ENSG00000068878

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000404125 ENSG00000068878 HEK293_OSMI2_2hA HEK293_TMG_2hB PSME4 protein_coding protein_coding 25.60365 17.68999 29.18972 2.158266 0.3431216 0.7222061 3.609184 2.9617735 4.357818 0.2624758 0.1705585 0.5555886 0.1436042 0.16926667 0.1492333 -0.02003333 6.470642e-01 2.925689e-12 FALSE TRUE
ENST00000476586 ENSG00000068878 HEK293_OSMI2_2hA HEK293_TMG_2hB PSME4 protein_coding processed_transcript 25.60365 17.68999 29.18972 2.158266 0.3431216 0.7222061 10.720862 12.1565591 8.954473 2.0065064 0.3482937 -0.4406305 0.4569542 0.68056667 0.3069000 -0.37366667 2.925689e-12 2.925689e-12 FALSE TRUE
MSTRG.18404.5 ENSG00000068878 HEK293_OSMI2_2hA HEK293_TMG_2hB PSME4 protein_coding   25.60365 17.68999 29.18972 2.158266 0.3431216 0.7222061 3.307766 0.8981597 5.221347 0.1455103 0.6851547 2.5261645 0.1134417 0.05436667 0.1784000 0.12403333 2.740843e-03 2.925689e-12 FALSE TRUE
MSTRG.18404.6 ENSG00000068878 HEK293_OSMI2_2hA HEK293_TMG_2hB PSME4 protein_coding   25.60365 17.68999 29.18972 2.158266 0.3431216 0.7222061 6.877812 1.3715137 9.089225 0.4888248 0.7069350 2.7194939 0.2421792 0.07696667 0.3118667 0.23490000 2.593601e-04 2.925689e-12 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000068878 E001 36.0970718 0.0409514473 2.380387e-03 8.399387e-03 2 53864069 53864433 365 - 1.373 1.769 1.356
ENSG00000068878 E002 36.3830244 0.0005779983 2.735855e-08 3.104147e-07 2 53864434 53864860 427 - 1.394 1.754 1.231
ENSG00000068878 E003 7.6179892 0.0027263208 2.464910e-04 1.160663e-03 2 53864861 53864869 9 - 0.714 1.167 1.714
ENSG00000068878 E004 24.7128680 0.0149950337 8.033001e-08 8.310550e-07 2 53864870 53864913 44 - 1.144 1.668 1.817
ENSG00000068878 E005 103.9549208 0.0028438839 1.072867e-24 1.139941e-22 2 53864914 53864978 65 - 1.780 2.257 1.602
ENSG00000068878 E006 242.0268225 0.0092670257 2.158847e-14 6.760116e-13 2 53864979 53865152 174 - 2.167 2.600 1.445
ENSG00000068878 E007 400.4516396 0.0064922602 1.333922e-14 4.313889e-13 2 53865153 53865573 421 - 2.427 2.784 1.188
ENSG00000068878 E008 11.7545974 0.0066595686 9.357464e-01 9.635837e-01 2 53865574 53866084 511 - 1.074 1.119 0.162
ENSG00000068878 E009 141.9973886 0.0003507978 5.013843e-13 1.290918e-11 2 53866085 53866147 63 - 2.031 2.290 0.867
ENSG00000068878 E010 144.0107294 0.0015700376 3.533734e-07 3.220857e-06 2 53866148 53866223 76 - 2.056 2.272 0.722
ENSG00000068878 E011 158.7115969 0.0003712681 8.191193e-10 1.233935e-08 2 53866747 53866880 134 - 2.097 2.316 0.729
ENSG00000068878 E012 4.9598725 0.0641483329 1.571227e-02 4.208934e-02 2 53869364 53869375 12 - 0.569 1.000 1.734
ENSG00000068878 E013 153.8857633 0.0002178131 4.210851e-15 1.464536e-13 2 53869376 53869538 163 - 2.062 2.327 0.887
ENSG00000068878 E014 5.9009483 0.0192688770 1.129623e-01 2.098672e-01 2 53869539 53870960 1422 - 0.874 0.659 -0.864
ENSG00000068878 E015 156.3584720 0.0002880304 1.719140e-08 2.029195e-07 2 53874339 53874494 156 - 2.097 2.299 0.678
