ENSG00000068724

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000319190 ENSG00000068724 HEK293_OSMI2_2hA HEK293_TMG_2hB TTC7A protein_coding protein_coding 6.9693 10.63721 5.233429 0.7061903 0.1742876 -1.021892 2.8942914 4.2782249 2.7332604 0.7961195 0.46856626 -0.644488982 0.41307917 0.40306667 0.52023333 0.11716667 0.63292473 0.03529766 FALSE  
ENST00000409245 ENSG00000068724 HEK293_OSMI2_2hA HEK293_TMG_2hB TTC7A protein_coding protein_coding 6.9693 10.63721 5.233429 0.7061903 0.1742876 -1.021892 1.0625545 1.3107134 1.1160929 0.1615591 0.02136902 -0.229991573 0.16586667 0.12410000 0.21363333 0.08953333 0.03529766 0.03529766 FALSE  
ENST00000461601 ENSG00000068724 HEK293_OSMI2_2hA HEK293_TMG_2hB TTC7A protein_coding processed_transcript 6.9693 10.63721 5.233429 0.7061903 0.1742876 -1.021892 0.5365667 0.4810888 0.4841121 0.3007546 0.37574179 0.008854564 0.08883750 0.04210000 0.09553333 0.05343333 0.94124083 0.03529766 FALSE  
ENST00000491786 ENSG00000068724 HEK293_OSMI2_2hA HEK293_TMG_2hB TTC7A protein_coding retained_intron 6.9693 10.63721 5.233429 0.7061903 0.1742876 -1.021892 0.2490475 1.0721170 0.0000000 0.5372809 0.00000000 -6.757712619 0.02647083 0.09986667 0.00000000 -0.09986667 0.22346793 0.03529766 FALSE  
MSTRG.18344.2 ENSG00000068724 HEK293_OSMI2_2hA HEK293_TMG_2hB TTC7A protein_coding   6.9693 10.63721 5.233429 0.7061903 0.1742876 -1.021892 1.2534589 2.4028710 0.2308961 0.2409272 0.23089612 -3.324267712 0.17098333 0.22853333 0.04553333 -0.18300000 0.10066655 0.03529766 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000068724 E001 12.6909788 0.0015712199 0.110910530 0.20688828 2 46916157 46916447 291 + 1.179 1.042 -0.494
ENSG00000068724 E002 7.2443107 0.0091290746 0.116433959 0.21486941 2 46916448 46916577 130 + 0.989 0.810 -0.684
ENSG00000068724 E003 2.9150760 0.0061980263 0.422086883 0.56525002 2 46917184 46917277 94 + 0.644 0.530 -0.510
ENSG00000068724 E004 2.4596004 0.0101795013 0.182604276 0.30447493 2 46941224 46941274 51 + 0.644 0.438 -0.968
ENSG00000068724 E005 2.6111159 0.0094014207 0.100411263 0.19109753 2 46941275 46941285 11 + 0.690 0.438 -1.160
ENSG00000068724 E006 18.4934197 0.0261752677 0.076869557 0.15449181 2 46941286 46941542 257 + 1.351 1.181 -0.597
ENSG00000068724 E007 38.9546174 0.0144854605 0.409242201 0.55284529 2 46941543 46941725 183 + 1.574 1.532 -0.142
ENSG00000068724 E008 39.8620840 0.0033431289 0.525417902 0.65879191 2 46950363 46950420 58 + 1.568 1.548 -0.069
ENSG00000068724 E009 57.5340201 0.0020457675 0.503992266 0.63990659 2 46950421 46950526 106 + 1.721 1.706 -0.051
ENSG00000068724 E010 0.0000000       2 46951602 46951733 132 +      
ENSG00000068724 E011 76.4611890 0.0003839565 0.136724494 0.24351809 2 46956839 46957007 169 + 1.863 1.819 -0.150
ENSG00000068724 E012 3.9545347 0.1862116069 0.911209063 0.94761152 2 46958495 46958552 58 + 0.593 0.662 0.299
