ENSG00000068745

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000328631 ENSG00000068745 HEK293_OSMI2_2hA HEK293_TMG_2hB IP6K2 protein_coding protein_coding 76.96528 82.94034 68.73374 2.854014 0.8993567 -0.2710194 23.399224 27.958601 21.186704 0.47177691 0.49791958 -0.3999681 0.30381250 0.33753333 0.30853333 -0.02900000 4.720233e-01 4.321094e-31 FALSE TRUE
ENST00000340879 ENSG00000068745 HEK293_OSMI2_2hA HEK293_TMG_2hB IP6K2 protein_coding protein_coding 76.96528 82.94034 68.73374 2.854014 0.8993567 -0.2710194 7.885918 16.889427 1.418347 1.58762054 1.41834702 -3.5645559 0.10043333 0.20303333 0.02050000 -0.18253333 4.046528e-02 4.321094e-31   TRUE
ENST00000416707 ENSG00000068745 HEK293_OSMI2_2hA HEK293_TMG_2hB IP6K2 protein_coding nonsense_mediated_decay 76.96528 82.94034 68.73374 2.854014 0.8993567 -0.2710194 4.374677 6.131668 3.422940 0.07104358 0.51352128 -0.8391861 0.05645833 0.07413333 0.05000000 -0.02413333 2.037495e-01 4.321094e-31   TRUE
ENST00000449610 ENSG00000068745 HEK293_OSMI2_2hA HEK293_TMG_2hB IP6K2 protein_coding protein_coding 76.96528 82.94034 68.73374 2.854014 0.8993567 -0.2710194 7.209291 3.143398 4.272699 0.39174936 0.09788335 0.4416129 0.09259583 0.03806667 0.06216667 0.02410000 3.075444e-02 4.321094e-31 FALSE FALSE
ENST00000491686 ENSG00000068745 HEK293_OSMI2_2hA HEK293_TMG_2hB IP6K2 protein_coding retained_intron 76.96528 82.94034 68.73374 2.854014 0.8993567 -0.2710194 6.390939 2.787095 6.227500 0.38947085 0.51790952 1.1570388 0.08360000 0.03363333 0.09080000 0.05716667 7.415527e-05 4.321094e-31 FALSE FALSE
MSTRG.22918.15 ENSG00000068745 HEK293_OSMI2_2hA HEK293_TMG_2hB IP6K2 protein_coding   76.96528 82.94034 68.73374 2.854014 0.8993567 -0.2710194 1.212108 0.000000 5.344541 0.00000000 0.69865141 9.0646192 0.01748750 0.00000000 0.07783333 0.07783333 4.321094e-31 4.321094e-31   TRUE
MSTRG.22918.2 ENSG00000068745 HEK293_OSMI2_2hA HEK293_TMG_2hB IP6K2 protein_coding   76.96528 82.94034 68.73374 2.854014 0.8993567 -0.2710194 13.656427 13.421028 16.320393 2.02288456 1.45263316 0.2819898 0.17881667 0.16090000 0.23700000 0.07610000 1.345243e-01 4.321094e-31 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000068745 E001 117.0236702 0.0003182618 6.168647e-08 6.527939e-07 3 48688003 48688148 146 - 1.929 2.122 0.648
ENSG00000068745 E002 261.4816182 0.0010749510 1.373006e-03 5.218415e-03 3 48688149 48688285 137 - 2.350 2.441 0.303
ENSG00000068745 E003 275.4294931 0.0027481685 3.580597e-01 5.024485e-01 3 48688286 48688350 65 - 2.409 2.443 0.115
ENSG00000068745 E004 328.3193599 0.0041189269 7.820553e-01 8.600488e-01 3 48688351 48688404 54 - 2.497 2.511 0.046
ENSG00000068745 E005 821.8784886 0.0028469191 5.227100e-01 6.564654e-01 3 48688405 48688773 369 - 2.913 2.897 -0.053
ENSG00000068745 E006 384.6381806 0.0012805317 6.585898e-02 1.364776e-01 3 48689538 48689609 72 - 2.601 2.557 -0.145
ENSG00000068745 E007 328.1152971 0.0024733956 3.537438e-01 4.980073e-01 3 48689610 48689675 66 - 2.521 2.496 -0.082
ENSG00000068745 E008 241.6495042 0.0038393566 5.389637e-01 6.702930e-01 3 48689676 48689713 38 - 2.385 2.367 -0.059
ENSG00000068745 E009 19.4731457 0.0029318045 3.345015e-03 1.127678e-02 3 48691272 48691306 35 - 1.432 1.202 -0.803
