ENSG00000069869

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000435532 ENSG00000069869 HEK293_OSMI2_2hA HEK293_TMG_2hB NEDD4 protein_coding protein_coding 5.97093 3.482979 8.472071 0.7610402 0.5640237 1.279959 1.036850 0.2218714 2.1475070 0.01537892 0.15414763 3.217968 0.1406417 0.07196667 0.2552667 0.1833000 8.603758e-05 5.430405e-09 FALSE TRUE
ENST00000508075 ENSG00000069869 HEK293_OSMI2_2hA HEK293_TMG_2hB NEDD4 protein_coding processed_transcript 5.97093 3.482979 8.472071 0.7610402 0.5640237 1.279959 4.323496 3.1833746 5.2739169 0.72711342 0.56317426 0.726526 0.7728583 0.90870000 0.6193667 -0.2893333 7.925086e-09 5.430405e-09 FALSE FALSE
MSTRG.10865.8 ENSG00000069869 HEK293_OSMI2_2hA HEK293_TMG_2hB NEDD4 protein_coding   5.97093 3.482979 8.472071 0.7610402 0.5640237 1.279959 0.509091 0.0000000 0.8949579 0.00000000 0.05289834 6.499779 0.0646875 0.00000000 0.1061000 0.1061000 5.430405e-09 5.430405e-09 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000069869 E001 0.2214452 0.039042442 1.858313e-02   15 55826922 55826996 75 - 0.000 0.333 12.903
ENSG00000069869 E002 10.4358788 0.002295816 5.080186e-06 3.610135e-05 15 55826997 55827334 338 - 0.755 1.313 2.061
ENSG00000069869 E003 83.6798129 0.001703013 8.540761e-10 1.281398e-08 15 55827335 55829804 2470 - 1.647 1.953 1.031
ENSG00000069869 E004 11.2857650 0.007617837 8.039544e-01 8.752411e-01 15 55829805 55829999 195 - 0.866 0.898 0.124
ENSG00000069869 E005 8.4875786 0.004113767 3.469187e-01 4.910654e-01 15 55830514 55830586 73 - 0.748 0.898 0.589
ENSG00000069869 E006 8.7434818 0.004909809 6.943043e-01 7.951701e-01 15 55833008 55833104 97 - 0.769 0.830 0.241
ENSG00000069869 E007 14.5006082 0.001226412 6.982168e-01 7.982372e-01 15 55834038 55834145 108 - 0.967 0.898 -0.260
ENSG00000069869 E008 12.7905376 0.001356740 9.472679e-01 9.708621e-01 15 55834227 55834286 60 - 0.917 0.898 -0.072
ENSG00000069869 E009 10.2451208 0.001789436 6.536824e-01 7.640889e-01 15 55837789 55837849 61 - 0.838 0.749 -0.353
ENSG00000069869 E010 10.0007597 0.001744873 3.463439e-01 4.904899e-01 15 55838107 55838180 74 - 0.838 0.649 -0.768
ENSG00000069869 E011 9.3655664 0.001806698 4.164015e-01 5.597611e-01 15 55838509 55838604 96 - 0.814 0.649 -0.675
ENSG00000069869 E012 9.4905530 0.001857774 1.524323e-01 2.649830e-01 15 55840447 55840517 71 - 0.826 0.519 -1.307
ENSG00000069869 E013 13.1415034 0.001739290 1.209802e-01 2.213359e-01 15 55840606 55840727 122 - 0.945 0.649 -1.178
ENSG00000069869 E014 17.4616472 0.001091468 8.299109e-01 8.932073e-01 15 55841934 55842163 230 - 1.035 1.056 0.075
ENSG00000069869 E015 8.1349058 0.002034528 9.628746e-01 9.805290e-01 15 55846969 55847034 66 - 0.748 0.749 0.003
ENSG00000069869 E016 9.6817206 0.001808007 7.258540e-01 8.190290e-01 15 55848372 55848430 59 - 0.820 0.749 -0.284
ENSG00000069869 E017 8.5851752 0.001961882 5.297297e-02 1.144367e-01 15 55848521 55848575 55 - 0.795 0.333 -2.186
