ENSG00000070371

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000412649 ENSG00000070371 HEK293_OSMI2_2hA HEK293_TMG_2hB CLTCL1 protein_coding retained_intron 10.09511 12.96018 7.476711 0.4261296 0.3279553 -0.792794 1.3207186 1.3052602 0.7782609 0.0416576 0.11590546 -0.73860302 0.12442500 0.10093333 0.10573333 0.00480000 9.777659e-01 2.080635e-14   FALSE
ENST00000427926 ENSG00000070371 HEK293_OSMI2_2hA HEK293_TMG_2hB CLTCL1 protein_coding protein_coding 10.09511 12.96018 7.476711 0.4261296 0.3279553 -0.792794 0.8526627 1.0400983 0.3986811 0.6745648 0.39868113 -1.36147687 0.08197083 0.08286667 0.04903333 -0.03383333 6.656697e-01 2.080635e-14 FALSE TRUE
ENST00000615606 ENSG00000070371 HEK293_OSMI2_2hA HEK293_TMG_2hB CLTCL1 protein_coding retained_intron 10.09511 12.96018 7.476711 0.4261296 0.3279553 -0.792794 1.0717612 0.4446827 1.1169036 0.0692436 0.03269881 1.30943205 0.11589167 0.03470000 0.15016667 0.11546667 2.387082e-07 2.080635e-14 TRUE TRUE
ENST00000617926 ENSG00000070371 HEK293_OSMI2_2hA HEK293_TMG_2hB CLTCL1 protein_coding protein_coding 10.09511 12.96018 7.476711 0.4261296 0.3279553 -0.792794 0.7572614 2.1957388 0.0000000 0.3874083 0.00000000 -7.78511812 0.05817500 0.16830000 0.00000000 -0.16830000 2.080635e-14 2.080635e-14 FALSE TRUE
ENST00000621271 ENSG00000070371 HEK293_OSMI2_2hA HEK293_TMG_2hB CLTCL1 protein_coding protein_coding 10.09511 12.96018 7.476711 0.4261296 0.3279553 -0.792794 2.7643185 3.4001078 2.5535830 0.2279399 0.29032975 -0.41165570 0.28878750 0.26176667 0.34606667 0.08430000 4.668091e-01 2.080635e-14 FALSE TRUE
ENST00000622493 ENSG00000070371 HEK293_OSMI2_2hA HEK293_TMG_2hB CLTCL1 protein_coding protein_coding 10.09511 12.96018 7.476711 0.4261296 0.3279553 -0.792794 1.5237963 3.3580377 0.5427175 0.5607006 0.03918764 -2.60729407 0.13397500 0.25846667 0.07326667 -0.18520000 1.816476e-04 2.080635e-14 FALSE TRUE
MSTRG.21621.7 ENSG00000070371 HEK293_OSMI2_2hA HEK293_TMG_2hB CLTCL1 protein_coding   10.09511 12.96018 7.476711 0.4261296 0.3279553 -0.792794 0.5135865 0.4058385 0.4185294 0.1449041 0.23664056 0.04337103 0.05823750 0.03123333 0.05846667 0.02723333 9.530220e-01 2.080635e-14 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000070371 E001 2.2100400 0.0069508830 6.346518e-01 7.490678e-01 22 19179085 19179383 299 - 0.430 0.512 0.410
ENSG00000070371 E002 1.6585696 0.1177736584 3.844868e-01 5.286334e-01 22 19179384 19179472 89 - 0.266 0.444 1.073
ENSG00000070371 E003 0.5180316 0.0220446189 2.000337e-01 3.262996e-01 22 19179473 19179475 3 - 0.000 0.243 10.884
ENSG00000070371 E004 27.5471938 0.0089494839 2.031405e-04 9.772813e-04 22 19179476 19179544 69 - 1.187 1.517 1.146
ENSG00000070371 E005 111.2909579 0.0088336587 2.992409e-07 2.769839e-06 22 19179545 19179774 230 - 1.795 2.102 1.030
ENSG00000070371 E006 144.0840881 0.0060202135 8.314376e-08 8.579159e-07 22 19179775 19179969 195 - 1.940 2.205 0.890
