ENSG00000070882

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000313367 ENSG00000070882 HEK293_OSMI2_2hA HEK293_TMG_2hB OSBPL3 protein_coding protein_coding 6.234123 2.714988 9.595848 0.1292694 0.3052206 1.817663 3.3986056 2.2252385 5.4344859 0.04464304 0.2708613 1.284367 0.60135000 0.8225333 0.56750000 -0.25503333 7.644025e-04 1.87686e-10 FALSE TRUE
ENST00000396429 ENSG00000070882 HEK293_OSMI2_2hA HEK293_TMG_2hB OSBPL3 protein_coding protein_coding 6.234123 2.714988 9.595848 0.1292694 0.3052206 1.817663 0.9173087 0.0000000 1.8133834 0.00000000 0.1969572 7.510474 0.10175000 0.0000000 0.18960000 0.18960000 1.876860e-10 1.87686e-10 FALSE TRUE
ENST00000396431 ENSG00000070882 HEK293_OSMI2_2hA HEK293_TMG_2hB OSBPL3 protein_coding protein_coding 6.234123 2.714988 9.595848 0.1292694 0.3052206 1.817663 0.7111618 0.0000000 0.9395075 0.00000000 0.1888672 6.569107 0.08162083 0.0000000 0.09736667 0.09736667 9.543813e-06 1.87686e-10 FALSE TRUE
ENST00000461835 ENSG00000070882 HEK293_OSMI2_2hA HEK293_TMG_2hB OSBPL3 protein_coding retained_intron 6.234123 2.714988 9.595848 0.1292694 0.3052206 1.817663 0.4291850 0.2379832 0.6688386 0.12161925 0.2293266 1.452826 0.06928750 0.0838000 0.06836667 -0.01543333 9.860483e-01 1.87686e-10   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000070882 E001 0.3332198 0.0300549690 4.814616e-01   7 24796374 24796513 140 - 0.078 0.187 1.456
ENSG00000070882 E002 339.5611645 0.0054108197 6.571662e-05 0.0003594577 7 24796540 24799765 3226 - 2.444 2.598 0.514
ENSG00000070882 E003 20.3172244 0.0026064192 4.229412e-01 0.5660739322 7 24799766 24799924 159 - 1.267 1.353 0.301
ENSG00000070882 E004 20.5308204 0.0074871956 8.487601e-03 0.0250058410 7 24799925 24800004 80 - 1.202 1.448 0.857
ENSG00000070882 E005 14.6125630 0.0016313147 4.042778e-02 0.0918049626 7 24800005 24800021 17 - 1.079 1.286 0.737
ENSG00000070882 E006 15.2508769 0.0013732935 4.674675e-02 0.1033737781 7 24800022 24800028 7 - 1.100 1.298 0.703
ENSG00000070882 E007 18.4187079 0.0010601567 5.836631e-03 0.0181813033 7 24800029 24800059 31 - 1.157 1.403 0.861
ENSG00000070882 E008 25.6273187 0.0008659477 1.067922e-01 0.2008185751 7 24800060 24800134 75 - 1.343 1.479 0.469
ENSG00000070882 E009 22.9583628 0.0008790863 1.404793e-01 0.2486907179 7 24800135 24800178 44 - 1.298 1.429 0.456
ENSG00000070882 E010 40.4174181 0.0005313075 7.369769e-03 0.0221788481 7 24800179 24800279 101 - 1.521 1.695 0.590
ENSG00000070882 E011 48.8828273 0.0020470038 6.351122e-01 0.7494712182 7 24804315 24804437 123 - 1.647 1.695 0.161
ENSG00000070882 E012 41.6498987 0.0006083183 9.160660e-01 0.9509367790 7 24806776 24806819 44 - 1.586 1.600 0.049
ENSG00000070882 E013 49.6975154 0.0033758318 8.553745e-01 0.9105790934 7 24806820 24806902 83 - 1.663 1.672 0.030
ENSG00000070882 E014 59.8066343 0.0004508028 5.648491e-01 0.6920681698 7 24809807 24809951 145 - 1.751 1.744 -0.025
ENSG00000070882 E015 0.2998086 0.0291738146 4.836177e-01   7 24809952 24810359 408 - 0.078 0.187 1.453
