ENSG00000070718

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000396926 ENSG00000070718 HEK293_OSMI2_2hA HEK293_TMG_2hB AP3M2 protein_coding protein_coding 19.36055 14.08717 22.26619 2.284858 0.3893003 0.660097 12.265691 9.9309868 12.318172 1.32668513 0.5047760 0.3104979 0.64064583 0.71413333 0.55366667 -0.16046667 2.822877e-02 2.692518e-06 FALSE TRUE
ENST00000517922 ENSG00000070718 HEK293_OSMI2_2hA HEK293_TMG_2hB AP3M2 protein_coding protein_coding 19.36055 14.08717 22.26619 2.284858 0.3893003 0.660097 1.720369 2.1743442 2.070396 0.48492157 0.1941768 -0.0703423 0.09382500 0.15420000 0.09326667 -0.06093333 1.568754e-01 2.692518e-06 FALSE TRUE
ENST00000523249 ENSG00000070718 HEK293_OSMI2_2hA HEK293_TMG_2hB AP3M2 protein_coding retained_intron 19.36055 14.08717 22.26619 2.284858 0.3893003 0.660097 1.505666 0.2404407 2.333495 0.06644166 0.4093931 3.2261207 0.07073333 0.01633333 0.10456667 0.08823333 2.692518e-06 2.692518e-06 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000070718 E001 0.0000000       8 42152946 42152992 47 +      
ENSG00000070718 E002 0.1451727 0.0441046176 6.172652e-01   8 42152993 42153028 36 + 0.109 0.000 -8.587
ENSG00000070718 E003 0.3268771 0.0306077772 8.759533e-01   8 42153029 42153045 17 + 0.109 0.137 0.372
ENSG00000070718 E004 2.9507565 0.0052823555 3.391701e-02 7.958429e-02 8 42153046 42153062 17 + 0.724 0.395 -1.535
ENSG00000070718 E005 10.3527060 0.0016605176 2.762523e-02 6.726454e-02 8 42153063 42153073 11 + 1.151 0.943 -0.760
ENSG00000070718 E006 22.4967673 0.0008366702 3.222039e-01 4.655133e-01 8 42153074 42153084 11 + 1.403 1.351 -0.181
ENSG00000070718 E007 37.9020301 0.0005884866 2.322292e-01 3.650896e-01 8 42153085 42153105 21 + 1.619 1.571 -0.164
ENSG00000070718 E008 0.0000000       8 42153106 42153143 38 +      
ENSG00000070718 E009 0.0000000       8 42153144 42153159 16 +      
ENSG00000070718 E010 1.9478985 0.0078687785 8.401396e-01 9.001690e-01 8 42153160 42153227 68 + 0.478 0.455 -0.113
ENSG00000070718 E011 3.8365676 0.1009649249 2.000579e-02 5.149927e-02 8 42153228 42154130 903 + 0.846 0.396 -2.015
ENSG00000070718 E012 3.9454736 0.1441253277 1.305894e-02 3.604858e-02 8 42154131 42154477 347 + 0.882 0.323 -2.580
ENSG00000070718 E013 7.4581552 0.0439180500 8.856042e-03 2.592282e-02 8 42154478 42154536 59 + 1.075 0.673 -1.556
ENSG00000070718 E014 1.3359641 0.0522784001 3.708525e-03 1.232210e-02 8 42154537 42154565 29 + 0.553 0.000 -13.678
ENSG00000070718 E015 1.0361675 0.0117112126 8.871925e-02 1.731671e-01 8 42154566 42154615 50 + 0.434 0.137 -2.214
ENSG00000070718 E016 175.4922456 0.0017232576 4.394653e-01 5.812219e-01 8 42154616 42154960 345 + 2.256 2.247 -0.030
ENSG00000070718 E017 10.1039103 0.0017245832 1.007954e-08 1.241653e-07 8 42155762 42155978 217 + 1.252 0.598 -2.511
ENSG00000070718 E018 5.2678207 0.0032856230 2.502189e-05 1.517000e-04 8 42155979 42156039 61 + 0.994 0.394 -2.583
ENSG00000070718 E019 137.8438044 0.0002586475 7.687579e-02 1.544978e-01 8 42157941 42158112 172 + 2.166 2.133 -0.110
ENSG00000070718 E020 1.1415848 0.0170058047 3.949130e-01 5.387496e-01 8 42162069 42162280 212 + 0.386 0.241 -0.948
ENSG00000070718 E021 119.7825492 0.0002584097 6.184825e-02 1.297316e-01 8 42162281 42162418 138 + 2.107 2.067 -0.134
ENSG00000070718 E022 92.9584518 0.0002935637 2.310465e-01 3.637192e-01 8 42165071 42165156 86 + 1.991 1.967 -0.081
ENSG00000070718 E023 108.0963620 0.0002627778 9.409816e-01 9.668832e-01 8 42165427 42165560 134 + 2.035 2.056 0.072
ENSG00000070718 E024 25.8036827 0.0042194797 6.545955e-02 1.358089e-01 8 42165561 42165779 219 + 1.357 1.510 0.527
ENSG00000070718 E025 4.9228695 0.0034396094 7.956365e-03 2.366671e-02 8 42166916 42167163 248 + 0.911 0.555 -1.465
ENSG00000070718 E026 97.4563239 0.0028979227 5.166399e-03 1.638090e-02 8 42167164 42167288 125 + 2.047 1.944 -0.343
ENSG00000070718 E027 90.2839731 0.0027187432 2.911345e-02 7.022479e-02 8 42167289 42167371 83 + 2.003 1.928 -0.254
ENSG00000070718 E028 91.1710578 0.0003199476 1.581944e-03 5.899954e-03 8 42167666 42167764 99 + 2.016 1.920 -0.323
ENSG00000070718 E029 76.8437221 0.0005406355 2.663458e-02 6.523305e-02 8 42167765 42167810 46 + 1.930 1.859 -0.237
ENSG00000070718 E030 1.3524354 0.0589290485 1.974444e-01 3.230328e-01 8 42168197 42168249 53 + 0.477 0.240 -1.437
ENSG00000070718 E031 147.8147418 0.0009971858 2.685867e-01 4.070668e-01 8 42168961 42169285 325 + 2.185 2.166 -0.065
ENSG00000070718 E032 253.0918194 0.0002549301 2.432625e-01 3.780036e-01 8 42169286 42169888 603 + 2.389 2.432 0.145
ENSG00000070718 E033 132.7680139 0.0010812615 9.645126e-02 1.850314e-01 8 42169889 42170059 171 + 2.095 2.166 0.238
ENSG00000070718 E034 390.9832766 0.0026533635 7.992139e-14 2.304897e-12 8 42170060 42171183 1124 + 2.482 2.694 0.707
ENSG00000070718 E035 1.7745114 0.0092166204 5.216433e-01 6.555256e-01 8 42171529 42171673 145 + 0.386 0.508 0.633