ENSG00000068745 E010 491.2965075 0.0028309411 2.278150e-02 5.729230e-02 3 48691307 48691482 176 - 2.720 2.653 -0.224
ENSG00000068745 E011 386.3158684 0.0011290379 2.448095e-07 2.306811e-06 3 48692954 48693058 105 - 2.648 2.527 -0.406
ENSG00000068745 E012 209.4763569 0.0022781195 6.042551e-05 3.335402e-04 3 48693059 48693067 9 - 2.390 2.255 -0.449
ENSG00000068745 E013 212.2551628 0.0002067754 1.257056e-08 1.521794e-07 3 48693068 48693080 13 - 2.399 2.260 -0.462
ENSG00000068745 E014 230.2636886 0.0001925177 2.434915e-08 2.791282e-07 3 48693081 48693108 28 - 2.430 2.299 -0.435
ENSG00000068745 E015 193.7293216 0.0002159369 3.474360e-07 3.172846e-06 3 48693109 48693120 12 - 2.353 2.223 -0.435
ENSG00000068745 E016 166.5316030 0.0002413401 3.611047e-07 3.285635e-06 3 48693121 48693122 2 - 2.292 2.152 -0.468
ENSG00000068745 E017 238.7792661 0.0001675554 2.312909e-12 5.348800e-11 3 48693123 48693179 57 - 2.461 2.300 -0.536
ENSG00000068745 E018 23.6368423 0.0007847616 7.420562e-06 5.077485e-05 3 48693180 48693269 90 - 1.550 1.238 -1.078
ENSG00000068745 E019 24.9336274 0.0007712022 1.638036e-15 6.020973e-14 3 48693270 48693338 69 - 1.661 1.101 -1.946
ENSG00000068745 E020 23.8080390 0.0010092521 1.239913e-16 5.271494e-15 3 48693339 48693447 109 - 1.653 1.051 -2.104
ENSG00000068745 E021 8.7435242 0.0019413947 1.878248e-04 9.116093e-04 3 48693448 48693452 5 - 1.181 0.777 -1.508
ENSG00000068745 E022 9.4872700 0.0017627522 4.717204e-05 2.674428e-04 3 48693453 48693455 3 - 1.223 0.796 -1.578
ENSG00000068745 E023 13.0851155 0.0013656201 7.881789e-03 2.348249e-02 3 48693456 48693487 32 - 1.270 1.029 -0.862
ENSG00000068745 E024 52.6410140 0.0006948109 3.561946e-01 5.005897e-01 3 48693488 48693520 33 - 1.746 1.703 -0.145
ENSG00000068745 E025 223.8794364 0.0003444513 8.706232e-08 8.941611e-07 3 48693521 48693784 264 - 2.246 2.388 0.472
ENSG00000068745 E026 239.7483535 0.0002253061 6.263157e-20 3.932835e-18 3 48693785 48693932 148 - 2.208 2.441 0.778
ENSG00000068745 E027 147.5843906 0.0002633682 7.966617e-16 3.047146e-14 3 48693933 48693952 20 - 1.980 2.241 0.873
ENSG00000068745 E028 153.4728841 0.0003824777 4.331811e-18 2.209608e-16 3 48693953 48693983 31 - 1.980 2.262 0.942
ENSG00000068745 E029 207.9874903 0.0002209285 1.200977e-24 1.268236e-22 3 48693984 48694050 67 - 2.111 2.394 0.944
ENSG00000068745 E030 280.5660069 0.0026723256 3.024737e-09 4.100374e-08 3 48694051 48694171 121 - 2.299 2.499 0.670
ENSG00000068745 E031 152.4605834 0.0047808688 1.817927e-03 6.657018e-03 3 48694172 48694174 3 - 2.077 2.217 0.469
ENSG00000068745 E032 249.0643216 0.0029746679 3.475373e-06 2.565657e-05 3 48694175 48694240 66 - 2.272 2.437 0.552
ENSG00000068745 E033 62.5374497 0.0092745265 2.221092e-01 3.529257e-01 3 48694241 48694344 104 - 1.832 1.753 -0.268
ENSG00000068745 E034 42.8825324 0.0091832319 3.856168e-01 5.298026e-01 3 48694345 48694458 114 - 1.661 1.599 -0.208
ENSG00000068745 E035 37.4599080 0.0046728638 8.492937e-01 9.064419e-01 3 48694459 48694525 67 - 1.577 1.565 -0.040
ENSG00000068745 E036 30.2712190 0.0006828117 6.340806e-02 1.323717e-01 3 48694526 48694623 98 - 1.554 1.440 -0.392
