ENSG00000068383

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000342652 ENSG00000068383 HEK293_OSMI2_2hA HEK293_TMG_2hB INPP5A protein_coding protein_coding 20.21025 25.67918 19.30264 2.056523 0.3949294 -0.4116152 0.5798934 0.1924246 1.2604288 0.1042901 0.08524994 2.64985932 0.02901667 0.0071000 0.06526667 0.05816667 0.0001842707 0.0001842707 FALSE  
ENST00000368594 ENSG00000068383 HEK293_OSMI2_2hA HEK293_TMG_2hB INPP5A protein_coding protein_coding 20.21025 25.67918 19.30264 2.056523 0.3949294 -0.4116152 11.2419983 11.0577676 12.7507762 1.1645326 1.69110402 0.20535183 0.56444167 0.4369333 0.65886667 0.22193333 0.1732920390 0.0001842707 FALSE  
ENST00000445580 ENSG00000068383 HEK293_OSMI2_2hA HEK293_TMG_2hB INPP5A protein_coding protein_coding 20.21025 25.67918 19.30264 2.056523 0.3949294 -0.4116152 1.1435218 4.9118574 0.0000000 2.6716592 0.00000000 -8.94305906 0.04022500 0.1810667 0.00000000 -0.18106667 0.1690341924 0.0001842707 FALSE  
ENST00000487614 ENSG00000068383 HEK293_OSMI2_2hA HEK293_TMG_2hB INPP5A protein_coding processed_transcript 20.21025 25.67918 19.30264 2.056523 0.3949294 -0.4116152 1.1292191 2.5961321 0.3815497 0.3250824 0.09713168 -2.73464282 0.05343750 0.1042000 0.01990000 -0.08430000 0.0001879144 0.0001842707 FALSE  
MSTRG.4833.3 ENSG00000068383 HEK293_OSMI2_2hA HEK293_TMG_2hB INPP5A protein_coding   20.21025 25.67918 19.30264 2.056523 0.3949294 -0.4116152 1.8749265 1.6836297 1.8032802 1.6836297 1.53766529 0.09848343 0.10069583 0.0565000 0.09550000 0.03900000 0.6486270265 0.0001842707 FALSE  
MSTRG.4833.4 ENSG00000068383 HEK293_OSMI2_2hA HEK293_TMG_2hB INPP5A protein_coding   20.21025 25.67918 19.30264 2.056523 0.3949294 -0.4116152 3.5586816 5.0759946 2.5476215 1.4840282 0.21075318 -0.99172716 0.17574583 0.2083667 0.13166667 -0.07670000 0.7364989953 0.0001842707 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000068383 E001 5.9501108 0.0345772327 2.139785e-03 7.658282e-03 10 132537787 132537848 62 + 1.022 0.592 -1.710
ENSG00000068383 E002 6.9893868 0.0359447234 2.378860e-04 1.124559e-03 10 132537849 132537921 73 + 1.108 0.592 -2.022
ENSG00000068383 E003 28.7180362 0.0113899368 1.211603e-06 9.885633e-06 10 132537922 132538138 217 + 1.634 1.278 -1.226
ENSG00000068383 E004 40.3699171 0.0005911539 7.007960e-05 3.804336e-04 10 132538139 132538171 33 + 1.702 1.537 -0.560
ENSG00000068383 E005 42.3663618 0.0045009792 5.581493e-03 1.750454e-02 10 132607915 132607925 11 + 1.702 1.582 -0.406
ENSG00000068383 E006 59.5341004 0.0026176999 1.997856e-03 7.219191e-03 10 132607926 132607956 31 + 1.839 1.735 -0.353
ENSG00000068383 E007 112.4884685 0.0002967750 3.059613e-04 1.403677e-03 10 132645868 132645968 101 + 2.092 2.026 -0.222
ENSG00000068383 E008 130.7571827 0.0002735556 4.050412e-01 5.487259e-01 10 132650418 132650505 88 + 2.107 2.135 0.093
ENSG00000068383 E009 126.7311088 0.0002957981 9.648804e-02 1.850926e-01 10 132690392 132690455 64 + 2.108 2.110 0.005
ENSG00000068383 E010 152.1073613 0.0002119964 1.157439e-01 2.138751e-01 10 132697816 132697919 104 + 2.183 2.192 0.029
ENSG00000068383 E011 133.6324853 0.0028876668 6.115108e-02 1.285681e-01 10 132708313 132708365 53 + 2.141 2.118 -0.079
ENSG00000068383 E012 89.5887971 0.0051621282 5.599183e-01 6.879950e-01 10 132710337 132710347 11 + 1.945 1.963 0.060
ENSG00000068383 E013 170.5044200 0.0049750779 7.766564e-02 1.557118e-01 10 132710348 132710456 109 + 2.247 2.220 -0.091
ENSG00000068383 E014 158.2278625 0.0036147740 6.499283e-03 1.992120e-02 10 132726821 132726905 85 + 2.231 2.173 -0.195
ENSG00000068383 E015 21.7151622 0.0222117816 8.700181e-12 1.829936e-10 10 132726906 132727349 444 + 0.694 1.562 3.168
ENSG00000068383 E016 157.5810338 0.0002958985 4.142520e-03 1.354203e-02 10 132749517 132749612 96 + 2.215 2.187 -0.094
ENSG00000068383 E017 140.5464521 0.0002880749 6.483906e-02 1.347745e-01 10 132749771 132749845 75 + 2.154 2.152 -0.006
ENSG00000068383 E018 0.6599951 0.0173621719 5.165482e-02 1.121035e-01 10 132753773 132753972 200 + 0.000 0.359 12.044
ENSG00000068383 E019 115.7219697 0.0003741054 1.186002e-02 3.319561e-02 10 132765773 132765823 51 + 2.084 2.054 -0.100
ENSG00000068383 E020 112.4564378 0.0002798489 2.000296e-02 5.149549e-02 10 132765824 132765846 23 + 2.067 2.043 -0.081
ENSG00000068383 E021 172.9518441 0.0002746031 4.556261e-02 1.012267e-01 10 132777671 132777782 112 + 2.242 2.242 -0.002
ENSG00000068383 E022 0.7406253 0.0156623465 1.144711e-02 3.222799e-02 10 132777783 132777877 95 + 0.422 0.000 -12.706
ENSG00000068383 E023 138.3380446 0.0002504988 2.448374e-02 6.082072e-02 10 132780849 132780917 69 + 2.155 2.141 -0.046
ENSG00000068383 E024 105.7507202 0.0002699327 8.111582e-01 8.801972e-01 10 132781861 132781897 37 + 2.004 2.049 0.151
ENSG00000068383 E025 99.7862174 0.0003657862 5.600593e-01 6.880993e-01 10 132781898 132781948 51 + 1.966 2.040 0.249
ENSG00000068383 E026 830.8704123 0.0064140595 1.684886e-10 2.861722e-09 10 132782037 132783480 1444 + 2.759 3.015 0.852