ENSG00000068650

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000375630 ENSG00000068650 HEK293_OSMI2_2hA HEK293_TMG_2hB ATP11A protein_coding protein_coding 6.119899 3.661704 7.472414 0.5127567 0.1073629 1.027054 0.72567332 0.0000000 0.8993046 0.00000000 0.32974646 6.506692 0.11027917 0.00000000 0.11926667 0.119266667 3.756017e-04 1.439682e-05 FALSE TRUE
ENST00000375645 ENSG00000068650 HEK293_OSMI2_2hA HEK293_TMG_2hB ATP11A protein_coding protein_coding 6.119899 3.661704 7.472414 0.5127567 0.1073629 1.027054 0.34417518 0.1291303 0.8641083 0.06822278 0.17381977 2.651375 0.05502917 0.03550000 0.11626667 0.080766667 1.932679e-01 1.439682e-05 FALSE TRUE
ENST00000415301 ENSG00000068650 HEK293_OSMI2_2hA HEK293_TMG_2hB ATP11A protein_coding protein_coding 6.119899 3.661704 7.472414 0.5127567 0.1073629 1.027054 0.06576814 0.4074675 0.0000000 0.21009686 0.00000000 -5.383592 0.01944167 0.12670000 0.00000000 -0.126700000 9.370830e-02 1.439682e-05 FALSE TRUE
ENST00000418678 ENSG00000068650 HEK293_OSMI2_2hA HEK293_TMG_2hB ATP11A protein_coding protein_coding 6.119899 3.661704 7.472414 0.5127567 0.1073629 1.027054 0.51328430 0.2783331 0.9442202 0.08959107 0.08788689 1.726586 0.07696667 0.08483333 0.12673333 0.041900000 6.179820e-01 1.439682e-05 FALSE TRUE
ENST00000419631 ENSG00000068650 HEK293_OSMI2_2hA HEK293_TMG_2hB ATP11A protein_coding protein_coding 6.119899 3.661704 7.472414 0.5127567 0.1073629 1.027054 0.03961141 0.2416061 0.0000000 0.24160612 0.00000000 -4.653095 0.01353333 0.08656667 0.00000000 -0.086566667 6.887088e-01 1.439682e-05 FALSE TRUE
ENST00000479193 ENSG00000068650 HEK293_OSMI2_2hA HEK293_TMG_2hB ATP11A protein_coding retained_intron 6.119899 3.661704 7.472414 0.5127567 0.1073629 1.027054 0.51905842 0.7769048 0.3039229 0.56206564 0.03210844 -1.325779 0.10023750 0.17886667 0.04060000 -0.138266667 7.636540e-01 1.439682e-05 FALSE TRUE
ENST00000487903 ENSG00000068650 HEK293_OSMI2_2hA HEK293_TMG_2hB ATP11A protein_coding protein_coding 6.119899 3.661704 7.472414 0.5127567 0.1073629 1.027054 0.34831482 0.3304022 0.1461725 0.04302742 0.14617251 -1.124100 0.05270417 0.09100000 0.01976667 -0.071233333 1.477999e-01 1.439682e-05 FALSE TRUE
ENST00000493489 ENSG00000068650 HEK293_OSMI2_2hA HEK293_TMG_2hB ATP11A protein_coding retained_intron 6.119899 3.661704 7.472414 0.5127567 0.1073629 1.027054 1.03221670 0.4536513 1.2112796 0.21667728 0.25825093 1.397281 0.16162500 0.11160000 0.16116667 0.049566667 7.052035e-01 1.439682e-05   TRUE
ENST00000614170 ENSG00000068650 HEK293_OSMI2_2hA HEK293_TMG_2hB ATP11A protein_coding retained_intron 6.119899 3.661704 7.472414 0.5127567 0.1073629 1.027054 0.78440306 0.3557493 0.8070819 0.04738684 0.06062493 1.159626 0.13270000 0.10466667 0.10810000 0.003433333 9.908721e-01 1.439682e-05 FALSE TRUE
MSTRG.9085.3 ENSG00000068650 HEK293_OSMI2_2hA HEK293_TMG_2hB ATP11A protein_coding   6.119899 3.661704 7.472414 0.5127567 0.1073629 1.027054 0.33405393 0.1479096 0.5107084 0.14790962 0.26595749 1.721377 0.05421667 0.04076667 0.06826667 0.027500000 7.206735e-01 1.439682e-05 FALSE TRUE
MSTRG.9085.5 ENSG00000068650 HEK293_OSMI2_2hA HEK293_TMG_2hB ATP11A protein_coding   6.119899 3.661704 7.472414 0.5127567 0.1073629 1.027054 0.34564829 0.0000000 0.6270109 0.00000000 0.12240601 5.993246 0.04867917 0.00000000 0.08433333 0.084333333 1.439682e-05 1.439682e-05 FALSE TRUE
