ENSG00000068912

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000185150 ENSG00000068912 HEK293_OSMI2_2hA HEK293_TMG_2hB ERLEC1 protein_coding protein_coding 18.72142 7.538077 27.46073 0.2691141 1.293591 1.863714 3.090302 1.6214758 5.6449862 1.6214758 0.9626073 1.793346 0.19533750 0.2064333 0.2048667 -0.001566667 0.314887559 0.003354433 FALSE TRUE
ENST00000378239 ENSG00000068912 HEK293_OSMI2_2hA HEK293_TMG_2hB ERLEC1 protein_coding protein_coding 18.72142 7.538077 27.46073 0.2691141 1.293591 1.863714 1.829795 0.6971035 3.2373591 0.1813439 0.2644988 2.199274 0.09576667 0.0944000 0.1185333 0.024133333 0.710593390 0.003354433 FALSE TRUE
ENST00000689496 ENSG00000068912 HEK293_OSMI2_2hA HEK293_TMG_2hB ERLEC1 protein_coding protein_coding 18.72142 7.538077 27.46073 0.2691141 1.293591 1.863714 10.275571 2.3827378 15.9909481 0.3505564 0.7744612 2.741423 0.49401250 0.3203000 0.5823000 0.262000000 0.003354433 0.003354433 FALSE TRUE
MSTRG.18401.35 ENSG00000068912 HEK293_OSMI2_2hA HEK293_TMG_2hB ERLEC1 protein_coding   18.72142 7.538077 27.46073 0.2691141 1.293591 1.863714 2.100985 2.2209699 0.6135998 1.2046321 0.6135998 -1.838979 0.13088333 0.2980000 0.0216000 -0.276400000 0.337749592 0.003354433 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000068912 E001 0.0000000       2 53787009 53787014 6 +      
ENSG00000068912 E002 0.0000000       2 53787015 53787020 6 +      
ENSG00000068912 E003 1.1426289 0.0114136696 3.292819e-01 4.727804e-01 2 53787021 53787035 15 + 0.247 0.425 1.112
ENSG00000068912 E004 1.2878016 0.0103073505 4.664399e-01 6.059663e-01 2 53787036 53787039 4 + 0.292 0.424 0.790
ENSG00000068912 E005 1.7317388 0.0080824577 9.039626e-01 9.428882e-01 2 53787040 53787043 4 + 0.404 0.424 0.112
ENSG00000068912 E006 11.3968957 0.0014804304 4.575812e-02 1.015922e-01 2 53787044 53787063 20 + 1.117 0.882 -0.866
ENSG00000068912 E007 12.0029574 0.0015330643 2.569299e-02 6.330419e-02 2 53787064 53787065 2 + 1.141 0.882 -0.955
ENSG00000068912 E008 18.4666124 0.0010042313 1.697226e-02 4.487464e-02 2 53787066 53787074 9 + 1.309 1.081 -0.810
ENSG00000068912 E009 21.3515787 0.0008812325 9.334327e-03 2.711918e-02 2 53787075 53787079 5 + 1.370 1.137 -0.820
ENSG00000068912 E010 37.2998947 0.0005578170 3.644393e-01 5.088060e-01 2 53787080 53787106 27 + 1.564 1.504 -0.205
ENSG00000068912 E011 37.4502642 0.0005662868 4.262718e-01 5.691405e-01 2 53787107 53787121 15 + 1.564 1.512 -0.180
ENSG00000068912 E012 60.8711260 0.0004225012 2.158781e-01 3.454544e-01 2 53787122 53787223 102 + 1.774 1.710 -0.219
ENSG00000068912 E013 99.3801491 0.0003743284 2.170319e-03 7.751016e-03 2 53787224 53787372 149 + 1.997 1.869 -0.432
ENSG00000068912 E014 0.5149111 0.0201739180 1.392163e-01 2.469857e-01 2 53788496 53788582 87 + 0.076 0.323 2.527
ENSG00000068912 E015 0.1482932 0.0409023488 1.607502e-01   2 53788583 53788584 2 + 0.000 0.191 11.914
ENSG00000068912 E016 0.4417591 0.0571235228 1.511430e-01 2.632271e-01 2 53788585 53788705 121 + 0.076 0.322 2.518
ENSG00000068912 E017 0.7394768 0.0181035020 1.994645e-03 7.209651e-03 2 53788706 53789297 592 + 0.000 0.507 14.186
ENSG00000068912 E018 0.2966881 0.0268209283 7.083518e-01   2 53789531 53789731 201 + 0.141 0.000 -11.863
ENSG00000068912 E019 117.2248430 0.0027248556 3.736206e-04 1.672091e-03 2 53794345 53794449 105 + 2.075 1.910 -0.556
