ENSG00000069667

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000335670 ENSG00000069667 HEK293_OSMI2_2hA HEK293_TMG_2hB RORA protein_coding protein_coding 1.298774 1.017395 1.832521 0.489206 0.3090477 0.8426903 0.38611405 0.06330669 0.5889871 0.009604395 0.01491224 3.0305082 0.28763333 0.11956667 0.33906667 0.21950000 0.004652566 0.004652566 FALSE TRUE
ENST00000449337 ENSG00000069667 HEK293_OSMI2_2hA HEK293_TMG_2hB RORA protein_coding protein_coding 1.298774 1.017395 1.832521 0.489206 0.3090477 0.8426903 0.31955296 0.11436351 0.5941702 0.059959188 0.13931291 2.2803918 0.20357083 0.08293333 0.31680000 0.23386667 0.019431360 0.004652566 FALSE TRUE
ENST00000558904 ENSG00000069667 HEK293_OSMI2_2hA HEK293_TMG_2hB RORA protein_coding protein_coding 1.298774 1.017395 1.832521 0.489206 0.3090477 0.8426903 0.43085816 0.54668674 0.4047357 0.206975409 0.10661997 -0.4246734 0.41605833 0.64116667 0.21443333 -0.42673333 0.060383751 0.004652566   FALSE
ENST00000559343 ENSG00000069667 HEK293_OSMI2_2hA HEK293_TMG_2hB RORA protein_coding protein_coding 1.298774 1.017395 1.832521 0.489206 0.3090477 0.8426903 0.04196477 0.00000000 0.1633259 0.000000000 0.04929554 4.1154154 0.02864583 0.00000000 0.09486667 0.09486667 0.043566329 0.004652566   FALSE
ENST00000614169 ENSG00000069667 HEK293_OSMI2_2hA HEK293_TMG_2hB RORA protein_coding misc_RNA 1.298774 1.017395 1.832521 0.489206 0.3090477 0.8426903 0.03314797 0.26518375 0.0000000 0.265183752 0.00000000 -4.7823234 0.01768750 0.14150000 0.00000000 -0.14150000 0.458308779 0.004652566   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000069667 E001 68.9628177 0.003193490 2.319281e-05 1.416672e-04 15 60488284 60497263 8980 - 1.773 1.579 -0.658
ENSG00000069667 E002 1.1802960 0.010877669 2.026469e-01 3.295192e-01 15 60497264 60497284 21 - 0.332 0.000 -13.749
ENSG00000069667 E003 6.7551985 0.007576675 5.509731e-01 6.805156e-01 15 60497285 60497619 335 - 0.819 0.735 -0.335
ENSG00000069667 E004 3.8680395 0.050824238 3.995994e-01 5.433354e-01 15 60499892 60500004 113 - 0.571 0.734 0.697
ENSG00000069667 E005 3.3329543 0.008163600 4.543041e-01 5.949454e-01 15 60500959 60501069 111 - 0.536 0.671 0.601
ENSG00000069667 E006 5.3549273 0.030529569 7.031560e-01 8.018689e-01 15 60502760 60502867 108 - 0.735 0.670 -0.273
ENSG00000069667 E007 6.2417669 0.002809624 3.557918e-01 5.001461e-01 15 60503535 60503667 133 - 0.747 0.884 0.538
ENSG00000069667 E008 4.3909909 0.003740428 1.069085e-01 2.009754e-01 15 60505508 60505605 98 - 0.587 0.840 1.047
ENSG00000069667 E009 3.3611662 0.004853516 5.797165e-02 1.231546e-01 15 60505606 60505629 24 - 0.478 0.791 1.369
ENSG00000069667 E010 4.7735191 0.003490191 9.633167e-01 9.808422e-01 15 60511226 60511293 68 - 0.674 0.672 -0.010
ENSG00000069667 E011 5.5798103 0.002942662 1.333091e-01 2.387193e-01 15 60511294 60511456 163 - 0.769 0.508 -1.134
ENSG00000069667 E012 3.7215456 0.004565943 5.927670e-01 7.152507e-01 15 60511457 60511591 135 - 0.603 0.508 -0.437
ENSG00000069667 E013 2.2488279 0.007052697 6.226520e-01 7.394107e-01 15 60511592 60511621 30 - 0.411 0.508 0.496
ENSG00000069667 E014 0.1482932 0.041159753 7.368356e-02   15 60512033 60512097 65 - 0.000 0.240 13.784
ENSG00000069667 E015 4.4462632 0.033721995 7.487311e-01 8.358812e-01 15 60514616 60514757 142 - 0.660 0.599 -0.268
ENSG00000069667 E016 0.1451727 0.049791410 1.000000e+00   15 60528073 60531527 3455 - 0.058 0.000 -11.067
ENSG00000069667 E017 0.0000000       15 60531528 60531765 238 -      
ENSG00000069667 E018 2.3690230 0.006451638 6.554425e-01 7.653199e-01 15 60531766 60531851 86 - 0.478 0.394 -0.440
ENSG00000069667 E019 0.0000000       15 60556853 60556928 76 -      
ENSG00000069667 E020 0.1515154 0.050711231 1.000000e+00   15 60558225 60558306 82 - 0.058 0.000 -11.067
ENSG00000069667 E021 1.1834165 0.010734231 7.965471e-01 8.701455e-01 15 60592387 60592541 155 - 0.302 0.240 -0.439
ENSG00000069667 E022 0.5954526 0.019387492 6.166539e-01 7.346634e-01 15 60592808 60593126 319 - 0.197 0.000 -12.900
ENSG00000069667 E023 0.0000000       15 60614894 60615027 134 -      
ENSG00000069667 E024 0.0000000       15 60627238 60627463 226 -      
ENSG00000069667 E025 0.0000000       15 60650621 60650708 88 -      
ENSG00000069667 E026 0.0000000       15 60677109 60677150 42 -      
ENSG00000069667 E027 0.2955422 0.028158178 2.303283e-01   15 60677151 60677232 82 - 0.058 0.240 2.366
ENSG00000069667 E028 0.1482932 0.041159753 7.368356e-02   15 60677233 60677272 40 - 0.000 0.240 13.784
ENSG00000069667 E029 0.0000000       15 60678224 60678656 433 -      
ENSG00000069667 E030 0.7427016 0.015815506 4.485991e-01 5.898798e-01 15 60678657 60678686 30 - 0.235 0.000 -13.178
ENSG00000069667 E031 0.0000000       15 60706232 60706352 121 -      
ENSG00000069667 E032 0.1482932 0.041159753 7.368356e-02   15 61038826 61039127 302 - 0.000 0.240 13.784
ENSG00000069667 E033 0.3299976 0.028148900 1.188498e-02   15 61041104 61041134 31 - 0.000 0.394 14.792
ENSG00000069667 E034 4.3261510 0.004059470 2.039751e-07 1.951344e-06 15 61176068 61176456 389 - 0.386 1.108 3.046
ENSG00000069667 E035 5.1844909 0.052116041 8.983421e-03 2.623891e-02 15 61229053 61229302 250 - 0.586 0.997 1.645