ENSG00000070961

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000261173 ENSG00000070961 HEK293_OSMI2_2hA HEK293_TMG_2hB ATP2B1 protein_coding protein_coding 20.35954 3.834562 30.28532 0.6066192 0.2416414 2.978204 3.167149 2.30117301 2.454718 0.03293948 1.2328075 0.09279761 0.29414583 0.6344333 0.08043333 -0.55400000 1.200850e-01 2.313622e-14 FALSE TRUE
ENST00000393164 ENSG00000070961 HEK293_OSMI2_2hA HEK293_TMG_2hB ATP2B1 protein_coding protein_coding 20.35954 3.834562 30.28532 0.6066192 0.2416414 2.978204 2.091551 0.27233367 2.675602 0.13622618 0.5290458 3.24977262 0.09780833 0.0614000 0.08820000 0.02680000 7.636878e-01 2.313622e-14 FALSE TRUE
ENST00000428670 ENSG00000070961 HEK293_OSMI2_2hA HEK293_TMG_2hB ATP2B1 protein_coding protein_coding 20.35954 3.834562 30.28532 0.6066192 0.2416414 2.978204 3.081719 0.08847813 6.199561 0.04826946 0.6301619 5.97854419 0.11545833 0.0283000 0.20503333 0.17673333 9.120485e-04 2.313622e-14 FALSE TRUE
ENST00000635033 ENSG00000070961 HEK293_OSMI2_2hA HEK293_TMG_2hB ATP2B1 protein_coding protein_coding 20.35954 3.834562 30.28532 0.6066192 0.2416414 2.978204 3.679036 0.80184924 4.629218 0.40857139 0.4507461 2.51459777 0.20292083 0.1803000 0.15266667 -0.02763333 9.573131e-01 2.313622e-14 FALSE TRUE
MSTRG.7745.6 ENSG00000070961 HEK293_OSMI2_2hA HEK293_TMG_2hB ATP2B1 protein_coding   20.35954 3.834562 30.28532 0.6066192 0.2416414 2.978204 3.404450 0.00000000 6.106560 0.00000000 0.5866216 9.25657661 0.09206250 0.0000000 0.20190000 0.20190000 2.313622e-14 2.313622e-14 FALSE TRUE
MSTRG.7745.7 ENSG00000070961 HEK293_OSMI2_2hA HEK293_TMG_2hB ATP2B1 protein_coding   20.35954 3.834562 30.28532 0.6066192 0.2416414 2.978204 3.630607 0.00000000 5.971467 0.00000000 0.9858555 9.22435547 0.11003750 0.0000000 0.19690000 0.19690000 7.514045e-11 2.313622e-14 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000070961 E001 0.5922303 0.0179787794 5.150485e-01 6.497596e-01 12 89588049 89588050 2 - 0.134 0.274 1.282
ENSG00000070961 E002 349.1547661 0.0187529638 8.205585e-11 1.469165e-09 12 89588051 89590527 2477 - 2.285 2.747 1.538
ENSG00000070961 E003 156.1383177 0.0002997981 2.643284e-14 8.169040e-13 12 89590528 89590841 314 - 1.977 2.295 1.063
ENSG00000070961 E004 179.2812609 0.0002074151 7.801093e-12 1.653680e-10 12 89590842 89591102 261 - 2.046 2.323 0.928
ENSG00000070961 E005 170.9454874 0.0002574970 2.047868e-04 9.844763e-04 12 89591103 89591295 193 - 2.046 2.230 0.617
ENSG00000070961 E006 0.1472490 0.0431071166 8.582413e-01   12 89598590 89598656 67 - 0.049 0.000 -9.328
ENSG00000070961 E007 0.2944980 0.3688255251 1.000000e+00   12 89598657 89598743 87 - 0.094 0.000 -10.327
ENSG00000070961 E008 153.9798350 0.0002536876 6.453921e-01 7.574970e-01 12 89599117 89599299 183 - 2.022 2.094 0.240
ENSG00000070961 E009 100.6769681 0.0005318314 4.152101e-01 5.586084e-01 12 89601326 89601403 78 - 1.852 1.864 0.041
ENSG00000070961 E010 57.0843181 0.0180425983 8.995240e-01 9.398834e-01 12 89601404 89601433 30 - 1.603 1.667 0.218
ENSG00000070961 E011 117.1078150 0.0038511752 8.888820e-01 9.329354e-01 12 89603043 89603254 212 - 1.911 1.958 0.156
ENSG00000070961 E012 3.1095226 0.0425059766 3.389212e-02 7.953868e-02 12 89603255 89603711 457 - 0.548 0.000 -13.721
