ENSG00000070610

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000378088 ENSG00000070610 HEK293_OSMI2_2hA HEK293_TMG_2hB GBA2 protein_coding protein_coding 53.27223 57.55593 38.72912 3.349805 1.994911 -0.571424 7.195687 6.289443 5.249832 0.56011171 0.5226613 -0.2602076 0.13218333 0.10953333 0.13490000 0.02536667 3.819366e-01 6.063017e-16 FALSE TRUE
ENST00000378103 ENSG00000070610 HEK293_OSMI2_2hA HEK293_TMG_2hB GBA2 protein_coding protein_coding 53.27223 57.55593 38.72912 3.349805 1.994911 -0.571424 17.090619 25.070166 9.995494 1.42701291 0.1812057 -1.3257545 0.31746250 0.43566667 0.25896667 -0.17670000 6.063017e-16 6.063017e-16 FALSE TRUE
ENST00000467252 ENSG00000070610 HEK293_OSMI2_2hA HEK293_TMG_2hB GBA2 protein_coding processed_transcript 53.27223 57.55593 38.72912 3.349805 1.994911 -0.571424 3.553947 2.269081 3.174194 0.56485319 0.6006853 0.4824759 0.06870833 0.03866667 0.08200000 0.04333333 1.466238e-01 6.063017e-16 FALSE TRUE
ENST00000486797 ENSG00000070610 HEK293_OSMI2_2hA HEK293_TMG_2hB GBA2 protein_coding processed_transcript 53.27223 57.55593 38.72912 3.349805 1.994911 -0.571424 3.202700 2.665790 3.268772 0.08031267 0.4324232 0.2931907 0.06052917 0.04660000 0.08420000 0.03760000 1.752954e-02 6.063017e-16 FALSE TRUE
ENST00000488292 ENSG00000070610 HEK293_OSMI2_2hA HEK293_TMG_2hB GBA2 protein_coding processed_transcript 53.27223 57.55593 38.72912 3.349805 1.994911 -0.571424 4.260653 2.285874 3.268681 0.41658646 0.3742287 0.5140718 0.08167500 0.03953333 0.08390000 0.04436667 3.868814e-03 6.063017e-16 FALSE TRUE
MSTRG.32634.4 ENSG00000070610 HEK293_OSMI2_2hA HEK293_TMG_2hB GBA2 protein_coding   53.27223 57.55593 38.72912 3.349805 1.994911 -0.571424 3.773032 5.918781 1.700469 0.54198288 0.3865108 -1.7933438 0.07073333 0.10273333 0.04316667 -0.05956667 6.866140e-04 6.063017e-16 FALSE TRUE
MSTRG.32634.5 ENSG00000070610 HEK293_OSMI2_2hA HEK293_TMG_2hB GBA2 protein_coding   53.27223 57.55593 38.72912 3.349805 1.994911 -0.571424 9.284895 9.441400 7.360465 1.04711628 0.9208859 -0.3587725 0.17291250 0.16420000 0.18916667 0.02496667 7.226926e-01 6.063017e-16 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000070610 E001 8.103348 0.0634078481 5.088390e-01 6.442168e-01 9 35736866 35736866 1 - 0.855 0.949 0.358
ENSG00000070610 E002 20.372140 0.0009166800 4.280796e-02 9.619301e-02 9 35736867 35736879 13 - 1.155 1.324 0.598
ENSG00000070610 E003 147.125625 0.0002446359 5.527813e-12 1.199711e-10 9 35736880 35736982 103 - 1.941 2.176 0.787
ENSG00000070610 E004 725.857050 0.0015853652 1.929027e-10 3.240940e-09 9 35736983 35737357 375 - 2.702 2.850 0.494
ENSG00000070610 E005 198.076941 0.0014530748 7.229768e-03 2.182061e-02 9 35737358 35737360 3 - 2.185 2.272 0.288
ENSG00000070610 E006 242.455690 0.0010024679 6.671835e-04 2.778319e-03 9 35737361 35737382 22 - 2.265 2.361 0.322
ENSG00000070610 E007 363.555078 0.0017073036 4.808492e-02 1.057798e-01 9 35737383 35737447 65 - 2.473 2.527 0.180
ENSG00000070610 E008 29.955378 0.0074605922 2.262486e-06 1.739322e-05 9 35737448 35737488 41 - 1.668 1.311 -1.226
ENSG00000070610 E009 36.542603 0.0029948091 2.033035e-08 2.367545e-07 9 35737489 35737554 66 - 1.752 1.396 -1.215
ENSG00000070610 E010 30.019455 0.0013175180 1.254441e-06 1.020352e-05 9 35737555 35737604 50 - 1.650 1.329 -1.102
ENSG00000070610 E011 47.207843 0.0004813143 8.003516e-06 5.435144e-05 9 35737605 35737747 143 - 1.794 1.554 -0.812
ENSG00000070610 E012 510.400294 0.0001533009 4.568351e-06 3.282113e-05 9 35737748 35737911 164 - 2.601 2.678 0.255
