ENSG00000071205

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000336498 ENSG00000071205 HEK293_OSMI2_2hA HEK293_TMG_2hB ARHGAP10 protein_coding protein_coding 4.703993 5.345963 4.823625 0.1712134 0.2020011 -0.1480403 2.5421047 2.5897763 2.5583376 0.22117767 0.09345785 -0.01755267 0.5479625 0.484033333 0.5334667 0.04943333 7.650282e-01 1.776513e-15 FALSE TRUE
ENST00000507661 ENSG00000071205 HEK293_OSMI2_2hA HEK293_TMG_2hB ARHGAP10 protein_coding protein_coding 4.703993 5.345963 4.823625 0.1712134 0.2020011 -0.1480403 0.5466851 1.4352579 0.0000000 0.20784698 0.00000000 -7.17518313 0.1033000 0.268400000 0.0000000 -0.26840000 1.776513e-15 1.776513e-15 FALSE TRUE
MSTRG.25584.2 ENSG00000071205 HEK293_OSMI2_2hA HEK293_TMG_2hB ARHGAP10 protein_coding   4.703993 5.345963 4.823625 0.1712134 0.2020011 -0.1480403 1.4182544 1.2417887 1.6256578 0.01479901 0.31853437 0.38587991 0.3046833 0.232933333 0.3329000 0.09996667 3.632652e-01 1.776513e-15 FALSE TRUE
MSTRG.25584.3 ENSG00000071205 HEK293_OSMI2_2hA HEK293_TMG_2hB ARHGAP10 protein_coding   4.703993 5.345963 4.823625 0.1712134 0.2020011 -0.1480403 0.1110276 0.0182245 0.5648636 0.01822450 0.18994764 4.34819963 0.0243250 0.003233333 0.1187000 0.11546667 8.907977e-04 1.776513e-15 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000071205 E001 0.6203429 0.0376048870 0.9011458444 0.940949975 4 147731593 147731744 152 + 0.228 0.208 -0.171
ENSG00000071205 E002 0.2903454 0.2988180279 0.2364352389   4 147731745 147731779 35 + 0.227 0.000 -10.714
ENSG00000071205 E003 1.4758382 0.0089624829 0.0041448395 0.013548448 4 147732063 147732087 25 + 0.613 0.116 -3.340
ENSG00000071205 E004 12.9671051 0.0014061680 0.0002614546 0.001222476 4 147732088 147732345 258 + 1.301 0.968 -1.196
ENSG00000071205 E005 21.1512368 0.0013182249 0.0659048810 0.136548865 4 147732346 147732455 110 + 1.418 1.288 -0.453
ENSG00000071205 E006 26.2338572 0.0008990849 0.2005124672 0.326847447 4 147822727 147822822 96 + 1.482 1.402 -0.276
ENSG00000071205 E007 19.7616627 0.0010539961 0.2164873972 0.346179196 4 147822896 147822957 62 + 1.363 1.274 -0.312
ENSG00000071205 E008 20.8178952 0.0009265355 0.9242034448 0.956266255 4 147847151 147847222 72 + 1.337 1.334 -0.010
ENSG00000071205 E009 31.4018461 0.0013160345 0.1338537287 0.239510624 4 147857553 147857654 102 + 1.555 1.466 -0.304
ENSG00000071205 E010 0.0000000       4 147857655 147858488 834 +      
ENSG00000071205 E011 0.5085815 0.2533416751 0.6980764344 0.798120014 4 147860983 147864845 3863 + 0.129 0.209 0.841
ENSG00000071205 E012 36.3803111 0.0107577478 0.1552634712 0.268747991 4 147864846 147864956 111 + 1.624 1.521 -0.353
ENSG00000071205 E013 0.0000000       4 147864957 147866711 1755 +      
ENSG00000071205 E014 38.9141787 0.0144941168 0.0256253904 0.063176260 4 147866712 147866816 105 + 1.688 1.513 -0.595
ENSG00000071205 E015 43.9946863 0.0075384591 0.0193122476 0.050011358 4 147875021 147875150 130 + 1.728 1.577 -0.513
ENSG00000071205 E016 39.6211840 0.0005970863 0.0510777170 0.111091572 4 147879232 147879338 107 + 1.661 1.560 -0.346
ENSG00000071205 E017 28.0734305 0.0008387188 0.1129319283 0.209821068 4 147881838 147881866 29 + 1.515 1.418 -0.336
ENSG00000071205 E018 32.4436871 0.0009333039 0.3032112616 0.445110747 4 147881867 147881932 66 + 1.555 1.497 -0.198
ENSG00000071205 E019 33.6374696 0.0006468280 0.3253211464 0.468756105 4 147906638 147906719 82 + 1.567 1.513 -0.183
ENSG00000071205 E020 32.1625860 0.0082127318 0.6044301252 0.724987805 4 147909732 147909777 46 + 1.533 1.498 -0.119
ENSG00000071205 E021 39.2790924 0.0006685529 0.4772628894 0.615845838 4 147913074 147913139 66 + 1.617 1.581 -0.120
ENSG00000071205 E022 38.8673413 0.0006209759 0.5461614142 0.676384992 4 147939825 147939899 75 + 1.571 1.609 0.128
ENSG00000071205 E023 0.0000000       4 147946239 147946616 378 +      
ENSG00000071205 E024 34.7232661 0.0117494424 0.2261471970 0.357781538 4 147946617 147946704 88 + 1.487 1.584 0.333
ENSG00000071205 E025 32.5680667 0.0047431268 0.1669871342 0.284270896 4 147955316 147955374 59 + 1.456 1.554 0.334
ENSG00000071205 E026 41.6347624 0.0005185899 0.1115050058 0.207764904 4 147965024 147965129 106 + 1.571 1.661 0.306
ENSG00000071205 E027 42.0641058 0.0132104357 0.4893922400 0.626826392 4 147966680 147966839 160 + 1.598 1.657 0.200
ENSG00000071205 E028 0.0000000       4 148023054 148023262 209 +      
ENSG00000071205 E029 46.3515205 0.0005747897 0.1327590911 0.237945237 4 148023263 148023413 151 + 1.624 1.705 0.275
ENSG00000071205 E030 56.8551240 0.0004856750 0.1647062955 0.281306806 4 148046892 148047051 160 + 1.714 1.782 0.231
ENSG00000071205 E031 15.2289554 0.0105239727 0.4539186179 0.594625292 4 148063148 148063152 5 + 1.160 1.237 0.272
ENSG00000071205 E032 32.7591893 0.0006890741 0.1867909457 0.309700375 4 148063153 148063300 148 + 1.472 1.556 0.289
ENSG00000071205 E033 40.4546245 0.0026950348 0.4982299134 0.634724869 4 148064416 148064507 92 + 1.583 1.625 0.145
ENSG00000071205 E034 0.4782907 0.0213818085 0.1056776104 0.199123812 4 148065240 148065660 421 + 0.000 0.283 10.687
ENSG00000071205 E035 42.5159039 0.0038877556 0.0036433953 0.012136771 4 148071993 148072179 187 + 1.515 1.696 0.616
ENSG00000071205 E036 31.8848561 0.0133917927 0.1314406679 0.236148134 4 148072180 148072357 178 + 1.435 1.569 0.461
ENSG00000071205 E037 54.4596222 0.0139867219 0.0058661398 0.018261512 4 148072358 148072776 419 + 1.610 1.823 0.724
ENSG00000071205 E038 0.5181333 0.0204088914 0.4987141845 0.635137683 4 148079828 148080460 633 + 0.228 0.116 -1.167