ENSG00000070785

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000360403 ENSG00000070785 HEK293_OSMI2_2hA HEK293_TMG_2hB EIF2B3 protein_coding protein_coding 32.43251 27.47524 38.48617 5.924431 0.6700007 0.4860579 20.635595 19.216406 23.627847 4.1778240 0.5263460 0.2980095 0.6418625 0.7017333 0.6139 -0.08783333 0.13911194 0.01264264 FALSE TRUE
ENST00000372183 ENSG00000070785 HEK293_OSMI2_2hA HEK293_TMG_2hB EIF2B3 protein_coding protein_coding 32.43251 27.47524 38.48617 5.924431 0.6700007 0.4860579 7.811560 4.009513 10.990706 0.7926388 0.3643099 1.4525036 0.2326083 0.1513333 0.2857 0.13436667 0.01575177 0.01264264 FALSE TRUE
ENST00000439363 ENSG00000070785 HEK293_OSMI2_2hA HEK293_TMG_2hB EIF2B3 protein_coding protein_coding 32.43251 27.47524 38.48617 5.924431 0.6700007 0.4860579 3.483141 3.955214 3.099818 1.3959538 0.1927446 -0.3505683 0.1085667 0.1361000 0.0805 -0.05560000 0.04653576 0.01264264 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000070785 E001 5.2157741 0.0210199315 3.178963e-01 4.608054e-01 1 44850522 44850775 254 - 0.723 0.858 0.538
ENSG00000070785 E002 199.5919056 0.0014516949 1.282907e-05 8.311714e-05 1 44850776 44851003 228 - 2.239 2.373 0.449
ENSG00000070785 E003 260.2910851 0.0023509315 1.486172e-03 5.591761e-03 1 44857704 44857807 104 - 2.371 2.469 0.327
ENSG00000070785 E004 0.4741261 0.0216818403 6.566982e-01 7.662052e-01 1 44863004 44863161 158 - 0.207 0.129 -0.822
ENSG00000070785 E005 12.0760941 0.0014278511 9.637321e-01 9.811053e-01 1 44874527 44874677 151 - 1.122 1.129 0.024
ENSG00000070785 E006 378.3281028 0.0038946265 1.700008e-01 2.881956e-01 1 44874678 44874826 149 - 2.561 2.605 0.148
ENSG00000070785 E007 271.0408523 0.0013381442 2.024598e-01 3.292875e-01 1 44875618 44875695 78 - 2.426 2.461 0.116
ENSG00000070785 E008 346.2967841 0.0003749142 3.768775e-03 1.249249e-02 1 44879818 44880008 191 - 2.521 2.581 0.199
ENSG00000070785 E009 264.1149316 0.0002779337 6.452600e-01 7.574077e-01 1 44881612 44881739 128 - 2.436 2.427 -0.032
ENSG00000070785 E010 225.1632256 0.0002493586 2.779179e-04 1.289731e-03 1 44897355 44897444 90 - 2.404 2.320 -0.280
ENSG00000070785 E011 1.2596890 0.0104305805 2.052638e-01 3.327509e-01 1 44924958 44925290 333 - 0.453 0.228 -1.408
ENSG00000070785 E012 278.0173391 0.0011054633 6.439374e-01 7.563754e-01 1 44926628 44926739 112 - 2.461 2.446 -0.050
ENSG00000070785 E013 0.9244060 0.0125143844 1.240211e-01 2.257048e-01 1 44937257 44937348 92 - 0.403 0.129 -2.144
ENSG00000070785 E014 0.8072441 0.0159240145 1.357491e-01 2.421520e-01 1 44940629 44940766 138 - 0.116 0.377 2.175
ENSG00000070785 E015 313.9657982 0.0002339997 4.116298e-01 5.551706e-01 1 44941506 44941665 160 - 2.515 2.500 -0.050
ENSG00000070785 E016 1.3799964 0.0874781776 1.808466e-01 3.022651e-01 1 44958561 44958907 347 - 0.498 0.228 -1.639
ENSG00000070785 E017 1.7296624 0.0085355340 1.870706e-01 3.100555e-01 1 44969978 44969987 10 - 0.538 0.309 -1.237
ENSG00000070785 E018 2.7752931 0.0054180243 9.855848e-02 1.882921e-01 1 44969988 44970044 57 - 0.697 0.436 -1.202
ENSG00000070785 E019 0.1515154 0.0453407016 5.794234e-01   1 44972477 44972574 98 - 0.116 0.000 -8.380
ENSG00000070785 E020 303.2172479 0.0014697639 2.682251e-02 6.562290e-02 1 44978315 44978460 146 - 2.522 2.456 -0.219
ENSG00000070785 E021 284.4017821 0.0057454838 2.117556e-02 5.396784e-02 1 44981021 44981177 157 - 2.513 2.400 -0.377
ENSG00000070785 E022 148.8499853 0.0063178929 1.604985e-03 5.977305e-03 1 44986493 44986722 230 - 2.257 2.089 -0.564