ENSG00000070423

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000292363 ENSG00000070423 HEK293_OSMI2_2hA HEK293_TMG_2hB RNF126 protein_coding protein_coding 94.59502 154.5582 72.77783 10.08882 1.974618 -1.086474 70.827237 125.92553 51.471565 6.782182 2.2384282 -1.2905575 0.7156583 0.81606667 0.7066667 -0.1094 8.835852e-05 3.487083e-07 FALSE TRUE
ENST00000589762 ENSG00000070423 HEK293_OSMI2_2hA HEK293_TMG_2hB RNF126 protein_coding protein_coding 94.59502 154.5582 72.77783 10.08882 1.974618 -1.086474 9.870426 12.45044 9.928173 1.237214 0.7685137 -0.3263028 0.1159250 0.08053333 0.1369333 0.0564 8.238696e-03 3.487083e-07 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000070423 E001 12.7684845 3.634219e-02 1.119043e-01 2.083715e-01 19 647526 647528 3 - 1.221 1.021 -0.720
ENSG00000070423 E002 12.9167776 3.928437e-02 1.312508e-01 2.358913e-01 19 647529 647529 1 - 1.221 1.029 -0.690
ENSG00000070423 E003 148.5583560 3.013073e-04 3.869831e-01 5.311404e-01 19 647530 647602 73 - 2.095 2.120 0.083
ENSG00000070423 E004 234.0911240 1.664892e-04 8.530718e-05 4.531132e-04 19 647603 647634 32 - 2.229 2.332 0.344
ENSG00000070423 E005 638.9939561 1.491073e-04 5.031450e-11 9.348697e-10 19 647635 647870 236 - 2.662 2.769 0.356
ENSG00000070423 E006 1381.4516922 8.085131e-05 1.421573e-26 1.771794e-24 19 647871 648131 261 - 2.988 3.104 0.385
ENSG00000070423 E007 1331.4588965 8.431327e-04 7.660806e-09 9.649071e-08 19 648132 648277 146 - 2.990 3.087 0.321
ENSG00000070423 E008 1096.2230830 3.846065e-03 2.364224e-02 5.907427e-02 19 648372 648487 116 - 2.927 2.998 0.236
ENSG00000070423 E009 7.4394133 6.219142e-03 5.158267e-01 6.504420e-01 19 648488 648538 51 - 0.816 0.899 0.320
ENSG00000070423 E010 895.6997001 1.771436e-03 9.781726e-01 9.904746e-01 19 648882 648975 94 - 2.892 2.893 0.002
ENSG00000070423 E011 42.0707136 1.322833e-03 4.413332e-01 5.829759e-01 19 648976 649052 77 - 1.606 1.555 -0.172
ENSG00000070423 E012 62.7362640 5.664267e-03 3.108835e-11 5.970798e-10 19 649053 649678 626 - 1.988 1.605 -1.295
ENSG00000070423 E013 684.3133044 3.388287e-04 1.013357e-10 1.786335e-09 19 649679 649748 70 - 2.853 2.744 -0.364
ENSG00000070423 E014 4.2966668 4.032581e-03 3.416953e-01 4.856164e-01 19 650096 650233 138 - 0.781 0.639 -0.586
ENSG00000070423 E015 579.8950478 8.241539e-04 7.798348e-15 2.606057e-13 19 650234 650296 63 - 2.814 2.655 -0.530
ENSG00000070423 E016 29.9686586 6.932302e-04 1.445526e-05 9.252020e-05 19 650297 650594 298 - 1.622 1.334 -0.988
ENSG00000070423 E017 27.4198837 5.357888e-03 1.953991e-08 2.283779e-07 19 651385 651610 226 - 1.657 1.237 -1.449
ENSG00000070423 E018 558.3167864 2.007124e-03 8.300712e-04 3.366685e-03 19 651611 651691 81 - 2.750 2.662 -0.293
ENSG00000070423 E019 741.7998459 1.133164e-03 1.654811e-02 4.394580e-02 19 651692 651784 93 - 2.846 2.796 -0.166
ENSG00000070423 E020 658.4084009 1.548772e-03 2.473082e-01 3.827761e-01 19 651785 651855 71 - 2.778 2.751 -0.090
ENSG00000070423 E021 20.4012288 9.657499e-04 4.253024e-01 5.682467e-01 19 651856 651915 60 - 1.315 1.246 -0.244
ENSG00000070423 E022 666.8281816 2.725954e-04 5.929364e-02 1.254243e-01 19 652233 652296 64 - 2.787 2.753 -0.114
ENSG00000070423 E023 16.1935779 2.434830e-03 7.916351e-12 1.674739e-10 19 652358 652825 468 - 1.522 0.933 -2.092
ENSG00000070423 E024 582.1280536 2.319327e-03 3.991494e-02 9.087677e-02 19 652826 652884 59 - 2.747 2.690 -0.190
ENSG00000070423 E025 1.4706348 3.166791e-01 1.318798e-01 2.367299e-01 19 661356 661402 47 - 0.000 0.412 11.028
ENSG00000070423 E026 0.8846495 1.921251e-02 6.337587e-01 7.483774e-01 19 662712 662753 42 - 0.177 0.265 0.737
ENSG00000070423 E027 468.1053848 3.293078e-03 3.152541e-02 7.492843e-02 19 663047 663234 188 - 2.660 2.592 -0.227