ENSG00000071054

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000324219 ENSG00000071054 HEK293_OSMI2_2hA HEK293_TMG_2hB MAP4K4 protein_coding protein_coding 23.07104 21.39879 27.60247 2.005584 0.430956 0.3671167 0.5782715 0.0000000 1.707070 0.0000000 0.7160647 7.4238051 0.02249583 0.000000000 0.06266667 0.06266667 1.987414e-04 1.325337e-26 FALSE TRUE
ENST00000347699 ENSG00000071054 HEK293_OSMI2_2hA HEK293_TMG_2hB MAP4K4 protein_coding protein_coding 23.07104 21.39879 27.60247 2.005584 0.430956 0.3671167 0.5648563 0.1035364 1.552350 0.1035364 1.2002608 3.7824909 0.02277500 0.004533333 0.05493333 0.05040000 5.640702e-01 1.325337e-26 FALSE TRUE
ENST00000625522 ENSG00000071054 HEK293_OSMI2_2hA HEK293_TMG_2hB MAP4K4 protein_coding protein_coding 23.07104 21.39879 27.60247 2.005584 0.430956 0.3671167 1.6385643 1.7273870 1.332614 0.4389453 0.9189437 -0.3718744 0.07320000 0.079800000 0.04886667 -0.03093333 6.615230e-01 1.325337e-26 FALSE TRUE
ENST00000634702 ENSG00000071054 HEK293_OSMI2_2hA HEK293_TMG_2hB MAP4K4 protein_coding protein_coding 23.07104 21.39879 27.60247 2.005584 0.430956 0.3671167 0.4691487 0.0000000 2.340279 0.0000000 1.1715012 7.8766882 0.01806250 0.000000000 0.08400000 0.08400000 2.040498e-01 1.325337e-26 FALSE TRUE
MSTRG.18958.16 ENSG00000071054 HEK293_OSMI2_2hA HEK293_TMG_2hB MAP4K4 protein_coding   23.07104 21.39879 27.60247 2.005584 0.430956 0.3671167 1.5084142 0.0000000 5.378786 0.0000000 0.9972909 9.0738164 0.05870000 0.000000000 0.19440000 0.19440000 3.135819e-19 1.325337e-26 FALSE TRUE
MSTRG.18958.19 ENSG00000071054 HEK293_OSMI2_2hA HEK293_TMG_2hB MAP4K4 protein_coding   23.07104 21.39879 27.60247 2.005584 0.430956 0.3671167 0.7971044 1.9756285 0.000000 0.3284242 0.0000000 -7.6334519 0.03784583 0.091366667 0.00000000 -0.09136667 1.325337e-26 1.325337e-26 FALSE TRUE
MSTRG.18958.24 ENSG00000071054 HEK293_OSMI2_2hA HEK293_TMG_2hB MAP4K4 protein_coding   23.07104 21.39879 27.60247 2.005584 0.430956 0.3671167 1.4740312 2.5670390 0.000000 0.4050166 0.0000000 -8.0095705 0.07108333 0.125833333 0.00000000 -0.12583333 7.621009e-16 1.325337e-26 FALSE TRUE
MSTRG.18958.25 ENSG00000071054 HEK293_OSMI2_2hA HEK293_TMG_2hB MAP4K4 protein_coding   23.07104 21.39879 27.60247 2.005584 0.430956 0.3671167 0.8615430 1.1100752 0.000000 0.1483014 0.0000000 -6.8074518 0.03882917 0.051466667 0.00000000 -0.05146667 4.140322e-22 1.325337e-26 FALSE TRUE
MSTRG.18958.3 ENSG00000071054 HEK293_OSMI2_2hA HEK293_TMG_2hB MAP4K4 protein_coding   23.07104 21.39879 27.60247 2.005584 0.430956 0.3671167 5.1820196 7.1861089 5.625663 0.6104020 0.6686463 -0.3526317 0.22750000 0.337566667 0.20460000 -0.13296667 2.802139e-02 1.325337e-26 FALSE TRUE
