ENSG00000069020

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000403625 ENSG00000069020 HEK293_OSMI2_2hA HEK293_TMG_2hB MAST4 protein_coding protein_coding 3.753867 7.484502 2.164739 0.6920702 0.3101392 -1.78499 0.35666867 0.2149897 0.5893188 0.04216438 0.20307037 1.413465 0.157775000 0.02840000 0.30706667 0.27866667 0.0143884620 0.0007600864 FALSE TRUE
ENST00000403666 ENSG00000069020 HEK293_OSMI2_2hA HEK293_TMG_2hB MAST4 protein_coding protein_coding 3.753867 7.484502 2.164739 0.6920702 0.3101392 -1.78499 0.05143068 0.0000000 0.1665539 0.00000000 0.16655385 4.142036 0.025183333 0.00000000 0.05986667 0.05986667 0.5736184892 0.0007600864 FALSE TRUE
ENST00000406039 ENSG00000069020 HEK293_OSMI2_2hA HEK293_TMG_2hB MAST4 protein_coding protein_coding 3.753867 7.484502 2.164739 0.6920702 0.3101392 -1.78499 0.70376379 1.7784320 0.2323881 0.34824232 0.17579192 -2.883304 0.164304167 0.23330000 0.11513333 -0.11816667 0.4096551544 0.0007600864 FALSE TRUE
ENST00000406374 ENSG00000069020 HEK293_OSMI2_2hA HEK293_TMG_2hB MAST4 protein_coding protein_coding 3.753867 7.484502 2.164739 0.6920702 0.3101392 -1.78499 0.85822828 2.0430043 0.3899740 0.33547394 0.38997405 -2.359758 0.167933333 0.26953333 0.14016667 -0.12936667 0.2919379400 0.0007600864 FALSE TRUE
ENST00000434115 ENSG00000069020 HEK293_OSMI2_2hA HEK293_TMG_2hB MAST4 protein_coding protein_coding 3.753867 7.484502 2.164739 0.6920702 0.3101392 -1.78499 0.07866737 0.4063531 0.0000000 0.07920104 0.00000000 -5.379736 0.018425000 0.05333333 0.00000000 -0.05333333 0.0007600864 0.0007600864   FALSE
ENST00000443808 ENSG00000069020 HEK293_OSMI2_2hA HEK293_TMG_2hB MAST4 protein_coding protein_coding 3.753867 7.484502 2.164739 0.6920702 0.3101392 -1.78499 0.44237774 0.7458173 0.2705638 0.05078502 0.02988634 -1.429709 0.131066667 0.10230000 0.12953333 0.02723333 0.7546103373 0.0007600864 FALSE TRUE
ENST00000447738 ENSG00000069020 HEK293_OSMI2_2hA HEK293_TMG_2hB MAST4 protein_coding nonsense_mediated_decay 3.753867 7.484502 2.164739 0.6920702 0.3101392 -1.78499 0.01276032 0.0000000 0.1020826 0.00000000 0.10208258 3.486490 0.007079167 0.00000000 0.05663333 0.05663333 0.6173116293 0.0007600864 FALSE TRUE
ENST00000452953 ENSG00000069020 HEK293_OSMI2_2hA HEK293_TMG_2hB MAST4 protein_coding protein_coding 3.753867 7.484502 2.164739 0.6920702 0.3101392 -1.78499 0.81778869 1.8565533 0.2962066 0.06269474 0.14826730 -2.607800 0.188095833 0.25206667 0.13460000 -0.11746667 0.5390966970 0.0007600864 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000069020 E001 3.7579069 0.0043430527 1.323092e-01 2.373210e-01 5 66596380 66596392 13 + 0.521 0.731 0.916
ENSG00000069020 E002 21.9908028 0.0039820295 4.956762e-03 1.581068e-02 5 66596393 66596617 225 + 1.207 1.409 0.708
ENSG00000069020 E003 17.5623047 0.0023313107 2.643561e-02 6.481865e-02 5 66596618 66596655 38 + 1.139 1.305 0.587
ENSG00000069020 E004 32.5970778 0.0009147513 3.456640e-03 1.160053e-02 5 66596656 66597018 363 + 1.398 1.557 0.548
ENSG00000069020 E005 0.0000000       5 66738031 66738257 227 +      
ENSG00000069020 E006 11.1211240 0.0017030132 1.360329e-01 2.425212e-01 5 66759709 66759727 19 + 0.978 1.106 0.469