ENSG00000070882 E016 50.4166908 0.0005827606 2.135234e-01 0.3426833030 7 24815059 24815203 145 - 1.691 1.645 -0.159
ENSG00000070882 E017 36.5268393 0.0006382807 9.087744e-01 0.9460579749 7 24816610 24816688 79 - 1.529 1.557 0.095
ENSG00000070882 E018 29.2274056 0.0006817380 6.502962e-01 0.7613659035 7 24820175 24820238 64 - 1.449 1.438 -0.038
ENSG00000070882 E019 33.9341405 0.0006166292 5.077141e-01 0.6431622970 7 24830768 24830905 138 - 1.516 1.494 -0.077
ENSG00000070882 E020 5.8816014 0.0032043224 5.309465e-01 0.6634581121 7 24834087 24834485 399 - 0.772 0.873 0.397
ENSG00000070882 E021 53.5178376 0.0019228502 5.475590e-01 0.6776020288 7 24834486 24834736 251 - 1.707 1.694 -0.042
ENSG00000070882 E022 27.1333004 0.0021658402 8.087092e-01 0.8785087027 7 24840690 24840783 94 - 1.417 1.420 0.010
ENSG00000070882 E023 32.9811388 0.0006086188 9.310247e-01 0.9605686991 7 24842279 24842375 97 - 1.489 1.516 0.091
ENSG00000070882 E024 25.4474994 0.0007254046 1.366680e-01 0.2434353722 7 24842376 24842413 38 - 1.414 1.321 -0.323
ENSG00000070882 E025 31.1371533 0.0006869928 3.334637e-01 0.4771924243 7 24849069 24849176 108 - 1.484 1.438 -0.158
ENSG00000070882 E026 2.3429973 0.0204232602 9.341600e-01 0.9625151769 7 24849177 24849336 160 - 0.500 0.499 -0.005
ENSG00000070882 E027 35.8029156 0.0005605712 1.618846e-02 0.0431404582 7 24852504 24852634 131 - 1.568 1.429 -0.475
ENSG00000070882 E028 38.6206967 0.0075060909 3.150869e-01 0.4578434861 7 24861613 24861769 157 - 1.579 1.524 -0.189
ENSG00000070882 E029 26.7294869 0.0009634833 3.768496e-01 0.5211664807 7 24863200 24863292 93 - 1.427 1.383 -0.152
ENSG00000070882 E030 32.4493565 0.0007379403 1.536911e-01 0.2666825394 7 24863496 24863599 104 - 1.514 1.438 -0.260
ENSG00000070882 E031 43.7319883 0.0041837506 3.847381e-03 0.0127138928 7 24865342 24865465 124 - 1.662 1.487 -0.600
ENSG00000070882 E032 49.0131415 0.0005375174 7.065127e-05 0.0003832624 7 24866070 24866237 168 - 1.720 1.509 -0.720
ENSG00000070882 E033 28.4944671 0.0006830519 5.896559e-03 0.0183393335 7 24870732 24870774 43 - 1.484 1.298 -0.644
ENSG00000070882 E034 29.3720569 0.0007641707 1.582599e-01 0.2728004546 7 24870775 24870845 71 - 1.473 1.393 -0.275
ENSG00000070882 E035 26.2425036 0.0123323623 2.216860e-01 0.3524070435 7 24871742 24871795 54 - 1.431 1.340 -0.314
ENSG00000070882 E036 24.4488465 0.0050671001 3.046021e-01 0.4466266763 7 24871953 24871982 30 - 1.394 1.331 -0.219
ENSG00000070882 E037 31.3439710 0.0006099864 7.821199e-03 0.0233316973 7 24871983 24872069 87 - 1.521 1.353 -0.580
ENSG00000070882 E038 40.7890107 0.0188412530 2.484056e-03 0.0087165339 7 24892377 24892621 245 - 1.654 1.398 -0.877
ENSG00000070882 E039 0.0000000       7 24917957 24918046 90 -      
ENSG00000070882 E040 0.0000000       7 24918047 24918093 47 -      
ENSG00000070882 E041 21.3489605 0.0009996212 7.103661e-03 0.0214971935 7 24979886 24980203 318 - 1.373 1.161 -0.746
ENSG00000070882 E042 0.0000000       7 24981399 24981634 236 -