ENSG00000070018

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000261349 ENSG00000070018 HEK293_OSMI2_2hA HEK293_TMG_2hB LRP6 protein_coding protein_coding 5.867922 1.697561 8.205989 0.1849084 0.1482994 2.266497 3.1097685 1.003345300 4.2918268 0.152885860 0.06475152 2.085824 0.55500833 0.586800000 0.5232333 -0.06356667 0.5937072292 0.0008780831 FALSE TRUE
ENST00000538239 ENSG00000070018 HEK293_OSMI2_2hA HEK293_TMG_2hB LRP6 protein_coding nonsense_mediated_decay 5.867922 1.697561 8.205989 0.1849084 0.1482994 2.266497 1.6409467 0.670662877 1.8577652 0.069108036 0.15260134 1.456301 0.31820833 0.398466667 0.2270000 -0.17146667 0.0354408666 0.0008780831 TRUE TRUE
ENST00000543091 ENSG00000070018 HEK293_OSMI2_2hA HEK293_TMG_2hB LRP6 protein_coding protein_coding 5.867922 1.697561 8.205989 0.1849084 0.1482994 2.266497 0.2579852 0.000000000 0.7368289 0.000000000 0.17568482 6.222706 0.02883750 0.000000000 0.0891000 0.08910000 0.0008780831 0.0008780831 FALSE TRUE
MSTRG.6831.6 ENSG00000070018 HEK293_OSMI2_2hA HEK293_TMG_2hB LRP6 protein_coding   5.867922 1.697561 8.205989 0.1849084 0.1482994 2.266497 0.3653042 0.006840819 0.9611481 0.006840819 0.26323843 5.849657 0.04015833 0.003333333 0.1177000 0.11436667 0.0032007324 0.0008780831 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000070018 E001 0.0000000       12 12103968 12104002 35 -      
ENSG00000070018 E002 0.1482932 0.0415703743 1.033328e-01   12 12116025 12116028 4 - 0.000 0.222 10.387
ENSG00000070018 E003 101.8579092 0.0047398981 5.168228e-25 5.656299e-23 12 12116029 12116865 837 - 1.769 2.262 1.654
ENSG00000070018 E004 46.2631330 0.0004670128 1.446312e-09 2.080166e-08 12 12116866 12117087 222 - 1.496 1.839 1.167
ENSG00000070018 E005 262.0015158 0.0017799945 2.595131e-03 9.051139e-03 12 12117088 12119179 2092 - 2.316 2.415 0.329
ENSG00000070018 E006 38.7671005 0.0006241601 3.632667e-01 5.076928e-01 12 12119180 12119330 151 - 1.504 1.576 0.246
ENSG00000070018 E007 75.0798803 0.0086857674 5.020206e-01 6.381425e-01 12 12119331 12120369 1039 - 1.788 1.843 0.186
ENSG00000070018 E008 18.7436977 0.0009950209 2.290907e-01 3.613430e-01 12 12120370 12120403 34 - 1.189 1.309 0.422
ENSG00000070018 E009 31.3797071 0.0006806169 2.774831e-01 4.170502e-01 12 12120404 12120576 173 - 1.411 1.501 0.310
ENSG00000070018 E010 54.2555521 0.0004419971 6.059871e-01 7.262623e-01 12 12120577 12121046 470 - 1.671 1.653 -0.059
ENSG00000070018 E011 15.3061447 0.0051924197 6.156277e-02 1.292644e-01 12 12121047 12121085 39 - 1.094 1.293 0.704
ENSG00000070018 E012 12.6053504 0.0014425578 1.757779e-01 2.956978e-01 12 12121086 12121092 7 - 1.022 1.176 0.557
ENSG00000070018 E013 57.4888924 0.0005003623 1.112950e-03 4.346870e-03 12 12121093 12121420 328 - 1.645 1.826 0.613
ENSG00000070018 E014 32.3794769 0.0006433602 7.282921e-02 1.480474e-01 12 12124565 12124662 98 - 1.416 1.553 0.468