MSTRG.18958.33 ENSG00000071054 HEK293_OSMI2_2hA HEK293_TMG_2hB MAP4K4 protein_coding   23.07104 21.39879 27.60247 2.005584 0.430956 0.3671167 2.5281252 3.7198057 1.347659 0.5060226 0.6763086 -1.4579793 0.11632083 0.172700000 0.04856667 -0.12413333 4.012801e-01 1.325337e-26 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000071054 E001 0.0000000       2 101696850 101697063 214 +      
ENSG00000071054 E002 3.9996094 0.0038570922 2.727536e-03 9.455315e-03 2 101697064 101697064 1 + 0.868 0.438 -1.869
ENSG00000071054 E003 6.1235906 0.0963180349 2.125581e-05 1.309742e-04 2 101697707 101697731 25 + 1.107 0.231 -4.066
ENSG00000071054 E004 6.1621881 0.1050435550 1.521319e-07 1.491689e-06 2 101697732 101697743 12 + 1.136 0.000 -16.699
ENSG00000071054 E005 7.6242967 0.1591742341 4.320751e-07 3.870229e-06 2 101697744 101697754 11 + 1.222 0.000 -17.005
ENSG00000071054 E006 9.9934215 0.0615272512 6.172237e-12 1.329065e-10 2 101697755 101697820 66 + 1.334 0.000 -17.396
ENSG00000071054 E007 6.4132706 0.0030440182 1.871086e-11 3.725790e-10 2 101697821 101697843 23 + 1.138 0.130 -5.191
ENSG00000071054 E008 4.3641285 0.0035891261 9.748392e-08 9.918919e-07 2 101697844 101697845 2 + 0.978 0.130 -4.606
ENSG00000071054 E009 4.3662048 0.0035353823 9.677803e-08 9.851858e-07 2 101697846 101697852 7 + 0.978 0.130 -4.606
ENSG00000071054 E010 4.7952664 0.0097554922 3.562147e-08 3.951505e-07 2 101697853 101697856 4 + 1.017 0.130 -4.752
ENSG00000071054 E011 10.6213898 0.0405174752 3.371495e-11 6.436759e-10 2 101697857 101697893 37 + 1.341 0.231 -4.897
ENSG00000071054 E012 11.8620637 0.0481106869 1.496561e-09 2.147546e-08 2 101697894 101697913 20 + 1.375 0.381 -4.014
ENSG00000071054 E013 11.4138601 0.0680682421 5.480915e-08 5.856088e-07 2 101697914 101697918 5 + 1.358 0.382 -3.949
ENSG00000071054 E014 11.8890304 0.0560236638 1.295429e-07 1.287795e-06 2 101697919 101697928 10 + 1.364 0.492 -3.391
ENSG00000071054 E015 14.7099382 0.0876096053 2.445683e-04 1.152527e-03 2 101697929 101697941 13 + 1.412 0.776 -2.320
ENSG00000071054 E016 26.5556472 0.0106495209 1.261821e-08 1.526880e-07 2 101697942 101698006 65 + 1.623 1.144 -1.664
ENSG00000071054 E017 23.4911654 0.0070426901 5.357406e-08 5.737391e-07 2 101698007 101698025 19 + 1.562 1.121 -1.539
ENSG00000071054 E018 41.7982878 0.0063595063 1.070870e-05 7.068751e-05 2 101698026 101698075 50 + 1.752 1.477 -0.939
ENSG00000071054 E019 38.9523097 0.0010036383 1.625154e-06 1.289066e-05 2 101698076 101698080 5 + 1.716 1.461 -0.869
ENSG00000071054 E020 81.0422019 0.0003492745 9.261023e-11 1.643380e-09 2 101698081 101698137 57 + 2.022 1.785 -0.795
ENSG00000071054 E021 111.5760940 0.0041261933 4.240038e-05 2.429564e-04 2 101698473 101698529 57 + 2.129 1.959 -0.570
ENSG00000071054 E022 83.8578216 0.0094213920 4.586339e-03 1.478220e-02 2 101698530 101698538 9 + 2.000 1.844 -0.525
