ENSG00000070214

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000374720 ENSG00000070214 HEK293_OSMI2_2hA HEK293_TMG_2hB SLC44A1 protein_coding protein_coding 11.97938 2.826053 19.16884 0.1031194 0.4815899 2.757559 3.185375 1.6641365 4.714587 0.13363269 0.1097870 1.496771 0.3628250 0.59096667 0.2459667 -0.34500000 3.794493e-07 3.794493e-07 FALSE TRUE
ENST00000374724 ENSG00000070214 HEK293_OSMI2_2hA HEK293_TMG_2hB SLC44A1 protein_coding protein_coding 11.97938 2.826053 19.16884 0.1031194 0.4815899 2.757559 1.814954 0.2643417 2.930615 0.02265447 0.3733834 3.422072 0.1434208 0.09323333 0.1523000 0.05906667 3.175238e-01 3.794493e-07 FALSE TRUE
MSTRG.33181.5 ENSG00000070214 HEK293_OSMI2_2hA HEK293_TMG_2hB SLC44A1 protein_coding   11.97938 2.826053 19.16884 0.1031194 0.4815899 2.757559 6.763712 0.8815572 11.105854 0.17507198 0.3283295 3.640148 0.4735042 0.31023333 0.5800667 0.26983333 2.368082e-03 3.794493e-07 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000070214 E001 3.0333612 0.0049670651 2.555190e-01 3.924163e-01 9 105244622 105244650 29 + 0.567 0.384 -0.920
ENSG00000070214 E002 12.9955721 0.0163586692 9.896788e-04 3.923077e-03 9 105244651 105244816 166 + 1.121 0.658 -1.783
ENSG00000070214 E003 15.0828948 0.0016274879 1.674560e-03 6.201311e-03 9 105244817 105244904 88 + 1.168 0.825 -1.273
ENSG00000070214 E004 0.0000000       9 105294666 105294798 133 +      
ENSG00000070214 E005 23.1433850 0.0008467984 6.841296e-03 2.081360e-02 9 105299220 105299309 90 + 1.325 1.116 -0.739
ENSG00000070214 E006 0.8899506 0.0138110005 2.316062e-01 3.643813e-01 9 105299743 105299937 195 + 0.278 0.000 -9.760
ENSG00000070214 E007 64.1152750 0.0004745529 6.024978e-05 3.326671e-04 9 105309724 105309866 143 + 1.752 1.570 -0.617
ENSG00000070214 E008 79.1398608 0.0043067782 2.421270e-03 8.525748e-03 9 105335563 105335699 137 + 1.834 1.705 -0.435
ENSG00000070214 E009 71.6981007 0.0022973295 3.511478e-03 1.175916e-02 9 105348358 105348451 94 + 1.789 1.673 -0.390
ENSG00000070214 E010 1.0695787 0.0115850045 7.370656e-01 8.273384e-01 9 105355917 105356211 295 + 0.278 0.233 -0.335
ENSG00000070214 E011 111.2462243 0.0005681489 3.801337e-06 2.780080e-05 9 105356212 105356381 170 + 1.983 1.831 -0.511
ENSG00000070214 E012 0.4783925 0.0210589486 5.444779e-01 6.749534e-01 9 105357151 105357243 93 + 0.113 0.233 1.250
ENSG00000070214 E013 80.3584117 0.0004080857 2.418762e-05 1.472263e-04 9 105358344 105358433 90 + 1.846 1.680 -0.561
ENSG00000070214 E014 109.8523830 0.0003004850 4.505647e-06 3.240997e-05 9 105361191 105361330 140 + 1.978 1.831 -0.495
ENSG00000070214 E015 121.5999470 0.0002503106 1.449804e-07 1.427849e-06 9 105362821 105363007 187 + 2.024 1.857 -0.562
ENSG00000070214 E016 113.6906143 0.0002937970 1.491938e-06 1.193897e-05 9 105364555 105364720 166 + 1.994 1.840 -0.519
ENSG00000070214 E017 87.3926423 0.0003382155 1.673390e-02 4.435132e-02 9 105365483 105365639 157 + 1.865 1.807 -0.194
ENSG00000070214 E018 70.1759040 0.0003681055 4.651188e-01 6.048265e-01 9 105366346 105366429 84 + 1.758 1.777 0.066
ENSG00000070214 E019 103.4098042 0.0005453311 4.055163e-02 9.203217e-02 9 105374598 105374735 138 + 1.932 1.898 -0.113
ENSG00000070214 E020 130.1974221 0.0019755677 1.889165e-01 3.123934e-01 9 105383123 105383359 237 + 2.024 2.023 -0.005
ENSG00000070214 E021 82.3206674 0.0003026806 3.177121e-01 4.605991e-01 9 105385422 105385502 81 + 1.826 1.835 0.032
ENSG00000070214 E022 0.1451727 0.0430798908 1.000000e+00   9 105386688 105386741 54 + 0.060 0.000 -7.175
ENSG00000070214 E023 52.0503485 0.0004693906 7.150671e-01 8.110990e-01 9 105389033 105389108 76 + 1.625 1.660 0.118
ENSG00000070214 E024 40.8576304 0.0005603415 7.476419e-01 8.350983e-01 9 105389109 105389186 78 + 1.510 1.587 0.264
ENSG00000070214 E025 232.2736541 0.0001930767 4.934717e-01 6.305041e-01 9 105389187 105389903 717 + 2.258 2.334 0.254
ENSG00000070214 E026 494.2708405 0.0056471998 2.115551e-13 5.741902e-12 9 105389904 105395496 5593 + 2.524 2.816 0.972
ENSG00000070214 E027 56.2889451 0.0004330050 2.904915e-31 5.291610e-29 9 105395497 105397346 1850 + 1.454 2.069 2.083
ENSG00000070214 E028 5.5796518 0.0029882163 1.286543e-04 6.530373e-04 9 105438281 105439171 891 + 0.567 1.116 2.166