ENSG00000071189

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000409076 ENSG00000071189 HEK293_OSMI2_2hA HEK293_TMG_2hB SNX13 protein_coding nonsense_mediated_decay 7.663145 1.384417 12.24677 0.1252703 0.5161127 3.135845 2.1877124 0.19119779 3.3036259 0.095624094 0.30999712 4.0417243 0.24901667 0.15156667 0.27163333 0.12006667 5.226717e-01 3.134613e-05 FALSE TRUE
ENST00000409604 ENSG00000071189 HEK293_OSMI2_2hA HEK293_TMG_2hB SNX13 protein_coding protein_coding 7.663145 1.384417 12.24677 0.1252703 0.5161127 3.135845 0.1466890 0.13189524 0.2708198 0.049439694 0.04228379 0.9848182 0.04642083 0.10200000 0.02193333 -0.08006667 2.099654e-02 3.134613e-05 FALSE TRUE
ENST00000428135 ENSG00000071189 HEK293_OSMI2_2hA HEK293_TMG_2hB SNX13 protein_coding protein_coding 7.663145 1.384417 12.24677 0.1252703 0.5161127 3.135845 1.9434864 0.56862937 3.5470926 0.059992109 0.21526575 2.6199871 0.32675417 0.41363333 0.28920000 -0.12443333 1.283025e-01 3.134613e-05 FALSE TRUE
ENST00000496855 ENSG00000071189 HEK293_OSMI2_2hA HEK293_TMG_2hB SNX13 protein_coding processed_transcript 7.663145 1.384417 12.24677 0.1252703 0.5161127 3.135845 0.4569859 0.31613838 0.5867863 0.205779738 0.58678630 0.8717302 0.10467917 0.20570000 0.04420000 -0.16150000 3.851197e-01 3.134613e-05 FALSE TRUE
ENST00000611725 ENSG00000071189 HEK293_OSMI2_2hA HEK293_TMG_2hB SNX13 protein_coding protein_coding 7.663145 1.384417 12.24677 0.1252703 0.5161127 3.135845 0.5535091 0.09953285 0.7484768 0.009714527 0.06408755 2.7917415 0.08068333 0.07186667 0.06096667 -0.01090000 8.762976e-01 3.134613e-05 FALSE TRUE
MSTRG.29530.4 ENSG00000071189 HEK293_OSMI2_2hA HEK293_TMG_2hB SNX13 protein_coding   7.663145 1.384417 12.24677 0.1252703 0.5161127 3.135845 1.5391633 0.00000000 2.6035326 0.000000000 0.49799867 8.0298574 0.12119583 0.00000000 0.21650000 0.21650000 3.134613e-05 3.134613e-05 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000071189 E001 90.0497715 0.0005407262 5.915848e-05 0.0003272997 7 17790761 17792841 2081 - 1.754 1.964 0.707
ENSG00000071189 E002 29.8631169 0.0100318967 4.129602e-02 0.0934238586 7 17792842 17793419 578 - 1.287 1.490 0.704
ENSG00000071189 E003 71.3751460 0.0041455255 5.126333e-03 0.0162729299 7 17793420 17793763 344 - 1.662 1.848 0.631
ENSG00000071189 E004 79.4950864 0.0021813074 1.656722e-02 0.0439876888 7 17793764 17794026 263 - 1.712 1.861 0.505
ENSG00000071189 E005 76.7171683 0.0022509706 1.960776e-01 0.3213210236 7 17794027 17794292 266 - 1.706 1.795 0.303
ENSG00000071189 E006 26.9296430 0.0007538092 6.045097e-01 0.7250379414 7 17794293 17796826 2534 - 1.271 1.332 0.213
ENSG00000071189 E007 46.4549254 0.0005293469 7.476620e-01 0.8351088569 7 17796827 17796939 113 - 1.502 1.538 0.123
ENSG00000071189 E008 36.7978332 0.0005886716 9.892870e-01 0.9973187335 7 17798690 17798758 69 - 1.406 1.417 0.037
ENSG00000071189 E009 47.1763197 0.0004778141 6.744332e-01 0.7799231793 7 17799009 17799154 146 - 1.506 1.549 0.147
ENSG00000071189 E010 35.6515809 0.0005987650 8.623561e-01 0.9152527394 7 17801588 17801659 72 - 1.390 1.417 0.091
ENSG00000071189 E011 52.7946334 0.0004715099 3.805804e-01 0.5248509300 7 17803419 17803580 162 - 1.567 1.513 -0.182
ENSG00000071189 E012 41.0881164 0.0005197730 2.726794e-01 0.4116388284 7 17814834 17814944 111 - 1.442 1.538 0.329
ENSG00000071189 E013 24.3180964 0.0009712774 7.819428e-01 0.8599750685 7 17816182 17816219 38 - 1.232 1.271 0.138
ENSG00000071189 E014 34.7128932 0.0006779836 8.793283e-01 0.9264820353 7 17816220 17816289 70 - 1.386 1.385 -0.006
ENSG00000071189 E015 48.4469886 0.0004572780 6.138738e-01 0.7324798431 7 17821509 17821648 140 - 1.527 1.501 -0.091
