ENSG00000070413

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000263196 ENSG00000070413 HEK293_OSMI2_2hA HEK293_TMG_2hB DGCR2 protein_coding protein_coding 87.65974 108.2838 68.58738 6.032479 1.643292 -0.6587252 63.694992 76.7716277 48.747548 6.9562036 2.232454229 -0.6551356 0.72446667 0.7061000 0.71003333 0.003933333 0.99792237 0.002389433 FALSE TRUE
ENST00000537045 ENSG00000070413 HEK293_OSMI2_2hA HEK293_TMG_2hB DGCR2 protein_coding protein_coding 87.65974 108.2838 68.58738 6.032479 1.643292 -0.6587252 8.189805 17.3843562 4.227368 2.6636637 0.795896728 -2.0373789 0.08883750 0.1637333 0.06226667 -0.101466667 0.02683003 0.002389433 FALSE TRUE
ENST00000608548 ENSG00000070413 HEK293_OSMI2_2hA HEK293_TMG_2hB DGCR2 protein_coding processed_transcript 87.65974 108.2838 68.58738 6.032479 1.643292 -0.6587252 3.786281 0.8702683 5.573888 0.5493516 0.646931133 2.6652547 0.04972917 0.0082000 0.08140000 0.073200000 0.07773638 0.002389433 FALSE FALSE
MSTRG.21611.6 ENSG00000070413 HEK293_OSMI2_2hA HEK293_TMG_2hB DGCR2 protein_coding   87.65974 108.2838 68.58738 6.032479 1.643292 -0.6587252 8.647531 10.6625322 6.944173 0.9853359 0.007534576 -0.6179516 0.09723750 0.0982000 0.10136667 0.003166667 0.90962081 0.002389433 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000070413 E001 1.7327935 0.0082723361 7.445615e-01 8.328533e-01 22 19036282 19036285 4 - 0.360 0.435 0.419
ENSG00000070413 E002 197.9856149 0.0085568712 2.326172e-03 8.231434e-03 22 19036286 19036357 72 - 2.129 2.322 0.646
ENSG00000070413 E003 368.7848604 0.0051165245 2.296128e-03 8.138041e-03 22 19036358 19036391 34 - 2.426 2.582 0.518
ENSG00000070413 E004 492.9660638 0.0030301217 4.129527e-06 2.993062e-05 22 19036392 19036418 27 - 2.533 2.714 0.601
ENSG00000070413 E005 494.3685872 0.0032025972 6.674254e-08 7.015577e-07 22 19036419 19036424 6 - 2.512 2.722 0.701
ENSG00000070413 E006 4916.2250266 0.0041270111 1.133283e-08 1.383089e-07 22 19036425 19037836 1412 - 3.539 3.710 0.567
ENSG00000070413 E007 2242.4391427 0.0001135252 7.435611e-08 7.742411e-07 22 19037837 19038566 730 - 3.264 3.341 0.257
ENSG00000070413 E008 1503.8158066 0.0012285657 1.793756e-01 3.003365e-01 22 19038567 19039121 555 - 3.141 3.149 0.024
ENSG00000070413 E009 826.8568070 0.0004580633 1.123687e-03 4.382845e-03 22 19041058 19041294 237 - 2.900 2.877 -0.075
ENSG00000070413 E010 19.9991205 0.0009449247 2.525423e-02 6.239454e-02 22 19041295 19041806 512 - 1.384 1.237 -0.514
ENSG00000070413 E011 650.2196581 0.0004553475 6.379769e-02 1.330195e-01 22 19041807 19041959 153 - 2.783 2.780 -0.010
ENSG00000070413 E012 6.3206474 0.0094405779 6.835194e-01 7.867040e-01 22 19045258 19045362 105 - 0.790 0.869 0.309
ENSG00000070413 E013 2.4909222 0.0578188383 4.204877e-01 5.636942e-01 22 19048379 19048439 61 - 0.603 0.474 -0.604
ENSG00000070413 E014 798.5169961 0.0015467853 1.096926e-04 5.665620e-04 22 19048440 19048643 204 - 2.909 2.853 -0.187
ENSG00000070413 E015 15.2850229 0.0013026972 3.629645e-03 1.209607e-02 22 19052481 19052605 125 - 1.318 1.091 -0.804
ENSG00000070413 E016 263.7688784 0.0040893260 1.288205e-03 4.937216e-03 22 19056986 19056993 8 - 2.453 2.360 -0.311
ENSG00000070413 E017 242.3743596 0.0049759919 3.609365e-03 1.203697e-02 22 19056994 19056994 1 - 2.414 2.324 -0.302
ENSG00000070413 E018 754.5845261 0.0015748551 1.751245e-11 3.501879e-10 22 19056995 19057162 168 - 2.926 2.804 -0.407
ENSG00000070413 E019 7.8310124 0.0021009442 9.843393e-01 9.942909e-01 22 19060566 19060955 390 - 0.897 0.924 0.103
ENSG00000070413 E020 426.5116478 0.0015514006 3.726300e-11 7.062188e-10 22 19063202 19063278 77 - 2.689 2.549 -0.465
ENSG00000070413 E021 614.0153760 0.0009070825 1.757104e-10 2.973187e-09 22 19064848 19065058 211 - 2.822 2.722 -0.331
ENSG00000070413 E022 156.2155377 0.0011788434 3.027322e-05 1.799664e-04 22 19065059 19065067 9 - 2.233 2.123 -0.368
ENSG00000070413 E023 0.1817044 0.0393574786 8.809533e-01   22 19065185 19065189 5 - 0.000 0.096 8.013
ENSG00000070413 E024 9.4482589 0.0017996835 8.998773e-01 9.401332e-01 22 19065756 19065904 149 - 0.982 0.994 0.044
ENSG00000070413 E025 2.0543600 0.0084821407 6.349238e-01 7.493142e-01 22 19068096 19068099 4 - 0.498 0.435 -0.317
ENSG00000070413 E026 452.9684341 0.0047082115 2.522056e-05 1.527676e-04 22 19068100 19068222 123 - 2.706 2.582 -0.415
ENSG00000070413 E027 218.7949103 0.0071691085 1.945424e-06 1.517279e-05 22 19068223 19068225 3 - 2.434 2.237 -0.657
ENSG00000070413 E028 453.6391477 0.0044331121 5.059026e-08 5.449268e-07 22 19089368 19089490 123 - 2.730 2.566 -0.545
ENSG00000070413 E029 653.6605552 0.0080463926 2.584775e-08 2.948978e-07 22 19122128 19122454 327 - 2.918 2.705 -0.709