ENSG00000070367

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000340918 ENSG00000070367 HEK293_OSMI2_2hA HEK293_TMG_2hB EXOC5 protein_coding protein_coding 17.97361 2.571704 33.61067 0.3039503 1.299828 3.702953 2.2310271 0.0000000 4.2007253 0.00000000 0.2039219 8.717925 0.06930000 0.00000000 0.12513333 0.12513333 3.309903e-10 5.469072e-11 FALSE TRUE
ENST00000554011 ENSG00000070367 HEK293_OSMI2_2hA HEK293_TMG_2hB EXOC5 protein_coding retained_intron 17.97361 2.571704 33.61067 0.3039503 1.299828 3.702953 0.1972039 0.3080996 0.3359054 0.30809956 0.1989976 0.120899 0.01805833 0.09763333 0.01006667 -0.08756667 9.051238e-01 5.469072e-11 FALSE TRUE
ENST00000555148 ENSG00000070367 HEK293_OSMI2_2hA HEK293_TMG_2hB EXOC5 protein_coding nonsense_mediated_decay 17.97361 2.571704 33.61067 0.3039503 1.299828 3.702953 1.4934833 0.0000000 4.3028241 0.00000000 0.2680207 8.752489 0.05354167 0.00000000 0.12873333 0.12873333 3.702638e-09 5.469072e-11 FALSE TRUE
ENST00000555749 ENSG00000070367 HEK293_OSMI2_2hA HEK293_TMG_2hB EXOC5 protein_coding retained_intron 17.97361 2.571704 33.61067 0.3039503 1.299828 3.702953 2.4945865 0.0000000 5.4143358 0.00000000 0.5697054 9.083303 0.09288750 0.00000000 0.16063333 0.16063333 5.469072e-11 5.469072e-11 FALSE TRUE
ENST00000621441 ENSG00000070367 HEK293_OSMI2_2hA HEK293_TMG_2hB EXOC5 protein_coding protein_coding 17.97361 2.571704 33.61067 0.3039503 1.299828 3.702953 0.7987542 0.2900426 1.7498824 0.02316224 0.1260371 2.552240 0.07121667 0.11376667 0.05206667 -0.06170000 2.205217e-02 5.469072e-11 FALSE TRUE
MSTRG.9608.3 ENSG00000070367 HEK293_OSMI2_2hA HEK293_TMG_2hB EXOC5 protein_coding   17.97361 2.571704 33.61067 0.3039503 1.299828 3.702953 9.0042842 1.8200006 15.7284980 0.06912545 0.9444572 3.104382 0.60084583 0.73226667 0.46726667 -0.26500000 1.230653e-01 5.469072e-11 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000070367 E001 39.6100953 0.0005683286 7.335952e-05 3.963422e-04 14 57200507 57202482 1976 - 1.324 1.706 1.311
ENSG00000070367 E002 195.4509224 0.0002553859 4.282889e-09 5.644779e-08 14 57202483 57206793 4311 - 2.018 2.314 0.992
ENSG00000070367 E003 424.9518295 0.0146638998 7.214682e-14 2.091827e-12 14 57206794 57208159 1366 - 2.315 2.803 1.625
ENSG00000070367 E004 70.5059306 0.0003587684 2.670625e-07 2.497368e-06 14 57208160 57208281 122 - 1.567 1.946 1.282
ENSG00000070367 E005 118.3193868 0.0002469184 9.771038e-03 2.819901e-02 14 57208282 57208473 192 - 1.817 2.027 0.707
ENSG00000070367 E006 97.4600099 0.0003115467 1.821264e-01 3.038733e-01 14 57208474 57208544 71 - 1.758 1.761 0.010
ENSG00000070367 E007 159.6368052 0.0002335460 1.257288e-01 2.281858e-01 14 57208545 57208797 253 - 1.966 1.978 0.040
ENSG00000070367 E008 143.0938642 0.0013512788 1.949446e-02 5.040009e-02 14 57209567 57209782 216 - 1.923 1.880 -0.146
ENSG00000070367 E009 99.8703503 0.0002978107 1.540114e-03 5.766318e-03 14 57209953 57210061 109 - 1.777 1.655 -0.413
ENSG00000070367 E010 0.0000000       14 57211699 57211703 5 -      
ENSG00000070367 E011 0.1451727 0.0431009446 5.770893e-01   14 57217978 57217981 4 - 0.039 0.000 -8.794
ENSG00000070367 E012 83.5618123 0.0010674209 5.093070e-02 1.108202e-01 14 57217982 57218068 87 - 1.696 1.644 -0.177
ENSG00000070367 E013 107.8703893 0.0023526470 9.293377e-02 1.797175e-01 14 57219322 57219442 121 - 1.801 1.778 -0.077
ENSG00000070367 E014 106.7547623 0.0002770102 1.450712e-02 3.937944e-02 14 57222308 57222416 109 - 1.800 1.735 -0.220
