ENSG00000068615

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000165698 ENSG00000068615 HEK293_OSMI2_2hA HEK293_TMG_2hB REEP1 protein_coding protein_coding 7.74461 8.180522 8.001387 0.9617602 0.359868 -0.0319034 3.664582 1.887286 5.297235 0.2240980 0.2535419 1.4840231 0.4493375 0.2311000 0.6657000 0.43460000 2.884154e-08 8.662712e-20 FALSE TRUE
ENST00000489855 ENSG00000068615 HEK293_OSMI2_2hA HEK293_TMG_2hB REEP1 protein_coding protein_coding 7.74461 8.180522 8.001387 0.9617602 0.359868 -0.0319034 2.709493 4.835578 1.249294 0.6138092 0.1346373 -1.9440536 0.3608792 0.5905000 0.1557333 -0.43476667 8.662712e-20 8.662712e-20 FALSE TRUE
MSTRG.18793.21 ENSG00000068615 HEK293_OSMI2_2hA HEK293_TMG_2hB REEP1 protein_coding   7.74461 8.180522 8.001387 0.9617602 0.359868 -0.0319034 1.086023 1.267612 1.032341 0.1858860 0.2580274 -0.2936218 0.1488542 0.1540333 0.1268000 -0.02723333 7.275679e-01 8.662712e-20 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000068615 E001 31.4508235 0.0007121693 5.845724e-05 3.237888e-04 2 86213993 86214250 258 - 1.390 1.643 0.867
ENSG00000068615 E002 110.3765529 0.0003570259 4.062066e-01 5.498604e-01 2 86214251 86215038 788 - 2.031 2.067 0.122
ENSG00000068615 E003 7.7794410 0.0025328103 7.645918e-02 1.538368e-01 2 86215039 86215056 18 - 1.009 0.805 -0.777
ENSG00000068615 E004 8.9316349 0.0021705285 6.374411e-02 1.329326e-01 2 86215057 86215063 7 - 1.061 0.858 -0.758
ENSG00000068615 E005 8.2059869 0.0382351054 1.361587e-01 2.427043e-01 2 86215064 86215067 4 - 1.031 0.810 -0.836
ENSG00000068615 E006 11.4060821 0.0173551297 8.704516e-01 9.206778e-01 2 86215068 86215095 28 - 1.089 1.073 -0.059
ENSG00000068615 E007 15.8667528 0.0011223476 9.646168e-01 9.816848e-01 2 86215096 86215155 60 - 1.221 1.234 0.046
ENSG00000068615 E008 30.3113240 0.0006379430 7.673248e-02 1.542598e-01 2 86215156 86215318 163 - 1.535 1.432 -0.354
ENSG00000068615 E009 40.9973744 0.0005921023 6.100768e-03 1.887419e-02 2 86215319 86215617 299 - 1.675 1.532 -0.487
ENSG00000068615 E010 107.0671353 0.0003655042 3.237037e-25 3.605215e-23 2 86215618 86216516 899 - 2.150 1.788 -1.217
ENSG00000068615 E011 19.2406557 0.0063850100 4.863676e-04 2.108053e-03 2 86216517 86216553 37 - 1.408 1.100 -1.087
ENSG00000068615 E012 14.3605745 0.0070666316 2.191798e-03 7.816675e-03 2 86216554 86216580 27 - 1.289 0.986 -1.088
ENSG00000068615 E013 21.8514558 0.0009634916 5.772070e-03 1.801396e-02 2 86216581 86216793 213 - 1.433 1.234 -0.696
ENSG00000068615 E014 11.3092242 0.0161944347 2.547348e-01 3.915040e-01 2 86216794 86216839 46 - 1.140 1.020 -0.435
ENSG00000068615 E015 29.8727482 0.0106038458 9.266943e-04 3.708480e-03 2 86216840 86217110 271 - 1.584 1.331 -0.872
ENSG00000068615 E016 0.3332198 0.0333248985 7.339792e-01   2 86219970 86220121 152 - 0.099 0.150 0.692
ENSG00000068615 E017 0.0000000       2 86220122 86220140 19 -      
ENSG00000068615 E018 0.3289534 0.0328852248 7.352260e-01   2 86223075 86223268 194 - 0.099 0.150 0.692
ENSG00000068615 E019 0.0000000       2 86223269 86223275 7 -      
ENSG00000068615 E020 0.0000000       2 86223489 86223785 297 -      
ENSG00000068615 E021 0.0000000       2 86224700 86225347 648 -      
ENSG00000068615 E022 0.0000000       2 86225348 86225589 242 -      
ENSG00000068615 E023 0.4428904 0.6005402480 2.103757e-01 3.389899e-01 2 86227363 86227398 36 - 0.000 0.275 10.654
ENSG00000068615 E024 12.6555656 0.0014105902 5.008733e-05 2.822815e-04 2 86232625 86232675 51 - 1.265 0.857 -1.490
ENSG00000068615 E025 14.0904635 0.0013902192 2.998482e-04 1.378938e-03 2 86232676 86232733 58 - 1.289 0.947 -1.230
ENSG00000068615 E026 18.5659727 0.0010469814 2.786422e-04 1.292808e-03 2 86232734 86232802 69 - 1.395 1.099 -1.041
ENSG00000068615 E027 0.0000000       2 86239922 86240020 99 -      
ENSG00000068615 E028 0.0000000       2 86240021 86240071 51 -      
ENSG00000068615 E029 6.8522715 0.0469092622 1.214765e-02 3.388604e-02 2 86247943 86248071 129 - 0.684 1.090 1.561
ENSG00000068615 E030 58.8753591 0.0027115745 2.762290e-54 2.198771e-51 2 86251352 86251956 605 - 1.207 2.079 2.979
ENSG00000068615 E031 54.0507957 0.0004276539 1.451925e-06 1.165027e-05 2 86251957 86252070 114 - 1.628 1.860 0.785
ENSG00000068615 E032 54.0394331 0.0004212665 2.559052e-05 1.547908e-04 2 86254694 86254814 121 - 1.641 1.845 0.691
ENSG00000068615 E033 0.3666179 0.0322197827 7.327787e-01 8.241818e-01 2 86254815 86255018 204 - 0.099 0.151 0.695
ENSG00000068615 E034 32.5863220 0.0006546574 2.451751e-02 6.088528e-02 2 86263965 86263993 29 - 1.461 1.605 0.492
ENSG00000068615 E035 30.5872355 0.0006849543 2.983459e-01 4.397842e-01 2 86263994 86264041 48 - 1.469 1.543 0.254
ENSG00000068615 E036 26.0493267 0.0062121473 5.543286e-01 6.833258e-01 2 86282170 86282242 73 - 1.408 1.457 0.170
ENSG00000068615 E037 0.5911836 0.0547812095 3.650910e-02 8.454923e-02 2 86336722 86337065 344 - 0.000 0.351 12.445
ENSG00000068615 E038 0.0000000       2 86337348 86337478 131 -      
ENSG00000068615 E039 19.2873818 0.0200620840 6.462175e-01 7.581887e-01 2 86337479 86337658 180 - 1.322 1.275 -0.165
ENSG00000068615 E040 0.0000000       2 86338024 86338083 60 -