ENSG00000071564

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000262965 ENSG00000071564 HEK293_OSMI2_2hA HEK293_TMG_2hB TCF3 protein_coding protein_coding 74.7565 114.2267 56.28266 8.479159 2.288737 -1.021008 11.515785 16.791599 10.671514 1.224405 0.8119524 -0.6534823 0.1545375 0.1470667 0.18973333 0.04266667 8.859975e-02 2.644049e-29 FALSE TRUE
ENST00000585731 ENSG00000071564 HEK293_OSMI2_2hA HEK293_TMG_2hB TCF3 protein_coding protein_coding 74.7565 114.2267 56.28266 8.479159 2.288737 -1.021008 6.370558 15.937493 2.184874 1.070007 1.2234299 -2.8611195 0.0780375 0.1400333 0.03873333 -0.10130000 4.349365e-01 2.644049e-29 FALSE TRUE
ENST00000590684 ENSG00000071564 HEK293_OSMI2_2hA HEK293_TMG_2hB TCF3 protein_coding protein_coding 74.7565 114.2267 56.28266 8.479159 2.288737 -1.021008 18.809002 22.943386 17.402604 1.647839 1.7125371 -0.3985750 0.2654167 0.2019000 0.30970000 0.10780000 3.959637e-02 2.644049e-29 FALSE TRUE
ENST00000592628 ENSG00000071564 HEK293_OSMI2_2hA HEK293_TMG_2hB TCF3 protein_coding protein_coding 74.7565 114.2267 56.28266 8.479159 2.288737 -1.021008 3.401453 9.706582 0.000000 1.578425 0.0000000 -9.9243051 0.0334375 0.0851000 0.00000000 -0.08510000 2.644049e-29 2.644049e-29 FALSE TRUE
ENST00000611869 ENSG00000071564 HEK293_OSMI2_2hA HEK293_TMG_2hB TCF3 protein_coding protein_coding 74.7565 114.2267 56.28266 8.479159 2.288737 -1.021008 14.093629 22.680498 7.762717 1.970903 0.3836971 -1.5455973 0.1861833 0.1982667 0.13846667 -0.05980000 5.134371e-03 2.644049e-29 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000071564 E001 0.0000000       19 1609290 1609290 1 -      
ENSG00000071564 E002 0.0000000       19 1609291 1609291 1 -      
ENSG00000071564 E003 0.5180316 0.0225773329 3.170868e-01 4.599346e-01 19 1609292 1609292 1 - 0.000 0.214 9.304
ENSG00000071564 E004 7.8151150 0.0629934490 2.079050e-02 5.314737e-02 19 1609293 1609304 12 - 0.544 0.985 1.792
ENSG00000071564 E005 126.2194027 0.0052154356 3.988443e-07 3.596718e-06 19 1609305 1609451 147 - 1.832 2.104 0.913
ENSG00000071564 E006 93.1756626 0.0036475399 4.764418e-06 3.408371e-05 19 1609452 1609454 3 - 1.720 1.968 0.835
ENSG00000071564 E007 117.1376809 0.0003845052 1.386411e-08 1.664352e-07 19 1609455 1609471 17 - 1.832 2.062 0.772
ENSG00000071564 E008 324.5951441 0.0030017570 6.233026e-05 3.429450e-04 19 1609472 1609599 128 - 2.345 2.489 0.480
ENSG00000071564 E009 306.8631181 0.0050685468 1.193399e-02 3.337406e-02 19 1609600 1609671 72 - 2.347 2.457 0.369
ENSG00000071564 E010 233.3653936 0.0030708580 1.643279e-04 8.106933e-04 19 1609672 1609688 17 - 2.198 2.346 0.495
ENSG00000071564 E011 328.0561409 0.0011345167 4.306046e-06 3.108870e-05 19 1609689 1609756 68 - 2.359 2.489 0.434
ENSG00000071564 E012 190.4842097 0.0002180735 1.344437e-03 5.124738e-03 19 1609757 1609761 5 - 2.149 2.245 0.321
