1.457
ENSG00000071626 E034 497.2832715 2.217307e-03 7.696789e-11 1.383297e-09 19 1426349 1428841 2493 + 2.771 2.571 -0.666
ENSG00000071626 E035 1738.8125383 2.220695e-04 2.381017e-11 4.667113e-10 19 1428842 1428995 154 + 3.127 3.188 0.205
ENSG00000071626 E036 32.1909312 1.401941e-02 7.595819e-01 8.439037e-01 19 1429835 1429966 132 + 1.488 1.442 -0.158
ENSG00000071626 E037 643.8205634 3.988126e-04 4.854945e-25 5.335005e-23 19 1429967 1429996 30 + 2.597 2.782 0.614
ENSG00000071626 E038 1293.7472890 8.601535e-04 2.045481e-16 8.459075e-15 19 1430222 1430362 141 + 2.942 3.074 0.440
ENSG00000071626 E039 10.6698658 3.433671e-02 4.425388e-01 5.841449e-01 19 1432043 1432513 471 + 1.097 0.983 -0.418
ENSG00000071626 E040 2237.3146891 5.799502e-04 5.879295e-20 3.707772e-18 19 1432514 1432690 177 + 3.196 3.308 0.370
ENSG00000071626 E041 36.3177056 1.046377e-03 3.913282e-01 5.352352e-01 19 1432691 1433738 1048 + 1.556 1.483 -0.250
ENSG00000071626 E042 57.1085327 4.271329e-04 2.771928e-02 6.745971e-02 19 1433739 1433827 89 + 1.621 1.723 0.349
ENSG00000071626 E043 52.1946359 1.099752e-03 5.989363e-02 1.264309e-01 19 1433828 1434736 909 + 1.592 1.685 0.314
ENSG00000071626 E044 977.7714377 9.483764e-05 9.887340e-18 4.865264e-16 19 1434737 1434739 3 + 2.845 2.946 0.337
ENSG00000071626 E045 4431.4738019 6.495291e-04 3.473044e-37 1.004516e-34 19 1434740 1435981 1242 + 3.471 3.610 0.461