ENSG00000071054 E023 138.8537826 0.0018974375 5.522150e-07 4.845777e-06 2 101790720 101790776 57 + 2.222 2.060 -0.544
ENSG00000071054 E024 0.1472490 0.0442259719 5.381403e-01   2 101797234 101797383 150 + 0.115 0.000 -11.314
ENSG00000071054 E025 223.7823339 0.0079045418 1.759093e-04 8.607454e-04 2 101823928 101824053 126 + 2.430 2.261 -0.561
ENSG00000071054 E026 197.3338944 0.0053883128 1.216246e-04 6.212465e-04 2 101825319 101825401 83 + 2.367 2.219 -0.497
ENSG00000071054 E027 149.1565894 0.0044496055 4.606896e-04 2.009215e-03 2 101825402 101825429 28 + 2.240 2.108 -0.442
ENSG00000071054 E028 220.8523084 0.0037670466 1.552575e-06 1.236727e-05 2 101829504 101829594 91 + 2.423 2.262 -0.538
ENSG00000071054 E029 0.0000000       2 101829595 101829754 160 +      
ENSG00000071054 E030 238.7258081 0.0047017919 3.937518e-04 1.750812e-03 2 101831721 101831851 131 + 2.439 2.319 -0.400
ENSG00000071054 E031 137.2271997 0.0046553636 1.545913e-04 7.674350e-04 2 101834409 101834463 55 + 2.212 2.064 -0.494
ENSG00000071054 E032 173.3753477 0.0037331534 2.323500e-03 8.223668e-03 2 101835900 101835978 79 + 2.291 2.192 -0.333
ENSG00000071054 E033 88.3357975 0.0003792722 6.755584e-03 2.058854e-02 2 101839819 101839827 9 + 1.992 1.912 -0.269
ENSG00000071054 E034 266.3669390 0.0001917242 5.585553e-08 5.955461e-07 2 101839828 101839994 167 + 2.476 2.378 -0.327
ENSG00000071054 E035 252.1943185 0.0024042400 1.159106e-01 2.141121e-01 2 101842609 101842681 73 + 2.421 2.389 -0.106
ENSG00000071054 E036 382.1305008 0.0036783702 9.540766e-02 1.835032e-01 2 101844101 101844311 211 + 2.603 2.566 -0.126
ENSG00000071054 E037 262.1133111 0.0023789802 4.537748e-01 5.944851e-01 2 101855977 101856138 162 + 2.425 2.419 -0.017
ENSG00000071054 E038 132.9747054 0.0029822703 1.500539e-01 2.617467e-01 2 101858996 101859082 87 + 2.088 2.165 0.259
ENSG00000071054 E039 73.3223464 0.0005700545 6.728064e-02 1.388299e-01 2 101859643 101859735 93 + 1.821 1.921 0.335
ENSG00000071054 E040 142.5731906 0.0003421671 5.180795e-01 6.523713e-01 2 101859736 101859864 129 + 2.139 2.181 0.141
ENSG00000071054 E041 0.6558305 0.0614394683 9.358241e-01 9.636288e-01 2 101859865 101860824 960 + 0.206 0.230 0.204
ENSG00000071054 E042 36.2256831 0.0005446904 5.288132e-01 6.616871e-01 2 101860825 101860986 162 + 1.544 1.603 0.201
ENSG00000071054 E043 0.3299976 0.0274424043 1.776748e-01   2 101860987 101862240 1254 + 0.000 0.230 12.440
ENSG00000071054 E044 4.9715254 0.0037657962 1.905433e-01 3.144440e-01 2 101863821 101863826 6 + 0.667 0.862 0.786
ENSG00000071054 E045 21.1870579 0.0122717663 6.971914e-01 7.973728e-01 2 101863827 101864051 225 + 1.317 1.369 0.180
ENSG00000071054 E046 164.2065161 0.0013631325 9.330821e-01 9.618254e-01 2 101864930 101865036 107 + 2.207 2.229 0.075
