ENSG00000068400

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000376423 ENSG00000068400 HEK293_OSMI2_2hA HEK293_TMG_2hB GRIPAP1 protein_coding protein_coding 23.5643 28.90256 18.60138 0.8353423 0.1802074 -0.6355114 7.204116 12.186771 4.223493 0.5901627 0.8065063 -1.52657881 0.29290417 0.4215000 0.22770000 -0.19380000 2.906648e-02 3.006028e-16 FALSE TRUE
ENST00000619149 ENSG00000068400 HEK293_OSMI2_2hA HEK293_TMG_2hB GRIPAP1 protein_coding retained_intron 23.5643 28.90256 18.60138 0.8353423 0.1802074 -0.6355114 4.070986 3.364215 3.158289 0.3820814 0.2332998 -0.09084797 0.17312083 0.1173000 0.17000000 0.05270000 2.515845e-01 3.006028e-16 TRUE TRUE
ENST00000622231 ENSG00000068400 HEK293_OSMI2_2hA HEK293_TMG_2hB GRIPAP1 protein_coding protein_coding 23.5643 28.90256 18.60138 0.8353423 0.1802074 -0.6355114 0.195507 0.000000 1.564056 0.0000000 0.2870194 7.29834323 0.01054583 0.0000000 0.08436667 0.08436667 3.006028e-16 3.006028e-16 FALSE FALSE
MSTRG.34228.5 ENSG00000068400 HEK293_OSMI2_2hA HEK293_TMG_2hB GRIPAP1 protein_coding   23.5643 28.90256 18.60138 0.8353423 0.1802074 -0.6355114 2.701041 3.605658 2.111410 0.3275054 1.3106442 -0.76923457 0.12112500 0.1245333 0.11233333 -0.01220000 8.261887e-01 3.006028e-16 FALSE TRUE
MSTRG.34228.6 ENSG00000068400 HEK293_OSMI2_2hA HEK293_TMG_2hB GRIPAP1 protein_coding   23.5643 28.90256 18.60138 0.8353423 0.1802074 -0.6355114 2.445823 2.808603 1.244617 1.0292376 0.4775691 -1.16773359 0.09937917 0.0974000 0.06720000 -0.03020000 7.797119e-01 3.006028e-16 FALSE TRUE
MSTRG.34228.7 ENSG00000068400 HEK293_OSMI2_2hA HEK293_TMG_2hB GRIPAP1 protein_coding   23.5643 28.90256 18.60138 0.8353423 0.1802074 -0.6355114 1.427314 1.880861 1.586777 0.4467267 0.3588268 -0.24387975 0.06488333 0.0660000 0.08556667 0.01956667 8.033354e-01 3.006028e-16 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000068400 E001 1.8497543 0.0091766342 6.196424e-02 1.299217e-01 X 48973720 48973722 3 - 0.638 0.323 -1.598
ENSG00000068400 E002 17.2293670 0.0037380157 1.738000e-02 4.577745e-02 X 48973723 48973781 59 - 1.043 1.276 0.833
ENSG00000068400 E003 35.7549485 0.0129273702 4.630569e-04 2.018377e-03 X 48973782 48973854 73 - 1.271 1.590 1.101
ENSG00000068400 E004 78.3842505 0.0056556943 3.860268e-03 1.275025e-02 X 48973855 48973930 76 - 1.725 1.895 0.574
ENSG00000068400 E005 70.3684419 0.0047204788 3.867350e-03 1.276986e-02 X 48973931 48973986 56 - 1.680 1.850 0.575
ENSG00000068400 E006 114.9333950 0.0043171154 3.327100e-03 1.122665e-02 X 48973987 48974068 82 - 1.910 2.055 0.485
ENSG00000068400 E007 224.6642747 0.0013763316 3.923052e-06 2.858282e-05 X 48974069 48974285 217 - 2.197 2.344 0.490
ENSG00000068400 E008 207.4763307 0.0002024033 7.160110e-07 6.136445e-06 X 48975155 48975291 137 - 2.167 2.305 0.461
ENSG00000068400 E009 102.6763272 0.0003458075 1.290823e-03 4.945149e-03 X 48975292 48975309 18 - 1.870 1.997 0.427
ENSG00000068400 E010 90.0047917 0.0143511292 5.795658e-06 4.066048e-05 X 48975310 48976017 708 - 2.110 1.800 -1.040
ENSG00000068400 E011 190.2678658 0.0008166546 1.056693e-03 4.155593e-03 X 48976018 48976111 94 - 2.155 2.257 0.339
ENSG00000068400 E012 18.6469557 0.0013101853 3.307825e-04 1.503822e-03 X 48976112 48976240 129 - 1.436 1.148 -1.010
ENSG00000068400 E013 119.0028606 0.0008934963 2.216599e-04 1.056582e-03 X 48976241 48976255 15 - 1.925 2.069 0.481
ENSG00000068400 E014 203.1780619 0.0005614920 3.356373e-04 1.523021e-03 X 48976256 48976363 108 - 2.185 2.290 0.350
ENSG00000068400 E015 14.4070738 0.0012098201 1.328275e-01 2.380430e-01 X 48976907 48977833 927 - 1.237 1.097 -0.498
ENSG00000068400 E016 12.1796476 0.0016459759 1.381152e-03 5.244640e-03 X 48977834 48978304 471 - 1.272 0.964 -1.111
ENSG00000068400 E017 225.0232484 0.0002431062 7.637842e-04 3.128070e-03 X 48978305 48978435 131 - 2.240 2.328 0.296
ENSG00000068400 E018 0.0000000       X 48980758 48980808 51 -      
ENSG00000068400 E019 191.4044612 0.0002504095 8.862379e-02 1.730217e-01 X 48981215 48981314 100 - 2.200 2.247 0.157
