ENSG00000070366

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000263073 ENSG00000070366 HEK293_OSMI2_2hA HEK293_TMG_2hB SMG6 protein_coding protein_coding 20.17403 29.86573 14.68934 1.598169 0.6543641 -1.023222 8.5682793 9.290412 9.45853496 1.4109273 0.09696449 0.02584665 0.47748750 0.31320000 0.646700000 0.33350000 2.598191e-04 5.845778e-07 FALSE TRUE
ENST00000354901 ENSG00000070366 HEK293_OSMI2_2hA HEK293_TMG_2hB SMG6 protein_coding protein_coding 20.17403 29.86573 14.68934 1.598169 0.6543641 -1.023222 0.7415279 2.925534 0.06356139 0.5923017 0.06356139 -5.31853028 0.02592917 0.09826667 0.004666667 -0.09360000 3.683578e-03 5.845778e-07 FALSE TRUE
ENST00000570756 ENSG00000070366 HEK293_OSMI2_2hA HEK293_TMG_2hB SMG6 protein_coding processed_transcript 20.17403 29.86573 14.68934 1.598169 0.6543641 -1.023222 6.3110190 12.780677 1.96657542 1.2755838 0.34441492 -2.69401776 0.26744167 0.42830000 0.132333333 -0.29596667 5.845778e-07 5.845778e-07 FALSE TRUE
MSTRG.13391.10 ENSG00000070366 HEK293_OSMI2_2hA HEK293_TMG_2hB SMG6 protein_coding   20.17403 29.86573 14.68934 1.598169 0.6543641 -1.023222 2.0077474 1.990422 2.19766426 0.2491775 0.36756549 0.14221637 0.11546250 0.06626667 0.148133333 0.08186667 1.398190e-03 5.845778e-07 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000070366 E001 0.1482932 0.0418207214 7.651841e-01   17 2059766 2059838 73 - 0.000 0.098 15.559
ENSG00000070366 E002 0.1482932 0.0418207214 7.651841e-01   17 2059839 2059842 4 - 0.000 0.098 15.562
ENSG00000070366 E003 0.6265839 0.0569184812 1.162237e-01 2.145797e-01 17 2059843 2059845 3 - 0.000 0.303 17.553
ENSG00000070366 E004 0.6265839 0.0569184812 1.162237e-01 2.145797e-01 17 2059846 2059849 4 - 0.000 0.303 17.553
ENSG00000070366 E005 2.2558198 0.2600039711 1.609084e-02 4.294070e-02 17 2059850 2059875 26 - 0.000 0.641 19.292
ENSG00000070366 E006 960.9445910 0.0064921280 1.148040e-07 1.153459e-06 17 2059876 2061373 1498 - 2.818 3.016 0.656
ENSG00000070366 E007 102.7898681 0.0032145364 4.803974e-02 1.057042e-01 17 2061374 2061404 31 - 1.922 2.020 0.328
ENSG00000070366 E008 98.0410312 0.0003698691 6.076306e-04 2.560930e-03 17 2061405 2061451 47 - 1.870 2.010 0.472
ENSG00000070366 E009 100.2520942 0.0003013929 3.679689e-02 8.508083e-02 17 2061452 2061550 99 - 1.922 2.008 0.286
ENSG00000070366 E010 115.9923633 0.0002684854 2.122556e-01 3.411862e-01 17 2061551 2061622 72 - 2.010 2.060 0.167
ENSG00000070366 E011 8.9770684 0.0626261249 8.783402e-01 9.258735e-01 17 2061623 2062257 635 - 0.988 0.986 -0.007
ENSG00000070366 E012 126.6183759 0.0008232965 4.093882e-02 9.276865e-02 17 2065073 2065154 82 - 2.027 2.106 0.266
ENSG00000070366 E013 210.0803582 0.0004641145 1.043228e-02 2.982192e-02 17 2065468 2065679 212 - 2.246 2.322 0.255
ENSG00000070366 E014 2.6112020 0.0336784827 8.803991e-01 9.272986e-01 17 2066003 2066089 87 - 0.543 0.520 -0.108
ENSG00000070366 E015 150.3726132 0.0017682129 1.084318e-03 4.250467e-03 17 2068778 2068886 109 - 2.066 2.192 0.423
ENSG00000070366 E016 103.5743713 0.0020190090 7.906231e-04 3.225818e-03 17 2068887 2068931 45 - 1.889 2.040 0.509
ENSG00000070366 E017 0.0000000       17 2071923 2072003 81 -      
ENSG00000070366 E018 163.4311238 0.0002092152 1.985201e-03 7.180214e-03 17 2081810 2081915 106 - 2.121 2.220 0.329
ENSG00000070366 E019 124.4856722 0.0002466657 9.077001e-02 1.763522e-01 17 2081916 2081956 41 - 2.029 2.092 0.213
ENSG00000070366 E020 0.2214452 0.0402527490 7.633341e-01   17 2082227 2082243 17 - 0.000 0.099 15.570
ENSG00000070366 E021 0.5169874 0.0205223730 8.880801e-01 9.324671e-01 17 2082244 2082310 67 - 0.151 0.179 0.298
ENSG00000070366 E022 119.8455115 0.0068394727 8.360935e-01 8.975099e-01 17 2085725 2085782 58 - 2.041 2.061 0.066
ENSG00000070366 E023 148.8009221 0.0080928103 7.509084e-01 8.374877e-01 17 2085783 2085901 119 - 2.131 2.157 0.087
ENSG00000070366 E024 1.6511958 0.4360027963 7.465969e-01 8.343073e-01 17 2087075 2088761 1687 - 0.351 0.419 0.385