ENSG00000070610 E013 266.172323 0.0001604883 1.298136e-06 1.052323e-05 9 35737912 35737939 28 - 2.291 2.405 0.382
ENSG00000070610 E014 4.016061 0.0269072104 5.290848e-01 6.619264e-01 9 35737940 35738036 97 - 0.722 0.618 -0.438
ENSG00000070610 E015 216.900411 0.0002009211 4.492577e-05 2.559806e-04 9 35738037 35738052 16 - 2.208 2.314 0.356
ENSG00000070610 E016 413.789590 0.0015686018 1.382059e-04 6.956639e-04 9 35738053 35738152 100 - 2.496 2.594 0.327
ENSG00000070610 E017 64.216087 0.0003969707 2.786432e-10 4.558560e-09 9 35738153 35738231 79 - 1.953 1.664 -0.975
ENSG00000070610 E018 278.621337 0.0002318357 1.368634e-03 5.204512e-03 9 35738232 35738269 38 - 2.342 2.414 0.240
ENSG00000070610 E019 305.188888 0.0001723715 3.672449e-03 1.221830e-02 9 35738270 35738366 97 - 2.391 2.452 0.202
ENSG00000070610 E020 151.003942 0.0002281793 1.236790e-01 2.251966e-01 9 35738367 35738374 8 - 2.101 2.145 0.145
ENSG00000070610 E021 42.082825 0.0009588518 1.567449e-07 1.533349e-06 9 35738375 35738404 30 - 1.780 1.484 -1.009
ENSG00000070610 E022 74.495343 0.0003577556 2.698275e-18 1.408254e-16 9 35738405 35738525 121 - 2.060 1.694 -1.232
ENSG00000070610 E023 418.149667 0.0001677256 2.982694e-02 7.162300e-02 9 35738526 35738632 107 - 2.547 2.583 0.122
ENSG00000070610 E024 36.038555 0.0029279258 8.407123e-10 1.263149e-08 9 35738633 35738751 119 - 1.763 1.372 -1.335
ENSG00000070610 E025 307.620070 0.0002792161 2.705554e-01 4.092190e-01 9 35738752 35738817 66 - 2.426 2.446 0.066
ENSG00000070610 E026 332.490159 0.0009229733 3.279872e-01 4.714466e-01 9 35738818 35738903 86 - 2.461 2.481 0.067
ENSG00000070610 E027 325.221285 0.0017102913 9.590941e-01 9.783638e-01 9 35739002 35739109 108 - 2.469 2.466 -0.010
ENSG00000070610 E028 2.392750 0.0117099508 7.932953e-01 8.678255e-01 9 35739110 35739110 1 - 0.528 0.479 -0.238
ENSG00000070610 E029 315.705497 0.0014383316 7.580827e-01 8.427456e-01 9 35739315 35739419 105 - 2.464 2.451 -0.043
ENSG00000070610 E030 372.737663 0.0014976673 3.549238e-01 4.992704e-01 9 35739628 35739800 173 - 2.546 2.517 -0.097
ENSG00000070610 E031 314.986264 0.0022114887 4.763136e-01 6.149459e-01 9 35739998 35740123 126 - 2.471 2.444 -0.088
ENSG00000070610 E032 317.518529 0.0011166589 8.340308e-01 8.960633e-01 9 35740209 35740362 154 - 2.461 2.451 -0.035
ENSG00000070610 E033 278.505358 0.0010246377 4.092776e-01 5.528798e-01 9 35740526 35740628 103 - 2.414 2.387 -0.091
ENSG00000070610 E034 447.252344 0.0021728552 2.782543e-03 9.622059e-03 9 35740825 35741064 240 - 2.661 2.576 -0.284
ENSG00000070610 E035 8.561592 0.0020318004 9.000546e-08 9.213413e-07 9 35741320 35741671 352 - 1.268 0.681 -2.209
ENSG00000070610 E036 219.351209 0.0002262781 5.650149e-04 2.402880e-03 9 35741672 35741890 219 - 2.357 2.262 -0.317
ENSG00000070610 E037 13.440337 0.0014333483 2.022718e-02 5.196175e-02 9 35741891 35741908 18 - 1.257 1.035 -0.797
ENSG00000070610 E038 15.357088 0.0155276713 3.585778e-08 3.975624e-07 9 35741909 35742029 121 - 1.490 0.914 -2.054
ENSG00000070610 E039 9.413747 0.0716707175 8.399887e-03 2.478899e-02 9 35743276 35743326 51 - 1.221 0.812 -1.513
ENSG00000070610 E040 285.442605 0.0002853326 8.516916e-08 8.763805e-07 9 35744297 35744412 116 - 2.496 2.367 -0.429
ENSG00000070610 E041 241.747310 0.0001783203 4.967338e-08 5.359039e-07 9 35744615 35744706 92 - 2.429 2.291 -0.460
ENSG00000070610 E042 569.145818 0.0068069316 1.698854e-04 8.345896e-04 9 35748346 35749228 883 - 2.816 2.658 -0.526