ENSG00000070367 E015 141.6037495 0.0032101086 1.567132e-04 7.770525e-04 14 57229734 57229881 148 - 1.926 1.770 -0.526
ENSG00000070367 E016 108.4196670 0.0017025988 3.464124e-04 1.565739e-03 14 57231506 57231570 65 - 1.812 1.655 -0.532
ENSG00000070367 E017 81.1370381 0.0003161572 3.392231e-01 4.831394e-01 14 57231571 57231612 42 - 1.676 1.697 0.070
ENSG00000070367 E018 97.1399548 0.0002883567 4.445223e-02 9.920767e-02 14 57231613 57231715 103 - 1.758 1.716 -0.144
ENSG00000070367 E019 1.6560605 0.3742779395 5.980678e-01 7.197397e-01 14 57231716 57232139 424 - 0.309 0.000 -12.270
ENSG00000070367 E020 0.9005597 0.2062475602 1.000000e+00 1.000000e+00 14 57232140 57232215 76 - 0.194 0.000 -11.386
ENSG00000070367 E021 1.3275450 0.0096858043 4.468173e-01 5.882800e-01 14 57232216 57232372 157 - 0.265 0.000 -11.964
ENSG00000070367 E022 85.2681554 0.0003202129 5.112073e-04 2.201612e-03 14 57232667 57232749 83 - 1.712 1.544 -0.572
ENSG00000070367 E023 0.4482035 0.0266714874 1.000000e+00 1.000000e+00 14 57232750 57233223 474 - 0.107 0.000 -10.380
ENSG00000070367 E024 94.5346472 0.0038627451 8.190483e-05 4.370018e-04 14 57233743 57233883 141 - 1.759 1.530 -0.779
ENSG00000070367 E025 51.3807163 0.0180029077 6.646192e-02 1.374910e-01 14 57233988 57234032 45 - 1.495 1.355 -0.482
ENSG00000070367 E026 85.0549223 0.0003255944 6.239697e-04 2.620581e-03 14 57235711 57235820 110 - 1.709 1.544 -0.561
ENSG00000070367 E027 54.3192719 0.0007330964 3.056575e-03 1.043293e-02 14 57237338 57237358 21 - 1.520 1.331 -0.656
ENSG00000070367 E028 46.8777618 0.0005138729 3.741116e-03 1.241403e-02 14 57237359 57237366 8 - 1.460 1.255 -0.712
ENSG00000070367 E029 3.1097501 0.0049956614 9.150963e-02 1.774852e-01 14 57237367 57237506 140 - 0.472 0.000 -13.187
ENSG00000070367 E030 0.1515154 0.0437850352 5.781950e-01   14 57237674 57237677 4 - 0.039 0.000 -8.795
ENSG00000070367 E031 0.0000000       14 57239528 57239590 63 -      
ENSG00000070367 E032 0.0000000       14 57239591 57239594 4 -      
ENSG00000070367 E033 62.9584396 0.0004672311 9.735381e-03 2.811235e-02 14 57239595 57239659 65 - 1.580 1.450 -0.444
ENSG00000070367 E034 0.4439371 0.0216001569 1.000000e+00 1.000000e+00 14 57243248 57243636 389 - 0.107 0.000 -10.380
ENSG00000070367 E035 0.2966881 0.0268564177 1.000000e+00   14 57244113 57244164 52 - 0.074 0.000 -9.795
ENSG00000070367 E036 78.4334185 0.0003600435 6.873955e-05 3.740593e-04 14 57244165 57244278 114 - 1.680 1.450 -0.783
ENSG00000070367 E037 68.0843280 0.0003737484 6.857409e-06 4.732965e-05 14 57244279 57244359 81 - 1.623 1.307 -1.090
ENSG00000070367 E038 80.8792057 0.0012376947 1.941355e-05 1.208265e-04 14 57246711 57246827 117 - 1.694 1.433 -0.895
ENSG00000070367 E039 38.7702231 0.0005776715 2.613350e-02 6.421419e-02 14 57246828 57246850 23 - 1.378 1.227 -0.529
ENSG00000070367 E040 27.1382090 0.0007184788 7.288662e-02 1.481386e-01 14 57246851 57246858 8 - 1.230 1.091 -0.495
ENSG00000070367 E041 57.8802447 0.0004236237 1.468817e-04 7.336560e-04 14 57247618 57247712 95 - 1.553 1.282 -0.939
ENSG00000070367 E042 0.1451727 0.0431009446 5.770893e-01   14 57268247 57268507 261 - 0.039 0.000 -8.794
ENSG00000070367 E043 2.9702121 0.1682451295 8.380812e-01 8.987585e-01 14 57268508 57268621 114 - 0.427 0.512 0.426
ENSG00000070367 E044 72.7079701 0.0018760861 5.183672e-06 3.675954e-05 14 57268622 57268905 284 - 1.652 1.330 -1.106