ENSG00000071054 E047 69.8845511 0.0010217335 1.787610e-01 2.996040e-01 2 101866428 101866430 3 + 1.809 1.891 0.274
ENSG00000071054 E048 139.5584399 0.0052059269 7.354792e-01 8.262431e-01 2 101866431 101866492 62 + 2.147 2.149 0.007
ENSG00000071054 E049 163.7276896 0.0023307890 3.159876e-01 4.587581e-01 2 101866493 101866579 87 + 2.227 2.212 -0.050
ENSG00000071054 E050 192.5928473 0.0002219888 2.789199e-01 4.186052e-01 2 101867212 101867309 98 + 2.293 2.288 -0.017
ENSG00000071054 E051 3.6912575 0.0042762479 1.151596e-06 9.439532e-06 2 101867310 101867535 226 + 0.918 0.130 -4.384
ENSG00000071054 E052 5.9891016 0.0204401272 7.560421e-05 4.071345e-04 2 101867536 101867855 320 + 1.054 0.489 -2.307
ENSG00000071054 E053 4.6388537 0.0177655283 1.041911e-02 2.979516e-02 2 101867856 101868028 173 + 0.902 0.536 -1.518
ENSG00000071054 E054 42.4192392 0.0004807815 4.068932e-03 1.333530e-02 2 101868029 101868037 9 + 1.703 1.571 -0.447
ENSG00000071054 E055 314.4921183 0.0001528393 3.231953e-04 1.473678e-03 2 101869622 101869797 176 + 2.527 2.477 -0.166
ENSG00000071054 E056 4.5039245 0.0036178012 9.706148e-03 2.803874e-02 2 101869798 101870085 288 + 0.885 0.537 -1.451
ENSG00000071054 E057 265.9941144 0.0001604281 3.011140e-01 4.428842e-01 2 101870295 101870415 121 + 2.430 2.431 0.001
ENSG00000071054 E058 2.7356290 0.0053113678 8.468581e-05 4.502294e-04 2 101870416 101870633 218 + 0.790 0.130 -3.886
ENSG00000071054 E059 141.3246542 0.0002674679 3.996720e-01 5.434106e-01 2 101871494 101871685 192 + 2.130 2.178 0.161
ENSG00000071054 E060 297.7787105 0.0001633209 6.974631e-01 7.975873e-01 2 101873647 101873764 118 + 2.472 2.487 0.050
ENSG00000071054 E061 374.0706857 0.0008251218 5.989007e-01 7.204222e-01 2 101874082 101874252 171 + 2.573 2.584 0.039
ENSG00000071054 E062 375.8915801 0.0001558918 1.737603e-02 4.576890e-02 2 101877003 101877146 144 + 2.545 2.612 0.224
ENSG00000071054 E063 338.1935773 0.0015421207 4.333571e-05 2.478286e-04 2 101882551 101882685 135 + 2.462 2.592 0.433
ENSG00000071054 E064 288.9064674 0.0012070844 1.535199e-11 3.101289e-10 2 101885187 101885287 101 + 2.351 2.551 0.666
ENSG00000071054 E065 438.9499623 0.0028037495 4.427027e-09 5.825833e-08 2 101887088 101887237 150 + 2.533 2.730 0.656
ENSG00000071054 E066 41.6924625 0.0045614546 2.943625e-01 4.354624e-01 2 101887238 101887261 24 + 1.587 1.674 0.297
ENSG00000071054 E067 550.3803661 0.0029550752 5.327397e-12 1.158869e-10 2 101887778 101887937 160 + 2.613 2.840 0.756
ENSG00000071054 E068 502.6458721 0.0048352089 1.382360e-11 2.814745e-10 2 101888796 101888935 140 + 2.545 2.815 0.901
ENSG00000071054 E069 1305.6844555 0.0027891935 1.322738e-05 8.542313e-05 2 101891166 101894690 3525 + 3.048 3.173 0.416