ENSG00000070366 E025 0.2214452 0.0402527490 7.633341e-01   17 2094785 2095112 328 - 0.000 0.099 15.570
ENSG00000070366 E026 70.7937339 0.0031149361 7.129347e-01 8.095187e-01 17 2172658 2172667 10 - 1.813 1.839 0.089
ENSG00000070366 E027 99.1991599 0.0025646922 6.627259e-01 7.709717e-01 17 2172668 2172711 44 - 1.983 1.971 -0.039
ENSG00000070366 E028 78.6667714 0.0004195709 7.656849e-01 8.483778e-01 17 2172712 2172736 25 - 1.879 1.874 -0.019
ENSG00000070366 E029 99.3078586 0.0009158102 4.551344e-01 5.956907e-01 17 2172737 2172796 60 - 1.994 1.972 -0.073
ENSG00000070366 E030 55.6109569 0.0045318110 1.519396e-01 2.643035e-01 17 2172797 2172801 5 - 1.781 1.708 -0.248
ENSG00000070366 E031 54.2896303 0.0072469449 2.337871e-01 3.668842e-01 17 2172802 2172803 2 - 1.766 1.700 -0.223
ENSG00000070366 E032 93.9639781 0.0003859581 2.254820e-01 3.569796e-01 17 2172804 2172859 56 - 1.981 1.942 -0.131
ENSG00000070366 E033 0.2214452 0.0402527490 7.633341e-01   17 2172860 2173071 212 - 0.000 0.099 15.570
ENSG00000070366 E034 0.3697384 0.0249634833 3.719102e-01 5.163823e-01 17 2173098 2173178 81 - 0.000 0.179 16.567
ENSG00000070366 E035 98.9348299 0.0002992080 4.293428e-01 5.720797e-01 17 2186663 2186724 62 - 1.990 1.968 -0.075
ENSG00000070366 E036 66.5513071 0.0004137381 8.187842e-01 8.855029e-01 17 2186725 2186736 12 - 1.793 1.810 0.058
ENSG00000070366 E037 103.7323787 0.0002792266 4.183846e-01 5.616577e-01 17 2186737 2186831 95 - 2.010 1.988 -0.075
ENSG00000070366 E038 100.2368933 0.0021351789 8.608516e-01 9.142520e-01 17 2188399 2188515 117 - 1.967 1.982 0.049
ENSG00000070366 E039 0.0000000       17 2212615 2212737 123 -      
ENSG00000070366 E040 0.0000000       17 2214139 2214349 211 -      
ENSG00000070366 E041 0.4031496 0.0249719500 3.709282e-01 5.153475e-01 17 2229323 2229464 142 - 0.000 0.179 16.569
ENSG00000070366 E042 105.1593878 0.0015191319 5.284592e-01 6.613795e-01 17 2236492 2236637 146 - 1.977 2.009 0.109
ENSG00000070366 E043 0.8385790 0.1028821816 4.372364e-01 5.792283e-01 17 2236797 2237037 241 - 0.151 0.305 1.295
ENSG00000070366 E044 0.2987644 0.0272859043 9.670486e-02   17 2237299 2237391 93 - 0.263 0.000 -18.247
ENSG00000070366 E045 0.0000000       17 2237495 2237580 86 -      
ENSG00000070366 E046 0.1451727 0.0433422809 3.023813e-01   17 2240003 2240191 189 - 0.151 0.000 -17.246
ENSG00000070366 E047 67.5409028 0.0007836478 6.336510e-01 7.483155e-01 17 2244658 2244719 62 - 1.818 1.803 -0.051
ENSG00000070366 E048 0.0000000       17 2244873 2244912 40 -      
ENSG00000070366 E049 0.0000000       17 2265930 2265967 38 -      
ENSG00000070366 E050 0.1817044 0.0400749952 7.641351e-01   17 2265968 2266199 232 - 0.000 0.099 15.567
ENSG00000070366 E051 156.4506466 0.0015258087 3.942696e-02 8.997013e-02 17 2282647 2282859 213 - 2.212 2.149 -0.209
ENSG00000070366 E052 135.5496100 0.0007715839 3.182791e-02 7.552044e-02 17 2283625 2283735 111 - 2.150 2.086 -0.216
ENSG00000070366 E053 107.0661350 0.0011087957 3.615647e-03 1.205472e-02 17 2292552 2292630 79 - 2.072 1.970 -0.344
ENSG00000070366 E054 115.6348747 0.0003470676 6.809468e-05 3.709551e-04 17 2292871 2292977 107 - 2.121 1.993 -0.429
ENSG00000070366 E055 107.5007954 0.0008059858 6.962755e-08 7.289307e-07 17 2297243 2297353 111 - 2.125 1.937 -0.631
ENSG00000070366 E056 113.5583407 0.0028401970 5.680989e-05 3.156369e-04 17 2297863 2298055 193 - 2.135 1.975 -0.536
ENSG00000070366 E057 580.3122048 0.0064114345 7.881699e-10 1.192052e-08 17 2298906 2300664 1759 - 2.873 2.652 -0.736
ENSG00000070366 E058 29.0944210 0.0009301371 3.255316e-03 1.101779e-02 17 2303014 2303152 139 - 1.565 1.380 -0.637
ENSG00000070366 E059 12.7320088 0.0221679389 1.031497e-01 1.952715e-01 17 2303153 2303156 4 - 1.225 1.041 -0.661
ENSG00000070366 E060 25.8108142 0.0048509309 4.499815e-03 1.454217e-02 17 2303157 2303354 198 - 1.523 1.316 -0.715
ENSG00000070366 E061 29.1123058 0.0200003077 1.089298e-05 7.176141e-05 17 2303633 2303916 284 - 1.669 1.270 -1.374