MSTRG.9085.7 ENSG00000068650 HEK293_OSMI2_2hA HEK293_TMG_2hB ATP11A protein_coding   6.119899 3.661704 7.472414 0.5127567 0.1073629 1.027054 0.37242964 0.0000000 0.3313941 0.00000000 0.06841852 5.093366 0.06018333 0.00000000 0.04460000 0.044600000 8.058332e-04 1.439682e-05 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000068650 E001 2.7366731 0.0054656137 7.465377e-02 1.509836e-01 13 112690038 112690116 79 + 0.595 0.333 -1.346
ENSG00000068650 E002 5.4660731 0.0030445147 2.786933e-03 9.635478e-03 13 112690117 112690328 212 + 0.848 0.437 -1.805
ENSG00000068650 E003 3.9816134 0.0039696521 1.159346e-01 2.141439e-01 13 112690329 112690403 75 + 0.702 0.520 -0.805
ENSG00000068650 E004 7.0647434 0.0045646213 8.325428e-02 1.646633e-01 13 112690404 112690455 52 + 0.901 0.750 -0.593
ENSG00000068650 E005 0.0000000       13 112696831 112696911 81 +      
ENSG00000068650 E006 0.2214452 0.0368085737 1.921851e-01   13 112703287 112703342 56 + 0.000 0.198 11.090
ENSG00000068650 E007 0.0000000       13 112717322 112717675 354 +      
ENSG00000068650 E008 5.3361252 0.0040760205 1.191096e-01 2.186654e-01 13 112785135 112785144 10 + 0.801 0.650 -0.619
ENSG00000068650 E009 6.8820200 0.0033339954 9.623014e-02 1.847194e-01 13 112785145 112785171 27 + 0.891 0.750 -0.555
ENSG00000068650 E010 13.2870584 0.0020799997 7.018372e-03 2.127137e-02 13 112785172 112785257 86 + 1.158 0.958 -0.728
ENSG00000068650 E011 21.0960663 0.0668444864 4.238009e-02 9.541520e-02 13 112804957 112805046 90 + 1.345 1.154 -0.672
ENSG00000068650 E012 23.0013393 0.0008416224 9.359506e-04 3.740071e-03 13 112806213 112806293 81 + 1.372 1.189 -0.644
ENSG00000068650 E013 26.4880612 0.0069595069 4.964382e-04 2.146398e-03 13 112810619 112810726 108 + 1.435 1.222 -0.742
ENSG00000068650 E014 28.0429788 0.0205839074 3.576684e-03 1.194647e-02 13 112816083 112816211 129 + 1.461 1.254 -0.720
ENSG00000068650 E015 22.6691271 0.0181345874 1.640532e-02 4.362632e-02 13 112819304 112819407 104 + 1.366 1.206 -0.561
ENSG00000068650 E016 17.2772657 0.0010467152 8.736353e-04 3.521963e-03 13 112819900 112819950 51 + 1.265 1.034 -0.828
ENSG00000068650 E017 22.1714829 0.0012900055 9.401624e-04 3.754684e-03 13 112823345 112823409 65 + 1.362 1.172 -0.668
ENSG00000068650 E018 22.5871786 0.0010979899 9.223106e-03 2.684215e-02 13 112824344 112824425 82 + 1.355 1.235 -0.421
ENSG00000068650 E019 27.7419716 0.0009407504 7.140231e-02 1.456610e-01 13 112825430 112825580 151 + 1.417 1.382 -0.121
ENSG00000068650 E020 33.7231081 0.0006095180 6.338277e-03 1.950279e-02 13 112826694 112826891 198 + 1.517 1.431 -0.297
ENSG00000068650 E021 27.9043186 0.0007913482 4.660650e-05 2.645611e-04 13 112831375 112831548 174 + 1.469 1.249 -0.764
ENSG00000068650 E022 27.4779583 0.0036149892 1.734951e-03 6.393085e-03 13 112832860 112833023 164 + 1.447 1.290 -0.545
ENSG00000068650 E023 19.5385762 0.0063463910 5.976760e-02 1.262195e-01 13 112834589 112834660 72 + 1.286 1.205 -0.287
ENSG00000068650 E024 18.8463528 0.0284560382 1.426082e-01 2.515872e-01 13 112836178 112836242 65 + 1.274 1.189 -0.298
ENSG00000068650 E025 10.8914208 0.0348704479 1.879493e-01 3.111335e-01 13 112836243 112836251 9 + 1.059 0.957 -0.374
ENSG00000068650 E026 12.8680051 0.0439811887 2.138576e-02 5.440533e-02 13 112842276 112842308 33 + 1.158 0.897 -0.960
ENSG00000068650 E027 20.2970772 0.0035083340 3.451571e-04 1.560671e-03 13 112842309 112842379 71 + 1.341 1.098 -0.858
ENSG00000068650 E028 25.7537030 0.0065865284 6.381857e-03 1.961554e-02 13 112851037 112851179 143 + 1.417 1.276 -0.488
