ENSG00000070081

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000323688 ENSG00000070081 HEK293_OSMI2_2hA HEK293_TMG_2hB NUCB2 protein_coding protein_coding 35.33699 12.54401 66.97121 0.6179882 2.342367 2.415608 13.028849 2.2703812 28.146118 0.9435609 0.4386887 3.6261015 0.32646667 0.18523333 0.42146667 0.236233333 7.579091e-02 2.59342e-17 FALSE TRUE
ENST00000533926 ENSG00000070081 HEK293_OSMI2_2hA HEK293_TMG_2hB NUCB2 protein_coding protein_coding 35.33699 12.54401 66.97121 0.6179882 2.342367 2.415608 2.630312 0.0000000 5.264674 0.0000000 0.6293103 9.0429380 0.04335417 0.00000000 0.07833333 0.078333333 2.593420e-17 2.59342e-17 FALSE FALSE
MSTRG.5229.11 ENSG00000070081 HEK293_OSMI2_2hA HEK293_TMG_2hB NUCB2 protein_coding   35.33699 12.54401 66.97121 0.6179882 2.342367 2.415608 2.404556 1.4753684 1.155140 0.1507496 0.5775864 -0.3503176 0.09340000 0.11726667 0.01666667 -0.100600000 1.783865e-01 2.59342e-17 FALSE TRUE
MSTRG.5229.14 ENSG00000070081 HEK293_OSMI2_2hA HEK293_TMG_2hB NUCB2 protein_coding   35.33699 12.54401 66.97121 0.6179882 2.342367 2.415608 2.470005 0.8405108 5.195568 0.2681953 1.4619053 2.6136542 0.05452500 0.06736667 0.07720000 0.009833333 9.055202e-01 2.59342e-17 FALSE TRUE
MSTRG.5229.15 ENSG00000070081 HEK293_OSMI2_2hA HEK293_TMG_2hB NUCB2 protein_coding   35.33699 12.54401 66.97121 0.6179882 2.342367 2.415608 1.606476 1.3354837 3.935645 0.6743410 0.9718319 1.5521363 0.05778333 0.10556667 0.05800000 -0.047566667 9.968011e-01 2.59342e-17 FALSE TRUE
MSTRG.5229.23 ENSG00000070081 HEK293_OSMI2_2hA HEK293_TMG_2hB NUCB2 protein_coding   35.33699 12.54401 66.97121 0.6179882 2.342367 2.415608 4.017382 1.9873896 5.849745 0.5537927 0.1787976 1.5527221 0.12322083 0.15696667 0.08740000 -0.069566667 3.673047e-01 2.59342e-17 FALSE TRUE
MSTRG.5229.31 ENSG00000070081 HEK293_OSMI2_2hA HEK293_TMG_2hB NUCB2 protein_coding   35.33699 12.54401 66.97121 0.6179882 2.342367 2.415608 2.197124 2.9683850 1.064846 0.3908952 1.0648459 -1.4704004 0.12309167 0.23480000 0.01710000 -0.217700000 2.769014e-02 2.59342e-17 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000070081 E001 0.6299079 0.0232638049 7.954715e-01 8.694029e-01 11 17208153 17208426 274 + 0.173 0.218 0.418
ENSG00000070081 E002 0.0000000       11 17260340 17260355 16 +      
ENSG00000070081 E003 0.0000000       11 17260356 17260501 146 +      
ENSG00000070081 E004 0.0000000       11 17260537 17261465 929 +      
ENSG00000070081 E005 0.0000000       11 17267588 17267681 94 +      
ENSG00000070081 E006 0.0000000       11 17268068 17268257 190 +      
ENSG00000070081 E007 0.1515154 0.0428007350 1.000000e+00   11 17269185 17269197 13 + 0.065 0.000 -9.962
ENSG00000070081 E008 0.7771569 0.0142352237 1.000000e+00 1.000000e+00 11 17269198 17269331 134 + 0.218 0.218 0.003
ENSG00000070081 E009 0.0000000       11 17275613 17275616 4 +      
