ENSG00000069702

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000212355 ENSG00000069702 HEK293_OSMI2_2hA HEK293_TMG_2hB TGFBR3 protein_coding protein_coding 4.664763 1.515472 6.124775 0.2047501 0.05492625 2.007755 3.7884683 1.459657 4.948062 0.1886819 0.1516890 1.754297 0.86726250 0.9647 0.8076667 -0.1570333 0.0003862495 0.0001844869 FALSE TRUE
ENST00000465892 ENSG00000069702 HEK293_OSMI2_2hA HEK293_TMG_2hB TGFBR3 protein_coding protein_coding 4.664763 1.515472 6.124775 0.2047501 0.05492625 2.007755 0.4010097 0.000000 0.678214 0.0000000 0.1202411 6.104785 0.05245417 0.0000 0.1109667 0.1109667 0.0001844869 0.0001844869 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000069702 E001 226.1926304 0.0060411049 3.059465e-38 9.424496e-36 1 91680343 91682425 2083 - 2.091 2.624 1.780
ENSG00000069702 E002 7.5331451 0.0065542985 7.527796e-01 8.388770e-01 1 91682426 91682429 4 - 0.818 0.951 0.511
ENSG00000069702 E003 27.7934277 0.0023570679 5.654555e-01 6.925559e-01 1 91682430 91682646 217 - 1.330 1.476 0.504
ENSG00000069702 E004 94.1093638 0.0004727050 3.475223e-02 8.117208e-02 1 91682647 91683728 1082 - 1.877 1.890 0.042
ENSG00000069702 E005 11.1566258 0.0015133963 1.014008e-02 2.910839e-02 1 91683729 91683857 129 - 1.034 0.782 -0.959
ENSG00000069702 E006 0.3729606 0.0306514878 3.202835e-01 4.633829e-01 1 91695490 91695671 182 - 0.059 0.236 2.303
ENSG00000069702 E007 20.1050182 0.0009157428 8.358353e-03 2.468718e-02 1 91695672 91695779 108 - 1.263 1.099 -0.583
ENSG00000069702 E008 16.9188553 0.0038610150 3.001481e-02 7.198875e-02 1 91698089 91698130 42 - 1.187 1.046 -0.508
ENSG00000069702 E009 28.7223304 0.0007450420 7.600269e-05 4.090943e-04 1 91708663 91708783 121 - 1.419 1.168 -0.878
ENSG00000069702 E010 20.4847475 0.0013077301 6.988468e-03 2.119430e-02 1 91712243 91712296 54 - 1.269 1.099 -0.607
ENSG00000069702 E011 37.3046551 0.0012221396 2.443608e-04 1.151635e-03 1 91712297 91712542 246 - 1.520 1.341 -0.617
ENSG00000069702 E012 28.8078196 0.0007078978 1.063398e-01 2.001466e-01 1 91716236 91716394 159 - 1.383 1.355 -0.097
ENSG00000069702 E013 31.0888370 0.0164062246 2.182194e-01 3.482580e-01 1 91716568 91716708 141 - 1.413 1.385 -0.098
ENSG00000069702 E014 30.7876878 0.0217214611 9.222519e-02 1.786006e-01 1 91719312 91719464 153 - 1.421 1.330 -0.316
ENSG00000069702 E015 46.0256989 0.0005045831 2.117113e-04 1.014060e-03 1 91719893 91720227 335 - 1.601 1.454 -0.502
ENSG00000069702 E016 8.2976316 0.0488398284 2.338225e-01 3.669246e-01 1 91720228 91720230 3 - 0.906 0.780 -0.488
ENSG00000069702 E017 29.6209836 0.0110720767 6.795839e-02 1.399769e-01 1 91721955 91722144 190 - 1.404 1.327 -0.269
ENSG00000069702 E018 20.5314515 0.0010542323 1.380034e-03 5.241130e-03 1 91727659 91727776 118 - 1.276 1.046 -0.823
ENSG00000069702 E019 14.0429024 0.0116916024 9.758608e-03 2.816933e-02 1 91727777 91727806 30 - 1.125 0.875 -0.924
ENSG00000069702 E020 0.0000000       1 91727807 91727918 112 -      
ENSG00000069702 E021 25.5935166 0.0052145913 9.452989e-03 2.741810e-02 1 91729805 91729973 169 - 1.356 1.208 -0.519
ENSG00000069702 E022 20.7265045 0.0009368651 7.119588e-02 1.453244e-01 1 91734776 91734898 123 - 1.259 1.189 -0.249
ENSG00000069702 E023 14.3997023 0.0012387558 8.230548e-02 1.631495e-01 1 91734899 91734959 61 - 1.115 1.017 -0.357
ENSG00000069702 E024 0.0000000       1 91754995 91755062 68 -      
ENSG00000069702 E025 20.2086488 0.0009343060 1.996978e-03 7.216571e-03 1 91758613 91758750 138 - 1.266 1.046 -0.787
ENSG00000069702 E026 0.0000000       1 91766385 91766432 48 -      
ENSG00000069702 E027 0.0000000       1 91770842 91770970 129 -      
ENSG00000069702 E028 0.0000000       1 91783206 91783264 59 -      
ENSG00000069702 E029 0.1817044 0.0450694421 1.094609e-01   1 91786186 91786227 42 - 0.000 0.236 11.778
ENSG00000069702 E030 20.2455618 0.0009137946 2.623198e-04 1.226025e-03 1 91797287 91797426 140 - 1.276 0.985 -1.046
ENSG00000069702 E031 10.2055432 0.0061817747 1.050302e-02 2.998621e-02 1 91797427 91797471 45 - 1.004 0.727 -1.071
ENSG00000069702 E032 0.4449813 0.0212072392 5.879576e-01 7.112005e-01 1 91800959 91801055 97 - 0.112 0.236 1.298
ENSG00000069702 E033 18.8739990 0.0009378547 2.882017e-05 1.721767e-04 1 91861471 91861644 174 - 1.259 0.875 -1.400
ENSG00000069702 E034 0.4407149 0.0217681645 5.880555e-01 7.112871e-01 1 91861645 91862046 402 - 0.112 0.236 1.299
ENSG00000069702 E035 0.0000000       1 91863839 91864279 441 -      
ENSG00000069702 E036 0.0000000       1 91866756 91866842 87 -      
ENSG00000069702 E037 14.0429535 0.0014770012 5.495589e-04 2.345241e-03 1 91885878 91886029 152 - 1.134 0.782 -1.318
ENSG00000069702 E038 10.6671993 0.0016698627 1.618864e-03 6.021301e-03 1 91886030 91886151 122 - 1.029 0.664 -1.422
ENSG00000069702 E039 0.0000000       1 91899637 91899697 61 -      
ENSG00000069702 E040 0.0000000       1 91905826 91906335 510 -