ENSG00000071564 E013 898.3536086 0.0008665466 4.973999e-06 3.542116e-05 19 1609762 1610266 505 - 2.827 2.917 0.301
ENSG00000071564 E014 370.0075117 0.0002713664 1.112015e-10 1.947202e-09 19 1610267 1610500 234 - 2.395 2.543 0.492
ENSG00000071564 E015 405.3706833 0.0017410251 2.008648e-01 3.272693e-01 19 1610501 1610924 424 - 2.522 2.561 0.129
ENSG00000071564 E016 47.9067475 0.0005028359 7.352062e-01 8.260196e-01 19 1610925 1610964 40 - 1.613 1.631 0.064
ENSG00000071564 E017 163.9645668 0.0069226035 1.255183e-03 4.827062e-03 19 1610965 1611055 91 - 2.023 2.197 0.582
ENSG00000071564 E018 223.9326295 0.0057610272 4.246851e-06 3.069994e-05 19 1611056 1611167 112 - 2.119 2.341 0.742
ENSG00000071564 E019 115.8898296 0.0007684921 3.615746e-09 4.831374e-08 19 1611168 1611169 2 - 1.806 2.057 0.844
ENSG00000071564 E020 317.4203781 0.0035896709 3.730113e-03 1.238297e-02 19 1611170 1611248 79 - 2.358 2.470 0.375
ENSG00000071564 E021 426.5410878 0.0001725362 6.258060e-01 7.418627e-01 19 1611249 1611313 65 - 2.563 2.572 0.031
ENSG00000071564 E022 469.4046220 0.0001767324 9.839712e-01 9.940615e-01 19 1611314 1611369 56 - 2.612 2.612 -0.002
ENSG00000071564 E023 805.8300737 0.0009335838 1.439038e-03 5.436445e-03 19 1611370 1611686 317 - 2.893 2.832 -0.202
ENSG00000071564 E024 255.7458075 0.0043748581 8.764143e-02 1.715529e-01 19 1611687 1611703 17 - 2.400 2.335 -0.219
ENSG00000071564 E025 541.1327989 0.0032702650 6.687758e-01 7.757043e-01 19 1611704 1611754 51 - 2.663 2.681 0.060
ENSG00000071564 E026 633.3313484 0.0011631062 3.853508e-01 5.295370e-01 19 1611755 1611849 95 - 2.727 2.749 0.074
ENSG00000071564 E027 499.9480799 0.0006107809 3.900337e-01 5.340696e-01 19 1612207 1612430 224 - 2.651 2.635 -0.055
ENSG00000071564 E028 162.3658667 0.0012204856 7.051014e-02 1.441916e-01 19 1612431 1612433 3 - 2.196 2.135 -0.205
ENSG00000071564 E029 379.5079876 0.0013216881 8.146309e-03 2.415246e-02 19 1615285 1615485 201 - 2.463 2.537 0.248
ENSG00000071564 E030 177.0165732 0.0039481256 1.464162e-01 2.568081e-01 19 1615486 1615515 30 - 2.141 2.207 0.220
ENSG00000071564 E031 148.7030662 0.0013214064 5.562593e-02 1.190524e-01 19 1615516 1615520 5 - 2.060 2.132 0.241
ENSG00000071564 E032 6.6218784 0.0121252649 1.668089e-01 2.840272e-01 19 1615521 1615685 165 - 0.954 0.770 -0.709
ENSG00000071564 E033 633.5581540 0.0001040757 3.225255e-01 4.658226e-01 19 1615686 1615790 105 - 2.753 2.736 -0.054
ENSG00000071564 E034 327.1591366 0.0004585429 6.963208e-03 2.112750e-02 19 1615791 1615810 20 - 2.501 2.438 -0.211
ENSG00000071564 E035 278.4741414 0.0010609132 3.182488e-02 7.551514e-02 19 1615811 1615821 11 - 2.428 2.369 -0.196
ENSG00000071564 E036 514.2925248 0.0015245028 4.026417e-02 9.152010e-02 19 1619111 1619234 124 - 2.686 2.638 -0.160
