ENSG00000070778

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000328736 ENSG00000070778 HEK293_OSMI2_2hA HEK293_TMG_2hB PTPN21 protein_coding protein_coding 1.993903 1.303993 2.652772 0.1122572 0.2241448 1.018972 1.14073809 0.9929653 0.9583358 0.09558952 0.1603569 -0.05069232 0.6073500 0.7638 0.3645333 -0.3992667 0.002433877 0.002433877 FALSE TRUE
ENST00000556564 ENSG00000070778 HEK293_OSMI2_2hA HEK293_TMG_2hB PTPN21 protein_coding protein_coding 1.993903 1.303993 2.652772 0.1122572 0.2241448 1.018972 0.45607878 0.1558299 0.8891142 0.02058591 0.1825647 2.43879997 0.2154167 0.1232 0.3402000 0.2170000 0.057200881 0.002433877 FALSE TRUE
ENST00000557249 ENSG00000070778 HEK293_OSMI2_2hA HEK293_TMG_2hB PTPN21 protein_coding retained_intron 1.993903 1.303993 2.652772 0.1122572 0.2241448 1.018972 0.06724881 0.0000000 0.3257284 0.00000000 0.3257284 5.06922262 0.0218000 0.0000 0.1053333 0.1053333 0.920627707 0.002433877 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000070778 E001 95.6250868 0.0111378361 7.589752e-06 5.181462e-05 14 88465778 88467769 1992 - 1.857 2.112 0.857
ENSG00000070778 E002 13.8571161 0.0016037893 9.181660e-01 9.522770e-01 14 88467770 88467954 185 - 1.164 1.180 0.055
ENSG00000070778 E003 26.0292675 0.0010276231 6.038235e-01 7.245034e-01 14 88467955 88468265 311 - 1.406 1.466 0.207
ENSG00000070778 E004 13.9176052 0.0013529416 2.817285e-01 4.216516e-01 14 88468916 88468986 71 - 1.118 1.237 0.426
ENSG00000070778 E005 12.9348341 0.0019530351 6.764812e-02 1.394470e-01 14 88468987 88469076 90 - 1.056 1.248 0.685
ENSG00000070778 E006 23.9966996 0.0008887709 2.692139e-01 4.077108e-01 14 88469499 88469733 235 - 1.352 1.453 0.349
ENSG00000070778 E007 1.6522295 0.0514794779 8.712712e-01 9.212053e-01 14 88469734 88469921 188 - 0.395 0.435 0.216
ENSG00000070778 E008 11.6843683 0.0017363503 3.802471e-01 5.245440e-01 14 88469922 88469964 43 - 1.047 1.155 0.390
ENSG00000070778 E009 13.1142418 0.0015167634 1.786230e-01 2.994283e-01 14 88469965 88470050 86 - 1.186 1.084 -0.365
ENSG00000070778 E010 26.2161310 0.0017055158 3.877260e-02 8.876559e-02 14 88472244 88472465 222 - 1.476 1.359 -0.406
ENSG00000070778 E011 19.0966075 0.0024790999 2.675636e-01 4.058961e-01 14 88473665 88473802 138 - 1.323 1.258 -0.225
ENSG00000070778 E012 0.0000000       14 88473803 88473932 130 -      
ENSG00000070778 E013 50.8690592 0.0005364105 1.855756e-03 6.775895e-03 14 88478920 88480352 1433 - 1.755 1.629 -0.427
ENSG00000070778 E014 12.1657742 0.0017781334 3.931289e-01 5.370234e-01 14 88485076 88485160 85 - 1.142 1.084 -0.207
ENSG00000070778 E015 10.7202423 0.0017296806 1.906544e-01 3.145753e-01 14 88485782 88485842 61 - 1.109 1.000 -0.400
ENSG00000070778 E016 0.2924217 0.0290785164 3.758166e-01   14 88492900 88493158 259 - 0.174 0.000 -9.109
ENSG00000070778 E017 10.1028828 0.1223052913 2.438520e-01 3.787153e-01 14 88496413 88496492 80 - 1.100 0.939 -0.590
ENSG00000070778 E018 8.1645321 0.0539167107 4.724451e-01 6.114951e-01 14 88497203 88497290 88 - 0.984 0.900 -0.317
ENSG00000070778 E019 8.9813281 0.0058556148 5.554861e-01 6.843362e-01 14 88500783 88500871 89 - 1.006 0.961 -0.166
ENSG00000070778 E020 8.6338376 0.0394021799 8.365348e-01 8.977960e-01 14 88501281 88501368 88 - 0.974 0.966 -0.030
ENSG00000070778 E021 8.1041673 0.1004716529 2.730367e-01 4.120148e-01 14 88504425 88504495 71 - 1.006 0.852 -0.582
ENSG00000070778 E022 8.5337083 0.0029149438 6.463297e-02 1.344326e-01 14 88505304 88505371 68 - 1.037 0.845 -0.721
ENSG00000070778 E023 7.5179639 0.0026994171 5.061586e-01 6.418399e-01 14 88507923 88508020 98 - 0.950 0.895 -0.207
ENSG00000070778 E024 0.9233738 0.0145844196 8.121447e-01 8.808467e-01 14 88512318 88512587 270 - 0.299 0.269 -0.208
ENSG00000070778 E025 11.1429732 0.0107913838 3.284555e-01 4.719550e-01 14 88517092 88517261 170 - 1.117 1.034 -0.301
ENSG00000070778 E026 0.9578041 0.0130249836 2.608179e-01 3.983969e-01 14 88547529 88547651 123 - 0.349 0.155 -1.527
ENSG00000070778 E027 15.2492570 0.0012799900 2.156477e-01 3.451832e-01 14 88550238 88550619 382 - 1.238 1.155 -0.297
ENSG00000070778 E028 0.0000000       14 88550620 88550622 3 -      
ENSG00000070778 E029 0.8010032 0.1364707132 9.286947e-01 9.591271e-01 14 88551236 88551311 76 - 0.241 0.269 0.215
ENSG00000070778 E030 2.3822838 0.1112111098 9.513276e-01 9.735445e-01 14 88551312 88551489 178 - 0.508 0.553 0.210
ENSG00000070778 E031 4.4621829 0.0042617179 1.596450e-02 4.264981e-02 14 88554651 88555007 357 - 0.841 0.497 -1.469