ENSG00000068903

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000249396 ENSG00000068903 HEK293_OSMI2_2hA HEK293_TMG_2hB SIRT2 protein_coding protein_coding 53.33494 89.15474 31.58245 3.955043 0.544609 -1.496894 8.806271 16.44223 6.93191 2.597045 0.6775417 -1.244878 0.1671583 0.1825 0.2203 0.0378 0.671035181 3.462046e-07 FALSE TRUE
ENST00000392081 ENSG00000068903 HEK293_OSMI2_2hA HEK293_TMG_2hB SIRT2 protein_coding protein_coding 53.33494 89.15474 31.58245 3.955043 0.544609 -1.496894 39.048759 68.36322 19.75492 1.040880 0.6199767 -1.790489 0.7088792 0.7689 0.6252 -0.1437 0.002732183 3.462046e-07 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000068903 E001 0.3332198 0.0284403940 3.892907e-01   19 38878555 38878556 2 - 0.199 0.073 -1.670
ENSG00000068903 E002 0.6287620 0.0180696617 2.539339e-01 3.905640e-01 19 38878557 38878559 3 - 0.335 0.135 -1.672
ENSG00000068903 E003 1429.1272418 0.0022156930 2.792928e-07 2.600953e-06 19 38878560 38879293 734 - 2.954 3.088 0.446
ENSG00000068903 E004 268.5509828 0.0006113135 5.934172e-03 1.843513e-02 19 38879294 38879310 17 - 2.263 2.355 0.306
ENSG00000068903 E005 7.1019544 0.0051566214 4.564489e-01 5.968587e-01 19 38879311 38879433 123 - 0.901 0.811 -0.349
ENSG00000068903 E006 414.4733878 0.0001816413 1.815877e-04 8.847829e-04 19 38879434 38879500 67 - 2.448 2.542 0.314
ENSG00000068903 E007 6.5662042 0.0249275733 5.660311e-01 6.930592e-01 19 38879501 38879631 131 - 0.869 0.795 -0.286
ENSG00000068903 E008 415.6439675 0.0001560269 3.372852e-02 7.921166e-02 19 38879632 38879702 71 - 2.478 2.535 0.190
ENSG00000068903 E009 43.4226872 0.0005515671 3.420485e-11 6.521745e-10 19 38879703 38880684 982 - 1.812 1.450 -1.232
ENSG00000068903 E010 453.5659196 0.0006126063 7.724080e-02 1.550674e-01 19 38880685 38880736 52 - 2.521 2.574 0.176
ENSG00000068903 E011 420.1449613 0.0011331800 2.261829e-01 3.578291e-01 19 38880821 38880849 29 - 2.495 2.539 0.147
ENSG00000068903 E012 416.5718884 0.0002009911 2.018334e-02 5.186655e-02 19 38880850 38880897 48 - 2.475 2.537 0.207
ENSG00000068903 E013 10.2638445 0.0074137761 4.884895e-02 1.071086e-01 19 38880898 38881099 202 - 1.120 0.901 -0.808
ENSG00000068903 E014 395.5933386 0.0001858211 3.794995e-02 8.725657e-02 19 38881100 38881155 56 - 2.457 2.515 0.191
ENSG00000068903 E015 5.9546847 0.0208583067 1.003598e-01 1.910225e-01 19 38881156 38881431 276 - 0.932 0.701 -0.909
ENSG00000068903 E016 367.4915310 0.0001880416 1.478320e-01 2.587310e-01 19 38881432 38881491 60 - 2.437 2.481 0.147
ENSG00000068903 E017 198.2075694 0.0012951408 5.031207e-01 6.391041e-01 19 38883627 38883638 12 - 2.178 2.213 0.117
ENSG00000068903 E018 560.0745575 0.0001676781 7.260510e-01 8.191878e-01 19 38883639 38883756 118 - 2.640 2.657 0.058
ENSG00000068903 E019 521.3324878 0.0001180868 2.897351e-03 9.962509e-03 19 38889087 38889155 69 - 2.657 2.613 -0.147
ENSG00000068903 E020 3.7684142 0.0748653235 5.922978e-01 7.148530e-01 19 38889156 38889168 13 - 0.522 0.630 0.489
ENSG00000068903 E021 4.0931013 0.0042433867 7.611524e-01 8.450623e-01 19 38889169 38889230 62 - 0.591 0.650 0.255