ENSG00000068878 E016 151.3693619 0.0009603022 3.314888e-06 2.458582e-05 2 53875627 53875755 129 - 2.090 2.278 0.629
ENSG00000068878 E017 0.0000000       2 53881456 53881508 53 -      
ENSG00000068878 E018 124.0282450 0.0002585309 1.158714e-03 4.501024e-03 2 53885690 53885775 86 - 2.022 2.166 0.484
ENSG00000068878 E019 169.1223472 0.0002424698 7.841977e-02 1.569503e-01 2 53887259 53887416 158 - 2.176 2.264 0.294
ENSG00000068878 E020 108.3479364 0.0003607628 2.976362e-01 4.389746e-01 2 53887417 53887467 51 - 1.989 2.063 0.251
ENSG00000068878 E021 141.3518332 0.0018151799 3.369466e-01 4.808081e-01 2 53887858 53887989 132 - 2.104 2.174 0.234
ENSG00000068878 E022 0.5117906 0.2915742013 8.613892e-01 9.145851e-01 2 53887990 53888320 331 - 0.151 0.181 0.315
ENSG00000068878 E023 114.5593087 0.0003025686 2.333973e-01 3.664365e-01 2 53888721 53888812 92 - 2.010 2.089 0.264
ENSG00000068878 E024 109.1219981 0.0004513456 2.199532e-01 3.503662e-01 2 53890104 53890208 105 - 1.988 2.069 0.273
ENSG00000068878 E025 125.3299834 0.0002545568 7.014865e-01 8.006415e-01 2 53892808 53892960 153 - 2.063 2.113 0.169
ENSG00000068878 E026 92.2441393 0.0003052004 6.684031e-01 7.754254e-01 2 53893674 53893799 126 - 1.928 1.982 0.181
ENSG00000068878 E027 86.4353460 0.0072337317 9.149934e-01 9.501773e-01 2 53895007 53895076 70 - 1.902 1.940 0.127
ENSG00000068878 E028 146.1332537 0.0027775116 4.464690e-02 9.955299e-02 2 53895583 53895736 154 - 2.158 2.113 -0.152
ENSG00000068878 E029 105.9365071 0.0002630315 3.187719e-03 1.081916e-02 2 53896804 53896885 82 - 2.029 1.956 -0.244
ENSG00000068878 E030 119.8419368 0.0002749226 1.444105e-04 7.227468e-04 2 53897870 53897999 130 - 2.089 1.991 -0.328
ENSG00000068878 E031 69.7380007 0.0039811333 4.615484e-02 1.023225e-01 2 53898301 53898354 54 - 1.848 1.773 -0.254
ENSG00000068878 E032 117.1038077 0.0032801452 1.337153e-03 5.100260e-03 2 53899881 53900017 137 - 2.081 1.968 -0.378
ENSG00000068878 E033 141.8217216 0.0026298421 4.294879e-04 1.888029e-03 2 53901350 53901559 210 - 2.163 2.055 -0.364
ENSG00000068878 E034 100.5067372 0.0070235108 1.676981e-02 4.442969e-02 2 53904025 53904156 132 - 2.012 1.914 -0.332
ENSG00000068878 E035 91.7617562 0.0003192514 1.309951e-05 8.464930e-05 2 53906598 53906693 96 - 1.987 1.845 -0.476
ENSG00000068878 E036 79.4258852 0.0006933313 1.480696e-05 9.463060e-05 2 53906806 53906868 63 - 1.929 1.770 -0.536
ENSG00000068878 E037 0.4460135 0.0315876368 3.049644e-01 4.469883e-01 2 53907973 53908319 347 - 0.211 0.000 -11.108
ENSG00000068878 E038 93.3892315 0.0003682347 2.462530e-06 1.878625e-05 2 53908320 53908418 99 - 1.996 1.839 -0.528
ENSG00000068878 E039 67.8293021 0.0003654668 1.279366e-08 1.546332e-07 2 53908510 53908565 56 - 1.879 1.635 -0.826
ENSG00000068878 E040 76.0415413 0.0003703579 4.913784e-03 1.569076e-02 2 53908784 53908840 57 - 1.890 1.802 -0.295