ENSG00000068912 E020 0.3268771 0.0327477028 4.337639e-01   2 53794450 53795179 730 + 0.076 0.191 1.528
ENSG00000068912 E021 0.0000000       2 53795180 53795261 82 +      
ENSG00000068912 E022 0.3729606 0.0318287234 4.338137e-01 5.762212e-01 2 53795262 53795932 671 + 0.076 0.191 1.530
ENSG00000068912 E023 130.0483608 0.0002810191 4.478906e-02 9.981796e-02 2 53795933 53796013 81 + 2.098 2.025 -0.245
ENSG00000068912 E024 0.0000000       2 53796014 53796251 238 +      
ENSG00000068912 E025 0.2955422 0.0293381970 4.380856e-01   2 53796945 53797514 570 + 0.076 0.191 1.524
ENSG00000068912 E026 134.5156274 0.0022911587 1.202211e-01 2.203153e-01 2 53797515 53797592 78 + 2.112 2.043 -0.232
ENSG00000068912 E027 122.8340526 0.0050524311 1.574168e-01 2.716735e-01 2 53797732 53797795 64 + 2.075 1.996 -0.265
ENSG00000068912 E028 124.1582595 0.0019944753 6.109501e-03 1.889614e-02 2 53799047 53799081 35 + 2.091 1.972 -0.400
ENSG00000068912 E029 2.9687420 0.0052648620 8.038474e-02 1.601633e-01 2 53799082 53800366 1285 + 0.648 0.323 -1.644
ENSG00000068912 E030 1.6284995 0.0082355019 2.131822e-02 5.425991e-02 2 53800911 53801396 486 + 0.493 0.000 -14.364
ENSG00000068912 E031 244.7820286 0.0001739686 8.029083e-03 2.385455e-02 2 53801397 53801620 224 + 2.371 2.302 -0.231
ENSG00000068912 E032 89.0687140 0.0003258779 6.866022e-01 7.890873e-01 2 53801713 53801718 6 + 1.919 1.900 -0.065
ENSG00000068912 E033 182.6831445 0.0001993141 8.660738e-02 1.699735e-01 2 53801719 53801842 124 + 2.240 2.188 -0.175
ENSG00000068912 E034 0.4545463 0.6241252701 7.304511e-01 8.224048e-01 2 53801843 53803532 1690 + 0.199 0.000 -11.274
ENSG00000068912 E035 59.9976557 0.0148431171 1.211566e-01 2.215881e-01 2 53808299 53808302 4 + 1.781 1.661 -0.407
ENSG00000068912 E036 181.4987894 0.0002515618 9.943538e-01 1.000000e+00 2 53808303 53808460 158 + 2.224 2.222 -0.008
ENSG00000068912 E037 1.4843710 0.0091786201 2.175795e-01 3.474781e-01 2 53808461 53808467 7 + 0.435 0.191 -1.644
ENSG00000068912 E038 2.3616362 0.0063066793 4.402293e-02 9.842929e-02 2 53808468 53809213 746 + 0.588 0.191 -2.381
ENSG00000068912 E039 153.4490695 0.0002648507 3.148333e-01 4.575809e-01 2 53809214 53809273 60 + 2.143 2.172 0.097
ENSG00000068912 E040 1.7735559 0.0101469760 9.050443e-01 9.435567e-01 2 53809274 53810214 941 + 0.404 0.425 0.113
ENSG00000068912 E041 231.9861782 0.0001754198 7.130128e-02 1.454846e-01 2 53812949 53813073 125 + 2.316 2.359 0.143
ENSG00000068912 E042 5.4702508 0.0028822345 8.798283e-02 1.720523e-01 2 53813074 53814542 1469 + 0.842 0.575 -1.106
ENSG00000068912 E043 169.7059430 0.0003311941 1.358322e-01 2.422523e-01 2 53814543 53814603 61 + 2.182 2.225 0.142
ENSG00000068912 E044 126.1270505 0.0021659216 5.163491e-02 1.120654e-01 2 53814604 53814620 17 + 2.041 2.116 0.252
ENSG00000068912 E045 1.9462922 0.1418986032 2.948206e-02 7.093420e-02 2 53814621 53814859 239 + 0.545 0.000 -13.895
ENSG00000068912 E046 182.3908407 0.0004601093 3.250182e-03 1.100199e-02 2 53814860 53814935 76 + 2.199 2.282 0.278
ENSG00000068912 E047 363.9801690 0.0002564849 6.969475e-24 6.837629e-22 2 53817898 53820193 2296 + 2.458 2.651 0.643
ENSG00000068912 E048 1.5843880 0.0088114592 1.054524e-01 1.987864e-01 2 53826372 53826866 495 + 0.292 0.575 1.526
ENSG00000068912 E049 1.4037158 0.0545603048 6.428749e-01 7.555584e-01 2 53831150 53833038 1889 + 0.332 0.424 0.524