ENSG00000070018 E015 30.7812351 0.0007472480 5.453812e-01 6.757279e-01 12 12125296 12125361 66 - 1.416 1.473 0.194
ENSG00000070018 E016 30.4931855 0.0009709699 6.518369e-01 7.626363e-01 12 12125362 12125432 71 - 1.432 1.409 -0.077
ENSG00000070018 E017 50.9631304 0.0009140362 1.130748e-01 2.100185e-01 12 12126691 12126921 231 - 1.616 1.719 0.349
ENSG00000070018 E018 28.1411916 0.0034379991 1.467178e-01 2.572206e-01 12 12130783 12130893 111 - 1.357 1.483 0.435
ENSG00000070018 E019 30.8108851 0.0007206505 6.410530e-01 7.541516e-01 12 12131821 12131922 102 - 1.416 1.463 0.160
ENSG00000070018 E020 34.0833911 0.0064890022 9.753994e-01 9.886495e-01 12 12131923 12132057 135 - 1.466 1.482 0.052
ENSG00000070018 E021 38.4630744 0.0062954786 3.473995e-01 4.916100e-01 12 12135175 12135300 126 - 1.534 1.472 -0.214
ENSG00000070018 E022 49.4927817 0.0004916947 1.189378e-01 2.184185e-01 12 12138325 12138534 210 - 1.645 1.561 -0.288
ENSG00000070018 E023 38.2548935 0.0041550076 1.536000e-02 4.130573e-02 12 12147366 12147556 191 - 1.553 1.374 -0.617
ENSG00000070018 E024 48.5783003 0.0008296740 3.717757e-03 1.234822e-02 12 12148942 12149153 212 - 1.653 1.473 -0.616
ENSG00000070018 E025 50.6298847 0.0005025390 1.918190e-03 6.971879e-03 12 12150836 12151038 203 - 1.671 1.482 -0.644
ENSG00000070018 E026 56.0039124 0.0004477929 1.978289e-03 7.159414e-03 12 12158829 12159155 327 - 1.713 1.536 -0.602
ENSG00000070018 E027 42.0767603 0.0013742945 6.912764e-03 2.099866e-02 12 12159780 12159964 185 - 1.592 1.410 -0.625
ENSG00000070018 E028 52.4074739 0.0004210991 5.663256e-02 1.208192e-01 12 12162193 12162419 227 - 1.672 1.569 -0.353
ENSG00000070018 E029 55.4523679 0.0004649764 1.545595e-03 5.783077e-03 12 12164273 12164562 290 - 1.710 1.528 -0.622
ENSG00000070018 E030 50.1422274 0.0007856813 5.402942e-04 2.310909e-03 12 12165079 12165295 217 - 1.671 1.453 -0.745
ENSG00000070018 E031 42.5081709 0.0005285797 1.004352e-04 5.238964e-04 12 12179810 12179981 172 - 1.609 1.336 -0.940
ENSG00000070018 E032 71.0645524 0.0032863957 1.119128e-03 4.367492e-03 12 12181043 12181439 397 - 1.814 1.628 -0.629
ENSG00000070018 E033 34.6506012 0.0191691156 2.680175e-01 4.064155e-01 12 12183980 12184111 132 - 1.493 1.391 -0.352
ENSG00000070018 E034 0.0000000       12 12186806 12186922 117 -      
ENSG00000070018 E035 34.4994617 0.0277323827 2.742737e-02 6.686023e-02 12 12186923 12187087 165 - 1.515 1.268 -0.855
ENSG00000070018 E036 18.5504164 0.0268760867 1.134404e-02 3.198722e-02 12 12187088 12187119 32 - 1.270 0.924 -1.252
ENSG00000070018 E037 38.4575611 0.0077841871 1.915744e-05 1.193581e-04 12 12203203 12203400 198 - 1.581 1.195 -1.339
ENSG00000070018 E038 50.5739380 0.0004304352 2.119830e-05 1.306698e-04 12 12244262 12244655 394 - 1.684 1.410 -0.938
ENSG00000070018 E039 21.9776022 0.0041321011 8.824289e-05 4.667174e-04 12 12266681 12267044 364 - 1.351 0.921 -1.545