ENSG00000070371 E007 71.5844879 0.0004181658 8.083437e-09 1.013423e-07 22 19180199 19180238 40 - 1.637 1.908 0.918
ENSG00000070371 E008 48.9644932 0.0005408025 3.879033e-06 2.830587e-05 22 19180731 19180732 2 - 1.486 1.746 0.885
ENSG00000070371 E009 85.6986999 0.0015774971 8.498861e-08 8.747602e-07 22 19180733 19180806 74 - 1.735 1.982 0.832
ENSG00000070371 E010 70.0575613 0.0080157324 6.357650e-01 7.499658e-01 22 19180807 19183389 2583 - 1.804 1.833 0.097
ENSG00000070371 E011 55.3290485 0.0004948941 9.376037e-05 4.926398e-04 22 19183390 19183413 24 - 1.578 1.782 0.692
ENSG00000070371 E012 67.0085937 0.0104721655 6.145374e-05 3.386534e-04 22 19183414 19183475 62 - 1.602 1.881 0.945
ENSG00000070371 E013 82.6516687 0.0076311830 1.902068e-04 9.220600e-04 22 19183476 19183611 136 - 1.736 1.959 0.752
ENSG00000070371 E014 33.2918296 0.0113279092 1.200594e-01 2.200700e-01 22 19183612 19184395 784 - 1.422 1.547 0.429
ENSG00000070371 E015 11.3120692 0.1891867508 9.815508e-01 9.925266e-01 22 19184396 19184536 141 - 1.124 1.033 -0.329
ENSG00000070371 E016 15.5687334 0.0011434854 1.397919e-01 2.477400e-01 22 19184537 19184831 295 - 1.274 1.146 -0.452
ENSG00000070371 E017 47.4072713 0.0005002838 3.560495e-02 8.281768e-02 22 19187558 19187728 171 - 1.578 1.693 0.390
ENSG00000070371 E018 74.7180024 0.0174184677 1.279858e-01 2.313556e-01 22 19187981 19188091 111 - 1.777 1.886 0.369
ENSG00000070371 E019 83.8792660 0.0003247032 6.463481e-03 1.982782e-02 22 19191304 19191435 132 - 1.824 1.936 0.378
ENSG00000070371 E020 64.0957966 0.0003751811 2.252267e-02 5.676798e-02 22 19196266 19196362 97 - 1.711 1.818 0.362
ENSG00000070371 E021 48.1873215 0.0005129252 1.372679e-01 2.442701e-01 22 19196363 19196415 53 - 1.606 1.686 0.271
ENSG00000070371 E022 9.4495884 0.0018648235 4.336922e-04 1.904095e-03 22 19196416 19196488 73 - 1.199 0.830 -1.365
ENSG00000070371 E023 75.5847931 0.0003527001 2.542892e-01 3.909460e-01 22 19196489 19196656 168 - 1.824 1.872 0.164
ENSG00000070371 E024 58.2567731 0.0006974540 5.009089e-01 6.371276e-01 22 19199734 19199841 108 - 1.722 1.754 0.111
ENSG00000070371 E025 37.9841122 0.0005840648 3.002666e-01 4.419291e-01 22 19201329 19201390 62 - 1.521 1.583 0.211
ENSG00000070371 E026 55.1465221 0.0008749104 9.545972e-01 9.755346e-01 22 19201391 19201493 103 - 1.725 1.728 0.011
ENSG00000070371 E027 1.5446577 0.0096818603 8.077919e-02 1.607565e-01 22 19207518 19207676 159 - 0.153 0.477 2.239
ENSG00000070371 E028 61.1416617 0.0003910199 9.567049e-03 2.770185e-02 22 19208154 19208311 158 - 1.681 1.806 0.423
ENSG00000070371 E029 81.6784993 0.0003354182 6.327674e-01 7.475643e-01 22 19208922 19209114 193 - 1.876 1.895 0.065
ENSG00000070371 E030 1.2554346 0.0118173402 4.630304e-01 6.028815e-01 22 19209115 19209327 213 - 0.430 0.301 -0.762