ENSG00000071564 E037 1.6962618 0.0082878492 4.985972e-01 6.350612e-01 19 1619235 1619315 81 - 0.477 0.356 -0.652
ENSG00000071564 E038 530.1520956 0.0003414125 2.048526e-04 9.847426e-04 19 1619316 1619471 156 - 2.713 2.644 -0.230
ENSG00000071564 E039 237.9237514 0.0001819139 2.004393e-03 7.239638e-03 19 1619472 1619474 3 - 2.374 2.295 -0.264
ENSG00000071564 E040 428.4069196 0.0007469806 2.945144e-03 1.010264e-02 19 1619780 1619853 74 - 2.621 2.554 -0.222
ENSG00000071564 E041 462.7276334 0.0005367167 3.610177e-03 1.203945e-02 19 1620968 1621046 79 - 2.648 2.588 -0.200
ENSG00000071564 E042 381.8754711 0.0017058469 3.851033e-02 8.829544e-02 19 1621133 1621191 59 - 2.562 2.507 -0.184
ENSG00000071564 E043 1.1081987 0.0224093147 4.735611e-01 6.125085e-01 19 1621192 1621206 15 - 0.398 0.266 -0.826
ENSG00000071564 E044 412.2189888 0.0019957847 8.864388e-01 9.313787e-01 19 1621838 1621970 133 - 2.549 2.557 0.026
ENSG00000071564 E045 397.0625460 0.0039100348 5.617880e-01 6.895193e-01 19 1622054 1622223 170 - 2.553 2.536 -0.055
ENSG00000071564 E046 0.5212538 0.0200942300 8.915789e-01 9.347576e-01 19 1622224 1622236 13 - 0.176 0.154 -0.237
ENSG00000071564 E047 367.1022082 0.0028904170 3.202121e-01 4.633150e-01 19 1622313 1622415 103 - 2.528 2.498 -0.098
ENSG00000071564 E048 299.9983642 0.0014262648 6.554557e-03 2.006725e-02 19 1623951 1624000 50 - 2.471 2.396 -0.251
ENSG00000071564 E049 316.4606200 0.0011080456 2.903548e-02 7.007688e-02 19 1625576 1625620 45 - 2.481 2.424 -0.191
ENSG00000071564 E050 358.7979215 0.0015347421 1.704455e-01 2.887350e-01 19 1625621 1625708 88 - 2.522 2.485 -0.123
ENSG00000071564 E051 327.0770454 0.0003646183 5.042359e-04 2.175941e-03 19 1627359 1627426 68 - 2.511 2.431 -0.266
ENSG00000071564 E052 37.4442255 0.0125174052 5.140365e-01 6.487897e-01 19 1631951 1632037 87 - 1.556 1.510 -0.160
ENSG00000071564 E053 208.3384107 0.0002366435 3.924745e-04 1.745788e-03 19 1632038 1632050 13 - 2.328 2.231 -0.323
ENSG00000071564 E054 304.1208925 0.0034983992 1.195525e-02 3.342314e-02 19 1632051 1632116 66 - 2.488 2.400 -0.295
ENSG00000071564 E055 283.7371122 0.0034386812 1.098379e-01 2.053290e-01 19 1632332 1632405 74 - 2.437 2.380 -0.190
ENSG00000071564 E056 299.1242187 0.0030828754 1.380855e-02 3.779293e-02 19 1646355 1646427 73 - 2.477 2.394 -0.275
ENSG00000071564 E057 233.2846608 0.0033529611 8.554385e-05 4.542175e-04 19 1650177 1650287 111 - 2.413 2.268 -0.484
ENSG00000071564 E058 6.8129348 0.0024933556 2.866975e-02 6.934968e-02 19 1650288 1650290 3 - 1.021 0.753 -1.025
ENSG00000071564 E059 6.0379534 0.0028625538 3.618390e-01 5.062499e-01 19 1650291 1650745 455 - 0.875 0.753 -0.477
ENSG00000071564 E060 5.8841465 0.1201379123 8.630124e-01 9.156577e-01 19 1651050 1651356 307 - 0.776 0.797 0.080
ENSG00000071564 E061 74.9564207 0.0103244653 1.173254e-08 1.428559e-07 19 1652300 1652637 338 - 2.057 1.693 -1.223