ENSG00000070961 E013 87.7900857 0.0008326204 3.197702e-01 4.628558e-01 12 89603712 89603795 84 - 1.792 1.791 -0.005
ENSG00000070961 E014 77.8101954 0.0003744155 3.178082e-01 4.607059e-01 12 89603796 89603837 42 - 1.742 1.738 -0.014
ENSG00000070961 E015 100.9376270 0.0005535806 8.743090e-01 9.231858e-01 12 89603838 89603925 88 - 1.843 1.904 0.206
ENSG00000070961 E016 2.6700793 0.0102734040 4.540738e-02 1.009406e-01 12 89603926 89604154 229 - 0.501 0.000 -13.499
ENSG00000070961 E017 138.2268609 0.0005200979 8.966021e-01 9.379011e-01 12 89604155 89604346 192 - 1.980 2.028 0.162
ENSG00000070961 E018 94.1162864 0.0038259568 2.999029e-01 4.415030e-01 12 89609937 89610043 107 - 1.824 1.816 -0.027
ENSG00000070961 E019 98.0072338 0.0002766200 8.688793e-03 2.550814e-02 12 89610421 89610508 88 - 1.852 1.765 -0.294
ENSG00000070961 E020 2.8606406 0.0861029028 7.418002e-01 8.308364e-01 12 89610509 89610705 197 - 0.483 0.441 -0.212
ENSG00000070961 E021 141.3378339 0.0002432326 2.174244e-02 5.514258e-02 12 89611193 89611372 180 - 2.004 1.958 -0.156
ENSG00000070961 E022 1.2973666 0.0101188012 3.848417e-01 5.289908e-01 12 89611373 89612147 775 - 0.236 0.441 1.285
ENSG00000070961 E023 155.0583517 0.0002501759 1.289576e-02 3.567035e-02 12 89616802 89617039 238 - 2.044 1.994 -0.168
ENSG00000070961 E024 132.1184786 0.0003281116 6.905128e-04 2.864491e-03 12 89619999 89620240 242 - 1.980 1.875 -0.355
ENSG00000070961 E025 117.0456830 0.0033799375 3.372290e-04 1.529276e-03 12 89621549 89621791 243 - 1.934 1.780 -0.519
ENSG00000070961 E026 95.3076675 0.0037532902 1.149165e-04 5.905331e-04 12 89624183 89624397 215 - 1.852 1.654 -0.668
ENSG00000070961 E027 89.1668007 0.0086926596 1.398394e-02 3.818853e-02 12 89626454 89626615 162 - 1.814 1.690 -0.419
ENSG00000070961 E028 55.0469605 0.0184405343 1.177554e-02 3.299523e-02 12 89627678 89627716 39 - 1.617 1.414 -0.696
ENSG00000070961 E029 82.2119003 0.0008260725 4.837109e-06 3.456326e-05 12 89630505 89630645 141 - 1.792 1.548 -0.828
ENSG00000070961 E030 0.1472490 0.0431071166 8.582413e-01   12 89630646 89630754 109 - 0.049 0.000 -9.328
ENSG00000070961 E031 94.4822527 0.0003002942 3.124587e-07 2.880364e-06 12 89634778 89634903 126 - 1.852 1.599 -0.859
ENSG00000070961 E032 152.7725786 0.0002815281 4.991558e-11 9.280037e-10 12 89634997 89635251 255 - 2.060 1.802 -0.867
ENSG00000070961 E033 0.1472490 0.0431071166 8.582413e-01   12 89641823 89642157 335 - 0.049 0.000 -9.328
ENSG00000070961 E034 115.4210680 0.0002670534 6.074441e-10 9.381142e-09 12 89642158 89642355 198 - 1.942 1.653 -0.977
ENSG00000070961 E035 0.1515154 0.0426124552 8.577339e-01   12 89655583 89655678 96 - 0.049 0.000 -9.329
ENSG00000070961 E036 128.1525506 0.0002970519 3.326050e-19 1.939397e-17 12 89655679 89656107 429 - 1.999 1.526 -1.601
ENSG00000070961 E037 0.0000000       12 89656108 89656111 4 -      
ENSG00000070961 E038 0.6631923 0.5091342425 4.916384e-01 6.289294e-01 12 89708394 89708595 202 - 0.134 0.281 1.333
ENSG00000070961 E039 17.4206162 0.0011834656 5.311477e-06 3.757303e-05 12 89708596 89708838 243 - 1.172 0.441 -2.977
ENSG00000070961 E040 22.2701453 0.0008602609 2.655733e-05 1.599901e-04 12 89709219 89709484 266 - 1.263 0.732 -1.979