ENSG00000071537

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000336735 ENSG00000071537 HEK293_OSMI2_2hA HEK293_TMG_2hB SEL1L protein_coding protein_coding 10.92005 2.629846 17.39237 0.1007745 0.2273375 2.720758 5.454537 2.559107 7.566695 0.07281155 0.4476776 1.560302 0.6574917 0.9739667 0.4346000 -0.5393667 1.057787e-25 7.723124e-28 FALSE TRUE
MSTRG.10016.2 ENSG00000071537 HEK293_OSMI2_2hA HEK293_TMG_2hB SEL1L protein_coding   10.92005 2.629846 17.39237 0.1007745 0.2273375 2.720758 5.013942 0.000000 9.019328 0.00000000 0.3561693 9.818475 0.3061500 0.0000000 0.5191333 0.5191333 7.723124e-28 7.723124e-28 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000071537 E001 283.2748261 0.0135724510 2.606639e-19 1.541261e-17 14 81471547 81473929 2383 - 2.155 2.739 1.949
ENSG00000071537 E002 809.5215475 0.0016189199 2.765980e-03 9.570534e-03 14 81473930 81477181 3252 - 2.734 2.892 0.527
ENSG00000071537 E003 1.0955012 0.2100685124 4.473917e-01 5.887887e-01 14 81479278 81479611 334 - 0.209 0.434 1.477
ENSG00000071537 E004 79.2125879 0.0022663888 2.092046e-02 5.342190e-02 14 81479612 81479740 129 - 1.765 1.732 -0.111
ENSG00000071537 E005 86.3375276 0.0009525376 2.271459e-02 5.716046e-02 14 81484225 81484397 173 - 1.802 1.784 -0.061
ENSG00000071537 E006 0.8846520 0.0136070596 1.000000e+00 1.000000e+00 14 81484398 81484528 131 - 0.209 0.268 0.465
ENSG00000071537 E007 53.1584143 0.0005206015 4.819717e-02 1.059836e-01 14 81485672 81485746 75 - 1.597 1.567 -0.101
ENSG00000071537 E008 73.8622886 0.0028141738 5.448782e-02 1.171035e-01 14 81486289 81486454 166 - 1.733 1.718 -0.051
ENSG00000071537 E009 68.0523465 0.0007472196 9.526474e-02 1.832748e-01 14 81487390 81487538 149 - 1.693 1.697 0.014
ENSG00000071537 E010 52.0100041 0.0004141027 1.484145e-01 2.595178e-01 14 81487855 81487942 88 - 1.580 1.587 0.024
ENSG00000071537 E011 2.8300138 0.0325162975 2.644567e-02 6.483994e-02 14 81488797 81489251 455 - 0.526 0.000 -13.696
ENSG00000071537 E012 49.3079176 0.0004925152 4.502515e-02 1.002484e-01 14 81489252 81489314 63 - 1.563 1.525 -0.129
ENSG00000071537 E013 50.6366717 0.0004610862 3.552407e-03 1.187606e-02 14 81490388 81490465 78 - 1.584 1.478 -0.363
ENSG00000071537 E014 0.3030308 0.3892241508 1.000000e+00   14 81490466 81490473 8 - 0.097 0.000 -8.509
ENSG00000071537 E015 40.6071041 0.0024806931 7.804972e-05 4.187917e-04 14 81492480 81492548 69 - 1.508 1.257 -0.868
ENSG00000071537 E016 42.7072992 0.0024173213 6.712720e-03 2.047669e-02 14 81495081 81495137 57 - 1.515 1.397 -0.406
ENSG00000071537 E017 71.6669518 0.0004906090 2.811879e-05 1.683475e-04 14 81497892 81498046 155 - 1.736 1.577 -0.540
ENSG00000071537 E018 0.2955422 0.0290996268 2.206013e-01   14 81498358 81498412 55 - 0.051 0.268 2.786
ENSG00000071537 E019 57.0969585 0.0004382572 3.598302e-05 2.097201e-04 14 81498413 81498494 82 - 1.643 1.453 -0.650
ENSG00000071537 E020 0.3030308 0.3892241508 1.000000e+00   14 81498808 81499458 651 - 0.097 0.000 -8.509
ENSG00000071537 E021 44.5116208 0.0005572083 6.580920e-04 2.745025e-03 14 81499459 81499518 60 - 1.534 1.366 -0.577
ENSG00000071537 E022 37.1843744 0.0183671254 1.843821e-02 4.809528e-02 14 81499609 81499662 54 - 1.458 1.299 -0.550
ENSG00000071537 E023 74.6310572 0.0013921473 2.893472e-03 9.952064e-03 14 81502721 81502883 163 - 1.744 1.666 -0.264
ENSG00000071537 E024 57.4011458 0.0004279868 1.337486e-04 6.755971e-04 14 81504201 81504262 62 - 1.642 1.478 -0.559
ENSG00000071537 E025 55.9679505 0.0004438221 1.214293e-06 9.905451e-06 14 81504263 81504306 44 - 1.641 1.382 -0.887
ENSG00000071537 E026 69.1543088 0.0015597704 3.617571e-06 2.659750e-05 14 81506074 81506178 105 - 1.726 1.514 -0.722
ENSG00000071537 E027 49.0564996 0.0004855246 8.447992e-06 5.707727e-05 14 81506179 81506241 63 - 1.583 1.333 -0.860
ENSG00000071537 E028 84.8404539 0.0005757756 1.965166e-05 1.221400e-04 14 81526733 81526964 232 - 1.807 1.666 -0.478
ENSG00000071537 E029 37.3960095 0.0005716163 5.584029e-03 1.751050e-02 14 81527701 81527738 38 - 1.462 1.333 -0.447
ENSG00000071537 E030 39.0325337 0.0007036722 1.528690e-02 4.113892e-02 14 81533675 81533853 179 - 1.475 1.382 -0.321