ENSG00000068650 E029 12.6058519 0.0014453288 1.945202e-01 3.194049e-01 13 112851180 112851218 39 + 1.099 1.057 -0.153
ENSG00000068650 E030 0.1472490 0.0421860678 1.000000e+00   13 112851541 112851854 314 + 0.073 0.000 -9.891
ENSG00000068650 E031 26.8423533 0.0178152830 2.011481e-01 3.276238e-01 13 112854279 112854530 252 + 1.404 1.374 -0.103
ENSG00000068650 E032 8.2632233 0.0021653140 2.157823e-02 5.480535e-02 13 112855911 112855920 10 + 0.966 0.750 -0.837
ENSG00000068650 E033 16.7084676 0.0011408421 1.600003e-02 4.273390e-02 13 112855921 112856085 165 + 1.234 1.099 -0.483
ENSG00000068650 E034 1.0425102 0.0126188144 3.747086e-01 5.191311e-01 13 112856086 112856805 720 + 0.322 0.198 -0.932
ENSG00000068650 E035 14.9067951 0.0015204321 9.561617e-02 1.838164e-01 13 112857818 112857920 103 + 1.169 1.099 -0.252
ENSG00000068650 E036 0.8888047 0.2448958673 6.185513e-01 7.361554e-01 13 112857921 112858144 224 + 0.283 0.196 -0.688
ENSG00000068650 E037 14.8695023 0.0012661851 8.089528e-01 8.786618e-01 13 112858145 112858177 33 + 1.117 1.235 0.418
ENSG00000068650 E038 23.9302791 0.0008609246 4.143503e-01 5.577673e-01 13 112858178 112858290 113 + 1.337 1.372 0.120
ENSG00000068650 E039 1.9845188 0.0079994459 7.260635e-01 8.191946e-01 13 112858291 112859392 1102 + 0.392 0.520 0.656
ENSG00000068650 E040 18.7759906 0.0010683840 2.511115e-01 3.872714e-01 13 112859393 112859452 60 + 1.252 1.249 -0.011
ENSG00000068650 E041 27.8838435 0.0007847417 4.792570e-01 6.176407e-01 13 112860287 112860414 128 + 1.402 1.449 0.164
ENSG00000068650 E042 3.2000196 0.0051560456 7.404676e-06 5.067713e-05 13 112860415 112860798 384 + 0.239 0.985 3.560
ENSG00000068650 E043 24.8488628 0.0008077226 3.045406e-01 4.465503e-01 13 112862440 112862575 136 + 1.362 1.382 0.069
ENSG00000068650 E044 13.8248200 0.0180215043 6.684320e-01 7.754319e-01 13 112871735 112871767 33 + 1.112 1.155 0.155
ENSG00000068650 E045 14.5784919 0.0029599298 7.645092e-01 8.475671e-01 13 112871768 112871800 33 + 1.111 1.234 0.438
ENSG00000068650 E046 0.0000000       13 112873432 112873502 71 +      
ENSG00000068650 E047 0.1451727 0.0423370057 1.000000e+00   13 112873503 112873572 70 + 0.073 0.000 -9.890
ENSG00000068650 E048 25.1756105 0.0007526093 7.123567e-01 8.091303e-01 13 112873573 112873676 104 + 1.351 1.422 0.243
ENSG00000068650 E049 27.9802674 0.0139173850 8.792021e-01 9.264065e-01 13 112875776 112875941 166 + 1.385 1.471 0.297
ENSG00000068650 E050 2.2662428 0.1291567153 3.568119e-01 5.011940e-01 13 112875942 112876094 153 + 0.391 0.652 1.253
ENSG00000068650 E051 13.8471109 0.0014288149 3.923412e-01 5.362936e-01 13 112878217 112878303 87 + 1.059 1.235 0.630
ENSG00000068650 E052 5.9299899 0.0194290972 8.479179e-01 9.055703e-01 13 112878304 112878459 156 + 0.775 0.832 0.226
ENSG00000068650 E053 5.1985377 0.0032608608 9.493893e-01 9.723156e-01 13 112880301 112880545 245 + 0.718 0.793 0.302
ENSG00000068650 E054 6.8162257 0.0029657133 6.584440e-01 7.675850e-01 13 112880546 112880649 104 + 0.837 0.867 0.115
ENSG00000068650 E055 18.4312400 0.0010588329 4.377432e-01 5.796403e-01 13 112880972 112881812 841 + 1.234 1.263 0.102
ENSG00000068650 E056 5.6974445 0.0113869861 3.581437e-01 5.025237e-01 13 112881813 112881815 3 + 0.800 0.750 -0.203
ENSG00000068650 E057 14.5289632 0.0012780955 3.582469e-02 8.324396e-02 13 112881816 112881875 60 + 1.174 1.057 -0.423
ENSG00000068650 E058 486.7252738 0.0059228121 4.195450e-22 3.377984e-20 13 112881876 112887168 5293 + 2.506 2.866 1.200