ENSG00000070081 E010 0.2987644 0.0274543854 1.000000e+00   11 17275617 17275909 293 + 0.122 0.000 -11.082
ENSG00000070081 E011 0.1472490 0.0440867045 1.000000e+00   11 17275910 17276007 98 + 0.065 0.000 -9.952
ENSG00000070081 E012 0.2987644 0.0274543854 1.000000e+00   11 17276008 17276010 3 + 0.122 0.000 -11.082
ENSG00000070081 E013 0.4439371 0.0215727200 6.122356e-01 7.312128e-01 11 17276011 17276203 193 + 0.172 0.000 -11.712
ENSG00000070081 E014 0.2966881 0.0290785164 1.000000e+00   11 17276718 17276720 3 + 0.122 0.000 -11.067
ENSG00000070081 E015 0.2966881 0.0290785164 1.000000e+00   11 17276721 17276724 4 + 0.122 0.000 -11.067
ENSG00000070081 E016 0.2966881 0.0290785164 1.000000e+00   11 17276725 17276725 1 + 0.122 0.000 -11.067
ENSG00000070081 E017 0.4482035 0.0257381270 6.144944e-01 7.329525e-01 11 17276726 17276730 5 + 0.173 0.000 -11.673
ENSG00000070081 E018 1.1888288 0.0116020817 1.217767e-01 2.224567e-01 11 17276731 17276733 3 + 0.362 0.000 -13.171
ENSG00000070081 E019 1.6433751 0.1127726798 8.348076e-02 1.650010e-01 11 17276734 17276738 5 + 0.446 0.000 -13.008
ENSG00000070081 E020 1.6433751 0.1127726798 8.348076e-02 1.650010e-01 11 17276739 17276740 2 + 0.446 0.000 -13.008
ENSG00000070081 E021 4.5094400 0.0272270665 1.775109e-01 2.980151e-01 11 17276741 17276749 9 + 0.732 0.470 -1.168
ENSG00000070081 E022 106.1261947 0.0011193336 7.329538e-04 3.017885e-03 11 17276750 17276828 79 + 1.988 1.829 -0.536
ENSG00000070081 E023 8.9233216 0.0024538792 3.951149e-01 5.389513e-01 11 17276829 17276830 2 + 0.952 0.837 -0.441
ENSG00000070081 E024 9.9669777 0.0018666205 2.062677e-01 3.340439e-01 11 17276831 17276848 18 + 1.004 0.837 -0.634
ENSG00000070081 E025 0.4804688 0.0214846569 5.643447e-01 6.916502e-01 11 17276984 17276985 2 + 0.122 0.218 1.003
ENSG00000070081 E026 1.2274368 0.0181533507 5.900555e-01 7.129940e-01 11 17276986 17277003 18 + 0.330 0.218 -0.804
ENSG00000070081 E027 1.5543139 0.0147673673 9.911809e-01 9.986133e-01 11 17277004 17277013 10 + 0.362 0.362 0.003
ENSG00000070081 E028 4.3095227 0.0093901493 4.519594e-01 5.928705e-01 11 17277014 17277022 9 + 0.690 0.557 -0.580
ENSG00000070081 E029 14.4046337 0.0891904674 3.154959e-01 4.582797e-01 11 17277023 17277095 73 + 1.151 0.983 -0.609
ENSG00000070081 E030 3.1440891 0.0049074847 9.918981e-01 9.990331e-01 11 17277096 17277194 99 + 0.556 0.557 0.004
ENSG00000070081 E031 5.9110649 0.0027766184 8.192604e-01 8.858713e-01 11 17277195 17277297 103 + 0.781 0.745 -0.143
ENSG00000070081 E032 0.4418608 0.0247918990 6.148469e-01 7.332391e-01 11 17278362 17278537 176 + 0.172 0.000 -11.682
ENSG00000070081 E033 229.4517196 0.0040645785 2.969410e-03 1.017207e-02 11 17282789 17282943 155 + 2.315 2.187 -0.428
ENSG00000070081 E034 1.5145600 0.0088525117 9.944120e-01 1.000000e+00 11 17283461 17283564 104 + 0.362 0.362 0.003
ENSG00000070081 E035 33.5081324 0.0006147081 3.333982e-04 1.513933e-03 11 17286634 17286713 80 + 1.519 1.221 -1.034