ENSG00000068745 E037 43.3508623 0.0005203993 2.151180e-03 7.693515e-03 3 48694624 48694693 70 - 1.731 1.571 -0.544
ENSG00000068745 E038 53.8839274 0.0040514796 1.448451e-01 2.546255e-01 3 48694694 48694701 8 - 1.775 1.692 -0.282
ENSG00000068745 E039 96.4293870 0.0033886641 3.903537e-01 5.343321e-01 3 48694702 48694770 69 - 1.999 1.959 -0.135
ENSG00000068745 E040 79.8465251 0.0003318764 2.039086e-02 5.230784e-02 3 48694771 48694824 54 - 1.950 1.860 -0.303
ENSG00000068745 E041 35.3444118 0.0101313787 1.026159e-04 5.341322e-04 3 48694825 48694841 17 - 1.702 1.414 -0.986
ENSG00000068745 E042 38.9211638 0.0006516668 5.386753e-09 6.986405e-08 3 48694842 48694871 30 - 1.758 1.432 -1.113
ENSG00000068745 E043 86.8430784 0.0023118101 9.402015e-14 2.684527e-12 3 48694872 48695089 218 - 2.104 1.777 -1.097
ENSG00000068745 E044 401.9109897 0.0007729377 1.855276e-01 3.081624e-01 3 48695090 48695127 38 - 2.609 2.580 -0.097
ENSG00000068745 E045 287.9702367 0.0012527061 1.458424e-01 2.560080e-01 3 48695128 48695129 2 - 2.471 2.432 -0.131
ENSG00000068745 E046 416.0650130 0.0014725362 3.746337e-01 5.190606e-01 3 48695130 48695168 39 - 2.593 2.615 0.072
ENSG00000068745 E047 768.4004885 0.0015620744 1.624759e-02 4.326949e-02 3 48695169 48695418 250 - 2.839 2.891 0.172
ENSG00000068745 E048 191.3226674 0.0020694209 2.340717e-03 8.278729e-03 3 48695419 48695421 3 - 2.200 2.305 0.348
ENSG00000068745 E049 2.3563455 0.0168557064 9.450532e-01 9.695432e-01 3 48695422 48695558 137 - 0.518 0.507 -0.051
ENSG00000068745 E050 0.2998086 0.0290673776 8.084091e-01   3 48695559 48695588 30 - 0.141 0.106 -0.471
ENSG00000068745 E051 4.4159023 0.0036857550 7.271124e-01 8.199409e-01 3 48699362 48699788 427 - 0.684 0.735 0.211
ENSG00000068745 E052 14.9080979 0.0013294326 1.507681e-03 5.660998e-03 3 48708120 48708237 118 - 0.974 1.278 1.095
ENSG00000068745 E053 9.7582844 0.0031968737 4.460475e-01 5.875891e-01 3 48711367 48711459 93 - 0.956 1.040 0.311
ENSG00000068745 E054 21.7956792 0.0008384800 8.902937e-01 9.339062e-01 3 48715315 48715388 74 - 1.351 1.343 -0.028
ENSG00000068745 E055 41.5382231 0.0005986977 3.640020e-01 5.084129e-01 3 48715389 48715527 139 - 1.581 1.634 0.180
ENSG00000068745 E056 0.8846626 0.0142130221 3.051861e-01 4.472261e-01 3 48715528 48715529 2 - 0.141 0.324 1.532
ENSG00000068745 E057 2.0292675 0.0168100886 8.305463e-01 8.937003e-01 3 48716432 48716477 46 - 0.464 0.506 0.204
ENSG00000068745 E058 0.4448795 0.3908977335 3.039269e-01 4.458989e-01 3 48717058 48717156 99 - 0.000 0.253 12.194
ENSG00000068745 E059 307.0588994 0.0003901500 9.826995e-06 6.545583e-05 3 48717157 48717487 331 - 2.408 2.510 0.339
ENSG00000068745 E060 0.1482932 0.0410640323 6.480668e-01   3 48717870 48717889 20 - 0.000 0.106 10.676
ENSG00000068745 E061 0.3030308 0.3842357340 2.077280e-01   3 48718648 48718757 110 - 0.248 0.000 -12.892
ENSG00000068745 E062 0.1515154 0.0434942868 3.622307e-01   3 48729655 48729777 123 - 0.141 0.000 -11.890
ENSG00000068745 E063 0.0000000       3 48738882 48738966 85 -      
ENSG00000068745 E064 0.0000000       3 48739587 48739746 160 -      
ENSG00000068745 E065 0.0000000       3 48740206 48740353 148 -