ENSG00000068697

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000175091 ENSG00000068697 HEK293_OSMI2_2hA HEK293_TMG_2hB LAPTM4A protein_coding protein_coding 111.2559 93.24943 119.1506 16.81618 1.490532 0.3535855 104.606001 92.2291460 108.73167 16.7568622 1.838064 0.2374538 0.94564583 0.98866667 0.91296667 -0.0757 4.319634e-07 4.319634e-07 FALSE  
MSTRG.18003.2 ENSG00000068697 HEK293_OSMI2_2hA HEK293_TMG_2hB LAPTM4A protein_coding   111.2559 93.24943 119.1506 16.81618 1.490532 0.3535855 6.225231 0.9447132 10.16889 0.2196518 2.766880 3.4143692 0.05060833 0.01023333 0.08493333 0.0747 1.504317e-06 4.319634e-07 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000068697 E001 1247.720146 1.081163e-04 1.976215e-50 1.235604e-47 2 20032650 20033168 519 - 3.019 3.168 0.496
ENSG00000068697 E002 953.151822 5.580230e-04 1.028264e-01 1.947957e-01 2 20033169 20033279 111 - 2.975 2.994 0.063
ENSG00000068697 E003 906.874493 1.126064e-03 3.536602e-01 4.979256e-01 2 20034317 20034415 99 - 2.975 2.950 -0.081
ENSG00000068697 E004 829.597771 5.943408e-04 9.820612e-02 1.877913e-01 2 20034967 20035062 96 - 2.942 2.908 -0.111
ENSG00000068697 E005 1.919659 1.994732e-01 5.192062e-01 6.533327e-01 2 20035063 20035243 181 - 0.549 0.369 -0.924
ENSG00000068697 E006 952.408913 9.488809e-05 4.081941e-06 2.961631e-05 2 20037316 20037438 123 - 3.015 2.961 -0.179
ENSG00000068697 E007 724.713242 9.562733e-04 1.931625e-01 3.177450e-01 2 20037538 20037614 77 - 2.882 2.851 -0.104
ENSG00000068697 E008 886.645182 4.515600e-04 9.364608e-03 2.719381e-02 2 20040891 20041007 117 - 2.977 2.934 -0.144
ENSG00000068697 E009 384.867801 2.092478e-04 6.201837e-01 7.374496e-01 2 20041008 20041011 4 - 2.601 2.590 -0.035
ENSG00000068697 E010 798.337549 5.013901e-04 5.339115e-08 5.720066e-07 2 20051410 20051695 286 - 2.954 2.865 -0.298