ENSG00000070371 E031 75.0044048 0.0003338453 5.431724e-01 6.738066e-01 22 19210326 19210509 184 - 1.871 1.845 -0.086
ENSG00000070371 E032 62.7944636 0.0004225818 2.802058e-01 4.200326e-01 22 19216111 19216256 146 - 1.813 1.763 -0.166
ENSG00000070371 E033 48.5941977 0.0004528785 9.204134e-03 2.679558e-02 22 19219885 19220007 123 - 1.755 1.623 -0.447
ENSG00000070371 E034 64.9846009 0.0004727372 1.555630e-03 5.815678e-03 22 19221377 19221572 196 - 1.885 1.746 -0.470
ENSG00000070371 E035 33.8007313 0.0006370763 2.509116e-02 6.206271e-02 22 19221573 19221611 39 - 1.602 1.466 -0.463
ENSG00000070371 E036 59.5849017 0.0061488601 1.486933e-03 5.593850e-03 22 19221951 19222093 143 - 1.873 1.688 -0.625
ENSG00000070371 E037 52.3594809 0.0004428176 1.038172e-02 2.969943e-02 22 19222684 19222809 126 - 1.783 1.658 -0.424
ENSG00000070371 E038 56.3454905 0.0004482520 7.026794e-03 2.129485e-02 22 19223891 19224054 164 - 1.815 1.688 -0.431
ENSG00000070371 E039 40.7908237 0.0059071081 4.892507e-02 1.072482e-01 22 19225453 19225633 181 - 1.674 1.543 -0.444
ENSG00000070371 E040 38.5067340 0.0094458216 2.967144e-03 1.016504e-02 22 19226219 19226383 165 - 1.700 1.486 -0.729
ENSG00000070371 E041 17.1844512 0.0482449700 2.727618e-02 6.655064e-02 22 19229838 19229844 7 - 1.400 1.123 -0.976
ENSG00000070371 E042 38.4569940 0.0187521378 2.598171e-03 9.059908e-03 22 19229845 19229975 131 - 1.722 1.468 -0.864
ENSG00000070371 E043 33.6926884 0.0091360764 1.395038e-03 5.290583e-03 22 19232476 19232598 123 - 1.654 1.414 -0.820
ENSG00000070371 E044 0.3299976 0.0274424043 3.833832e-01   22 19232599 19232821 223 - 0.000 0.176 10.298
ENSG00000070371 E045 39.2691750 0.0076406968 3.857337e-03 1.274146e-02 22 19233166 19233318 153 - 1.696 1.495 -0.687
ENSG00000070371 E046 44.9719244 0.0112865077 2.672196e-03 9.289139e-03 22 19233422 19233622 201 - 1.767 1.548 -0.747
ENSG00000070371 E047 40.2682089 0.0014563790 4.822287e-06 3.447035e-05 22 19234509 19234706 198 - 1.742 1.481 -0.888
ENSG00000070371 E048 46.2307176 0.0147982363 1.574784e-04 7.804585e-04 22 19235696 19235869 174 - 1.823 1.526 -1.009
ENSG00000070371 E049 35.9210075 0.0183812967 8.950143e-04 3.596440e-03 22 19239275 19239388 114 - 1.714 1.421 -1.002
ENSG00000070371 E050 39.4926464 0.0268634708 3.402660e-03 1.144594e-02 22 19242775 19242936 162 - 1.745 1.467 -0.950
ENSG00000070371 E051 31.6455309 0.0112550224 4.043310e-03 1.326349e-02 22 19253959 19254033 75 - 1.629 1.401 -0.782
ENSG00000070371 E052 48.9688229 0.0007823743 3.916857e-08 4.315673e-07 22 19254034 19254227 194 - 1.837 1.560 -0.942
ENSG00000070371 E053 0.8148214 0.0237581056 5.485615e-02 1.177479e-01 22 19257805 19257867 63 - 0.430 0.097 -2.757
ENSG00000070371 E054 46.7897968 0.0094461249 2.247907e-08 2.595595e-07 22 19275623 19275830 208 - 1.868 1.486 -1.298
ENSG00000070371 E055 19.6657842 0.0059313208 9.011966e-05 4.755815e-04 22 19291600 19291719 120 - 1.480 1.154 -1.140