ENSG00000068724 E013 70.6677859 0.0003646043 0.003047364 0.01040580 2 46974973 46975103 131 + 1.878 1.767 -0.373
ENSG00000068724 E014 0.0000000       2 46978118 46978249 132 +      
ENSG00000068724 E015 0.1515154 0.0429160256 0.206858302   2 46978740 46978791 52 + 0.172 0.000 -15.634
ENSG00000068724 E016 70.6090637 0.0045061860 0.065503491 0.13588069 2 46978792 46978907 116 + 1.855 1.778 -0.260
ENSG00000068724 E017 53.6760093 0.0015439173 0.648845267 0.76026826 2 46993450 46993528 79 + 1.646 1.692 0.155
ENSG00000068724 E018 1.1707416 0.0111578671 0.474960879 0.61373654 2 46994231 46994356 126 + 0.391 0.272 -0.745
ENSG00000068724 E019 83.1637018 0.0003706601 0.696541827 0.79686245 2 46994357 46994514 158 + 1.846 1.883 0.124
ENSG00000068724 E020 62.1059372 0.0119750556 0.562232979 0.68988459 2 46995136 46995199 64 + 1.763 1.744 -0.065
ENSG00000068724 E021 42.5546308 0.0005627730 0.834216399 0.89618646 2 47005922 47005931 10 + 1.580 1.587 0.026
ENSG00000068724 E022 82.9835333 0.0003380289 0.995046297 1.00000000 2 47005932 47006059 128 + 1.855 1.875 0.069
ENSG00000068724 E023 53.8106635 0.0011554013 0.980272276 0.99167316 2 47006641 47006724 84 + 1.665 1.684 0.065
ENSG00000068724 E024 0.0000000       2 47007004 47007049 46 +      
ENSG00000068724 E025 0.0000000       2 47008545 47008701 157 +      
ENSG00000068724 E026 0.0000000       2 47008702 47008779 78 +      
ENSG00000068724 E027 56.3180308 0.0004889357 0.928786884 0.95920654 2 47011331 47011435 105 + 1.687 1.703 0.053
ENSG00000068724 E028 58.7894350 0.0011239438 0.866682487 0.91819324 2 47021862 47021979 118 + 1.696 1.725 0.100
ENSG00000068724 E029 48.5810900 0.0004723117 0.832689384 0.89516530 2 47023408 47023465 58 + 1.632 1.640 0.029
ENSG00000068724 E030 42.9357482 0.0008334162 0.523297116 0.65700679 2 47024287 47024359 73 + 1.539 1.597 0.201
ENSG00000068724 E031 76.2829418 0.0003612190 0.498987629 0.63534498 2 47029224 47029384 161 + 1.840 1.830 -0.032
ENSG00000068724 E032 0.5503986 0.0201508057 0.897206890 0.93835240 2 47034155 47034369 215 + 0.172 0.157 -0.158
ENSG00000068724 E033 67.2891060 0.0004216644 0.755774322 0.84102169 2 47046315 47046431 117 + 1.777 1.783 0.019
ENSG00000068724 E034 0.3697384 0.0246868622 0.546966979 0.67704626 2 47047266 47047337 72 + 0.000 0.157 14.038
ENSG00000068724 E035 65.8888704 0.0003950762 0.631123607 0.74621461 2 47049949 47050046 98 + 1.737 1.780 0.146
ENSG00000068724 E036 2.6257497 0.0177821813 0.527387224 0.66046362 2 47050340 47050827 488 + 0.593 0.501 -0.427
ENSG00000068724 E037 64.9238602 0.0012861636 0.604371251 0.72495850 2 47051746 47051880 135 + 1.767 1.761 -0.018
ENSG00000068724 E038 91.6447819 0.0035248304 0.671183089 0.77747450 2 47060769 47060971 203 + 1.880 1.923 0.145
ENSG00000068724 E039 478.7219015 0.0111311502 0.037800313 0.08696528 2 47073702 47076137 2436 + 2.544 2.657 0.375