ENSG00000068438

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000348411 ENSG00000068438 HEK293_OSMI2_2hA HEK293_TMG_2hB FTSJ1 protein_coding protein_coding 54.50053 79.82834 47.26968 1.704701 0.8968907 -0.7558615 27.995539 39.382967 26.212424 1.2183814 0.6307079 -0.5871370 0.51854583 0.49443333 0.55463333 0.06020000 0.3514118103 0.0003944716 FALSE TRUE
ENST00000466371 ENSG00000068438 HEK293_OSMI2_2hA HEK293_TMG_2hB FTSJ1 protein_coding processed_transcript 54.50053 79.82834 47.26968 1.704701 0.8968907 -0.7558615 8.328371 16.272788 5.138377 1.3688084 0.2164018 -1.6611582 0.13810417 0.20443333 0.10863333 -0.09580000 0.0003944716 0.0003944716 FALSE TRUE
ENST00000467954 ENSG00000068438 HEK293_OSMI2_2hA HEK293_TMG_2hB FTSJ1 protein_coding processed_transcript 54.50053 79.82834 47.26968 1.704701 0.8968907 -0.7558615 5.182677 6.911308 4.754563 0.5386829 0.4112311 -0.5387008 0.09967083 0.08640000 0.10076667 0.01436667 0.6318311526 0.0003944716 TRUE FALSE
MSTRG.34199.1 ENSG00000068438 HEK293_OSMI2_2hA HEK293_TMG_2hB FTSJ1 protein_coding   54.50053 79.82834 47.26968 1.704701 0.8968907 -0.7558615 2.441279 2.981712 2.401445 0.1263537 0.4683868 -0.3110735 0.05010417 0.03743333 0.05116667 0.01373333 0.6553443248 0.0003944716 FALSE TRUE
MSTRG.34199.4 ENSG00000068438 HEK293_OSMI2_2hA HEK293_TMG_2hB FTSJ1 protein_coding   54.50053 79.82834 47.26968 1.704701 0.8968907 -0.7558615 3.400525 6.087629 2.502052 1.7087056 1.2591518 -1.2793821 0.05593750 0.07603333 0.05210000 -0.02393333 0.8076491021 0.0003944716 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000068438 E001 0.147249 0.0434239866 2.695576e-01   X 48475967 48476020 54 + 0.160 0.000 -9.042
ENSG00000068438 E002 3.578266 0.0045579491 5.310592e-01 6.635640e-01 X 48476021 48476152 132 + 0.566 0.659 0.411
ENSG00000068438 E003 6.244085 0.0318015059 7.139917e-01 8.103352e-01 X 48476153 48476160 8 + 0.861 0.798 -0.245
ENSG00000068438 E004 30.961817 0.0153940132 2.925979e-01 4.335690e-01 X 48476161 48476198 38 + 1.531 1.431 -0.346
ENSG00000068438 E005 32.804281 0.0190913767 4.286714e-01 5.713980e-01 X 48476199 48476202 4 + 1.543 1.462 -0.276
ENSG00000068438 E006 77.417249 0.0117037275 1.219878e-04 6.229170e-04 X 48476203 48476217 15 + 2.019 1.758 -0.879
ENSG00000068438 E007 234.620377 0.0105178043 3.696351e-01 5.140367e-01 X 48476218 48476259 42 + 2.373 2.317 -0.185
ENSG00000068438 E008 424.883029 0.0028487096 1.040944e-01 1.967452e-01 X 48476260 48476396 137 + 2.630 2.574 -0.188
ENSG00000068438 E009 6.814854 0.1092617167 1.285601e-02 3.557910e-02 X 48476563 48476668 106 + 1.131 0.642 -1.888
ENSG00000068438 E010 309.310161 0.0002264247 8.871283e-03 2.595941e-02 X 48477961 48478009 49 + 2.498 2.434 -0.212
ENSG00000068438 E011 477.531364 0.0007272411 3.954782e-01 5.392876e-01 X 48478010 48478168 159 + 2.660 2.635 -0.083
ENSG00000068438 E012 17.201892 0.0015294894 1.756888e-05 1.103571e-04 X 48478169 48478448 280 + 1.437 1.076 -1.269
ENSG00000068438 E013 302.881618 0.0015425017 6.444678e-01 7.567544e-01 X 48478449 48478518 70 + 2.443 2.448 0.017
ENSG00000068438 E014 272.998109 0.0004187196 5.514600e-01 6.809172e-01 X 48478617 48478680 64 + 2.416 2.394 -0.072
ENSG00000068438 E015 215.687737 0.0007758273 2.874349e-01 4.279267e-01 X 48478681 48478707 27 + 2.283 2.306 0.077
ENSG00000068438 E016 293.452271 0.0012586450 4.986643e-02 1.089310e-01 X 48479038 48479116 79 + 2.402 2.449 0.157
ENSG00000068438 E017 190.892908 0.0032907750 2.522371e-01 3.885685e-01 X 48481151 48481164 14 + 2.223 2.261 0.128
ENSG00000068438 E018 220.765301 0.0030507768 5.750131e-02 1.223378e-01 X 48481165 48481203 39 + 2.267 2.330 0.212
ENSG00000068438 E019 243.623507 0.0004995175 4.147715e-02 9.376545e-02 X 48481289 48481342 54 + 2.323 2.369 0.155
ENSG00000068438 E020 281.305998 0.0001699734 7.051280e-02 1.441916e-01 X 48481426 48481481 56 + 2.392 2.427 0.115
ENSG00000068438 E021 290.934978 0.0001622982 8.385839e-03 2.475300e-02 X 48481482 48481528 47 + 2.393 2.446 0.175
ENSG00000068438 E022 28.196327 0.0009276920 8.374744e-01 8.984077e-01 X 48481529 48481631 103 + 1.422 1.429 0.025
ENSG00000068438 E023 352.171746 0.0001777292 1.795845e-03 6.586212e-03 X 48481632 48481715 84 + 2.473 2.531 0.192
ENSG00000068438 E024 143.095623 0.0002288137 8.185768e-01 8.853429e-01 X 48482403 48482408 6 + 2.123 2.123 0.001
ENSG00000068438 E025 218.165085 0.0013157302 6.392199e-01 7.526541e-01 X 48482409 48482419 11 + 2.301 2.309 0.026
ENSG00000068438 E026 354.226607 0.0012921275 5.284795e-01 6.613963e-01 X 48482420 48482506 87 + 2.509 2.520 0.034
ENSG00000068438 E027 574.837672 0.0012203135 8.657636e-02 1.699290e-01 X 48482597 48482794 198 + 2.704 2.736 0.106
ENSG00000068438 E028 175.252209 0.0003534379 5.235796e-07 4.612443e-06 X 48482795 48482985 191 + 2.105 2.251 0.489
ENSG00000068438 E029 236.709336 0.0008023346 4.080009e-02 9.251181e-02 X 48482986 48483027 42 + 2.385 2.323 -0.205
ENSG00000068438 E030 6.171116 0.0031187275 4.239900e-05 2.429559e-04 X 48483241 48483252 12 + 1.100 0.586 -2.025
ENSG00000068438 E031 9.851771 0.0145992244 2.258148e-05 1.382853e-04 X 48483253 48483341 89 + 1.275 0.778 -1.834
ENSG00000068438 E032 743.643197 0.0015238839 6.631600e-03 2.026742e-02 X 48485736 48486364 629 + 2.881 2.816 -0.215