ENSG00000068400 E020 157.2723813 0.0002721278 5.302351e-02 1.145255e-01 X 48981416 48981472 57 - 2.106 2.166 0.199
ENSG00000068400 E021 180.6984292 0.0002561698 9.425712e-01 9.679545e-01 X 48981596 48981691 96 - 2.214 2.210 -0.013
ENSG00000068400 E022 93.6070420 0.0002978785 5.592242e-01 6.873636e-01 X 48981795 48981872 78 - 1.913 1.935 0.073
ENSG00000068400 E023 170.4616251 0.0002332081 1.000355e-01 1.905355e-01 X 48982979 48983092 114 - 2.153 2.200 0.160
ENSG00000068400 E024 210.1963649 0.0013904747 9.028951e-02 1.755772e-01 X 48983228 48983391 164 - 2.238 2.291 0.174
ENSG00000068400 E025 138.5662584 0.0002510227 2.214973e-01 3.521986e-01 X 48983392 48983440 49 - 2.067 2.106 0.130
ENSG00000068400 E026 172.3857266 0.0012893787 8.563714e-01 9.111945e-01 X 48983775 48983870 96 - 2.190 2.195 0.016
ENSG00000068400 E027 184.9015403 0.0002160237 7.314456e-03 2.203619e-02 X 48985268 48985402 135 - 2.276 2.200 -0.254
ENSG00000068400 E028 135.0506528 0.0002313674 7.969267e-02 1.590738e-01 X 48987785 48987877 93 - 2.129 2.070 -0.196
ENSG00000068400 E029 111.1263140 0.0003469294 5.093726e-01 6.447027e-01 X 48988121 48988198 78 - 2.018 1.992 -0.087
ENSG00000068400 E030 11.4324006 0.0017426313 5.747021e-10 8.916190e-09 X 48988199 48988651 453 - 1.388 0.785 -2.202
ENSG00000068400 E031 144.9139955 0.0008351921 7.483614e-02 1.512652e-01 X 48989611 48989710 100 - 2.157 2.095 -0.208
ENSG00000068400 E032 99.9198070 0.0069897864 2.095017e-01 3.379466e-01 X 48989835 48989882 48 - 2.002 1.932 -0.236
ENSG00000068400 E033 86.1616675 0.0079114820 1.967151e-01 3.221456e-01 X 48989972 48990003 32 - 1.942 1.865 -0.259
ENSG00000068400 E034 92.6364896 0.0032415473 3.278642e-02 7.737950e-02 X 48990685 48990732 48 - 1.991 1.889 -0.346
ENSG00000068400 E035 104.6018317 0.0055136323 5.217959e-02 1.130391e-01 X 48990926 48991009 84 - 2.045 1.943 -0.343
ENSG00000068400 E036 104.0648172 0.0010667263 3.651657e-03 1.215937e-02 X 48991010 48991102 93 - 2.053 1.937 -0.387
ENSG00000068400 E037 55.7389812 0.0004383084 2.070837e-01 3.350447e-01 X 48991103 48991110 8 - 1.752 1.687 -0.220
ENSG00000068400 E038 0.3332198 0.0291833373 5.771981e-01   X 48991111 48991386 276 - 0.170 0.087 -1.111
ENSG00000068400 E039 62.1390110 0.0005571592 1.738180e-01 2.931556e-01 X 48993428 48993447 20 - 1.801 1.734 -0.226
ENSG00000068400 E040 132.5538514 0.0003436154 4.043748e-03 1.326469e-02 X 48993448 48993578 131 - 2.147 2.051 -0.322
ENSG00000068400 E041 70.1618555 0.0004016286 1.744384e-02 4.592070e-02 X 48997250 48997258 9 - 1.879 1.771 -0.363
ENSG00000068400 E042 135.8655466 0.0002256438 2.073251e-06 1.607281e-05 X 48997259 48997357 99 - 2.193 2.041 -0.508
ENSG00000068400 E043 3.8813878 0.0041469228 8.323616e-03 2.460153e-02 X 48997948 48998153 206 - 0.886 0.507 -1.596
ENSG00000068400 E044 75.2406917 0.0003705878 2.837340e-04 1.313729e-03 X 48998154 48998180 27 - 1.942 1.787 -0.523
ENSG00000068400 E045 0.6172225 0.4269564539 2.352175e-01 3.686159e-01 X 48998974 48999237 264 - 0.385 0.087 -2.681
ENSG00000068400 E046 103.6478430 0.0002699638 7.322397e-07 6.263064e-06 X 48999238 48999299 62 - 2.093 1.913 -0.605
ENSG00000068400 E047 0.1515154 0.0430204074 2.286226e-01   X 48999300 48999398 99 - 0.170 0.000 -10.425
ENSG00000068400 E048 103.0789814 0.0003195683 2.428601e-03 8.548067e-03 X 48999438 48999504 67 - 2.047 1.934 -0.381
ENSG00000068400 E049 4.7124146 0.0076137645 7.527131e-01 8.388289e-01 X 49000566 49000685 120 - 0.762 0.716 -0.188
ENSG00000068400 E050 0.3697384 0.0247812972 4.987792e-01 6.351778e-01 X 49000686 49000689 4 - 0.000 0.159 8.928
ENSG00000068400 E051 2.1056418 0.0071451994 2.842504e-01 4.244700e-01 X 49000861 49000959 99 - 0.588 0.406 -0.889
ENSG00000068400 E052 2.5088957 0.0059004452 4.689396e-04 2.041295e-03 X 49001184 49001313 130 - 0.829 0.276 -2.696
ENSG00000068400 E053 61.5627280 0.0004219318 9.051967e-02 1.759489e-01 X 49002188 49002264 77 - 1.804 1.721 -0.280