ENSG00000069020 E007 10.0366974 0.0018141409 5.126624e-02 1.114108e-01 5 66759728 66759729 2 + 0.901 1.087 0.689
ENSG00000069020 E008 26.9519337 0.0007655171 1.763170e-07 1.707794e-06 5 66759730 66759862 133 + 1.174 1.530 1.238
ENSG00000069020 E009 0.1482932 0.0420113100 6.258356e-01   5 66783335 66783384 50 + 0.000 0.105 11.003
ENSG00000069020 E010 14.4074666 0.0012824684 1.693142e-05 1.067459e-04 5 66788670 66788686 17 + 0.879 1.280 1.458
ENSG00000069020 E011 19.8487699 0.0010073331 2.010411e-09 2.812690e-08 5 66788687 66788731 45 + 0.922 1.432 1.823
ENSG00000069020 E012 19.9430384 0.0009843801 1.147461e-10 2.005009e-09 5 66788732 66788780 49 + 0.879 1.440 2.014
ENSG00000069020 E013 16.1370719 0.0018817707 2.119293e-10 3.533343e-09 5 66788781 66788794 14 + 0.721 1.360 2.365
ENSG00000069020 E014 0.1482932 0.0420113100 6.258356e-01   5 66792186 66792539 354 + 0.000 0.105 11.003
ENSG00000069020 E015 0.4031496 0.0244365567 2.858928e-01 4.262640e-01 5 66828774 66828775 2 + 0.000 0.190 11.986
ENSG00000069020 E016 0.6245948 0.0477923416 1.395493e-01 2.474050e-01 5 66828776 66828861 86 + 0.000 0.262 12.457
ENSG00000069020 E017 0.4031496 0.0244365567 2.858928e-01 4.262640e-01 5 66828862 66828882 21 + 0.000 0.190 11.986
ENSG00000069020 E018 1.3994719 0.0096362518 5.397727e-03 1.700819e-02 5 66870778 66870852 75 + 0.000 0.504 13.753
ENSG00000069020 E019 18.3536306 0.0072208515 1.161821e-07 1.166477e-06 5 66899951 66899982 32 + 0.880 1.392 1.847
ENSG00000069020 E020 0.1817044 0.0389071098 6.256426e-01   5 66902649 66902736 88 + 0.000 0.105 11.014
ENSG00000069020 E021 3.8058778 0.0708635272 3.497278e-02 8.160272e-02 5 66916983 66917018 36 + 0.406 0.786 1.721
ENSG00000069020 E022 0.0000000       5 66917019 66917373 355 +      
ENSG00000069020 E023 8.3303154 0.0022445262 1.130988e-04 5.820447e-04 5 66930747 66930961 215 + 0.612 1.077 1.823
ENSG00000069020 E024 0.0000000       5 66958870 66958896 27 +      
ENSG00000069020 E025 0.0000000       5 66958897 66958987 91 +      
ENSG00000069020 E026 0.9243042 0.0163174288 7.306026e-01 8.224961e-01 5 66958988 66959294 307 + 0.335 0.260 -0.502
ENSG00000069020 E027 1.2103937 0.0108647759 1.054508e-01 1.987854e-01 5 66963707 66963718 12 + 0.142 0.422 2.086
ENSG00000069020 E028 2.0584229 0.0070085943 8.139473e-03 2.413786e-02 5 66963719 66963787 69 + 0.142 0.603 2.959
ENSG00000069020 E029 0.4438354 0.1637869917 7.792231e-01 8.580230e-01 5 66964040 66964061 22 + 0.142 0.187 0.476
ENSG00000069020 E030 9.9603417 0.0017631970 1.886723e-08 2.210477e-07 5 66986444 66986523 80 + 0.468 1.175 2.852
ENSG00000069020 E031 0.5085815 0.1637880177 7.813982e-01 8.595657e-01 5 67004620 67004654 35 + 0.142 0.190 0.508
ENSG00000069020 E032 0.3268771 0.0284316232 8.355780e-01   5 67004655 67004691 37 + 0.142 0.105 -0.498
ENSG00000069020 E033 0.0000000       5 67004692 67004751 60 +      
ENSG00000069020 E034 0.2966881 0.0290785164 1.348217e-01   5 67004752 67004951 200 + 0.249 0.000 -13.508
ENSG00000069020 E035 0.5870335 0.1462512267 3.114452e-02 7.418134e-02 5 67004952 67005085 134 + 0.406 0.000 -14.065
ENSG00000069020 E036 2.4453973 0.0062406226 1.679660e-05 1.059805e-04 5 67054404 67054492 89 + 0.833 0.105 -4.405
ENSG00000069020 E037 3.2590728 0.0049747171 5.918646e-05 3.274258e-04 5 67090162 67090231 70 + 0.901 0.260 -3.083