ENSG00000070081 E036 10.9363108 0.0015161945 4.701914e-02 1.038610e-01 11 17286714 17286717 4 + 1.057 0.793 -0.997
ENSG00000070081 E037 28.2788529 0.0120807144 1.412065e-04 7.087901e-04 11 17291240 17291365 126 + 1.462 1.033 -1.514
ENSG00000070081 E038 297.3037990 0.0010420450 2.094286e-04 1.004293e-03 11 17295324 17295467 144 + 2.422 2.312 -0.369
ENSG00000070081 E039 0.5922303 0.0179996596 7.999789e-01 8.724655e-01 11 17295468 17295604 137 + 0.172 0.218 0.417
ENSG00000070081 E040 305.5492209 0.0002146009 1.534665e-03 5.748872e-03 11 17296104 17296211 108 + 2.429 2.348 -0.272
ENSG00000070081 E041 359.7851119 0.0001891208 4.972777e-03 1.585402e-02 11 17301744 17301870 127 + 2.498 2.432 -0.220
ENSG00000070081 E042 289.4344494 0.0002002511 1.655524e-01 2.824310e-01 11 17309572 17309675 104 + 2.398 2.361 -0.123
ENSG00000070081 E043 306.3850038 0.0006336027 4.922782e-02 1.077883e-01 11 17310825 17310919 95 + 2.426 2.371 -0.182
ENSG00000070081 E044 275.9657898 0.0001882894 6.715769e-03 2.048335e-02 11 17310920 17311010 91 + 2.385 2.312 -0.244
ENSG00000070081 E045 0.0000000       11 17311185 17311192 8 +      
ENSG00000070081 E046 318.8874761 0.0001627633 5.723179e-02 1.218630e-01 11 17311193 17311283 91 + 2.442 2.394 -0.158
ENSG00000070081 E047 0.5964967 0.0207831907 7.993490e-01 8.720168e-01 11 17311839 17311871 33 + 0.173 0.218 0.416
ENSG00000070081 E048 305.8552737 0.0006385214 7.970335e-01 8.704977e-01 11 17311872 17311930 59 + 2.415 2.407 -0.027
ENSG00000070081 E049 302.9565878 0.0001647533 1.553541e-01 2.688704e-01 11 17312028 17312080 53 + 2.401 2.434 0.110
ENSG00000070081 E050 265.8320567 0.0003804848 1.424187e-01 2.513419e-01 11 17312081 17312120 40 + 2.343 2.381 0.125
ENSG00000070081 E051 278.0173571 0.0003740249 5.313666e-08 5.696022e-07 11 17315386 17315475 90 + 2.337 2.472 0.450
ENSG00000070081 E052 0.1472490 0.0440867045 1.000000e+00   11 17317584 17317706 123 + 0.065 0.000 -9.952
ENSG00000070081 E053 334.9310038 0.0001949796 7.013555e-18 3.502101e-16 11 17330127 17330297 171 + 2.401 2.587 0.620
ENSG00000070081 E054 221.5042994 0.0009911330 9.294725e-09 1.152998e-07 11 17330902 17330983 82 + 2.226 2.398 0.573
ENSG00000070081 E055 1.7349610 0.0080624383 8.865950e-01 9.314860e-01 11 17330984 17331390 407 + 0.391 0.362 -0.166
ENSG00000070081 E056 120.0076387 0.0037204339 3.883386e-09 5.162054e-08 11 17331412 17332041 630 + 1.930 2.198 0.898
ENSG00000070081 E057 46.2215844 0.0020867716 2.076340e-03 7.460672e-03 11 17332042 17334480 2439 + 1.644 1.422 -0.761
ENSG00000070081 E058 4.4124127 0.0086798750 4.514156e-01 5.923663e-01 11 17337024 17337083 60 + 0.690 0.558 -0.579
ENSG00000070081 E059 7.7816467 0.0021415216 9.849381e-01 9.946055e-01 11 17337348 17337534 187 + 0.875 0.876 0.004
ENSG00000070081 E060 31.8444672 0.0006384350 1.546027e-04 7.674717e-04 11 17349345 17349980 636 + 1.370 1.624 0.872