ENSG00000068878 E041 0.1482932 0.0409964782 2.170043e-01   2 53908841 53908843 3 - 0.000 0.178 11.809
ENSG00000068878 E042 70.0699639 0.0003769642 5.327704e-02 1.149813e-01 2 53910075 53910130 56 - 1.843 1.792 -0.173
ENSG00000068878 E043 83.6473968 0.0011370177 5.463500e-03 1.719113e-02 2 53919151 53919246 96 - 1.930 1.842 -0.296
ENSG00000068878 E044 101.4475086 0.0002780181 1.916382e-10 3.221980e-09 2 53920193 53920350 158 - 2.048 1.829 -0.734
ENSG00000068878 E045 100.0565786 0.0003076372 3.088453e-13 8.183190e-12 2 53920889 53921104 216 - 2.049 1.785 -0.890
ENSG00000068878 E046 48.7018703 0.0009148644 4.135377e-05 2.375701e-04 2 53922517 53922584 68 - 1.727 1.525 -0.689
ENSG00000068878 E047 43.4460321 0.0029627306 8.944425e-04 3.594448e-03 2 53923049 53923118 70 - 1.673 1.491 -0.621
ENSG00000068878 E048 49.3679650 0.0198782194 2.375585e-03 8.385301e-03 2 53923321 53923419 99 - 1.742 1.500 -0.824
ENSG00000068878 E049 87.9189415 0.0050175052 2.495837e-07 2.348177e-06 2 53925539 53925689 151 - 1.993 1.735 -0.867
ENSG00000068878 E050 61.2695029 0.0020175091 1.303938e-11 2.665665e-10 2 53925959 53926023 65 - 1.858 1.498 -1.224
ENSG00000068878 E051 72.4839491 0.0003383100 2.629703e-16 1.076235e-14 2 53927394 53927483 90 - 1.933 1.557 -1.274
ENSG00000068878 E052 92.1198510 0.0004749394 2.028737e-18 1.076276e-16 2 53928117 53928303 187 - 2.033 1.674 -1.210
ENSG00000068878 E053 92.2797190 0.0008402455 3.522732e-14 1.068820e-12 2 53931835 53932055 221 - 2.023 1.714 -1.039
ENSG00000068878 E054 39.1001156 0.0005637354 1.736562e-07 1.685123e-06 2 53932056 53932100 45 - 1.657 1.349 -1.060
ENSG00000068878 E055 45.4826751 0.0004539226 8.407621e-08 8.663576e-07 2 53932668 53932760 93 - 1.719 1.429 -0.988
ENSG00000068878 E056 0.2903454 0.3621934756 6.501054e-01   2 53932761 53933169 409 - 0.151 0.000 -10.517
ENSG00000068878 E057 52.4947972 0.0004321142 1.027164e-10 1.808991e-09 2 53934605 53934727 123 - 1.790 1.453 -1.148
ENSG00000068878 E058 26.0014362 0.0007365884 1.108034e-08 1.354719e-07 2 53936087 53936094 8 - 1.512 1.067 -1.564
ENSG00000068878 E059 50.1456800 0.0004304413 9.781469e-17 4.209609e-15 2 53936095 53936161 67 - 1.795 1.307 -1.669
ENSG00000068878 E060 47.1375457 0.0005040621 2.197390e-13 5.952086e-12 2 53936764 53936827 64 - 1.758 1.328 -1.473
ENSG00000068878 E061 73.0951424 0.0003842988 4.185789e-17 1.882681e-15 2 53937391 53937540 150 - 1.939 1.550 -1.317
ENSG00000068878 E062 43.2255440 0.0004854916 3.728070e-09 4.969195e-08 2 53939956 53940000 45 - 1.706 1.368 -1.159
ENSG00000068878 E063 0.4407149 0.0215010519 9.521180e-01 9.740209e-01 2 53942159 53942224 66 - 0.151 0.178 0.281
ENSG00000068878 E064 56.2295708 0.0004303026 8.169120e-13 2.034730e-11 2 53948421 53948537 117 - 1.824 1.453 -1.262
ENSG00000068878 E065 47.6994075 0.0074052886 3.799789e-07 3.441171e-06 2 53949143 53949283 141 - 1.749 1.405 -1.176
ENSG00000068878 E066 53.2301589 0.0224613165 3.919034e-05 2.263910e-04 2 53970543 53971017 475 - 1.797 1.441 -1.215