ENSG00000069020 E038 0.0000000       5 67094157 67094165 9 +      
ENSG00000069020 E039 3.1722017 0.0049931122 4.075415e-03 1.335516e-02 5 67095597 67095675 79 + 0.833 0.375 -2.083
ENSG00000069020 E040 4.7835219 0.0518872839 1.436063e-04 7.191969e-04 5 67100435 67100592 158 + 1.043 0.376 -2.868
ENSG00000069020 E041 0.0000000       5 67102507 67102535 29 +      
ENSG00000069020 E042 3.1228708 0.0194847946 1.380510e-03 5.242413e-03 5 67102536 67102611 76 + 0.856 0.322 -2.495
ENSG00000069020 E043 6.1345890 0.0026327257 5.714707e-09 7.383442e-08 5 67104366 67104575 210 + 1.163 0.375 -3.306
ENSG00000069020 E044 4.7122344 0.0456740435 1.366962e-04 6.888700e-04 5 67110098 67110199 102 + 1.029 0.377 -2.812
ENSG00000069020 E045 4.2147119 0.0037876217 2.659745e-04 1.241024e-03 5 67114087 67114219 133 + 0.960 0.422 -2.306
ENSG00000069020 E046 0.0000000       5 67114220 67115075 856 +      
ENSG00000069020 E047 3.4937802 0.0066387060 1.946195e-02 5.033507e-02 5 67118682 67118749 68 + 0.833 0.465 -1.598
ENSG00000069020 E048 4.0183580 0.0478206411 4.499019e-03 1.454034e-02 5 67121017 67121102 86 + 0.922 0.425 -2.145
ENSG00000069020 E049 5.5493773 0.0733605518 2.314474e-03 8.196315e-03 5 67130210 67130418 209 + 1.058 0.509 -2.226
ENSG00000069020 E050 5.5815289 0.0681516626 4.276241e-03 1.391745e-02 5 67131813 67131951 139 + 1.043 0.545 -2.003
ENSG00000069020 E051 5.0696245 0.1447518424 1.843191e-02 4.808083e-02 5 67133514 67133646 133 + 1.011 0.511 -2.048
ENSG00000069020 E052 5.9124438 0.0375522974 1.366602e-02 3.746507e-02 5 67134523 67134688 166 + 1.028 0.634 -1.547
ENSG00000069020 E053 4.5748879 0.0034946389 3.992970e-05 2.301778e-04 5 67136563 67136664 102 + 1.012 0.422 -2.499
ENSG00000069020 E054 4.2480239 0.0038068024 2.472869e-05 1.501964e-04 5 67142115 67142163 49 + 0.996 0.374 -2.701
ENSG00000069020 E055 5.0408720 0.0178078993 1.374448e-03 5.223478e-03 5 67142164 67142237 74 + 1.012 0.538 -1.921
ENSG00000069020 E056 3.3685676 0.0063957521 1.917950e-02 4.972968e-02 5 67142421 67142433 13 + 0.833 0.464 -1.601
ENSG00000069020 E057 5.8472744 0.0029814354 1.477714e-04 7.374828e-04 5 67142434 67142533 100 + 1.073 0.572 -1.985
ENSG00000069020 E058 0.0000000       5 67142534 67143020 487 +      
ENSG00000069020 E059 7.0986460 0.0024766300 1.329066e-06 1.075005e-05 5 67144669 67144796 128 + 1.174 0.573 -2.347
ENSG00000069020 E060 9.1248814 0.0018896767 4.364235e-07 3.905301e-06 5 67145144 67145379 236 + 1.256 0.684 -2.151
ENSG00000069020 E061 0.6611159 0.0222370482 2.010942e-01 3.275500e-01 5 67149389 67149589 201 + 0.335 0.105 -2.081
ENSG00000069020 E062 9.1630220 0.0023592660 2.508321e-05 1.520377e-04 5 67152637 67152866 230 + 1.227 0.752 -1.768
ENSG00000069020 E063 6.7941141 0.0237099684 5.013428e-03 1.596777e-02 5 67153458 67153580 123 + 1.087 0.685 -1.546
ENSG00000069020 E064 5.5511469 0.0030932127 1.348189e-01 2.408463e-01 5 67160456 67160592 137 + 0.922 0.708 -0.839
ENSG00000069020 E065 7.4820090 0.1016182612 8.300265e-02 1.642496e-01 5 67162607 67162788 182 + 1.099 0.768 -1.252
ENSG00000069020 E066 178.4011508 0.0158996366 6.650850e-01 7.727969e-01 5 67163147 67169593 6447 + 2.267 2.220 -0.156