ENSG00000069869 E018 9.5357061 0.001748993 3.475508e-02 8.117473e-02 15 55848806 55848886 81 - 0.832 0.333 -2.330
ENSG00000069869 E019 13.3956584 0.001428592 3.148428e-02 7.485037e-02 15 55850542 55850742 201 - 0.959 0.519 -1.812
ENSG00000069869 E020 10.2996259 0.001738854 2.439120e-02 6.062502e-02 15 55852424 55852543 120 - 0.861 0.333 -2.440
ENSG00000069869 E021 6.9192241 0.002377340 4.141966e-01 5.576004e-01 15 55856131 55856196 66 - 0.703 0.519 -0.812
ENSG00000069869 E022 8.1790294 0.002092908 6.553497e-02 1.359296e-01 15 55860407 55860574 168 - 0.776 0.333 -2.108
ENSG00000069869 E023 7.2784696 0.002395838 9.956846e-02 1.898234e-01 15 55860661 55860714 54 - 0.733 0.333 -1.938
ENSG00000069869 E024 6.9514788 0.002323288 1.444764e-02 3.923879e-02 15 55860715 55860778 64 - 0.726 0.000 -15.857
ENSG00000069869 E025 8.6457555 0.001980179 5.313794e-02 1.147347e-01 15 55862913 55862982 70 - 0.795 0.333 -2.186
ENSG00000069869 E026 5.9079365 0.002839076 2.663427e-02 6.523305e-02 15 55862983 55862987 5 - 0.670 0.000 -15.735
ENSG00000069869 E027 6.8258860 0.002544105 1.223055e-01 2.232346e-01 15 55862988 55863031 44 - 0.711 0.333 -1.845
ENSG00000069869 E028 6.5328094 0.047349389 9.735668e-01 9.874999e-01 15 55863032 55863079 48 - 0.671 0.650 -0.086
ENSG00000069869 E029 8.4575165 0.002028308 6.358945e-01 7.500627e-01 15 55869579 55869681 103 - 0.755 0.830 0.297
ENSG00000069869 E030 6.4200172 0.004011620 9.447218e-01 9.693040e-01 15 55872415 55872476 62 - 0.670 0.649 -0.091
ENSG00000069869 E031 8.6958144 0.002030854 6.928612e-01 7.939758e-01 15 55873958 55874008 51 - 0.769 0.830 0.241
ENSG00000069869 E032 0.0000000       15 55905212 55905281 70 -      
ENSG00000069869 E033 1.5123699 0.009103582 1.934343e-01 3.180926e-01 15 55915284 55917131 1848 - 0.239 0.519 1.646
ENSG00000069869 E034 0.0000000       15 55924363 55924645 283 -      
ENSG00000069869 E035 8.8410888 0.001923753 4.982490e-01 6.347325e-01 15 55924646 55924699 54 - 0.789 0.649 -0.575
ENSG00000069869 E036 0.0000000       15 55934693 55934754 62 -      
ENSG00000069869 E037 7.3318394 0.002260434 3.530050e-01 4.972506e-01 15 55951376 55951414 39 - 0.726 0.519 -0.908
ENSG00000069869 E038 0.0000000       15 55951415 55951439 25 -      
ENSG00000069869 E039 9.5024217 0.001887406 3.481462e-02 8.129176e-02 15 55951511 55951589 79 - 0.832 0.333 -2.330
ENSG00000069869 E040 0.0000000       15 55952654 55952745 92 -      
ENSG00000069869 E041 8.4306650 0.002177231 2.276373e-01 3.595775e-01 15 55966473 55966546 74 - 0.782 0.519 -1.135
ENSG00000069869 E042 0.1472490 0.043277278 4.708819e-01   15 55987209 55987730 522 - 0.038 0.000 -11.701
ENSG00000069869 E043 0.2987644 0.027426066 1.000000e+00   15 55987731 55988001 271 - 0.073 0.000 -12.656
ENSG00000069869 E044 1.4663750 0.029999464 5.365446e-01 6.682894e-01 15 55991926 55992005 80 - 0.283 0.000 -14.480
ENSG00000069869 E045 6.6484600 0.002584149 4.357472e-01 5.779385e-01 15 55993511 55993660 150 - 0.695 0.519 -0.780