ENSG00000068903 E022 2.5388917 0.0063844750 7.502786e-01 8.370021e-01 19 38889231 38889253 23 - 0.438 0.503 0.329
ENSG00000068903 E023 4.4169450 0.0058986225 6.093669e-01 7.288833e-01 19 38889254 38889323 70 - 0.705 0.632 -0.305
ENSG00000068903 E024 1.9196841 0.0072839922 4.897545e-02 1.073362e-01 19 38889324 38889688 365 - 0.652 0.321 -1.671
ENSG00000068903 E025 352.9474551 0.0001613360 3.934548e-04 1.749615e-03 19 38889689 38889696 8 - 2.506 2.438 -0.228
ENSG00000068903 E026 466.5434043 0.0004916134 8.625484e-04 3.482380e-03 19 38889697 38889745 49 - 2.620 2.561 -0.199
ENSG00000068903 E027 1.2576232 0.0136322087 7.596123e-01 8.439157e-01 19 38889746 38889854 109 - 0.335 0.282 -0.346
ENSG00000068903 E028 301.0624544 0.0002176677 5.530827e-03 1.736808e-02 19 38889855 38889859 5 - 2.428 2.371 -0.191
ENSG00000068903 E029 357.7898079 0.0001917676 6.652668e-03 2.032295e-02 19 38889860 38889882 23 - 2.498 2.447 -0.168
ENSG00000068903 E030 295.2149053 0.0006130350 1.267534e-01 2.296339e-01 19 38889883 38889898 16 - 2.399 2.370 -0.098
ENSG00000068903 E031 435.5413686 0.0018942467 1.867522e-01 3.096551e-01 19 38889899 38889961 63 - 2.565 2.541 -0.081
ENSG00000068903 E032 1.3566106 0.0098460132 4.389274e-01 5.807290e-01 19 38889962 38890102 141 - 0.199 0.357 1.136
ENSG00000068903 E033 335.2149725 0.0032315415 9.318168e-01 9.610468e-01 19 38890103 38890144 42 - 2.419 2.436 0.057
ENSG00000068903 E034 0.1482932 0.0414811372 1.000000e+00   19 38890145 38890158 14 - 0.001 0.073 6.911
ENSG00000068903 E035 1.4456572 0.0138269471 9.212855e-01 9.543171e-01 19 38890565 38890662 98 - 0.335 0.321 -0.083
ENSG00000068903 E036 0.7019140 0.0173932806 2.547660e-01 3.915457e-01 19 38891794 38891966 173 - 0.335 0.135 -1.668
ENSG00000068903 E037 508.4067981 0.0012790859 5.477181e-01 6.777147e-01 19 38893414 38893527 114 - 2.614 2.612 -0.006
ENSG00000068903 E038 8.6475985 0.0544791992 1.258058e-02 3.492399e-02 19 38893528 38893818 291 - 1.173 0.805 -1.369
ENSG00000068903 E039 364.4849406 0.0002143135 6.702909e-02 1.384300e-01 19 38893819 38893867 49 - 2.493 2.462 -0.101
ENSG00000068903 E040 21.9775700 0.0008451825 9.377492e-06 6.274414e-05 19 38893868 38893971 104 - 1.510 1.178 -1.158
ENSG00000068903 E041 10.1310336 0.0017155457 1.149877e-03 4.470914e-03 19 38893972 38893998 27 - 1.207 0.868 -1.241
ENSG00000068903 E042 19.8056776 0.0052738239 2.356571e-07 2.227771e-06 19 38893999 38894410 412 - 1.525 1.097 -1.499
ENSG00000068903 E043 45.3327359 0.0069005700 2.514165e-03 8.806853e-03 19 38898379 38898379 1 - 1.717 1.520 -0.670
ENSG00000068903 E044 77.2198898 0.0066716093 2.399383e-03 8.459373e-03 19 38898380 38898425 46 - 1.924 1.757 -0.563
ENSG00000068903 E045 9.8452533 0.0016898444 1.376104e-11 2.803515e-10 19 38898426 38898793 368 - 1.384 0.700 -2.533
ENSG00000068903 E046 8.2092532 0.0028235568 1.262899e-07 1.258230e-06 19 38898794 38898914 121 - 1.265 0.684 -2.184
ENSG00000068903 E047 4.3793481 0.0042255582 1.792287e-05 1.123795e-04 19 38898915 38898918 4 - 1.036 0.451 -2.435
ENSG00000068903 E048 351.6318472 0.0001395257 4.507286e-03 1.456308e-02 19 38899506 38899862 357 - 2.494 2.441 -0.176