ENSG00000071189 E016 2.7752811 0.0063025819 4.909645e-01 0.6282880033 7 17821649 17821681 33 - 0.433 0.579 0.708
ENSG00000071189 E017 0.1482932 0.0414784392 4.033166e-02   7 17821682 17821697 16 - 0.000 0.285 13.384
ENSG00000071189 E018 31.8966052 0.0006703087 2.292977e-02 0.0575986709 7 17826022 17826091 70 - 1.372 1.147 -0.792
ENSG00000071189 E019 20.3051256 0.0009107396 1.411716e-01 0.2496426912 7 17830010 17830047 38 - 1.183 1.013 -0.614
ENSG00000071189 E020 40.4447551 0.0004991665 2.731084e-03 0.0094667487 7 17834052 17834184 133 - 1.476 1.201 -0.959
ENSG00000071189 E021 37.8457383 0.0005563910 8.362554e-03 0.0246950381 7 17834761 17834865 105 - 1.445 1.201 -0.853
ENSG00000071189 E022 55.5152280 0.0004290588 3.744257e-03 0.0124225723 7 17839807 17840000 194 - 1.604 1.385 -0.753
ENSG00000071189 E023 33.8750844 0.0011438950 4.852323e-03 0.0155201434 7 17845595 17845694 100 - 1.402 1.117 -1.004
ENSG00000071189 E024 31.0577830 0.0010011220 1.681293e-02 0.0445209011 7 17850347 17850435 89 - 1.361 1.117 -0.862
ENSG00000071189 E025 39.8320443 0.0010157156 1.320272e-01 0.2369316451 7 17850826 17850964 139 - 1.454 1.332 -0.424
ENSG00000071189 E026 0.0000000       7 17868282 17868406 125 -      
ENSG00000071189 E027 26.3405978 0.0007507794 4.071694e-01 0.5507781316 7 17868407 17868490 84 - 1.276 1.201 -0.265
ENSG00000071189 E028 26.1354216 0.0007095009 9.544677e-01 0.9754600764 7 17873528 17873616 89 - 1.265 1.271 0.020
ENSG00000071189 E029 29.4587440 0.0008213189 1.394382e-02 0.0380949954 7 17875480 17875581 102 - 1.344 1.085 -0.917
ENSG00000071189 E030 40.2532232 0.0006968937 2.108898e-04 0.0010104566 7 17875669 17875790 122 - 1.481 1.117 -1.276
ENSG00000071189 E031 19.4560291 0.0560274213 4.123830e-05 0.0002369642 7 17879427 17882943 3517 - 1.010 1.617 2.130
ENSG00000071189 E032 0.0000000       7 17888156 17888559 404 -      
ENSG00000071189 E033 0.2924217 0.0274624084 1.000000e+00   7 17888560 17888722 163 - 0.089 0.000 -8.605
ENSG00000071189 E034 0.2924217 0.0274624084 1.000000e+00   7 17888723 17890362 1640 - 0.089 0.000 -8.605
ENSG00000071189 E035 56.7555965 0.0048408715 5.073377e-01 0.6429147038 7 17890363 17890484 122 - 1.599 1.559 -0.135
ENSG00000071189 E036 27.8890255 0.0007104216 9.420888e-02 0.1817157471 7 17891546 17891561 16 - 1.314 1.147 -0.589
ENSG00000071189 E037 39.4810650 0.0005669917 5.075897e-01 0.6430433439 7 17891562 17891628 67 - 1.445 1.401 -0.153
ENSG00000071189 E038 22.3997664 0.0014452658 9.076191e-01 0.9453748349 7 17891629 17891635 7 - 1.202 1.226 0.084
ENSG00000071189 E039 27.0721476 0.0007605400 8.176968e-01 0.8847233673 7 17893332 17893347 16 - 1.279 1.312 0.118
ENSG00000071189 E040 39.4699894 0.0005688437 5.868745e-01 0.7103212338 7 17893348 17893434 87 - 1.433 1.488 0.190
ENSG00000071189 E041 41.0678961 0.0005189551 7.801442e-01 0.8586857133 7 17897334 17897446 113 - 1.457 1.447 -0.037
ENSG00000071189 E042 0.4375944 0.0277902019 1.000000e+00 1.0000000000 7 17897844 17897884 41 - 0.128 0.000 -9.190
ENSG00000071189 E043 0.0000000       7 17898217 17898300 84 -      
ENSG00000071189 E044 0.0000000       7 17898827 17898973 147 -      
ENSG00000071189 E045 0.1515154 0.0428274416 7.005809e-01   7 17898974 17900106 1133 - 0.047 0.000 -7.606
ENSG00000071189 E046 0.0000000       7 17900124 17900248 125 -      
ENSG00000071189 E047 1.0330575 0.0368531698 2.084043e-02 0.0532498522 7 17907249 17907340 92 - 0.128 0.580 3.034
ENSG00000071189 E048 33.3571552 0.0122833402 4.910257e-01 0.6283408467 7 17940284 17940501 218 - 1.376 1.313 -0.219