ENSG00000070761

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000262498 ENSG00000070761 HEK293_OSMI2_2hA HEK293_TMG_2hB CFAP20 protein_coding protein_coding 51.38194 54.85375 58.15885 7.426802 0.09187963 0.08439359 46.64844 51.85084 51.59495 6.838213 0.2405532 -0.007136148 0.9042458 0.9462 0.8871667 -0.05903333 1.901058e-06 1.901058e-06 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000070761 E001 10.454431 0.0016995311 1.765222e-05 1.108329e-04 16 58113592 58113605 14 - 0.720 1.203 1.814
ENSG00000070761 E002 32.430102 0.0027269946 1.418394e-08 1.700377e-07 16 58113606 58113688 83 - 1.247 1.644 1.370
ENSG00000070761 E003 548.540669 0.0015854860 1.818526e-03 6.658697e-03 16 58113689 58113959 271 - 2.698 2.765 0.223
ENSG00000070761 E004 375.353649 0.0002253892 6.478966e-07 5.603381e-06 16 58113960 58114030 71 - 2.520 2.613 0.310
ENSG00000070761 E005 465.904937 0.0002063409 7.246155e-05 3.920610e-04 16 58114810 58114920 111 - 2.630 2.696 0.218
ENSG00000070761 E006 14.548876 0.0411830096 9.948952e-01 1.000000e+00 16 58114921 58114961 41 - 1.200 1.171 -0.104
ENSG00000070761 E007 18.850760 0.0015556399 2.094852e-01 3.379230e-01 16 58114962 58115055 94 - 1.354 1.256 -0.343
ENSG00000070761 E008 9.667584 0.0022070627 9.807396e-02 1.875896e-01 16 58115056 58115268 213 - 1.115 0.943 -0.631
ENSG00000070761 E009 500.267581 0.0002006014 6.784702e-01 7.829285e-01 16 58115269 58115400 132 - 2.706 2.699 -0.021
ENSG00000070761 E010 295.470267 0.0001952564 7.064107e-04 2.921613e-03 16 58115401 58115450 50 - 2.513 2.444 -0.229
ENSG00000070761 E011 168.849018 0.0003115638 1.239692e-01 2.256298e-01 16 58115451 58115457 7 - 2.257 2.215 -0.140
ENSG00000070761 E012 4.324207 0.0037989817 5.193901e-02 1.126170e-01 16 58115458 58115567 110 - 0.868 0.601 -1.093
ENSG00000070761 E013 5.540742 0.0315045716 4.126692e-01 5.562318e-01 16 58115792 58116040 249 - 0.888 0.779 -0.427
ENSG00000070761 E014 386.424772 0.0001658856 4.309623e-04 1.893382e-03 16 58116041 58116152 112 - 2.623 2.560 -0.210
ENSG00000070761 E015 3.316116 0.0072097073 3.156287e-03 1.072596e-02 16 58116558 58116871 314 - 0.846 0.397 -2.011
ENSG00000070761 E016 333.394301 0.0024482164 4.642929e-02 1.028062e-01 16 58116872 58116951 80 - 2.558 2.491 -0.226
ENSG00000070761 E017 530.067812 0.0015980710 5.662949e-03 1.772157e-02 16 58129032 58129381 350 - 2.761 2.690 -0.237